Patents Represented by Attorney Donald J. Perrella

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  • Assay for hepatitis A antigen
    Patent number: 4293538
    Abstract: Liquid containing hepatitis A antibody is adsorbed on a surface. The surface is then coated with a proteinaceous material and incubated in the presence of the sample to form a complex of hepatitis A antigen and hepatitis A antibody. The complex is incubated again in the presence of excess radioactively labelled hepatitis A antibody, and the resulting radionuclide is measured.
    Type: Grant
    Filed: April 20, 1979
    Date of Patent: October 6, 1981
    Assignee: Merck & Co. Inc.
    Inventors: William J. McAleer, William M. Hurni, William J. Miller
  • Surfactant assay
    Patent number: 4292041
    Abstract: Thin layer chromatography is used to separate various surfactants. The support medium is silica gel on a glass or acrylamide plate. The developing solvent is chloroform/methanol/water. After drying, the surfactants are detected at extremely low levels with iodine vapor, rhodamine 6G in methanol or phosphomolybdic acid in ethanol/ether, or radiolabelled surfactant. A method is given for the separation of surfactants from proteins or glycoproteins or lipoproteins or polysaccharides, or lipopolysaccharides.
    Type: Grant
    Filed: November 2, 1979
    Date of Patent: September 29, 1981
    Assignee: Merck & Co., Inc.
    Inventor: W. Wardle Fullerton
  • Bacterial or bacterial antibody assay
    Patent number: 4288539
    Abstract: Automated tests to evaluate the antibody titer of a sample by incubating a test sample, bacteria, and complement, and detecting bacterial growth in the incubated mixture, and to identify bacteria and its titer in a sample by incubating a test sample, bacterial antiserum, and complement, and detecting inhibition of bacterial growth in the incubated mixture. The automated tests lend themselves to diagnostic use and may be provided in the form of diagnostic test kits.
    Type: Grant
    Filed: February 28, 1979
    Date of Patent: September 8, 1981
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Henry Z. Markus, Roy A. Machlowitz
  • Vaccine for dental caries
    Patent number: 4287173
    Abstract: A vaccine against dental caries is prepared from capsular polysaccharides (one or more strains), of Streptococcus pneumoniae.
    Type: Grant
    Filed: September 24, 1979
    Date of Patent: September 1, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Dennis J. Carlo, Jesse J. Jackson, Thomas H. Stoudt
  • E. coli enterotoxin vaccine for veterinary and human use
    Patent number: 4285931
    Abstract: A vaccine against E. coli caused diarrhea is prepared from an isolate of the homogeneous heat-labile enterotoxin of human strain MB3353 of Escherichia coli, ATCC 31361, or of the porcine strain MB3708, ATCC 31362. The toxin, which is a protein, is a low molecular weight species of 10,000-13,000.
    Type: Grant
    Filed: February 15, 1980
    Date of Patent: August 25, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Guadalupe A. Limjuco, Yashwant D. Karkhanis, Dennis J. Carlo
  • Polysaccharide and bacterial fermentation process for its preparation
    Patent number: 4286059
    Abstract: A process for producing a heteropolysaccharide by a bacterial fermentation procedure in which a species of bacteria or a mutant thereof is incubated in a fermentation medium which contains a carbon source, preferably a hydrolyxed starch, a source of magnesium ions, a source of phosphorous, a source of nitrogen and water with the incubation taking place at a temperature of about 28.degree. to about 35.degree. C.
    Type: Grant
    Filed: November 4, 1977
    Date of Patent: August 25, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth Suk Kang, George T. Veeder, III, Danny D. Richey
  • Lyophilization process for live viral compositions
    Patent number: 4273762
    Abstract: Lyophilization time of live viral compositions is reduced and output per lyophilization unit is increased by lyophilizing a reduced volume of a more concentrated viral composition.
    Type: Grant
    Filed: December 3, 1979
    Date of Patent: June 16, 1981
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Henry Z. Markus
  • Plow protective member
    Patent number: 4271225
    Abstract: A protective member for the plows of an automatic pinspotter bowling machine is formed of an outer layer of a wear-resistant ball-contacting member, an intermediate strengthening member, and an inner layer of cushioning material.
    Type: Grant
    Filed: December 13, 1978
    Date of Patent: June 2, 1981
    Inventor: Thomas M. Camilleri
  • Meningitis vaccine
    Patent number: 4264764
    Abstract: A high molecular weight capsular polysaccharide from H. influenza type b is an effective immunogenic agent against infection caused by the H. influenza type b bacterium.
    Type: Grant
    Filed: September 24, 1979
    Date of Patent: April 28, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Peter J. Kniskern, Arpi Hagopian, Dennis J. Carlo
  • Sparger for cell culture system
    Patent number: 4264739
    Abstract: A sparger for mass cell culture systems is formed from an elongated tube having a plurality of ports.
    Type: Grant
    Filed: January 5, 1979
    Date of Patent: April 28, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Roy Grabner, Edgar Scattergood, Miguel O. Villarejos
  • Viral liposome particle
    Patent number: 4261975
    Abstract: The outer membrane of influenza virus is attached to a liposome by two different techniques. In addition, one of the techniques allows the entrapment of intact virus, usually one virus per liposome. The techniques can be performed with either influenza virus A or B.
    Type: Grant
    Filed: September 19, 1979
    Date of Patent: April 14, 1981
    Assignee: Merck & Co., Inc.
    Inventors: W. Wardle Fullerton, Bohdan Wolanski
  • Immunologic adjuvant thio glycoside compounds and compositions
    Patent number: 4259324
    Abstract: Compounds of the formulae Y--R wherein Y is 1-thio-.beta.-L-fucose, 1-thio-.beta.-D-galactose or 1-thio-.beta.-lactose and R is 2-(1-adamantyl)ethyl, 3-[(p-tetrafluorophenethyl)phenyl]propyl, 6-(5-cholesten-3.beta.-yloxy)hex-3-ynl, oleyl, or hexadecyl are useful immunologic adjuvants in vaccines.
    Type: Grant
    Filed: July 31, 1979
    Date of Patent: March 31, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Mitree M. Ponpipom, Tsung-Ying Shen, Robert L. Bugianesi
  • Cephalosporin compounds
    Patent number: 4258040
    Abstract: Novel cephalosporin compounds having a 3'-.alpha.-methyl, a 3-aryl or 3-heterocycle substituent are prepared by total synthesis. The novel cephalosporin compounds are active against gram-negative and gram-positive microorganisms.
    Type: Grant
    Filed: May 4, 1978
    Date of Patent: March 24, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Ronald W. Ratcliffe
  • Immunologically active dipeptidyl saccharides and methods of preparation
    Patent number: 4256735
    Abstract: 2-Amino-2-deoxy-glycoses of the general structural formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl (1-7C), substituted alkyl (1-7C), phenyl, substituted phenyl, benzyl, or substituted benzyl;R.sub.2 is alkyl, substituted alkyl, phenyl, or substituted phenyl;R.sub.3 is H or lower alkyl (1-10C) with the proviso that when the aminoglycose has the 2-amino-2-deoxy-D-glucose configuration, R.sub.3 cannot be H;R.sub.4 and R.sub.5 are same or different and are H, aliphatic or aromatic acyl (2-21C) or substituted acyl (2-21C);R.sub.6 is H, or R.sub.6 -R.sub.7 together is --CH.sub.2 --CH.sub.2 --CH.sub.2 --,R.sub.7 is H, alkyl (1-7C), hydroxymethyl, mercaptomethyl, benzyl, or substituted benzyl;R.sub.8 and R.sub.9 each is carboxyl, esterified carboxyl (1-7C), amidated carboxyl, or mono- or di-alkyl-(1-3C)-amidated carboxyl;Provided that when R.sub.
    Type: Grant
    Filed: January 29, 1979
    Date of Patent: March 17, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Philippe L. Durette, Tsung-Ying Shen
  • Process for recording data in the leucocyte migration inhibition assay
    Patent number: 4254219
    Abstract: A method of detecting and quantitating the migration of leucocytes in agar gel by (1) fixing the cells; (2) staining them with Ponceau S or a similar dye; (3) destaining; and (4) dissolving the gel by gentle heating in the destaining solution. The stained cells remain adhered to the glass surface of the culture dish, and the cells can be read through a projection microscope or photographed for a permanent record.
    Type: Grant
    Filed: September 21, 1979
    Date of Patent: March 3, 1981
    Assignee: Merck & Co., Inc.
    Inventor: W. Wardle Fullerton
  • Shock absorber
    Patent number: 4251064
    Abstract: A shock absorber having controlled, continuous, adjustable resistance in both directions is obtained by means of a slide piston passing through a fixed collar and through two movable collars and elastic compression means abutting each movable collar.
    Type: Grant
    Filed: March 29, 1979
    Date of Patent: February 17, 1981
    Assignee: Sycam Advanced Technology Corp.
    Inventor: Thomas M. Camilleri
  • Method of obtaining an antigenic fraction from Bordetella bronchiseptica
    Patent number: 4250265
    Abstract: A sub-cellular antigenic fraction of Bordetella bronchiseptica protects against the incidence and severity of swine atropic rhinitis.
    Type: Grant
    Filed: October 15, 1979
    Date of Patent: February 10, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Dennis J. Carlo, Arpi Hagopian, Peter J. Kniskern
  • Flour compositions
    Patent number: 4244980
    Abstract: Yeast-raised dough products containing 0-60% hard flour, 0-100% bleached soft wheat flour, from 0-70% bleached clear flour and, based on total amount of bleached soft wheat flour and bleached clear flour, from 0.20-1.00 part of sodium calcium alginate per 100 parts of bleached soft wheat flour and/or bleached clear flour.
    Type: Grant
    Filed: May 10, 1977
    Date of Patent: January 13, 1981
    Assignees: Merck & Co., Inc., DCA Food Industries, Inc.
    Inventors: Leonard G. Fischer, Peter Kovacs, Alvin W. Russell, John E. Vey
  • Automated virus harvesting
    Patent number: 4242457
    Abstract: Automated means are provided to harvest virus at a time when the yield is optimized and store the harvest with minimum loss thereby eliminating difficulties when the optimum yield time does not fall within normal working hours, enhancing sterility by limiting human contact and enhancing stability of the product.
    Type: Grant
    Filed: February 21, 1979
    Date of Patent: December 30, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, William M. Hurni
  • Hepatitis B antigen
    Patent number: 4242324
    Abstract: An improved process for the preparation of hepatitis B antigen by subjecting plasma of hepatitis B donors to isopycanic banding wherein the step gradient is NaBr. Faster and more economical processing is obtained by multiple loading of the step gradient, either NaBr or conventional gradients.
    Type: Grant
    Filed: April 4, 1979
    Date of Patent: December 30, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth