Patents Represented by Attorney, Agent or Law Firm Doreen Y. Trujillo
  • Combined meningitis vaccine
    Patent number: 6251401
    Abstract: A combined vaccine for bacterial meningitis comprises Hib and MenC oligosaccharide conjugates.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: June 26, 2001
    Assignee: Chiron S.p.A.
    Inventors: Costante Ceccarini, Paolo Costantino, Sandro D'Ascenzi, Francesco Norelli, Aldo Giannozzi
  • HCV NS3 protein fragments having helicase activity and improved solubility
    Patent number: 6194140
    Abstract: The Hepatitis C Virus (HCV) NS3 protein contains amino acid motifs of a serine proteinase, a nucleotide triphosphatase (NTPase), and an RNA helicase. A carboxy fragment of the HCV NS3 protein was purified and possessed RNA helicase activity. Deletions from the amino terminus resulted in the protein becoming soluble. Deletions from the carboxy terminus do not result in a loss of helicase activity until at least 50 amino acids are deleted. The helicase activity requires ATP and divalent cations such as Mg2+ and Mn2+. The helicase activity was blocked by monoclonal antibody specific to the HCV NS3 protein.
    Type: Grant
    Filed: September 15, 1995
    Date of Patent: February 27, 2001
    Assignee: Chiron Corporation
    Inventors: Michael Houghton, Qui-Lim Choo, Jang Han, Joonho Choe
  • HCV genomic sequences for diagnostics and therapeutics
    Patent number: 6190864
    Abstract: The present application features nucleic acid, peptide and antibody compositions relating to genotypes of hepatitis C virus and methods of using such compositions for diagnostic and therapeutic purposes.
    Type: Grant
    Filed: April 1, 1994
    Date of Patent: February 20, 2001
    Assignee: Chiron Corporation
    Inventors: Tai-An Cha, Eileen Beall, Bruce Irvine, Janice Kolberg, Michael S. Urdea
  • Immunogenic detoxified mutants of cholera toxin and of the toxin LT, their preparation and their use for the preparation of vaccines
    Patent number: 6149919
    Abstract: An immunogenic detoxified protein comprising the amino acid sequence of subunit A of cholera toxin (CT-A) or subunit A of an Escherichia coli heat labile toxin (LT-A) or a fragment thereof wherein one or more amino acids at, or in positions corresponding to Val-53, Ser-63, Val-97, Tyr-104 or Pro-106 are replaced with another amino acid or deleted. Examples of specific replacements include Val-53-Asp, Val-53-Glu, Val-53-Tyr, Ser-63-Lys, Val-97-Lys, Val-97-Tyr, Tyr-104-Lys, Tyr-104-Asp, Tyr-104-Ser, Pro-106-Ser. The immunogenic detoxified protein is useful as vaccine for Vibrio cholerae or an enterotoxigenic strain of Escherichia coli and is produced by recombinant DNA means by site-directed mutagenesis.
    Type: Grant
    Filed: March 25, 1997
    Date of Patent: November 21, 2000
    Assignee: Biocine S.p.A.
    Inventors: Mario Domenighini, Rino Rappuoli, Mariagrazia Pizza, Wim Hol
  • Chlamydia trachomatis serotype D proteins
    Patent number: 6096519
    Abstract: A plasmid isolated from Clamydia trachomatis is described, which comprises 8 genes encoding proteins useful in the formulation of vaccines or diagnostic test for determining the bacterium or specific antibodies generated during C. trachomatis infections; in particular the recombinant fusion MS2-pgp3D protein is described comprising polypeptidic sequences encoded by pCT and immunogenic in the course of infections in man. A method for preparing said protein in E. coli further described.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: August 1, 2000
    Assignee: Sclavo SpA
    Inventors: Givlio Ratti, Maurizio Comanducci, Mario F. Tecce, Marzia M. Giuliani
  • T cell activation
    Patent number: 6074635
    Abstract: Methods for activating T cells in the absence of antigen, and compositions for effecting the same, are described.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: June 13, 2000
    Assignee: Chiron Corporation
    Inventor: Sergio Abrignani
  • HCV genomic sequences for diagnostics and therapeutics
    Patent number: 6071693
    Abstract: The present application features nucleic acid, peptide and antibody compositions relating to genotypes of hepatitis C virus and methods of using such compositions for diagnostic and therapeutic purposes.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: June 6, 2000
    Assignee: Chiron Corporation
    Inventors: Tai-An Cha, Eileen Beall, Bruce Irvine, Janice Kolberg, Michael S. Urdea
  • Interleukin-5 specific recombinant antibodies
    Patent number: RE39548
    Abstract: An effective anti-IL-5 recombinant antibody molecule comprising heavy and/or light chain antigen-binding residues from a donor antibody.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: April 3, 2007
    Assignee: Celltech R&D Limited
    Inventors: Mark William Bodmer, Diljeet Singh Athwal, John Spencer Emtage