Patents Represented by Attorney Douglas E. Reedich
  • Patent number: 5266575
    Abstract: 2-Ethyl 1H-imidazo[4,5-c]quinolin-4-amines, which are active as immunomodulators and antiviral agents, and intermediates in the preparation of such compounds, pharmaceutical compositions and pharmacological methods of use.
    Type: Grant
    Filed: November 6, 1991
    Date of Patent: November 30, 1993
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: John F. Gerster, Charles E. Weeks
  • Patent number: 5264219
    Abstract: Polymer blends containing a very low density polyethylene copolymer of ethylene and 1-butene, 1-hexene, or 1-octene and about 15 to about 600 parts by weight of a linear low density polyethylene copolymer of ethylene and 1-octene, based on 100 parts by weight of the very low density polyethylene copolymer.
    Type: Grant
    Filed: August 7, 1992
    Date of Patent: November 23, 1993
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Kristin J. Godbey, Philip G. Martin
  • Patent number: 5244677
    Abstract: The invention deals with devices, in particular with bandage strips, for a transdermal delivery of drugs to patients, whereby the drug formulations include highly viscous preparations, topical solutions of a low viscosity and micro-emulsions of a low viscosity containing the drugs. Depending on the consistency of the medium containing the drug, the drug formulation is stored in a reservoir, consisting, e.g., of a punched out cavity or of an absorbent piece of material, which is encased or supported by a carrier element (a foamed material piece or a non-woven fleece tape) adhering to the skin by means of a skin-compatible adhesive, whereby specially formed protective films are applied at the filling and delivery side during the storage of the device to prevent a lateral migration, and whereby during its use, the device can be refilled with dosed amounts by the patient without requiring a removal of the device from the skin surface to be treated (FIG. 2).
    Type: Grant
    Filed: November 20, 1992
    Date of Patent: September 14, 1993
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Karl W. Kreckel, Horst-Georg Zerbe
  • Patent number: 5238944
    Abstract: Pharmaceutical formulations and adhesive-coated sheet materials for the topical and/or transdermal delivery of 1-isobutyl-1H-imidazo[4,5-c]-quinolin-4-amine, including creams, ointments and pressure-sensitive adhesive compositions. Pharmacological methods of using the formulations and the adhesive-coated sheet materials of the invention in the treatment of viral infections.
    Type: Grant
    Filed: March 3, 1992
    Date of Patent: August 24, 1993
    Assignee: Riker Laboratories, Inc.
    Inventors: Steven M. Wick, Helen J. Schultz, Gregory R. Nelson, Amit K. Mitra, Stephen M. Berge
  • Patent number: 5237070
    Abstract: Novel compounds which are 2,6-di-t-butylphenols substituted on the 4 position by an anilino group, which anilino group is substituted by a carboxyl substituent, a tetrazolyl substituent or an N-methyltetrazolyl substituent, are useful antiallergic agents. Pharmaceutical compositions containing and pharmacological methods of using such compounds are also disclosed, as are synthetic intermediates for preparing such compounds. Certain of the synthetic intermediates also exhibit useful antiallergic activity.
    Type: Grant
    Filed: May 16, 1991
    Date of Patent: August 17, 1993
    Assignee: Riker Laboratories, Inc.
    Inventor: Robert A. Scherrer
  • Patent number: 5225183
    Abstract: A self-propelling aerosol formulation which may be free from CFC's which comprises a medicament, 1,1,1,2-tetrafluoroethane, a surface active agent and at least one compound having a higher polarity than 1,1,1,2-tetrafluoroethane.
    Type: Grant
    Filed: January 30, 1991
    Date of Patent: July 6, 1993
    Assignee: Riker Laboratories, Inc.
    Inventors: Tarlochan S. Purewal, David J. Greenleaf
  • Patent number: 5225201
    Abstract: A salsalate tablet containing hydroxypropyl cellulose as a binder substantially uniformly dispersed in the tablet. The tablet has good mechanical strength, exhibits a relatively low incidence of capping, and does not require a discrete outer film coating to prevent esophageal irritation.
    Type: Grant
    Filed: August 23, 1991
    Date of Patent: July 6, 1993
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Joseph M. Beaurline
  • Patent number: 5223261
    Abstract: A pressure-sensitive adhesive sheet material for delivering estradiol to skin, the sheet material comprising a backing with a layer of a pressure-sensitive adhesive adjacent thereto, said pressure-sensitive adhesive layer comprising a pressure-sensitive adhesive polymer, two or more skin penetration-enhancing ingredients and estradiol. The sheet material is useful for systemic treatment of conditions associated with estradiol deficiency. Methods of using such adhesive sheet material are also described.
    Type: Grant
    Filed: December 31, 1991
    Date of Patent: June 29, 1993
    Assignee: Riker Laboratories, Inc.
    Inventors: Gregory R. Nelson, Horst-Georg Zerbe, Cheryl L. Moore, Steven M. Wick
  • Patent number: 5192548
    Abstract: A sheet material comprising discrete depressions which are at least partially filled with micronized medicament and which are useful as or in a drug delivery device. This sheet material is useful in devices which provide for aerosolization of the medicament, for delivery to a patient by inhalation.
    Type: Grant
    Filed: April 30, 1990
    Date of Patent: March 9, 1993
    Assignee: Riker Laboratoires, Inc.
    Inventors: David J. Velasquez, Peter D. Hodson, Clyde D. Calhoun
  • Patent number: 5190795
    Abstract: A method of applying a layer of exogenous inorganic oxide to a metal article which method involves heating a coating of a coupling agent for a temperature and for a time sufficient to convert the coating to a layer of exogenous inorganic oxide. Also a method of adhering a metal article to an adhesive and/or a composite and a method of adhering a metal article to a substrate.
    Type: Grant
    Filed: February 11, 1991
    Date of Patent: March 2, 1993
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Scott R. Culler
  • Patent number: 5175296
    Abstract: A process and intermediates for preparing 1-substituted-1H-imidazo[4,5-c]quinolin-4-amines. The process involves reacting a 1-substituted-1H-imidazo[4,5-c]quinoline-5N-oxide with an isocyanate and hydrolysing the product thereof. Also, a process for preparing the intermediates is disclosed.
    Type: Grant
    Filed: March 1, 1991
    Date of Patent: December 29, 1992
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: John F. Gerster
  • Patent number: 5166343
    Abstract: Substituted 1,2,4-triazolo[1,5-c]pyrimido[1,4]azines have been found to have potent bronchodilator activity. Pharmacological methods for inducing bronchodilation using such compounds, pharmaceutical compositions containing such compounds, and synthetic intermediates for preparing such compounds are also described.
    Type: Grant
    Filed: November 5, 1991
    Date of Patent: November 24, 1992
    Assignee: Riker Laboratories, Inc.
    Inventor: James J. Wade
  • Patent number: 5147938
    Abstract: Pressure-sensitive acrylate-based adhesive copolymers comprising polymerized acrylate units and polymerized fluorochemical surfactant units and a process for preparing same. Also prepolymeric compositions comprising the monomeric components of an acrylate-based pressure-sensitive adhesive and a polymerizable fluorochemical surfactant. The prepolymeric compositions generally have surface energy lower than that of the monomeric components of the acrylate-based pressure sensitive adhesive alone. Also, the adhesive compositions better maintain adhesive properties when aged when compared to corresponding adhesive compositions involving non-polymerizable fluorochemical surfactants.
    Type: Grant
    Filed: April 2, 1991
    Date of Patent: September 15, 1992
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Douglas H. Kuller
  • Patent number: 5118494
    Abstract: Pharmaceutical suspension aerosol formulations using one or more perfluorinated carboxylic acids or esters thereof as surface-active dispersing agents and 1,1,1,2-tetra-fluorethane or 1,1,1,2,3,3,3-heptafluoropropane as the propellant are described.
    Type: Grant
    Filed: March 13, 1991
    Date of Patent: June 2, 1992
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Robert K. Schultz, Stephen N. Quessy
  • Patent number: 5115803
    Abstract: An actuator for use in inhalation therapy comprising a nozzle block having an orifice and at least one bleed hole, a conduit chamber, a deagglomeration chamber, and an exit chamber, together configured as a means for increasing the respirable fraction of an aerosol formulation. This invention also provides an actuator as described above in combination with an aerosol canister comprising a pharmaceutical formulation, and a method of administering a pharmaceutical formulation via inhalation therapy. The actuator finds particular use in improving the respirable fraction of drug in aerosol formulations. The actuator also retains non-respirable particles, thus reducing the amount of drug that is inadvertently administered orally.
    Type: Grant
    Filed: August 31, 1990
    Date of Patent: May 26, 1992
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Constantinos Sioutas
  • Patent number: 5113860
    Abstract: Non-invasive transmucosal drug monitoring methods involving devices comprising an acid-functional polymeric resin dispersed substantially throughout a hydrophobic support matrix. The device when adhered to a mucosal surface can absorb some chemicals in amounts proportional to the actual blood levels of the chemicals.
    Type: Grant
    Filed: March 15, 1991
    Date of Patent: May 19, 1992
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: Roy L. McQuinn
  • Patent number: 5108433
    Abstract: This invention provides improved prosthetic devices for the replacement of a ligament or a tendon. The tension borne by the prosthetic ligament or tendon can be readily increased or decreased without disturbing the attachment of the device to bone and without removal of the prosthetic ligament or tendon from the other components of the device.
    Type: Grant
    Filed: February 22, 1991
    Date of Patent: April 28, 1992
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Steven J. May, Craig L. Van Kampen, David L. Butler, Edward S. Grood, Steven D. Hoffman, Frank R. Noyes
  • Patent number: 5103037
    Abstract: Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by a carbamyl or acylamino group, which carbamyl or acylamino group is substituted by a group which includes an acidic substituent are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents. Pharmacological methods for using such compounds and synthetic intermediates for preparing such compounds are also disclosed.
    Type: Grant
    Filed: May 13, 1991
    Date of Patent: April 7, 1992
    Assignee: Riker Laboratories, Inc.
    Inventors: Robert A. Scherrer, Mark A. Rustad
  • Patent number: 5100320
    Abstract: A cartridge made of a material that does not to a significant extend absorb polar components from a dental composition stored therein. The force required to extrude a dental composition from the cartridge increases less over time in a cartridge of the invention than in a cartridge of the same configuration made of conventionally employed materials such as nylon-6.
    Type: Grant
    Filed: January 16, 1990
    Date of Patent: March 31, 1992
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Thomas W. Martin, Jeffrey S. Steinmetz, Scott R. Culler
  • Patent number: D334057
    Type: Grant
    Filed: June 27, 1991
    Date of Patent: March 16, 1993
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: David C. Byram