Patents Represented by Attorney Edward H. Gorman, Jr.
  • Patent number: 4552697
    Abstract: A novel compound is disclosed having the structure ##STR1## in which R is H or lower alkyl, R* is intermediate alkyl, and X is halogen or pseudohalogen. Also disclosed is a method for preparing the compound, the method including the steps of reacting (intermediate alkyl)benzene (I) with succinic anhydride to form (intermediate alkyl)-benzoylpropionic acid (II), successively reducing and dehydrating (II) to form 7-(intermediate alkyl)-1-tetralone (III), alkylating (III) to form 2-hydroxy(lower alkylidene)-7-(intermediate alkyl)-1-tetralone (IV), acrylating (IV) to form 2-acyloxy(lower alkylidene)-7-(intermediate alkyl)-1-tetralone (V), reacting (V) in the presence of an cycloalkene to form 7(intermediate alkyl)-2-(lower alkyl)-1-naphthol (VI), reacting (VI) with a 2,6-dihaloquinone-4-haloimide to form the compound (I), and isolating it.
    Type: Grant
    Filed: May 12, 1983
    Date of Patent: November 12, 1985
    Assignee: Miles Laboratories, Inc.
    Inventors: Kin F. Yip, Steven C. Charlton
  • Patent number: 4545831
    Abstract: A method is described for transferring a thin tissue section affixed to a substrate by a first pressure-sensitive adhesive layer to a microscope slide which supports a second pressure-sensitive adhesive layer of polymerizable material. The tissue section is contacted to the second adhesive layer to form a laminate. Following polymerization of the second layer to form a positive bond between the tissue section and microscope slide, the substrate and first adhesive layer are completely removed to expose the tissue section, now affixed to the microscope slide by the polymerized second adhesive layer, for subsequent processing.
    Type: Grant
    Filed: September 13, 1982
    Date of Patent: October 8, 1985
    Assignee: The Mount Sinai School of Medicine
    Inventor: Leonard Ornstein
  • Patent number: 4540520
    Abstract: A novel compound is disclosed having the structure ##STR1## in which R is lower alkyl and X is halogen or pseudohalogen. Also disclosed in a novel process for preparing the compound which comprises the steps of combining a compound having the structure ##STR2## in which X is a halogen or pseudohalogen, and a compound having the structure ##STR3## in which R is lower alkyl and A is lower alkylidene to produce a first reaction mixture; adjusting the pH of the first reaction mixture to at least about 8 to produce a second reaction mixture; and recovering the compound or its salt from the second reaction mixture.
    Type: Grant
    Filed: May 12, 1983
    Date of Patent: September 10, 1985
    Assignee: Miles Laboratories, Inc.
    Inventors: Steven C. Charlton, Roger L. Fleming, Authur L. Y. Lau
  • Patent number: 4532216
    Abstract: A test means, test device, and method for determining the ionic strength or specific gravity of a test sample as well as a method for making the device, are disclosed. The test means comprises a weakly acidic polyelectrolyte polymer, at least 50 percent of the carboxyl groups of which are present in the form of the salt of a quaternary ammonium ion having the structure ##STR1## in which the R substituents, same or different, are hydrogen, lower alkyl or aryl, with the proviso that at least one of R is other than hydrogen; and an indicator means capable of producing a detectable response to ion exchange between the polyelectrolyte salt and the test sample. The device comprises a carrier matrix incorporated with the test means. The method for determining the ionic strength or specific gravity comprises contacting the test sample with the test means or device and observing a detectable response.
    Type: Grant
    Filed: December 27, 1982
    Date of Patent: July 30, 1985
    Assignee: Miles Laboratories, Inc.
    Inventor: Joseph Y. Wang
  • Patent number: 4529704
    Abstract: A device for preparing a control solution for ketone analysis is disclosed, as well as a method for preparing it. The device comprises a carrier vehicle incorporated with an ester of a .beta.-ketoalkanoic acid, and a hydrolyzing substance capable of converting the ester to the corresponding .beta.-ketoalkanoic acid. The ester has the structure ##STR1## in which R is a lower alkyl group and R' is an aliphatic or cyclic group having 1 to about 7 carbon atoms. The method comprises contacting a predetermined volume of solvent with the device.
    Type: Grant
    Filed: November 25, 1981
    Date of Patent: July 16, 1985
    Assignee: Miles Laboratories, Inc.
    Inventors: Robert W. Trimmer, William I. White
  • Patent number: 4499185
    Abstract: A composition, test device and method for determining the presence of leukocytes, esterase and/or esterase activity in a test sample is disclosed. The composition comprises an ester which, when cleaved by esterolytic activity, produces a detectable response such as color formation. In addition the composition comprises the compound 3-quinuclidinol. The device is prepared by incorporating a carrier matrix, such as paper, with the composition. The method comprises contacting a test sample with the device and observing a detectable response.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: February 12, 1985
    Assignee: Miles Laboratories, Inc.
    Inventors: A. Christopher Skjold, Lonnie R. Stover, Robert W. Trimmer
  • Patent number: 4473650
    Abstract: An improved test means, device and method for determining the ionic strength or specific gravity of an aqueous sample are disclosed. The test means comprises a weakly basic polyelectrolyte polymer salt and an indicator means capable of producing a detectable response to ion exchange between the polymer salt and the test sample. The polymer salt is one in which one or more of the basic moieties of the polymer is present as the salt of a strong organic acid.
    Type: Grant
    Filed: December 27, 1982
    Date of Patent: September 25, 1984
    Assignee: Miles Laboratories, Inc.
    Inventor: Joseph Y. Wang
  • Patent number: 4461829
    Abstract: A homogeneous specific binding assay element, a method for its preparation, and a method for its use in determining a ligand in or the ligand binding capacity of a liquid sample are disclosed. The test element comprises a solid carrier incorporated with reagents for a homogeneous specific binding assay system which produces a detectable response, usually an electromagnetic radiation signal, that is a function of the presence or amount of the ligand in or the ligand binding capacity of the sample.
    Type: Grant
    Filed: September 14, 1981
    Date of Patent: July 24, 1984
    Assignee: Miles Laboratories, Inc.
    Inventor: Alfred C. Greenquist
  • Patent number: 4460684
    Abstract: A composition, test device and method for detecting the presence and/or determining concentration of glucose in a liquid test sample are disclosed. The composition is capable of determining glucose concentration over a broad range, e.g. 0 to about 5,000 milligrams (mg) of glucose per deciliter (dl) of test sample. Moreover, the composition is resistant to interference from the presence of ascorbate in the sample. The composition comprises glucose oxidase, peroxidase and, as an indicator capable of producing a detectable response in the presence of peroxidase and H.sub.2 O.sub.2, a mixture of two compounds. One has the structure ##STR1## and the other has the structure ##STR2## in which R, same of different, is H or lower alkyl, R' is aryl and R" is lower alkyl.
    Type: Grant
    Filed: August 2, 1982
    Date of Patent: July 17, 1984
    Assignee: Miles Laboratories, Inc.
    Inventor: Robert Bauer
  • Patent number: 4447529
    Abstract: A homogeneous specific binding assay element, a method for its preparation, and a method for its use in determining a ligand in or the ligand binding capacity of a liquid sample. The test element comprises a solid carrier incorporated with reagents for a homogeneous specific binding assay system which produces a detectable response, usually an electromagnetic radiation signal, that is a function of the presence or amount of the ligand in or the ligand binding capacity of the sample.
    Type: Grant
    Filed: July 6, 1981
    Date of Patent: May 8, 1984
    Assignee: Miles Laboratories, Inc.
    Inventors: Alfred C. Greenquist, Patricia A. Rupchock, Richard J. Tyhach, Bert Walter
  • Patent number: 4447526
    Abstract: A method for determining the presence of a ligand in, or the ligand binding capacity of a liquid test sample which includes the steps of (a) adding to the sample a conjugate of the ligand and a label, (b) contacting the sample with a test device containing reagents which in conjunction with the conjugate and ligand, are capable of producing a detectable response, and (c) measuring the response.
    Type: Grant
    Filed: April 20, 1981
    Date of Patent: May 8, 1984
    Assignee: Miles Laboratories, Inc.
    Inventors: Patricia A. Rupchock, Richard J. Tyhach
  • Patent number: 4442204
    Abstract: A homogeneous specific binding assay device, a method for its preparation, and a method for its use in determining a ligand, such as antigen, hapten, or antibody, in a liquid sample. The test device comprises a solid carrier member, such as a fibrous web matrix, e.g., paper, or a polymeric film or gel, incorporated with reagents for a homogeneous specific binding assay system which produces a detectable response, usually an electromagnetic radiation signal, that is a function of the presence or amount of the ligand in the sample.
    Type: Grant
    Filed: April 10, 1981
    Date of Patent: April 10, 1984
    Assignee: Miles Laboratories, Inc.
    Inventors: Alfred C. Greenquist, Bert Walter
  • Patent number: 4380585
    Abstract: An improved composition, device and method, whereby enhanced sensitivity is achieved in detecting test sample constituents such as glucose and blood. The improvement resides in the use of a broad range of compounds as enhancers for benzidine-type indicators. The enhancer tends to stabilize the blue colorform of such indicators.
    Type: Grant
    Filed: July 23, 1981
    Date of Patent: April 19, 1983
    Assignee: Miles Laboratories, Inc.
    Inventors: Thomas A. Magers, David L. Tabb
  • Patent number: 4376828
    Abstract: A test kit for the determination of bilirubin in a test sample is disclosed. It comprises a reagent capable of producing a color change or other detectable response in the presence of bilirubin, and a test mat comprising finely divided silica gel. The kit is utilized by wetting the test mat with a portion of a liquid test sample suspected of containing bilirubin, contacting the wetted mat with the reagent, causing the reagent to at least partially wet the mat and observing the appearance of a color change or other detectable response.
    Type: Grant
    Filed: August 20, 1981
    Date of Patent: March 15, 1983
    Assignee: Miles Laboratories, Inc.
    Inventors: Patricia A. Rupchock, Arthur C. Skjold
  • Patent number: 4376827
    Abstract: A composition is disclosed for determining the ionic strength or specific gravity of an aqueous test sample, the composition comprising a strongly acidic or strongly basic polyelectrolyte, a buffer substance capable of providing a pH of about 5.5, and an indicator means capable of producing a detectable response to ion exchange between the polyelectrolyte and the sample. The test device comprises a carrier matrix incorporated with the test composition, and the method for its use comprises contacting an aqueous test sample with the device and observing a detectable response.
    Type: Grant
    Filed: March 23, 1981
    Date of Patent: March 15, 1983
    Assignee: Miles Laboratories, Inc.
    Inventors: Sisto N. Stiso, Rodric H. White-Stevens
  • Patent number: 4366243
    Abstract: A stabilized composition comprising apoglucose oxidase is disclosed. In addition to the apoenzyme, a stabilizing agent comprising poly(vinyl alcohol), bovine serum albumin or mixtures thereof is included. The composition can also comprise, in addition to the apoenzyme and stabilizing agent, reagents for a homogeneous specific binding assay system capable of producing a detectable response which is a function of a ligand in, or the ligand binding capacity of a test sample, wherein the apoenzyme is itself one of the reagents in the assay system. The stabilized composition can be utilized in a test device for assaying a ligand in, or the ligand binding capacity of a liquid sample, whereby the device comprises a test device incorporated with the composition.
    Type: Grant
    Filed: April 17, 1981
    Date of Patent: December 28, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: Patricia A. Rupchock, Richard J. Tyhach
  • Patent number: 4362697
    Abstract: A test device for performing homogeneous specific binding assays is composed of a carrier matrix having incorporated therein reagents and an enhancer substance. The enhancer substance is a copolymer of vinyl pyrrolidone and a type of acrylic comonomer.
    Type: Grant
    Filed: April 20, 1981
    Date of Patent: December 7, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: David L. Tabb, Richard J. Tyhach
  • Patent number: 4340395
    Abstract: An improved composition, device and method, whereby enhanced sensitivity is achieved in detecting test sample constituents such as glucose and blood. The improvement resides in the use of a broad range of compounds as enhancers for benzidine-type indicators. The enhancer tends to stabilize the blue colorform of such indicators.
    Type: Grant
    Filed: July 23, 1981
    Date of Patent: July 20, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: Thomas A. Magers, David L. Tabb
  • Patent number: 4340393
    Abstract: An improved composition, device and method, whereby enhanced sensitivity is achieved in detecting test sample constituents such as glucose and blood. The improvement resides in the use of a broad range of compounds as enhancers for benzidine-type indicators. The enhancer tends to stabilize the blue colorform of such indicators.
    Type: Grant
    Filed: July 23, 1981
    Date of Patent: July 20, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: Thomas A. Magers, David L. Tabb
  • Patent number: 4340392
    Abstract: An improved composition, device and method, whereby enhanced sensitivity is achieved in detecting test sample constituents such as glucose and blood. The improvement resides in the use of a broad range of compounds as enhancers for benzidine-type indicators. The enhancer tends to stabilize the blue colorform of such indicators.
    Type: Grant
    Filed: July 23, 1981
    Date of Patent: July 20, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: Thomas A. Magers, David L. Tabb