Patents Represented by Attorney Edward H. Gorman, Jr.
  • Patent number: 4340394
    Abstract: An improved composition, device and method, whereby enhanced sensitivity is achieved in detecting test sample constituents such as glucose and blood. The improvement resides in the use of a broad range of compounds as enhancers for benzidine-type indicators. The enhancer tends to stabilize the blue colorform of such indicators.
    Type: Grant
    Filed: July 23, 1981
    Date of Patent: July 20, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: Thomas A. Magers, David L. Tabb
  • Patent number: 4339242
    Abstract: An improved composition, device and method, whereby enhanced sensitivity is achieved in detecting test sample constituents such as glucose and blood. The improvement resides in the use of a broad range of compounds as enhancers for benzidine-type indicators. The enhancer tends to stabilize the blue color form of such indicators.
    Type: Grant
    Filed: July 23, 1981
    Date of Patent: July 13, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: Thomas A. Magers, David L. Tabb
  • Patent number: 4339243
    Abstract: An improved composition, device and method, whereby enhanced sensitivity is achieved in detecting test sample constituents such as glucose and blood. The improvement resides in the use of a broad range of compounds as enhancers for benzidine-type indicators. The enhancer tends to stabilize the blue colorform of such indicators.
    Type: Grant
    Filed: July 23, 1981
    Date of Patent: July 13, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: Thomas A. Magers, David L. Tabb
  • Patent number: 4318709
    Abstract: A test means for determining the ionic strength or specific gravity of an aqueous test sample, the test means comprising a weakly acidic or weakly basic polyelectrolyte which is at least partially neutralized, and an indicator means capable of producing a detectable response to ion exchange between the polyelectrolyte and the sample. The test device comprises a carrier matrix incorporated with the test means, and the method for its use comprises contacting an aqueous test sample with the device and observing a detectable response.
    Type: Grant
    Filed: July 10, 1980
    Date of Patent: March 9, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: Richard D. Falb, Sisto N. Stiso, Yung-Chyung Wang, William I. White, Rodric H. White-Stevens
  • Patent number: 4318984
    Abstract: An improved composition, test device and method for detecting the presence of a sugar in a test sample are disclosed. The composition comprises a sugar oxidase, a peroxidase, a chromogen compound capable of producing a detectable response in the presence of hydrogen peroxide and peroxidase, and an enhancer compound having the structure ##STR1## in which the R substituents, same or different, are hydrogen, lower alkyl, lower alkyloxy, aryl or aryloxy; or in which two of the R substituents bound to a common atom together form a closed ring having 3 to about 6 atoms, said ring being saturated, unsaturated or aromatic. R' is hydrogen or an alkyl or alkenyl group having 1 to about 20 carbon atoms. The composition can be incorporated with a carrier matrix to form a test device. The method comprises contacting a test solution with the device and observing any detectable response.
    Type: Grant
    Filed: November 13, 1979
    Date of Patent: March 9, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: Thomas A. Magers, David L. Tabb
  • Patent number: 4310626
    Abstract: A composition, test device and method of use in determining the presence of a peroxidatively active component in a test sample are disclosed. The composition comprises an organic peroxide, an indicator capable of providing a detectable response in the presence of the peroxide and a peroxidatively active substance, and a complex of Co(III). Inclusion of the Co(III) complex renders the composition resistant to the adverse effects of ascorbate, which might be present in the test sample. The test device comprises a carrier matrix incorporated with the composition. The method comprises contacting the test sample with the device and observing a detectable response therein.
    Type: Grant
    Filed: June 2, 1980
    Date of Patent: January 12, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: Alan E. Burkhardt, Ann M. Tideman
  • Patent number: 4301115
    Abstract: A test device for detecting the presence of constituents in a liquid test sample, and method for preparing it are disclosed. The device comprises a base support member coated with a hydrophobic barrier layer onto which is affixed a plurality of spaced apart reagents respectively responsive to different constituents of the test sample. The barrier layer comprises finely divided silica particles, to the surface of which are randomly covalently bound groups having the structure--O--SiR.sub.3wherein the R substituents, same or different, are hydrogen, lower alkyl or aryl.
    Type: Grant
    Filed: June 22, 1979
    Date of Patent: November 17, 1981
    Assignee: Miles Laboratories, Inc.
    Inventors: Myron C. Rapkin, David L. Tabb
  • Patent number: 4290773
    Abstract: An improved composition, device and method, whereby enhanced sensitivity is achieved in detecting test sample constituents such as glucose and blood. The improvement resides in the use of a broad range of compounds as enhancers for benzidine-type indicators. The enhancer tends to stabilize the blue colorform of such indicators.
    Type: Grant
    Filed: November 13, 1979
    Date of Patent: September 22, 1981
    Assignee: Miles Laboratories, Inc.
    Inventors: Thomas A. Magers, David L. Tabb
  • Patent number: 4288541
    Abstract: A composition, device and method for determining the presence of a component in a test sample which contains an interfering substance, such as ascorbic acid, are disclosed. The composition comprises an oxidase or other substance capable of producing peroxide in the presence of the component, a peroxidatively active substance, a chromogen capable of providing a detectable response (such as a color change) in the presence of peroxide and a peroxidatively active substance, and a complex of mercuric ion and one or more ligands wherein (a) the ligand binds covalently to the ion to form a water-soluble complex, and the ligand is not oxidizable by the complexed ion, and (b) the complex has a stability constant, K.sub.s, of at least 10.sup.7 and is substantially noninterfering with respect to the detectable response.
    Type: Grant
    Filed: October 15, 1979
    Date of Patent: September 8, 1981
    Assignee: Miles Laboratories, Inc.
    Inventors: Thomas A. Magers, John E. Sheats, David L. Tabb
  • Patent number: 4267936
    Abstract: A remotely operable lid for storage bins to be used in conjunction with a storage bin (10) having an access opening (11). A cover plate (18) is carried within a pair of guides (20, 22) such that the plate may be slid laterally in the guides. The guides (20, 22) are held spaced apart by end members (26, 28) which in conjunction with the guides, form a frame. Affixed to the bottom of the frame is a cylindrical band (46) which is sized to accept within a ridge (48) extending upward and around the access opening perimeter of the storage bin. The lid and frame are thus fixed atop the access opening of the bin. Attached to the lid are two eyelets (30, 32) and attached to the frame is a pulley (30). Ropes are attached to the eyelets, one of which is threaded through the pulley. The ropes are extended downward along the side of the bin to ground level.
    Type: Grant
    Filed: November 13, 1979
    Date of Patent: May 19, 1981
    Assignee: Miles Laboratories, Inc.
    Inventor: Cleone J. Pavlicek
  • Patent number: 4260579
    Abstract: A device and method are disclosed for preparing a bilirubin-containing control solution. The device comprises a carrier vehicle having incorporated with it unconjugated bilirubin and certain dyes. Upon contact with a predetermined quantity of water a control solution results, which will simulate a pathological specimen of conjugated bilirubin-containing solution, upon analysis.
    Type: Grant
    Filed: May 10, 1979
    Date of Patent: April 7, 1981
    Assignee: Miles Laboratories, Inc.
    Inventors: Nancy K. Barton, Carmine M. Greene, Myron C. Rapkin
  • Patent number: 4216245
    Abstract: A test device for determining the presence of a constituent in a sample, and a method for making it are disclosed. The test device comprises reactants (e.g. reagents, enzymes, etc.) incorporated with a carrier matrix such that when the device is wetted with a test sample, the reactants and the constituent react to produce a detectable response. The reactants are positioned separately from each other on the matrix in substantially, discrete, non-contacting areas. Hence, reactants are maintained substantially separate from each other until the test device is wetted with the sample.
    Type: Grant
    Filed: July 25, 1978
    Date of Patent: August 5, 1980
    Assignee: Miles Laboratories, Inc.
    Inventor: Leighton C. Johnson
  • Patent number: 4209012
    Abstract: An apparatus for use in knee surgery or a related procedure, whereby the patient's knee can be maintained at a predetermined degree of inflection for a desired time interval. The device comprises a foot engaging means attached to an adjustable strap to engage the patient's thigh and a means for fixing the strap length once it has been adjusted. Also disclosed is the method for using the device.
    Type: Grant
    Filed: October 19, 1978
    Date of Patent: June 24, 1980
    Inventor: Don M. Smucker
  • Patent number: 4193766
    Abstract: A device and method for preparing a ketone body control solution. The device comprises a carrier vehicle having incorporated with it a metal ion complex of a dione compound. The dione compound is characterized as having the structure ##STR1## wherein R and R', same or different, are alkyl groups having 1 to about 6 carbon atoms. The method for preparing the control solution comprises contacting a predetermined volume of liquid with the device.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: March 18, 1980
    Assignee: Miles Laboratories, Inc.
    Inventors: Louis G. Daunora, Charles T. W. Lam, Myron C. Rapkin
  • Patent number: 4160008
    Abstract: A test device for determining the presence of a liquid sample constituent. The device comprises a base support member having attached to it an indicator member which produces a detectable response, such as a color change, in the presence of the sample constituent. The indicator member comprises an upper reagent layer, a lower absorbent layer and a substantially sample-impervious barrier layer between the upper and lower layers. The indicator member is attached to the base member along the lower side of the absorbent layer.
    Type: Grant
    Filed: January 26, 1978
    Date of Patent: July 3, 1979
    Assignee: Miles Laboratories, Inc.
    Inventors: Leonard P. Fenocketti, Myron C. Rapkin
  • Patent number: 4158546
    Abstract: A novel test composition, device and method for determining the presence of urobilinogen in a test sample. The composition is capable of producing a detectable response, such as a change in color or change in light absorption, thus indicating the presence of urobilinogen, both on a qualitative and a semi-quantitative basis. Briefly, the composition comprises para-di(lower alkyl)aminobenzaldehyde as an indicator compound, a buffer substance capable of producing a pH of about 0.5 to 3, and a compound having the structure ##STR1## in which X is O or S, and in which R and R', same or different, are lower alkyl, or R and R' together are lower alkylene or ##STR2## wherein n is an integer of 1 to about 6. The device comprises a carrier matrix incorporated with the composition. The method of use comprises contacting a test sample with the composition or device and observing any detectable response formed therein.
    Type: Grant
    Filed: July 24, 1978
    Date of Patent: June 19, 1979
    Assignee: Miles Laboratories, Inc.
    Inventors: Charles T. W. Lam, Chauncey O. Rupe
  • Patent number: 4038485
    Abstract: A test device, test composition, and method are disclosed for determining the presence of a component in a sample. The device comprises a carrier matrix incorporated with a reactant system which produces a detectable response upon contact with the sample component. After a predetermined time interval elapses, the production of the detectable response is terminated by an inhibitor system also incorporated with the matrix. The test composition comprises the reactant and inhibitor systems. The method of use comprises contacting the test device with a test sample suspected of containing the component, permitting a predetermined time to elapse after contacting, and observing any detectable response produced.
    Type: Grant
    Filed: September 17, 1976
    Date of Patent: July 26, 1977
    Assignee: Miles Laboratories, Inc.
    Inventors: Katharine Gentry Johnston, Jerome Greyson