Patents Represented by Attorney Edwards Angell Palmer & Dodge LLP
  • Patent number: 8119665
    Abstract: The invention provides packaged pharmaceutical preparations of Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formula where the variables are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of the invention act bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory and immune system disorders.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: February 21, 2012
    Assignee: Novartis International Pharmaceutical Ltd.
    Inventors: George P. Luke, George D. Maynard, Scott Mitchell, Andrew Thurkauf, Linghong Xie, LuYan Zhang, Suoming Zhang, He Zhao, Bertrand L. Chenard, Yang Gao, Bingsong Han, Xiao Shu He
  • Patent number: 8106064
    Abstract: The invention is related to pyrimidine-2,4-dione HIV reverse transcriptase inhibitors of Formula (I), (II), or (III): or a pharmaceutically acceptable salt, thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: January 31, 2012
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Hongyan Guo, Choung U. Kim, Thorsten A. Kirschberg, Ill Young Lee, Michael L. Mitchell, Jong Chan Son, Lianhong Xu
  • Patent number: 8092490
    Abstract: Photochemical tissue bonding methods include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair and corneal repair.
    Type: Grant
    Filed: August 16, 2005
    Date of Patent: January 10, 2012
    Assignee: The General Hospital Corporation
    Inventors: Robert W. Redmond, Irene E. Kochevar
  • Patent number: 8081460
    Abstract: A liquid-cooled heat radiator 1 includes a heat radiation base 2 having a cooling-liquid channel 5, and an expansion tank 7 provided on the heat radiation base 2. The expansion tank 7 has a tank body 26 having an expanded portion 27, which expands upward and opens downward, and a bottom plate 28 joined to the lower end of the tank body 26 to thereby close a bottom opening of the expanded portion 27. A through-hole 29 is formed in the top wall of the expanded portion 27 of the tank body 26 and serves as a communication section for establishing communication between the interior and the exterior of the cooling-liquid channel 5. A hydrogen-permeable member 31 is fixedly fitted into the through-hole 29 so as to stop the through-hole 29. The hydrogen-permeable member 31 satisfies the relation B?50 A, where A and B are water-vapor permeability and hydrogen permeability, respectively, of the hydrogen-permeable member 31.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: December 20, 2011
    Assignees: NEC Corporation, Showa Denko K.K.
    Inventors: Tomotaka Ishida, Mitsuru Yamamoto, Sakae Kitajo, Kazuhiro Kumakura
  • Patent number: 8080387
    Abstract: The present invention relates to a method for producing a recombinant protein capable of increasing expression rate of a target protein and also improving solubility and folding of the expressed target protein using a modified protein disulfide isomerase (PDI) as a fusion partner, and an expression vector containing the modified PDI gene as a fusion partner. The method for preparing a recombinant protein using a modified PDI as a fusion partner according to the present invention may solve the problems concerning a low yield and solubility and folding that conventional fusion partners have, and be widely used for protein drug and industrial protein production.
    Type: Grant
    Filed: October 24, 2005
    Date of Patent: December 20, 2011
    Assignee: Vexxon, Inc.
    Inventors: Hang-Cheol Shin, Yean-Hee Park, Hyang-Do Song, Eung-Yoon Kim, Ha-A-Rin Chon, Hye-Ran Hyun
  • Patent number: 8078835
    Abstract: A processor for performing floating-point operations includes an array of processing elements arranged to enable a floating-point operation. Each processing element includes an arithmetic logic unit to receive two input values and perform integer arithmetic on the received input values. The processing elements in the array are connected together in groups of two or more processing elements to enable floating-point operation.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: December 13, 2011
    Assignee: Core Logic, Inc.
    Inventors: Hoon Mo Yang, Man Hwee Jo, Il Hyun Park, Ki Young Choi
  • Patent number: 8071314
    Abstract: Class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central nervous system, demonstrating that molecules can perform critical roles in both systems. Similarities in the cellular signaling mechanisms of the immune and nervous systems provide for development of therapeutic and diagnostic agents in abnormal neuronal cellular function.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: December 6, 2011
    Assignee: President and Fellows of Harvard College
    Inventors: Carla J. Shatz, Joshua Syken
  • Patent number: 8067477
    Abstract: An object of the present invention is to provide the resin composition for electro-photographic toner, which the electro-photographic toner to be obtained by it is superior to low temperature fixing properties and a hot offset resistance, and the electro-photographic toner thereof. To be achieved this purpose, multi-branched state polyester structure having a structure representing the following structural formula (1) as a repeating unit, is made into a main skeleton (In the formula, R expresses an aliphatic hydrocarbon group, and n shows the number of repeating units of a branched structure and is an average of 1-5.) *a is a node of the carbon atom of a carbonyl group, *b is a node of an oxygen atom, and *b is bonded to *a in the other repeating unit of the structural formula (1)).
    Type: Grant
    Filed: January 21, 2009
    Date of Patent: November 29, 2011
    Assignee: DIC Corporation
    Inventors: Yasunobu Hirota, Nobuyoshi Shirai
  • Patent number: 8066529
    Abstract: Disclosed herein is a condenser connector for a vehicle, in which a condenser is installed at a position which is nearest or virtually nearest to a noise source, thus effectively eliminating or reducing noise. The condenser connector includes a housing having an insertion part. One end of a terminal is connected to a wire, and the other end thereof is fitted into and secured to one end of the insertion part. A holder is fitted into and secured to the other end of the insertion part. A condenser has a contact terminal which is in contact with the terminal, and is mounted to the holder.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: November 29, 2011
    Assignees: Hyundai Motor Company, Korea Electric Terminal Co., Ltd.
    Inventors: Ji Hyoung Kim, Jong Wook Lee, Jong Hyun Lee, Sung Ho Heo
  • Patent number: 8066367
    Abstract: A droplet applying apparatus includes a base having a mounting surface on which a substrate is to be mounted, an arm part which is fitted to the base so as to be movable relative to the base in an arrow A direction, and a plurality of droplet ejecting sections which are fitted to the arm part so as to be movable in an arrow B direction and which eject droplets to the substrate mounted on the mounting surface. The droplet ejecting sections are fitted on a fitting surface of a first beam member of the arm part as well as on a fitting surface of a second beam member of the arm part.
    Type: Grant
    Filed: April 16, 2007
    Date of Patent: November 29, 2011
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Yoshinori Nakajima, Kaoru Higuchi, Toshihiro Tamura
  • Patent number: 8067036
    Abstract: Gnetum extract which can be obtained from Gnetum fruit or Gnetum seeds that provide antimicrobial action and antioxidative effect (radical scavenging action) without carrying out special operation. The relevant Gnetum extract has various physiological (pharmacological) actions and can be used as active ingredients of foods , nourishments (nutritional supplements), medicines, cosmetics, etc. In addition, Gnetum extract is obtained by immersing sliced or ground Gnetum fruit or Gnetum seeds in water or water containing organic solvent and aging.
    Type: Grant
    Filed: September 13, 2005
    Date of Patent: November 29, 2011
    Assignee: Hosoda SHC Inc.
    Inventors: Eishin Kato, Shinya Hosoda
  • Patent number: 8066737
    Abstract: An apparatus and a method for surgical suturing with thread management. An apparatus for tissue suturing including a cartridge having a suturing needle having a pointed end, a blunt end and notches, the suturing needle capable of rotating about an axis; a pusher assembly comprising a cartridge holder having a needle rotation drive capable of releasably engaging the cartridge and rotating the suturing needle about the axis; and an actuator capable of releasably engaging the needle rotation drive to rotate the needle rotation drive. A method for suturing tissue including placing a suturing device having a cartridge containing a suturing needle to span separated tissue segments; activating an actuator to cause rotational movement of the suturing needle through the separated tissue segments; and deactivating the actuator to stop an advancing movement of the suturing needle to cause a suturing material to be pulled through the separated tissue segments forming a stitch.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: November 29, 2011
    Assignee: EndoEvolution, LLC
    Inventors: John C. Meade, Niall G. Deloughery, Gerald I. Brecher, James H. Bleck
  • Patent number: 8068297
    Abstract: The present invention relates to a pigment composition or pigment dispersion that is ideal for producing the blue pixel portion of a color filter for a liquid crystal display device, and a color filter. The invention has an object of providing a color filter having a blue pixel portion that yields a liquid crystal display device having a high degree of contrast that enables the display screen to be viewed with improved clarity, and a high level of brightness that produces a brighter display screen, as well as providing a pigment composition or dispersion that can be used to produce the color filter. The above object can be realized by using a dioxazine derivative that is substituted with a sulfamoyl group having a specific polyalkylene oxide group, and a pigment composition or dispersion for a color filter that includes this dioxazine derivative and a blue organic pigment or violet organic pigment.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: November 29, 2011
    Assignee: DIC Corporation
    Inventors: Arata Kudou, Seiji Funakura, Hitoshi Kondou
  • Patent number: 8062078
    Abstract: A press-contact pogo pin connector is provided which has a machining cost lower than those of conventional connectors, can be easily reduced in height, and does not cause instantaneous interruption. A molded insulating housing has a cylinder hole. A pin installed inside the cylinder hole is urged by a coil spring installed inside the cylinder hole so as to protrude from the housing. A flange portion on the rear side of the pin urged by the coil spring abuts against the peripheral portion of the front opening of the cylinder hole on the front side of the housing so that the pin is prevented from falling off. A contact integrally includes a substrate connection terminal portion and a contact spring portion that extends inside the cylinder hole and is brought into press-contact with the pin at all times. The contact is secured to the housing.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: November 22, 2011
    Assignee: SMK Corporation
    Inventors: Kiyoshi Asai, Manabu Dobashi
  • Patent number: 8061158
    Abstract: A system for use with a consumable beverage includes a container having a mouth. A lid is detachably engaged with the container. A collar is adapted to be seated in the mouth of the container. The collar defines an opening therein. A thermal energy storing member is detachably engagable with the opening in the collar and/or the lid. A collar for supporting an end of a thermal energy storing member; a lid for a container adapted to engage a thermal energy storing member; and method of providing a chilled consumable beverage are each separately detailed herein.
    Type: Grant
    Filed: December 30, 2006
    Date of Patent: November 22, 2011
    Assignee: Cool Gear International, LLC
    Inventors: Henry Roth, Donna Roth
  • Patent number: 8057754
    Abstract: Apparatuses and methods of aligning at least one tip of a tip manifold with a plurality of wells of a multiwell plate. The tip manifold includes a plate, at least one tip depending from the plate, a first tip alignment pin depending from the plate, and a second tip alignment pin depending from the plate. The second tip alignment pin opposes the first tip alignment pin. The multiwell plate includes a body defining a plurality of non-porous wells for holding biological material, a first alignment hole, and a second alignment hole. The second alignment hole opposes the first alignment hole.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: November 15, 2011
    Assignee: Cellectricon AB
    Inventors: Johan Pihl, Mattias Karlsson
  • Patent number: 8058061
    Abstract: Recombinant lentiviral vectors having a region encoding a functional ?-globin gene; and large portions of the ?-globin locus control regions which include DNase I hypersensitive sites HS2, HS3 and HS4 provides expression of ?-globin when introduced into a mammal, for example a human, in vivo. Optionally, the vector further includes a region encoding a dihydrofolate reductase. The vector may be used in treatment of hemoglobinopathies, including ?-thalessemia and sickle-cell disease. For example, hematopoietic progenitor or stem cells may be transformed ex vivo and then restored to the patient. Selection processes may be used to increase the percentage of transformed cells in the returned population. For example, a selection marker which makes transformed cells more drug resistant than untransformed cells allows selection by treatment of the cells with the corresponding drug.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: November 15, 2011
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Michel Sadelain, Stefano Rivella, Chad May, Joseph Bertino
  • Patent number: 8057220
    Abstract: Disclosed is an air-assisted simplex spray nozzle assembly for a fuel burner that includes, inter alia, a nozzle body that has opposed upstream and downstream ends, wherein the downstream end of the nozzle body defines a fuel outlet, an adapter member that is engaged with the upstream end of the nozzle body and defines concentrically positioned air and fuel inlets for the nozzle assembly and an air cap that is positioned over the downstream end of the nozzle body. The nozzle assembly further includes a fuel circuit and a first air circuit. The fuel circuit directs fuel from a fuel pump toward the fuel outlet of the nozzle body. The fuel circuit extends from the fuel inlet of the adapter member through the nozzle body to the fuel outlet. The first air circuit directs assist air towards the fuel exiting from the fuel outlet.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: November 15, 2011
    Assignee: Delavan Inc
    Inventor: David H. Bretz
  • Patent number: 8058737
    Abstract: An electronic element wafer module is provided, in which a transparent support substrate is disposed facing a plurality of electronic elements formed on a wafer and a plurality of wafer-shaped optical elements are disposed on the transparent support substrate, where a groove is formed along a dicing line between the adjacent electronic elements, penetrating from the optical elements through the transparent support substrate, with a depth reaching a surface of the wafer or with a depth short of the surface of the wafer; and a light shielding material is applied on side surfaces and a bottom surface of the groove or is filled in the groove, and the light shielding material is applied or formed on a peripheral portion of a surface of the optical element, except for on a light opening in a center of the surface.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: November 15, 2011
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Masahiro Hasegawa, Aiji Suetake
  • Patent number: D649117
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: November 22, 2011
    Assignee: SMK Corporation
    Inventors: Ryo Sasaki, Hidenori Yachi, Hiroyasu Kamatani