Patents Represented by Attorney Edwards Angell Palmer & Dodge LLP
  • Patent number: 8038995
    Abstract: The invention pertains to a human N-type calcium channel isoform, h?1B+SFVG, which is involved in central nervous system signaling, and nucleic acids relating thereto. The present invention also includes fragments and biologically functional variants of the human h?1B+SFVG channel. Also included are human N-type calcium channel h?1B+SFVG subunit inhibitors which inhibit human N-type calcium channel h?1B+SFVG subunit activity by inhibiting the expression or function of human N-type calcium channel h?1B+SFVG subunit. The invention further relates to methods of using such nucleic acids, polypeptides, and inhibitors in the treatment and/or diagnosis of disease, such as in methods for treating stroke, pain, e.g., neuropathic pain, and traumatic brain injury.
    Type: Grant
    Filed: February 7, 2006
    Date of Patent: October 18, 2011
    Assignee: Scion Pharmaceuticals, Inc.
    Inventors: Diane Lipscombe, Stephanie Schorge
  • Patent number: 8041100
    Abstract: A first defect distribution superimposed image is formed by superimposing defect distributions on individual substrates processed by a causal equipment unit candidate on one another. Second defect distribution superimposed images are formed by superimposing, on one another, defect distributions on individual substrates processed by equipment units other than the causal equipment unit candidate in one same step as that executed by the causal equipment unit candidate. The first defect distribution superimposed image and the second defect distribution superimposed images are displayed in contrast on one display screen.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: October 18, 2011
    Assignee: Sharp Kabushiki Kaisha
    Inventor: Toshio Yamamoto
  • Patent number: 8037754
    Abstract: An inertial measurement system having a triangular cupola shaped base structure with three mutually orthogonal sides and a bottom surface surrounding a hollow core. The bottom surface includes an aperture providing access to the hollow core. An inertial module is mounted on each of the sides and includes a gyroscopic rotational rate sensor and a linear accelerometer connected to a circuit board. The inertial measurement system also includes a motherboard and a plurality of metallization elements. The metallization elements extend from the bottom surface to the sides of the base structure and conductively connect the inertial module to the motherboard. The inertial measurement system may also include a non-conductive adhesive underfill positioned between the inertial module and the base structure.
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: October 18, 2011
    Assignee: Rosemount Aerospace Inc.
    Inventors: Odd Harald Steen Eriksen, Robert William Stuelke
  • Patent number: 8039003
    Abstract: The invention provides compositions featuring an attenuated dengue virus mutant or an attenuated chimeric dengue virus mutant.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: October 18, 2011
    Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
    Inventors: Stephen S. Whitehead, Brian R. Murphy, Kathryn A. Hanley, Joseph E. Blaney
  • Patent number: 8039448
    Abstract: The invention pertains to N-acetylated, N, O-carboxyalkylchitosans and methods for using the chitosans to treat disorders, such as cancer, nervous system disorders, urinary tract disorders, and reproductive tract disorders.
    Type: Grant
    Filed: November 14, 2008
    Date of Patent: October 18, 2011
    Assignee: Kytogenics Pharmaceuticals, Inc.
    Inventors: Clive M. Elson, Agis Kydonieus, Susan Elizabeth Henderson
  • Patent number: 8039641
    Abstract: The present invention relates to a process for preparing a compound of formula (Ia), (Ib), (Ic) or (Id), or a pharmaceutically acceptable salt, hydrate, solvate, complex or prodrug thereof, said process comprising the steps of: (A) (i) treating a compound of formula (IVa), where R48 is alkyl or tosyl, with an oxidizing agent to form a compound of formula (Va); and (ii) converting said compound of formula (Va) to a compound of formula (Ia) or (Ic); or (B) (i) treating a compound of formula (IVb), where R48 is alkyl or tosyl, with an oxidizing agent to form a compound of formula (Vb); and (ii) converting said compound of formula (Vb) to a compound of formula (Ib) or (Id).
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: October 18, 2011
    Assignee: Amura Therapeutics Limited
    Inventors: Martin Quibell, James Nally, Lee Patient, Yikang Wang, Claudio Dagostin, John Paul Watts
  • Patent number: 8034623
    Abstract: The present invention relates to a free radical initiator and a method for peptide sequencing using the same. Compared with diazo or peroxy functionalized precursors, the precursors using the present compounds are chemically more robust and can generate radical species by homolytic cleavage upon thermal activation, enabling sequencing of a wider variety of peptides. In addition, the present invention makes it feasible to sequence peptides carrying disulfide bonds.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: October 11, 2011
    Assignee: University-Industry Cooperation Foundation, Sogang University
    Inventors: Han-Bin Oh, Bong-Jin Moon, Min-hyuck Kang, Min-Hee Lee
  • Patent number: 8034837
    Abstract: The present invention relates to a new crystalline modification of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,S-dihydro-1H-pyrrolizin-S-ylacetic acid which is referred to as polymorph B. It has a peak in the solid state 13C-NMR spectrum (with adamantane as external reference standard; CH group d=29.45 ppm) in the range from 179.8 to 180.2 ppm and can be processed directly to a pharmaceutical formulation.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: October 11, 2011
    Assignee: Merckle GmbH
    Inventors: Wolfgang Albrecht, Thomas Kammermeier, Hans-Gunter Striegel, Philipp Merckle, Stefan Laufer
  • Patent number: 8033283
    Abstract: A urology drape is disclosed which comprises a flexible sheet (12) which has a flexible hood (22) overlying part of the sheet (12) to form a repository (24) between the sheet (12) and the hood (22). The sheet (12) has a hole (18) to enable a procedure to be performed on a patient when the drape is located on the patient. Bodily fluid is able to flow from the hole down the sheet (12) into the repository (24) and when the procedure is finished, the drape can be folded or otherwise collapsed into a disposable package so that the drape and fluid can be disposed of in a hygienic manner.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: October 11, 2011
    Assignee: Urotech Pty Ltd
    Inventor: Nathan Lawrentschuk
  • Patent number: 8035875
    Abstract: An object detector has a light projecting unit that projects light, a light scanning actuator that scans the light, and a light receiving unit. The light scanning actuator includes plate springs, each having a thin-plate shape and one end in a longitudinal direction thereof being fixed; a movable part attached to the other ends in the longitudinal directions of the plate springs; and an electromagnetic driving unit having a magnet that generates a magnetic flux, a yoke that forms a closed magnetic circuit with the magnet and has a part being stacked on the magnet, and a coil held by the movable part and positioned in a gap between the magnet and the yoke such that an aperture plane is substantially orthogonal to a stacking direction of the magnet and the yoke, the electromagnetic driving unit configured to drive the movable part by an electromagnetic force applied to the coil.
    Type: Grant
    Filed: June 3, 2008
    Date of Patent: October 11, 2011
    Assignee: NHK Spring Co., Ltd.
    Inventors: Ryohei Shigematsu, Hiroshi Imamura, Takafumi Hirata
  • Patent number: 8034909
    Abstract: The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked Nucleoside Analogues), are able to provide valuable improvements to oligonucleotides with respect to affinity and specificity towards complementary RNA and DNA oligomers. The novel type of LNA modified oligonucleotides, as well as the LNAs as such, are useful in a wide range of diagnostic applications as well as therapeutic applications. Among these can be mentioned antisense applications, PCR applications, strand displacement oligomers, as substrates for nucleic acid polymerases, as nucleotide based drugs, etc. The present invention also relates to such applications.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: October 11, 2011
    Assignee: Exiqon A/S
    Inventors: Jesper Wengel, Poul Nielsen
  • Patent number: 8034300
    Abstract: This apparatus for producing trichlorosilane includes: a vessel having a gas inlet that introduces a feed gas into the vessel and a gas outlet that discharges a reaction product gas to the outside; a plurality of silicon core rods provided inside the vessel; and a heating mechanism that heats the silicon core rods, wherein a feed gas containing silicon tetrachloride and hydrogen is reacted to produce a reaction product gas containing trichlorosilane and hydrogen chloride. The silicon core rods may be disposed so as to stand upright on the bottom of the vessel, and the heating mechanism may have electrode portions that hold the lower end portions of the silicon core rods on the bottom of the vessel and a power supply that applies an electric current to the silicon core rods through the electrode portions to heat the silicon core rods.
    Type: Grant
    Filed: November 27, 2007
    Date of Patent: October 11, 2011
    Assignee: Mitsubishi Materials Corporation
    Inventor: Toshiyuki Ishii
  • Patent number: 8034514
    Abstract: The present invention relates to a volume phase hologram recording material excellent in transparency, sensitivity, low curing shrinkage, and transparency, a volume phase hologram recording medium, and a volume phase hologram. A photosensitive resin composition for volume phase hologram recording contains a low-molecular-weight solvent-soluble aromatic copolymer (A) having a structural unit of a divinyl aromatic compound and a structural unit of a monovinyl aromatic compound, a photoradical polymerizable compound (B) which is copolymerizable with the soluble aromatic copolymer (A), and a photopolymerization initiator (C) as essential components. The photosensitive resin composition further contains, one kind or more of a polymer binder (D) and a plasticizer (E), and the soluble aromatic copolymer (A) is incorporated in an amount of 5 to 60% by weight.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: October 11, 2011
    Assignee: Nippon Steel Chemical Co., Ltd.
    Inventors: Kouhei Tomari, Yasuji Shichijo, Masanao Kawabe
  • Patent number: 8035998
    Abstract: A switching power supply includes an active device for pulling out a part of a control signal from a control terminal of the switching device in an RCC, and a control signal generation circuit that applies adjustment voltage as ON/OFF time control voltage to a control terminal of the active device. The active device pulls out the control signal so as to decrease or increase an OFF time of the switching device while fixing the ON time of the switching device when the adjustment voltage is decreased or increased in the active region of the active device, respectively. An element of a timing circuit in the RCC pulls out the control signal so as to increase or decrease an ON time of the switching device while fixing the OFF time of the switching device when the adjustment voltage is decreased or increased in the cut-off region of the active device, respectively.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: October 11, 2011
    Assignee: Panasonic Electric Works Co., Ltd.
    Inventors: Kyohei Kada, Mikio Itou, Sumio Wada, Shousuke Akisada, Atsushi Isaka, Kenji Obata
  • Patent number: 8034576
    Abstract: The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I: or a prodrug or pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: October 11, 2011
    Assignee: Naturon, Inc.
    Inventors: Neal Bricker, Stewart Shankel, Christopher D. Cain, Mark Mitchnick, Michael Schmertzler
  • Patent number: 8034602
    Abstract: Disclosed herein are a microorganism producing L-arginine and a method of producing L-arginine using the same. The microorganism is a mutant strain of the genus Corynebacterium, Corynebacterium glutamicum CJR0500. The method for L-arginine production comprises activating the mutant strain C. glutamicum CJR0500 in a fermentation medium at 30° C. for 16 hours and then culturing the activated mutant strain for 72 hours with shaking.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: October 11, 2011
    Assignee: CJ Cheiljedang Corporation
    Inventors: Young Hoon Park, Hye Won Kim, Ji-Hye Lee, Soo-Youn Hwang
  • Patent number: D646715
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: October 11, 2011
    Assignee: Dong-A Pencil Co., Ltd.
    Inventor: Jewon Kim
  • Patent number: D646718
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: October 11, 2011
    Assignee: Dong-A Pencil Co., Ltd.
    Inventor: Jewon Kim
  • Patent number: D646719
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: October 11, 2011
    Assignee: Dong-A Pencil Co., Ltd.
    Inventor: Jewon Kim
  • Patent number: D647005
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: October 18, 2011
    Assignee: Kia Motors Corporation
    Inventor: Sung Wook Kim