Patents Represented by Attorney Edwards Angell Palmer & Dodge
  • Patent number: 8058721
    Abstract: Disclosed is a package structure including a semiconductor chip disposed in a core board having a first surface and an opposite second surface. The package structure further includes a plurality of first and second electrode pads disposed on an active surface and an opposite inactive surface of the semiconductor chip respectively, the semiconductor chip having a plurality of through-silicon vias for electrically connecting the first and second electrode pads. As a result, the semiconductor chip is electrically connected to the two sides of the package structure via the through-silicon vias instead of conductive through holes, so as to enhance electrical quality and prevent the inactive surface of the semiconductor chip from occupying wiring layout space of the second surface of the core board to thereby increase wiring layout density and enhance electrical performance.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: November 15, 2011
    Assignee: Unimicron Technology Corporation
    Inventor: Shih Ping Hsu
  • Patent number: 8057220
    Abstract: Disclosed is an air-assisted simplex spray nozzle assembly for a fuel burner that includes, inter alia, a nozzle body that has opposed upstream and downstream ends, wherein the downstream end of the nozzle body defines a fuel outlet, an adapter member that is engaged with the upstream end of the nozzle body and defines concentrically positioned air and fuel inlets for the nozzle assembly and an air cap that is positioned over the downstream end of the nozzle body. The nozzle assembly further includes a fuel circuit and a first air circuit. The fuel circuit directs fuel from a fuel pump toward the fuel outlet of the nozzle body. The fuel circuit extends from the fuel inlet of the adapter member through the nozzle body to the fuel outlet. The first air circuit directs assist air towards the fuel exiting from the fuel outlet.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: November 15, 2011
    Assignee: Delavan Inc
    Inventor: David H. Bretz
  • Patent number: 8060195
    Abstract: Featured are apparatuses for measuring bioimpendence of tissues of the cervix, more specifically the mammalian cervix. Also featured are methods for examining the tissues of the cervix for clinical or diagnostic purposes such as during routine gynecological examinations to determine early onset of labor in pregnant patients or to assess such tissues for the presence of abnormalities such as cancerous lesions in both pregnant and non-pregnant women. Also featured are methods for treating onset of early or pre-term labor that embody such devices, apparatuses and methods of the present invention. Also featured are systems embodying such devices, apparatuses and/or methods, where such systems preferably are configured to provide diagnostic and/or clinical information to further assist the diagnostician or clinician in diagnosing and/or examining pregnant or non-pregnant patients.
    Type: Grant
    Filed: May 3, 2004
    Date of Patent: November 15, 2011
    Assignee: The Johns Hopkins University
    Inventors: Edith D. Gurewitsch, Melanie Ruffner, Kenny H. Ching, Somponnat Sampattavanich, Ashkon Shaahinfar, Yen S. Hoe, Elbert S. Hu
  • Patent number: 8057754
    Abstract: Apparatuses and methods of aligning at least one tip of a tip manifold with a plurality of wells of a multiwell plate. The tip manifold includes a plate, at least one tip depending from the plate, a first tip alignment pin depending from the plate, and a second tip alignment pin depending from the plate. The second tip alignment pin opposes the first tip alignment pin. The multiwell plate includes a body defining a plurality of non-porous wells for holding biological material, a first alignment hole, and a second alignment hole. The second alignment hole opposes the first alignment hole.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: November 15, 2011
    Assignee: Cellectricon AB
    Inventors: Johan Pihl, Mattias Karlsson
  • Patent number: 8058280
    Abstract: The present invention provides a compound represented by the formula: wherein R1 is a C1-4 alkyl; R2 is (1) a 5- to 7-membered nitrogen-containing heterocyclic group which may have a substituent selected from the group consisting of (1?) a halogen, (2?) a hydroxy group, (3?) a C1-4 alkyl and (4?) a C1-4 alkoxy, (2) a phenyl which may have a substituent selected from the group consisting of (1?) a halogen, (2?) a C1-4 alkoxy-C1-4 alkyl, (3?) a mono-C1-4 alkyl-carbamoyl-C1-4 alkyl, (4?) a C1-4 alkoxy and (5?) a mono-C1-4 alkylcarbamoyl-C1-4 alkoxy, or the like; R3 is a C1-4 alkyl; R4 is a C1-4 alkoxy, or the like; n is an integer of 1 to 4; or a salt thereof, as a thienopyrimidine compound having gonadotropin-releasing hormone antagonistic activity.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: November 15, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Nobuo Cho, Takashi Imada, Takenori Hitaka, Kazuhiro Miwa, Masami Kusaka, Nobuhiro Suzuki
  • Patent number: 8058061
    Abstract: Recombinant lentiviral vectors having a region encoding a functional ?-globin gene; and large portions of the ?-globin locus control regions which include DNase I hypersensitive sites HS2, HS3 and HS4 provides expression of ?-globin when introduced into a mammal, for example a human, in vivo. Optionally, the vector further includes a region encoding a dihydrofolate reductase. The vector may be used in treatment of hemoglobinopathies, including ?-thalessemia and sickle-cell disease. For example, hematopoietic progenitor or stem cells may be transformed ex vivo and then restored to the patient. Selection processes may be used to increase the percentage of transformed cells in the returned population. For example, a selection marker which makes transformed cells more drug resistant than untransformed cells allows selection by treatment of the cells with the corresponding drug.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: November 15, 2011
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Michel Sadelain, Stefano Rivella, Chad May, Joseph Bertino
  • Patent number: 8055439
    Abstract: A system for providing fuel-efficient driving information for a vehicle includes a fuel-efficient driving area calculation unit and a display unit. The fuel-efficient driving area calculation unit calculates a variable fuel-efficient driving area, which is divided into economical, semi-economical, and uneconomical regions, depending on the increase or decrease of the speed of the vehicle, calculates a current fuel efficiency of the vehicle, receives information about the type and condition of a road from a GPS, and adjusts the regions in the fuel-efficient driving area to prompt the driver to increase or decrease the vehicle speed in advance. The display unit displays the fuel-efficient driving area using information calculated by the fuel-efficient driving area calculation unit, and indicates the current fuel efficiency using the regions.
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: November 8, 2011
    Assignees: Hyundai Motor Company, Kia Motors Corporation
    Inventors: Sang Woo Ji, Dong Jin Shin, Jae Hoon Jeong
  • Patent number: 8053131
    Abstract: The present invention provides an apparatus and method for determining deterioration of a fuel cell, the method including measuring in real time fluoride ion concentration or pH value of outflow water from a fuel cell stack during operation in a fuel cell vehicle, calculating a fluoride emission rate from the measured value and, if the calculated fluoride emission rate is out of a predetermined normal range, determining deterioration of an electrolyte membrane of the fuel cell stack.
    Type: Grant
    Filed: January 28, 2009
    Date of Patent: November 8, 2011
    Assignees: Hyundai Motor Company, Industry-Academy Cooperation Foundation, SCNU
    Inventors: Ik Jae Son, Byung Ki Ahn, Tae Won Lim, Jong Hyun Lee, Kwon Pil Park, Ho Lee, Chang Won Jung, Seung Chan Oh, Jae Jun Ko, Young Min Kim, Sae Hoon Kim, Jong Jin Yoon, Se Joon Im
  • Patent number: 8052633
    Abstract: A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. A spacing between projections is also at least partially determined based on an arrangement of the targets within the body.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: November 8, 2011
    Inventor: Mark Anthony Fernance Kendall
  • Patent number: 8054989
    Abstract: Disclosed herein is an acoustic correction apparatus and method for vehicle audio systems which is capable of providing optimal sound at a reference level to a listener even though the acoustic spatial response characteristics in the room of a vehicle vary due to a change in the material of seat covers or the like. A first acoustic analysis unit obtains target frequency characteristic data at a specific listening location based on generated acoustic signals played from an audio system. A second acoustic analysis unit obtains measured frequency characteristic data at the listening location based on measured acoustic signals collected by the microphone unit. An acoustic correction unit adjusts the equalizer of the audio system based on the target and measured frequency data.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: November 8, 2011
    Assignee: Hyundai Motor Company
    Inventor: Soon Kwon Paik
  • Patent number: 8053204
    Abstract: The present invention provides ?2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: November 8, 2011
    Assignees: Vermillion, Inc., Board of Trustees of the Leland Stanford Junior University
    Inventors: John Cooke, Eric T. Fung, Eiichiro Kimura
  • Patent number: 8055398
    Abstract: A method of reducing current consumption of an electric hydraulic power steering system for a vehicle includes determining whether or not a steering wheel is manipulated after an engine is started, and activating a sleep mode if it is determined that the steering wheel is not manipulated and if a vehicle speed is lower than a reference value for activating the sleep mode, or if it is determined that the steering wheel is manipulated and if an amount of current conducted in a motor, a vehicle speed and a steering angular velocity are lower than respective reference values for a predetermined time. According to the method, it is possible to reduce current consumption when the steering wheel is not manipulated and improve the vehicular fuel efficiency.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: November 8, 2011
    Assignee: Hyundai Motor Company
    Inventor: Hoon Choi
  • Patent number: 8054479
    Abstract: The present invention is intended to improve the processing efficiency by shortening a time taken until completion of return processing when image processing is carried out via an external storage device such as a USB memory.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: November 8, 2011
    Assignee: Sharp Kabushiki Kaisha
    Inventor: Yukinari Sato
  • Patent number: 8051932
    Abstract: The present invention provides a method of compensating for auxiliary loads of a hybrid vehicle, which divides the auxiliary loads into a mechanical auxiliary load and an electrical auxiliary load and performs an appropriate auxiliary load compensation according to the kind of auxiliary loads, thus improving system efficiency as well as power performance of the vehicle.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: November 8, 2011
    Assignees: Hyundai Motor Company, Kia Motors Corporation
    Inventor: Joon Young Park
  • Patent number: 8054947
    Abstract: In a PBX environment, a middleware module abstracts communication cards so that the plurality of channels associated therewith are grouped for efficiency. The middleware module recognizes unoperational channels, and restarts the hardware associated with the channels as well as allowing conferencing and transferring calls when the PBX switch does not support same. Preferably, for outgoing calls, the middleware adapter controls the state of interfaces for all hardware adapters and tries to deliver calls over active interfaces. In case of failure, the middleware adapter investigates and makes a decision if the call should be delivered over another adapter. In this way, redundant and highly available solutions are implemented transparent to application and interface drivers. For incoming calls, the middleware adapter accepts calls from all hardware adapters and presents these calls to applications as if these calls are issued by one adapter.
    Type: Grant
    Filed: January 31, 2005
    Date of Patent: November 8, 2011
    Assignee: Eicon Networks Corporation
    Inventors: Vladimir Startsev, Rainer Mielich
  • Patent number: 8051674
    Abstract: A system for use with a consumable beverage includes a container having a mouth. A lid is detachably engaged with the container. A collar is adapted to be seated in the mouth of the container. The collar defines an opening therein. A thermal energy storing member is detachably engagable with the opening in the collar and/or the lid. A collar for supporting an end of a thermal energy storing member; a lid for a container adapted to engage a thermal energy storing member; and method of providing a chilled consumable beverage are each separately detailed herein.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: November 8, 2011
    Assignee: Cool Gear International, LLC
    Inventors: Henry Roth, Donna Roth
  • Patent number: 8055092
    Abstract: An image processing apparatus is provided, including a brightness change level classifying unit, a dynamic weight calculating unit, and a brightness correcting unit. The brightness change level classifying unit compares a brightness change average value representing brightness changes from a pixel of interest to neighboring pixels around the pixel of interest with an upper threshold value and a lower threshold value and classifies the brightness change level of the pixel of interest into three types of levels according to the result of the comparison. An upper threshold value and a lower threshold value are predetermined based on the brightness of the pixel of interest. The dynamic weight calculating unit calculates different dynamic weights according to the brightness change level of the pixel of interest. The brightness correcting unit corrects the brightness of the pixel of interest, based on the dynamic weights.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: November 8, 2011
    Assignee: Core Logic, Inc.
    Inventor: Bong-Su Kang
  • Patent number: 8052774
    Abstract: Disclosed herein is a method for concentrating gold contained in a leach residue obtained in a copper hydrometallurgical process for recovering copper from a copper sulfide mineral to efficiently separate and recover gold from the leach residue: a gold-bearing copper sulfide mineral is subjected to pressure leaching with sulfuric acid at a temperature higher than 102° C. and 112° C. or lower to obtain a leach residue, and the leach residue is subjected to flotation to separate it into a float fraction and a sink fraction; the float fraction obtained by flotation is desulfurized to obtain a desulfurized product; the desulfurized product is subjected to oxidative roasting to obtain an oxidatively-roasted product; the oxidatively-roasted product is dissolved in a sulfuric acid solution to obtain a copper solution, and a gold-bearing residue is separated and recovered from the copper solution.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: November 8, 2011
    Assignee: Sumitomo Metal Mining Co., Ltd.
    Inventors: Noriyuki Nagase, Satoshi Asano, Masatoshi Takano, Kenji Takeda, Shinichi Heguri, Atsushi Idegami
  • Patent number: 8053437
    Abstract: The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein: R3 is tert-butylmethyl, sec-butyl or tert-butyl; X is CH or N; and R4 is optionally substituted C1-8 alkyl or optionally substituted C3-8 cycloalkyl. The invention further relates to pharmaceutical compositions comprising compounds of formula (I), and the use of such compounds in the treatment of a disease selected from osteoporosis, Paget's disease, Chagas's disease, malaria, gingival diseases, hypercalaemia, metabolic bone disease, diseases involving matrix or cartilage degradation, and bone cancer disorders such as bone metastases and associated pain.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: November 8, 2011
    Assignee: Amura Therapeutics Limited
    Inventors: Martin Quibell, John Paul Watts
  • Patent number: 8054075
    Abstract: Featured are methods for magnetic resonance imaging of a volume, such a volume having susceptibility-generating objects or interfaces having susceptibility mismatches therein. Such a method includes selectively visualizing one of susceptibility-generating objects or interfaces having susceptibility mismatches as hyperintense signals, where such visualizing includes controlling variable imaging parameters so as to control a geometric extent of a signal enhancing effect, m more particular aspects of the present invention, such selectively visualizing includes attenuating or essentially suppressing signals from fat and/or water, namely on-resonant water protons, so as to thereby enhance a signal(s) associated with magnetic susceptibility gradient(s). Also featured are MRI systems, apparatuses and/or applications programs for execution on a computer system controlling the MRI data acquisition process embodying such methods.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: November 8, 2011
    Assignee: The Johns Hopkins University
    Inventors: Matthias Stuber, Wesley D. Gilson, Dara L. Kraitchman