Abstract: A technique for determining blood flow in a living body by changing the thermal energy level by a predetermined amount at a site in a blood flow path and detecting temperatures at locations upstream and downstream of the site. The temperature difference at such locations is determined and the blood flow is calculated as a function of the change in energy level and of the temperature differences measured prior to and following the change in energy level.

Abstract: The use of alkali metal, alkaline earth metal, ammonium and substituted ammonium salts of alkyl and alkanol sulfonic acids as additives in pure metal and metal alloy sulfonic acid electroplating baths has a number of unexpected benefits including wider useful current density range, improved appearance and in the case of tin improved oxidative stability. An additional significant appearance is to reduce the overall costs of this type of bath with the more economical salts of alkyl and alkanol sulfonic acids. The metals and metal alloys include but are not limited to tin, lead, copper, nickel, zinc, tin/lead, tin/lead/copper, tin/zinc and zinc/nickel.

Abstract: The use of alkali metal, alkaline earth metal, ammonium and substituted ammonium salts of alkyl and alkanol sulfonic acids as additives in pure metal and metal alloy fluoroborate electroplating baths has a number of unexpected benefits including wider useful current density range and improved appearance. The metals and metal alloys include but are not limited to tin, lead, copper, cadmium, indium, iron, tin/lead and tin/lead copper.

Abstract: A container with a flexible membrane sealed to a container end may be tested for leaks as the container moves along a conveyor. The conveyor carries the container through a first region in which a negative pressure differential is established between the first region and the interior of the container. The pressure differential can be established, for example, by cooling the first region with cold air. The conveyor also carries the container from the first region to a second region, in which a positive pressure differential is established between the second region and the interior of the container. The pressure differential in the second region can be established, for example, by heating the second region with hot air. In the second region, a sensor detects a transition of the membrane of the container between convex and concave orientations and produces a signal corresponding to the occurrence of the transition.

Abstract: The accuracy and temperature-independence of ion-selective electrode meters having a logarithm resistance temperature correction incorporated therein is enhanced by using a microprocessor controlled and measured circuit with switched reference and switched capacitor filter, and by adding a linear membrane resistance term to the algorithm to improve accuracy across a wide temperature range.

Abstract: This invention relates to a new use discovered for the compound known as Aplidine (dehydrodidemnin B) which has the following structure: Aplidine has been found to be a potent L-type calcium channel enhancer in the human heart. This effect makes Aplidine a very useful drug for the treatment of congestive heart failure, as well as useful for the treatment of atrial fibrillation.

Abstract: Antitumor isocoumarins are of general formula (III) where R is --CONH.sub.2 or --CH(CH.sub.3).sub.2, or a pharmaceutically acceptable addition salt thereof. The compound wherein R is --CONH.sub.2 is the known compound amicoumacin A. The compound wherein is --CH(CH.sub.3).sub.2 is a new compound which can be obtained from fermentation of the new marine bacterium Bacillus sp. strain M-00-PHD-090, CECT 4546.

Abstract: The present invention is directed to immunochemical detection procedures, e.g., using both Western blotting and direct immunoassays, for fragments of Factor Va, which can thus be used; (a) in a predictive manner to evaluate the existence and/or extent of a thrombotic complication; (b) to monitor the efficacy of prophylaxis for a thrombotic condition; and (c) as a means to evaluate potential risk of hemorrhage during thrombolytic therapy.

Abstract: Described is a combination, PVC-membrane, Ion-Selective Electrode (ISE) with a replaceable sensing module and a single-junction, sleeve-type reference electrode. pH and ion-selective electrodes (ISEs) in the "Combination" configuration, i.e., single probes containing both the sensing and reference half-cells, are more convenient, more economical, and can be used to analyze smaller samples than an equivalent pair of separate half-cell electrodes.

Abstract: A technique for determining blood flow in a living body by changing the thermal energy level by a predetermined amount at a site in a blood flow path and detecting temperatures at locations upstream and downstream of the site. The temperature difference at such locations is determined and the blood flow is calculated as a function of the change in energy level and of the temperature differences measured prior to and following the change in energy level.

Abstract: An end cap packaging component having a first pair of generally rectangular elements appropriately disposed at two sides thereof and a second pair of generally rectangular elements appropriately disposed at the remaining two sides thereof. The first and second pairs of elements are interconnected at their peripheries to form an interior element directly coupled to the first and second pairs of elements. All of such elements are inflatable and deflatable using an appropriately postioned valve. Each of the elements has one or more non-inflatable regions therein and further non-inflatable regions are located where the interior element is coupled to the first and second pairs of elements. When inflated, the component can be folded to form an end cap shaped configuration which encloses the end portion of a product for providing a firm and snug fit thereon which then acts as a retaining cushion therefor the product is then placed in a shipping container.

Abstract: The present invention is directed to several novel compounds isolated from the sponge Crambe crambe, and designated herein as Crambescidin 816 (Compound 1), Crambescidin 830 (Compound 2), Crambescidin 844 (Compound 3), and Crambescidin 800 (Compound 4), as well as several derivatives thereof. The 816, 830, 844 and 800 compounds are four preferred species of complex pentacyclic guanidines linked by a linear .omega.-hydroxy fatty acid to a hydroxyspermidine, that have been obtained by a bioassay-guided isolation procedure, involving solvent partition and chromatography on Sephadex LH-20, cyano, and C-18 columns, from extracts of the red, encrusting sponge Crambe crambe (Order Poecilosclerida, Family Esperiopsidae).

Abstract: A method of Treatment of treating migraine headaches in humans by the administration of the compound of the formula I ##STR1## or a pharmaceutically acceptable acid addition salt thereof in a non-toxic, effective therapeutic amount (calculated as base) to a human in need thereof.

Abstract: Disclosed are (1) a water-soluble mutein of an animal protein having activity as a receptor for a fibroblast growth factor (FGF) protein, (2) a recombinant DNA having a nucleotide sequence coding for the above water-soluble mutein, (3) a vector containing the above recombinant DNA, (4) a transformant transformed with the above vector, and (5) a process for producing the water-soluble mutein which comprises cultivating the above transformant in a culture medium, the mutein being useful as therapeutic agents or to enhance cell proliferation activity.

Abstract: A multiple section telescoping police baton is disclosed. The baton has a locking mechanism which is activated upon twisting of one section relative to the other in order to prevent sliding motion of one section relative to the other.