Patents Represented by Attorney Fanelli Haag PLLC
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Patent number: 8178502Abstract: The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat esophogeal adenocarcinoma by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a described dosage level that minimizes the toxicity of the drug but yet still exhibits efficacy; or (iii) use of a described dosage regimen that minimizes the toxicity of the drug.Type: GrantFiled: September 8, 2008Date of Patent: May 15, 2012Assignee: University of South FloridaInventor: Jin Q. Cheng
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Patent number: 8148152Abstract: Provided are means and methods for producing embryoid bodies (EBs) from multi- or pluripotent cells. In particular, a method of generating embryoid bodies (EBs) is described comprising agitation of a liquid suspension culture of multi- or pluripotent cells in a container until generation of cell aggregates, optionally diluting the suspension, and further agitation of the suspension until formation of EBs. Furthermore, the present invention relates to the use of the novel culturing method and EBs obtained thereby for a variety of applications including genomics, diagnostic assays, teratogenic/embryotoxicological and pharmacological assays as well as for the provision of tissue grafts.Type: GrantFiled: July 8, 2004Date of Patent: April 3, 2012Assignee: Axiogenesis AGInventors: Eugen Kolossov, Ralf Kettenhofen, Isabella Kopp, Heribert Bohlen, Silke Schwengberg
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Patent number: 8131333Abstract: This invention is generally related to a biocompatible sensor for detecting/measuring sugar, especially glucose, in an ocular fluid in a non-invasive or minimally invasive manner and a method for using the biocompatible sensor. A biocompatible sensor of the invention comprises, consists essentially, or consists of an ophthalmic device comprising a molecular sensing moiety which interacts or, reacts with sugar to provide an optical signal which is indicative of sugar level in an ocular fluid.Type: GrantFiled: August 6, 2004Date of Patent: March 6, 2012Assignee: EyeSense AGInventors: L. Lawrence Chapoy, Angelika Maria Domschke, Dawn Smith
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Patent number: 8124391Abstract: The invention relates to a thermostable polymerase based on thermococcus pacificus; DNA molecules which code for one such polymerase; expression vectors; host cells; methods for producing one such polymerase and the use thereof for polymerising nucleic acid, especially in the polymerase chain reaction.Type: GrantFiled: October 5, 2001Date of Patent: February 28, 2012Assignee: Qiagen GmbHInventors: Katja Decker, Dirk Löffert, Jie Kang
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Patent number: 8114983Abstract: The present invention relates to inhibitors of endothelial PAS domain protein 1 (EPAS1), and methods and compositions related to the EPAS1 inhibitors. In certain embodiments, the EPAS1 inhibitors include nucleic acids, such as for example siRNAs.Type: GrantFiled: April 3, 2009Date of Patent: February 14, 2012Assignee: Calando Pharmaceuticals, Inc.Inventors: Mark E. Davis, Jeremy D. Heidel, Joanna Yi-Ching Liu
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Patent number: 8092836Abstract: The invention relates to capsules coated with a polyelectrolyte shell and methods for the production thereof.Type: GrantFiled: August 10, 2006Date of Patent: January 10, 2012Assignee: Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V.Inventors: Edwin Donath, Gleb B. Sukhorukov, Karl-Heinz Lerche, Andreas Voigt, Hans Bäumler, Frank Caruso, Helmuth Möhwald
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Patent number: 8088357Abstract: The invention relates to recognition molecules which are directed towards tumors and can be used in the diagnosis and therapy of tumor diseases.Type: GrantFiled: December 1, 2003Date of Patent: January 3, 2012Assignee: Nemod Biotherapeutics GmbH & Co. KGInventors: Steffen Goletz, Antje Danielczyk, Uwe Karsten, Peter Ravn, Renate Stahn, Peter Astrup Christensen
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Patent number: 8079236Abstract: The invention relates to a process and a device for the winding of nets (1) knitted from thrums (2) and wefts (3) to a given winding width at a winding point. For this the thrums (2) of the knitted net are guided along spacer elements (5, 9, 14) ahead of the winding point.Type: GrantFiled: February 16, 2005Date of Patent: December 20, 2011Assignee: RKW SEInventors: Horst Willner, Kurt Gebhardt, Lutz Kaufmann, Jürgen Piazzi
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Patent number: 8075645Abstract: A system for producing hydrogen features a reactor including a reaction channel adapted to receive a reaction stream including a mixture of supercritical water and a hydrocarbon fuel. A catalyst is positioned in the reaction channel so that a product stream containing hydrogen is produced by a reaction in the reaction channel when the mixture is exposed to the catalyst; wherein the catalyst contains a catalytically active metal and a promoter in a metal format, selected from the group consisting of potassium, sodium, rubidium, lithium, cesium, beryllium, magnesium, calcium, strontium, and barium.Type: GrantFiled: April 8, 2009Date of Patent: December 13, 2011Assignee: Chart Inc.Inventors: Zhijun Jia, Mark Wood, Clay Thiele
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Patent number: 8067206Abstract: The present invention relates generally to the field of nucleic acid chemistry. More specifically, it relates to a method for enhancing the performance of coamplification reactions, e.g., multiplex PCR reactions.Type: GrantFiled: September 24, 2003Date of Patent: November 29, 2011Assignee: Qiagen GmbHInventors: Holger Engel, Dirk Löffert
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Patent number: 8057041Abstract: The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate.Type: GrantFiled: July 23, 2007Date of Patent: November 15, 2011Assignee: EyeSense AGInventors: Achim Müller, Peter Herbrechtsmeier, Klaus Haberstroh, Roman Gruler
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Patent number: 8034562Abstract: The invention relates to a process for isolation of plasmid DNA from biomass by means of an aqueous 2-phase system having a polymer component and a salt component, characterized in that the resuspension of the biomass employed, the alkaline lysis of the biomass, the neutralization of the alkaline lysis batch and the separation of the plasmid DNA from the contaminants are carried out in a single reaction vessel (one-pot process) rendered possible in that the neutralization of the alkaline lysis batch is carried out in one and the same container by addition of potassium phosphate and one component of the aqueous 2-phase system is therefore already present. The second component of the aqueous 2-phase system is a PEG having a molecular weight of the mathematical average of about 600 g/mol to 1,000 g/mol.Type: GrantFiled: May 28, 2004Date of Patent: October 11, 2011Assignee: QIAGEN GmbHInventors: Markus Müller, Jürgen Hubbuch, Andreas Frerix, Maria-Regina Kula
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Patent number: 8008475Abstract: The present invention involves a process for the isolation of nucleic acids on surfaces by means of at least the following steps: charging of a surface from a given direction with nucleic acids; immobilization of the nucleic acids on the surface; release of the immobilized nucleic acids from the surface; and removal of the released nucleic acids essentially in the direction of charging. Preferably the loading takes place from the top.Type: GrantFiled: March 28, 2000Date of Patent: August 30, 2011Assignee: QIAGEN GmbHInventors: Helge Bastian, Simone Gauch, Uwe Oelmüller, Susanne Ullmann
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Patent number: 7998666Abstract: An analyte test element for determining the concentration of at least one analyte in a physiological sample fluid having a first and a second surface in a predetermined distance opposite from each other, said both surfaces are provided with two substantially equivalent patterns forming areas of high and low surface energy which are aligned mostly congruent, whereby the areas with high surface energy create a sample distribution system with at least two detection areas, characterized in that the detection areas of first and second surface are also provided with two corresponding patterns of working and reference electrodes of electrochemical detection means.Type: GrantFiled: August 13, 2004Date of Patent: August 16, 2011Assignee: Egomedical Technologies AGInventors: Matthias Stiene, Ingrid Rohm
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Patent number: 7939103Abstract: A process for the production of CS particles (10) and microcapsules (12) is described, in which at least one active compound (4) is adsorbed in porous templates (2) (A), as a result of which templates (5) filled with active compounds are present. Subsequently, the templates (2) are provided (B) with a primer layer (6) which is intended to facilitate the subsequent construction of the capsule shell (9). The capsule shell is formed (C) by applying alternately charged polyelectrolyte layers (8). Filled CS particles (10) are obtained. By subsequent dissolution of the templates (2) the active compounds (4) are released (D) from the template into the interior of the microcapsules. The active compounds (4) remain enclosed there or are slowly released (E) from the capsule.Type: GrantFiled: March 16, 2005Date of Patent: May 10, 2011Assignee: Capsulution Pharma AGInventors: Lars Dahne, Barbara Baude
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Patent number: 7927519Abstract: This invention is generally related to a biocompatible sensor for detecting/measuring an analyte of interest in a body fluid and a method for making the biocompatible sensor. A biocompatible sensor of the invention comprises, consists essentially, or consists of a reflection hologram therein or thereon, wherein the reflection hologram is produced in a crosslinkable and/or polymerizable fluid material. The polymer matrix contains a molecular sensing moiety which interacts or reacts with an analyte of interest to provide an optical signal which is indicative of a change in one or more optical properties of the reflection hologram.Type: GrantFiled: June 16, 2004Date of Patent: April 19, 2011Assignee: Eyesense AGInventors: Angelika Maria Domschke, Xiaodong Hu, Jian S. Zhou
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Patent number: 7922917Abstract: Porous, ferro- or ferrimagnetic, glass particles are described that selectively bind molecules of interest, especially nucleic acid molecules, under appropriate conditions. Methods of preparing the porous, ferro- or ferrimagnetic, glass particles and their use for identifying or separating molecules of interest are also described. Kits comprising the porous, ferro- or ferrimagnetic, glass particles are also provided.Type: GrantFiled: December 7, 2006Date of Patent: April 12, 2011Assignee: QIAGEN GmbHInventors: Philippe Sauer, Bernd Springer, Thomas Manz, Christoph Ritt, Roland Fabis