Patents Represented by Attorney, Agent or Law Firm Felfe & Lynch
  • Patent number: 5854203
    Abstract: The invention relates to nucleic acid molecules coding for a tumor rejection antigen precursor. Specifically, the tumor rejection antigen precursor, or "TRAP", is processed into at least one tumor rejection antigen, which is presented by HLA-A2 molecules. Ramifications of the discovery are also set forth.
    Type: Grant
    Filed: March 3, 1995
    Date of Patent: December 29, 1998
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Vincent Brichard, Aline Van Pel, Catia Traversari, Thomas Wolfel, Thierry Boon-Falleur, Etienne De Plaen
  • Patent number: 5852184
    Abstract: The present invention is directed to a novel protein tyrosine kinase comprising a polypeptide having multiple protein kinase catalytic domains and, more particularly, two kinase catalytic domains and to genetic sequences encoding same. Two such kinases are described and designated JAK1 and JAK2.
    Type: Grant
    Filed: June 30, 1993
    Date of Patent: December 22, 1998
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Andrew Frederick Wilks, Ailsa Harpur
  • Patent number: 5851840
    Abstract: The invention concerns a binding matrix containing a carrier material with an oxidic surface and a solid phase reactant covalently bound thereto via anchor groups which is capable of binding to at least one free reaction partner, which is characterized in that the solid phase reactant forms a diluted and essentially laterally homogeneous binding layer on the surface of the carrier material and that the anchor groups are silane groups and are linked to the solid phase reactant via a spacer molecule.
    Type: Grant
    Filed: December 31, 1996
    Date of Patent: December 22, 1998
    Assignee: Boehringer Mannheim GmbH
    Inventors: Peter Sluka, Hans-Georg Batz
  • Patent number: 5851526
    Abstract: This invention relates to methods of reducing the effects of colon cancer tumors. Various agents are conjugated to monoclonal antibodies which are specific for colon cancer cells. The conjugates are administered to patients having colon cancer such that the effects of the cancer are reduced.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: December 22, 1998
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Sydney Welt, Gerd Ritter, Leonard Cohen, Clarence Williams, Jr., Elizabeth Carswell Richards, Mary John, Lloyd J. Old
  • Patent number: 5849087
    Abstract: In a vacuum treatment system for applying thin layers to substrates (2, 2', . . . ) such as headlight reflectors, with several treatment (8, 9, 10) and/or inward and outward transfer lock stations (20) supported on a stationary vacuum chamber wall (16, 16', . . . ) and with a rotatably supported internal cylinder (14), which is enclosed by the vacuum chamber wall and carries the substrate chambers (3-6), openings (24-27) are provided in the vacuum chamber wall (16, 16', . . . ), with which the substrate chambers (3-6) can be aligned and through which the treatment agents can be allowed to act on the substrates (2, 2', . . .
    Type: Grant
    Filed: July 1, 1997
    Date of Patent: December 15, 1998
    Assignee: Leybold Systems GmbH
    Inventors: Hermann Kloberdanz, Josef Hoffmann, Jurgen Henrich
  • Patent number: 5849904
    Abstract: Isolated nucleic acid molecules encoding polysialyl transferases, and the polysialyl transferases themselves are disclosed. SEQ ID NOS: 1, 2, 7 and 8 present examples of these. The nucleic acid molecules and the proteins can be used diagnostically or therapeutically. Additionally, antisense oligonucleotides and antibodies are described, which can also be used diagnostically or therapeutically.
    Type: Grant
    Filed: December 21, 1995
    Date of Patent: December 15, 1998
    Assignees: Boehringer Mannheim GmbH, La Jolla Cancer Research Foun.
    Inventors: Rita Gerardy-Schahn, Minoru Fukuda, Jun Nakayama, Matthias Eckhardt
  • Patent number: 5846826
    Abstract: The invention involves cytolytic T cell lines which are specific for complexes of HLA-B44 molecules and nonamers which bind to these.
    Type: Grant
    Filed: March 5, 1996
    Date of Patent: December 8, 1998
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Pierre Coulie, Thierry Boon-Falleur
  • Patent number: 5843859
    Abstract: A reaction-formed moulded ceramic body containing mullite is described which is obtainable by heat treating a body moulded from a finely dispersed powder mixture of aluminium, Al.sub.2 O.sub.3 and a material containing Si in an atmosphere containing oxygen. Due to their properties, in particular their low shrinkage of 0 to 4% on average, the moulded bodies are very well suited for use as wear-resistant and/or high temperature-resistant components in the construction of machines, apparatuses and motors, as a cutting tool, as a component for bearings and/or seals and as a functional part in electronic instruments.
    Type: Grant
    Filed: November 25, 1992
    Date of Patent: December 1, 1998
    Inventor: Nils Claussen
  • Patent number: 5844124
    Abstract: A method, an apparatus, and an integrated system using the apparatus for measuring a concentration of odorant in odorized gas which is produced by adding the odorant to un-odorized gas comprised mainly of hydrocarbon gas. In a detection absorbance measuring step, there is obtaining detection odorized gas absorbance which is absorbance of the odorized gas relative to a detecting ultraviolet light having high absorbability to the odorant and low absorbability to the un-odorized gas. In a subsequent concentration deriving step, the odorant concentration in the odorized gas is derived from the detection odorized gas absorbance.
    Type: Grant
    Filed: October 10, 1996
    Date of Patent: December 1, 1998
    Assignee: Osaka Gas Co., Ltd.
    Inventors: Takayuki Shimokawatoko, Koichi Sumida, Hirofumi Ueda
  • Patent number: 5843687
    Abstract: The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
    Type: Grant
    Filed: October 19, 1995
    Date of Patent: December 1, 1998
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Thomas Wolfel, Aline Van Pel, Vincent Brichard, Thierry Boon-Falleur
  • Patent number: 5843688
    Abstract: The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
    Type: Grant
    Filed: January 5, 1996
    Date of Patent: December 1, 1998
    Assignee: Ludwig Institute For Cancer Research
    Inventors: Thomas Wolfel, Aline Van Pel, Vincent Brichard, Thierry Boon-Falleur, Etienne DePlaen, Pierre Coulie, Jean-Christophe Renauld, Bernard Lethe
  • Patent number: 5840568
    Abstract: The invention describes identification and isolation of molecules associated specifically with Hodgkin's Disease. Uses of the molecules are described as well.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: November 24, 1998
    Assignee: Ludwig Institute for Cancer Research
    Inventor: Michael Pfreundschuh
  • Patent number: 5838457
    Abstract: A photographic printing apparatus capable of printing, as an index print, an inlaid composite image having images of a plurality of frames of a film. An exposure device 10 of this printing apparatus includes an exposure controller 104 for controlling this exposure device 10 according to exposure conditions determined based on image information read from the film. The apparatus incorporates an index printer 40 for printing an inlaid composite image. An image information converter 103 is provided for producing, from the read image information, index-print image information corresponding to an image which is expected to be obtained on a photosensitive material if the material is exposed under the determined exposure conditions, and also for sending this index-print information to the index printer 40. A monitor 30 is provided for displaying the image information produced by the image information converter 103 for allowing checking thereof.
    Type: Grant
    Filed: June 14, 1995
    Date of Patent: November 17, 1998
    Assignee: Noritsu Koki Co., Ltd.
    Inventor: Choji Umemoto
  • Patent number: 5830816
    Abstract: Zirconium dioxide containing 2 to 40 vol. % of stabilizing oxides is embedded in the matrix material of a sintered molding consisting of an aluminum oxide/chromium oxide mixed crystal. The quantity of stabilizing oxides added is chosen so that the zirconium dioxide is predominantly tetragonal. The molar ratio of the zirconium dioxide containing the stabilizing oxides to the chromium oxide is between 1000:1 and 20:1 and the zirconium dioxide has a maximum particle size of 2 .mu.m.
    Type: Grant
    Filed: July 2, 1996
    Date of Patent: November 3, 1998
    Assignee: Cerasiv GmbH Innovatives Keramik-Engineering
    Inventors: Wolfgang Burger, Stefan Gernsheimer, Hans Andersch, Kilian Friederich, Siegbert Lehmann, Johannes Schneider, Michael Fripan
  • Patent number: 5832402
    Abstract: The movement of a vehicle is controlled by actuating actuators which apply a braking force to the wheels. For this purpose, the rotational speeds of the wheels, the steering angle and at least one of the lateral acceleration and the yawing movement of the vehicle are detected. A first module is configured so that the actuators are actuated by means of the actuation signals with the effect of controlling a first variable. The second module is configured so that signals for influencing the actuation signals are formed with the effect of controlling a second control variable. In order to obtain this second control variable, at least the variable which represents the steering angle is processed. The second controller component brings about a control of a variable which is determined at least as a function of the lateral movement or the yawing movement of the vehicle.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: November 3, 1998
    Assignee: Robert Bosch GMBH
    Inventors: Jost Brachert, Elmar Mueller, Ralf Hadeler, Frank Leibeling, Juergen Schuh, Michael Schubert
  • Patent number: 5830454
    Abstract: A method for the treatment of cell mediated autoimmune disease is disclosed. The method involves administering interleukin-9 in an effective amount to the subject. Among the conditions treatable are thyroiditis and autoimmune diabetes.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: November 3, 1998
    Assignee: Ludwig Institute For Cancer Research
    Inventors: Jean-Christophe Renauld, Mary-Christine Many
  • Patent number: 5830753
    Abstract: A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as DAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: November 3, 1998
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Pierre Coulie, Hideyuki Ikeda, Thierry Boon-Falleur
  • Patent number: 5831309
    Abstract: Semifinished products designed as composite bodies for electronic or opto-electronic semiconductor components are known. The composite bodies are made of a disk-shaped, transparent quartz glass substrate and a wafer made of a semiconductor material. The directly bonded surfaces of the quartz glass substrate and wafer are polished before being mutually bonded. In order to create a semifinished product that resists temperatures above 900.degree. C., such as those used to produce semiconductor circuits in industrially feasible times, without raising fears of a substantial reduction of the adhesive forces, chipping of the wafers away from each other or an undesirable deformation of the composite body, the substrate quartz glass is a synthetic quartz glass with at least 10.sup.14.0 poise viscosity at 950.degree. C. which does not fall below 10.sup.12 poise at 1050.degree. C.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: November 3, 1998
    Assignee: Heraeus Quarzglas GmbH
    Inventors: Wolfgang Englisch, Reinhold Uebbing
  • Patent number: 5827566
    Abstract: Disclosed are a process and a device for wetting pneumatically transported particles with a fluid where the fluid is sprayed by means of nozzles into a transport line through which the particles are flowing. The nozzles are installed in an area of the transport line which has a diffusor-like expansion in its cross section to insure that the particles are wetted uniformly and in a finely divided manner.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: October 27, 1998
    Assignee: Carl Schenck
    Inventors: Albrecht Epple, Herbert Nopper, Wolfgang Haag
  • Patent number: 5827073
    Abstract: The invention relates to methods for making synthetic, photoreactive peptides and their use. A photoreactively labelled amino acid is incorporated into the peptide. The resulting peptide, when compared to the non-labelled form, is not impaired with respect to its ability to bind an MHC molecule.
    Type: Grant
    Filed: July 5, 1995
    Date of Patent: October 27, 1998
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Immanuel Luescher, Fabienee Anjuere, Andreas Layer, Pedro Romero, Jean-Charles Cerottini