Patents Represented by Attorney Frederick H. Weinfeldt
  • Patent number: 4420475
    Abstract: Compounds of the formula I: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 is, independently, (a) alkyl having from 1 to 22 carbon atoms; or(b) of the formula ##STR2## in which m is 0, 1 or 2, and each R' and R" is independently a hydrogen atom, alkyl having from 1 to 3 carbon atoms, alkoxy having from 1 to 3 carbon atoms, or halo having an atomic weight of from about 19 to 127; and R is of an aralkyl-, phenyl- tryptophanyl- or benzo-cycloalkyl-type, are obtained by hydrogenating corresponding .alpha.-.beta. ethylenically-unsaturated analogs (II), which in turn are obtained by hydrogenating corresponding .alpha.-.beta. acetylenically-unsaturated analogs. Compounds I and II are useful as anti-atheroslerotic agents.
    Type: Grant
    Filed: December 11, 1980
    Date of Patent: December 13, 1983
    Assignee: Sandoz, Inc.
    Inventor: Robert E. Damon, II
  • Patent number: 4416876
    Abstract: Compounds of the formula ##STR1## in which R.sup.1 is a mono-silicon-containing hydrocarbyl radical having up to 35 carbon atoms;each of R.sup.2 and R.sup.3 is, independently, a hydrogen atom or lower alkyl having from 1 to 3 carbon atoms;n is 0 or 1; andM is a hydrogen atom, an equivalent of a cation which forms a non-toxic, pharmaceutically acceptable salt, or a non-toxic pharmaceutically acceptable monovalent radical which is hydrolyzable or saponifiable to an alkali metal cation, eg sodium 4-(4,4-dimethyl-4-sila-tetradecylamino)-benzoate, are useful as pharmaceutical agents.
    Type: Grant
    Filed: May 19, 1982
    Date of Patent: November 22, 1983
    Assignee: Sandoz, Inc.
    Inventors: Sandor Barcza, Faizulla G. Kathawala
  • Patent number: 4415560
    Abstract: Silicon-containing amides, e.g., N-[1'-phenyl-2'-(4"-methylphenyl)ethyl]-2,2,6,6-tetramethyl-1-oxa-2,6-disi lacyclohexane-4-carboxamide, are useful as anti-atherosclerotic agents. The amides are obtainable by acylation of a primary amine (the substituents on the amine being of the aralkyl phenyl, tryptophanyl, benzocycloalkyl-type) with a corresponding silicon-containing carboxylic acid (or active form thereof).
    Type: Grant
    Filed: October 12, 1982
    Date of Patent: November 15, 1983
    Assignee: Sandoz, Inc.
    Inventor: Sandor Barcza
  • Patent number: 4415687
    Abstract: 1,3-dihydroxy-4,6-bis-4'-(2',2',6',6',-tetramethylpiperidyl) benzene, its 1'-alkyl or 1'-(substituted alkyl) derivatives and monomeric or polymeric products derived from these compounds by substitution of 1- and 3-hydroxy groups and/or by the linking of hydroxy groups on adjacent units through a bridging groups, are useful as light and heat stabilizers for polymeric organic materials.Corresponding bis(3',4'-dehydro) unsaturated compounds are useful as intermediates.
    Type: Grant
    Filed: July 2, 1982
    Date of Patent: November 15, 1983
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Evelyne Kalt, Hellmuth Reinshagen
  • Patent number: 4407993
    Abstract: N-(.beta.-aminoethyl)-3-hydroxy-1,1,6,6-tetramethyl-piperidine and certain of its N- and O-substituted derivatives are useful as light stabilizers for polymeric materials, particularly for thermoplastic polymers and automotive finishes. Preferred compounds include the N-, O-diacyl derivatives.
    Type: Grant
    Filed: March 15, 1982
    Date of Patent: October 4, 1983
    Assignee: Sandoz Ltd.
    Inventors: Hans Hinsken, Wolfgang Mueller, Hermann Schneider
  • Patent number: 4408051
    Abstract: Compounds obtained by the addition of unsaturated esters to the >NH group of compounds of formula II ##STR1## are useful as light stabilizers for polymeric materials, particularly for thermoplastic polymers and automotive finishes. Preferred compounds are those in which R, R.sub.1 and R.sub.2 are all hydrogen and R.sub.3 and R.sub.4 together with the carbon atom to which they are attached form a cyclododecylidene ring.
    Type: Grant
    Filed: December 18, 1981
    Date of Patent: October 4, 1983
    Assignee: Sandoz Ltd.
    Inventors: Hans Hinsken, Wolfgang Mueller, Hermann Schneider
  • Patent number: 4399050
    Abstract: A thickened aqueous bleach composition comprising(a) an alkali metal hypochloriteand (b) one or more carboxylated surfactants of formula IRO-- CH.sub.2 CH.sub.2 O ].sub.n R.sub.1 --COO.crclbar.A.sym.Iin whichR is a straight chain C.sub.6-20 alkyl, phenyl, a straight or branched chain C.sub.7-30 alkaryl or a straight or branched chain C.sub.7-30 aralkyl, unsubstituted or substituted with substituents unreactive to hypochlorite,R.sub.1 is C.sub.1-4 alkylene,A.sym. is hydrogen ion, an alkali metal cation, or an equivalently charged amount of an alkaline earth metal cation and n is 0.5 to 45. Additionally free ethoxylate can be present in the mixture together with further bleach additives including perfumes.
    Type: Grant
    Filed: May 13, 1981
    Date of Patent: August 16, 1983
    Assignee: Sandoz Products Limited
    Inventors: John Bentham, Jacqueline A. Coates, David L. Connell
  • Patent number: 4384124
    Abstract: Cyclopropanyl-group-bearing-amides, eg N-[1-(benzyl)-2-(phenyl)ethyl]-cis-2-octyl-cyclopropanoctanamide and N-(.alpha.-methyl-benzyl)-(cis)-2-octyl-cyclopropanoctanamide, are useful as pharmaceutical agents and are obtainable, eg by reacting a mixed anhydride of a cyclopropanyl-group bearing-long chain carboxylic acid with an appropriate amino compound.
    Type: Grant
    Filed: July 10, 1980
    Date of Patent: May 17, 1983
    Assignee: Sandoz, Inc.
    Inventors: Faizulla G. Kathawala, John G. Heider
  • Patent number: 4382951
    Abstract: Benzopyrane and benzothiopyrane derivatives which possess pharmaceutical in particular anti-mycotic activity.
    Type: Grant
    Filed: December 10, 1981
    Date of Patent: May 10, 1983
    Assignee: Sandoz Ltd.
    Inventors: Maximilian Grassberger, Gabor Petranyi
  • Patent number: 4366154
    Abstract: Tropyl derivatives of the formula: ##STR1## in which R.sup.1 is (a) phenyl linked through a direct bond, --O--, ##STR2## (in which m=2 or 3); (b) diphenylmethyl; or (c) 10H-phenothiazin-10-yl; (each of which type may be substituted, or unsubstituted); R.sup.2 is --H, --OH, or --O Si (CH.sub.3).sub.3 ; and R.sup.3 is substituted or unsubstituted phenyl, e.g. 4-[3-(4-fluorobenzoyl)-8-azabicyclo [3.2.1]oct-8-yl]-1-(-4-fluorophenyl)-1-butanone, in free base form or pharmaceutically acceptable acid addition salts are useful as pharmaceuticals.
    Type: Grant
    Filed: November 9, 1981
    Date of Patent: December 28, 1982
    Assignee: Sandoz, Inc.
    Inventor: John C. Tomesch
  • Patent number: 4344966
    Abstract: The compounds are 1-aryl-1-lower alkyl-substituted-1-buten-3-ols, butan-3-ols, and acylation products thereof, e.g., (p-biphenylyl)-2-penten-4-ol and are useful as pharmaceuticals.
    Type: Grant
    Filed: January 8, 1980
    Date of Patent: August 17, 1982
    Assignee: Sandoz, Inc.
    Inventors: Paul L. Anderson, Darryl A. Brittain
  • Patent number: 4335124
    Abstract: The compounds are 4-phenyl-4-lower alkyl-substituted-3-buten-2-ones, and -2-halo-1,3-butadienes, e.g., 2-(p-biphenylyl)-2-penten-4-one, and are useful as pharmaceuticals.
    Type: Grant
    Filed: October 14, 1980
    Date of Patent: June 15, 1982
    Assignee: Sandoz, Inc.
    Inventor: Eugene E. Galantay
  • Patent number: 4321269
    Abstract: The compounds are 1-(3-halo-1,2-dioxopropyl)-cycloamines, eg 1-(3-chloro-1,2-dioxopropyl)-piperidine, and are useful as fungicides and bactericides. They can be prepared by halogenation of a corresponding 1-(1,2-dioxopropyl)-cycloamine.
    Type: Grant
    Filed: December 22, 1980
    Date of Patent: March 23, 1982
    Assignee: Sandoz, Inc.
    Inventor: James R. Wareing
  • Patent number: 4320135
    Abstract: The compounds are free hydantoin derivatives of the formula: ##STR1## wherein X is a divalent radical consisting of from 2 to 5 linked units; one unit being --O--, and from one to 4 hydrocarbon units, independently, having the structure(a) --CH.sub.2 -- or (b) --C(R).sub.2 --in which R is alkyl having from 1 to 6 carbon atoms and being free of branching on the .alpha.-carbon atoms; provided that no more than 2 units are of type b; or a pharmaceutically acceptable salt form thereof with a suitable cation; e.g. 7-oxa-1,3-diazaspiro[4.4]nonane-2,4-dione, and are useful as pharmaceuticals.
    Type: Grant
    Filed: May 19, 1980
    Date of Patent: March 16, 1982
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4297349
    Abstract: The final products are compounds of the formula ##STR1## wherein (a) each of R.sup.1, R.sup.2 and R.sup.3 alkyl having from 1 to 22 carbon atoms; or(b) one or more is a phenyl or alkylphenyl type, n is from 3 to 20; andR is of an aralkyl-, phenyl-tryptophanyl- or benzocycloalkyl-type, eg D,L-5,5-dimethyl-5-sila-pentadecanoyl-1'-phenyl-2'-p-tolyl-ethylamide, are useful as antiatherosclerotic agents, and are prepared from corresponding carboxylic acids (or their derivatives).
    Type: Grant
    Filed: April 15, 1980
    Date of Patent: October 27, 1981
    Assignee: Sandoz, Inc.
    Inventor: Sandor Barcza
  • Patent number: 4296240
    Abstract: Anti-atherosclerotic agents of the formula: ##STR1## wherein R.sup.1 is (a) alkyl having from 1 to 22 carbon atoms; or(b) of the formula ##STR2## in which m is 0, 1 or 2, and each of R' and R" is, independently, hydrogen, halo or lower alkyl or alkoxy; R.sup.2 and R.sup.3 are joined to form with the silicon atom a heterocyclic ring having from 3 to 20 ring members; and R is an aralkyl-, phenyl- tryptophanyl- or benzocycloalkyl-type radical, eg 1-butyl-N-[(2-(4'-methyl-phenyl)-1-phenylethyl]-1-silacyclohexane propanamide, are obtained by reducing corresponding .alpha.,.beta.-unsaturated analogs.
    Type: Grant
    Filed: April 24, 1980
    Date of Patent: October 20, 1981
    Assignee: Sandoz, Inc.
    Inventor: Robert E. Damon, II
  • Patent number: 4287355
    Abstract: Carbalkoxy-phenyl (or tolyl)-dialkyl-or alkyl-phenyl-sulfonium salts, e.g. p-(.alpha.-carbethoxy) tolyl-n-octadecyl-phenyl sulfonium tetrafluoroborate, are useful as pharmaceuticals. The compounds are obtainable by reaction of a carbalkoxy-phenyl (or-tolyl)-dialkyl-or-alkyl-phenyl-sulfide with an alkylhalide in the presence of a metal salt, e.g. silver tetrafluoroborate.
    Type: Grant
    Filed: July 21, 1980
    Date of Patent: September 1, 1981
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4273787
    Abstract: The compounds are 4-phenyl-4-lower alkyl-substituted-3-buten-2-ones, and -2-halo-1,3-butadienes, e.g., 2-(p-biphenylyl)-2-penten-4-one, and are useful as pharmaceuticals.
    Type: Grant
    Filed: August 9, 1979
    Date of Patent: June 16, 1981
    Assignee: Sandoz, Inc.
    Inventor: Eugene E. Galantay
  • Patent number: 4251521
    Abstract: Alkyl diaryl sulfonium salts, e.g., cyclopropyl diphenylsulfonium tetrafluoroborate, are useful as hypoglycemic agents.
    Type: Grant
    Filed: February 7, 1979
    Date of Patent: February 17, 1981
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4248893
    Abstract: Cyclopropanyl-group-bearing-amides, eg N-[1-(benzyl)-2-(phenyl)ethyl]-cis-2-octyl-cyclopropanoctanamide and N-(.alpha.-methyl-benzyl)-(cis)-2-octyl-cyclopropanoctanamide, are useful as pharmaceutical agents and are obtainable, eg by reacting a mixed anhydride of a cyclopropanyl-group bearing-long chain carboxylic acid with an appropriate amino compound.
    Type: Grant
    Filed: February 5, 1979
    Date of Patent: February 3, 1981
    Assignee: Sandoz, Inc.
    Inventors: Faizulla G. Kathawala, John G. Heider