Patents Represented by Attorney Gilman Pergament LLP
  • Patent number: 8349819
    Abstract: A process in which urine is optionally filtered to remove solid extraneous matter and optionally treated so as to reduce the phenolic content of the urine to give and the resulting fluid is then subjected to a solid extraction of the major concentration steroids content therefrom by a first suitable resin (to yield a first resin laden with major concentration steroids and a minor concentration steroid laden first liquid remainder). The minor concentration steroid liquid remainder is subjected to a solid extraction of the minor concentration steroid content therefrom by a second suitable resin (to yield a second resin laden with minor concentration steroids and a second liquid remainder). The first and second resins laden with their respective steroids are then eluted and the eluates are collected separately and optionally subjected to further purification and chromatographic separations, with each resulting separate collection being analyzed for the steroid content thereof.
    Type: Grant
    Filed: February 10, 2005
    Date of Patent: January 8, 2013
    Assignee: Dr. Reddy's Laboratories New York, Inc.
    Inventors: John Lomans, Carmen Leiva-paredes
  • Patent number: 8344010
    Abstract: The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: January 1, 2013
    Assignee: Glenmark Pharmaceuticals S.A.
    Inventors: V. S. Prasadarao Lingam, Abraham Thomas, Shantaram Kashinath Phatangare, Ajit Shankar Mindhe, Javed Yusuf Khatik, Neelima Khairatkar-Joshi, Vidya Ganapati Kattige
  • Patent number: 8318928
    Abstract: The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: November 27, 2012
    Assignee: Glenmark Pharmaceuticals, S.A.
    Inventors: Sachin Sundarlal Chaudhari, Thomas Abraham, Ashok Bhausaheb Kadam, Sachin Vasantrao Dhone, Suresh Mahadev Kadam, Neelima Khairatkar-Joshi, Vidya Ganapati Kattige
  • Patent number: 8309724
    Abstract: There is provided an improved process for the preparation of Sitagliptin of Formula II by reduction of compound of Formula VIII to Formula IX followed by deprotection of Formula IX to afford Sitagliptin of Formula II.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: November 13, 2012
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Incorporated
    Inventors: Pratap Reddy Padi, Babu Ireni, Srinivas Polavarapu, Shailaja Padamata, Kavitha Nerella, Vijaya Anand Ramasamy, Ranga Reddy Vangala
  • Patent number: 8263160
    Abstract: A system and method for preparation of meat flavorants, and flavorants, having increased flavor and aromatic intensity and which more closely resemble the natural flavor and aroma of cooked meat. Preheated edible, food grade oils and fats are exposed to temperatures between 290° C. and 475° C. under vacuum, in the presence of oxygen. The developing flavor vapors are immediately and completely removed from the heated oils and fats. The mixture of air-purge/flavor-vapor is immediately carried away from the heat transfer surface of the edible oil or fat. An evaporator, preferably a spinning disc, spinning band or thin film evaporator, without a condenser is used as process equipment. The air-purged flavor-vapors are diffused and absorbed in an absorption device into suitable food-grade liquids.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: September 11, 2012
    Assignee: Flavor & Food Ingredients, Inc.
    Inventors: Jurgen D. Scheide, John M. Stefanicha
  • Patent number: 8263124
    Abstract: The present invention relates to pharmaceutical compositions of antihistamine-decongestant combination. Specifically the invention relates to bilayered tablet formulation comprising antihistaminic decongestant combination. More specifically present invention relates to the novel polymorph of fexofenadine or pharmaceutically accepted salts thereof, with at least one decongestant in the form of bilayered tablet. The preferred polymorphs are polymorph A and polymorph X of fexofenadine hydrochloride.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: September 11, 2012
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Kamalakar Talasila, Debashis Dash, Srinivas Irukula, Dhanorkar Vipin Tatyasaheb, Mailatur Sivaraman Mohan
  • Patent number: 8253003
    Abstract: A percussion instrument is disclosed that may include a body having a longitudinal axis extending from a butt end to a striking end thereof and at least one hole extending along a transverse axis through the thickness of the body; a grasping mechanism having a first grip plate at a first end thereof and a second grip plate at a second end thereof, and a shaft extending through the hole in the body; and a compliance mechanism disposed between the first and second grip plates, enabling the first and second grip plates to be brought closer together in response to a compressive force applied to the grasping mechanism.
    Type: Grant
    Filed: May 5, 2010
    Date of Patent: August 28, 2012
    Assignee: Hingestix LLC
    Inventor: Samuel Ruttenberg
  • Patent number: 8241625
    Abstract: The antibody based medicament contains ultra low doses of monoclonal, polyclonal, immune or natural antibodies to a protein or a peptide involved in the vascular tone regulation or mediating the effects of other regulators; these antibodies are used in activated (potentiated) form produced by multiple subsequent dilution and external impact, preferably in accordance with homeopathic technology. The method of treatment for diseases accompanied by disturbances of the vascular tone utilizes the use of ultra low doses of antibodies to a protein or a peptide involved in the vascular tone regulation or mediating the effects of other regulators; these antibodies are used in activated form produced by multiple subsequent dilution and external impact.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: August 14, 2012
    Inventors: Oleg Epshtein, Andrey Martyushev
  • Patent number: 8217039
    Abstract: Intimate mixtures of aprepitant crystalline Form I and crystalline Form II, having specific weight ratios of the forms.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: July 10, 2012
    Assignees: Dr. Reddy's Laboratories Ltd., Dr. Reddy's Laboratories, Inc.
    Inventors: Vijayavitthal Thippannachar Mathad, Pravinchandra Jayantilal Vankawala, Raviram Chandrasekhar Elati, Prabhakar Macharla, Srinivas Gangula, Naveen Kumar Kolla, Ravi Kumar Komareddy, Surya Narayana Devarkonda, Subbareddy Peddireddy
  • Patent number: 8205852
    Abstract: A flexure mount for economically producing pure translational motion with no arcuate or error motion in the vertical direction utilizing alignment pins and parts reducing structures including monolithic springs. A low profile embodiment utilizes a compound monolithic spring. The flexure mount may be used to translate a mirror or retroreflector in a purely linear direction of precisely controlled and known distance, useful in myriad interferometer applications including spectroscopy.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: June 26, 2012
    Assignee: FTRX LLC
    Inventors: Alexander Jacobson, Zvi Bleier
  • Patent number: 8205853
    Abstract: A flexure mount for economically producing pure translational motion with no arcuate or error motion in the vertical direction utilizing alignment pins and parts reducing structures including monolithic springs. A low profile embodiment utilizes a compound monolithic spring. The flexure mount may be used to translate a mirror or retroreflector in a purely linear direction of precisely controlled and known distance, useful in myriad interferometer applications including spectroscopy.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: June 26, 2012
    Assignee: FTRX LLC
    Inventors: Zvi Bleier, Alexander Jacobson
  • Patent number: 8202732
    Abstract: A chemical analysis method for the determination of RO(CH2CH2O)nH, RO(C2H4O)nA, and AO(C2H4O)nA in a mixture thereof, wherein R is an alkyl group, A is a functional group for coupling with a surface or a biologically active material or another thing of use and n is an integer greater than 10. The method includes derivatizing the A groups of the mixture with a derivatizing agent to form a derivatized mixture comprising RO(CH2CH2O)nH, RO(C2H4O)nAD, and DAO(C2H4O)nAD, wherein AD is the derivatized A group. The second step is chromatographing a sample of the derivatized mixture by liquid chromatography under critical conditions to determine the relative amounts of RO(CH2CH2O)nH, RO(C2H4O)nAD, and DAO(C2H4O)nAD in the derivatized mixture.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: June 19, 2012
    Assignee: Dr. Reddy's Laboratories (EU) Limited
    Inventors: Ross A Wallingford, Maciej Turowski
  • Patent number: 8178498
    Abstract: A medicinal composition includes an active medicinal substance in therapeutic dose and a potentiated medicinal preparation produced from the substance by homeopathis methods.
    Type: Grant
    Filed: February 10, 1997
    Date of Patent: May 15, 2012
    Inventor: Oleg Iliich Ephstein
  • Patent number: 8168182
    Abstract: A medicament based on antibodies contains an activated form of ultra-low doses of monoclonal, polyclonal, or natural antibodies to endothelial nitric oxide synthase (NO synthase), the activated form being prepared by multiple consecutive dilutions and exposure to external factors, preferably according to the homeopathic technology. A method of treating erectile dysfunctions and vegetative disturbances of male climax by regulating the level of cyclic guanosine monophosphate (cGMP) in the cavernous bodies on sexual stimulation, the method being characterized by the use of activated forms of ultra-low doses of antibodies to the entire molecule of the endothelial NO synthase or to its polypeptide fragments, activated forms being prepared by multiple consecutive dilutions and exposure to external factors.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: May 1, 2012
    Inventor: Oleg Iliich Epshtein
  • Patent number: 8137724
    Abstract: A system and method for preparation of meat flavorants, and flavorants, having increased flavor and aromatic intensity and which more closely resemble the natural flavor and aroma of cooked meat. Preheated edible, food grade oils and fats are exposed to temperatures between 290° C. and 475° C. under vacuum, in the presence of oxygen. The developing flavor vapors are immediately and completely removed from the heated oils and fats. The mixture of air-purge/flavor-vapor is immediately carried away from the heat transfer surface of the edible oil or fat. An evaporator, preferably a spinning disc, spinning band or thin film evaporator, without a condenser is used as process equipment. The air-purged flavor-vapors are diffused and absorbed in an absorption device into suitable food-grade liquids.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: March 20, 2012
    Assignee: Flavor & Food Ingredients, Inc.
    Inventors: Jurgen D. Scheide, John M. Stefanicha
  • Patent number: 8137504
    Abstract: A system and method for preparation of meat flavorants, and flavorants, having increased flavor and aromatic intensity and which more closely resemble the natural flavor and aroma of cooked meat. Preheated edible, food grade oils and fats are exposed to temperatures between 290° C. and 475° C. under vacuum, in the presence of oxygen. The developing flavor vapors are immediately and completely removed from the heated oils and fats. The mixture of air-purge/flavor-vapor is immediately carried away from the heat transfer surface of the edible oil or fat. An evaporator, preferably a spinning disc, spinning band or thin film evaporator, without a condenser is used as process equipment. The air-purged flavor-vapors are diffused and absorbed in an absorption device into suitable food-grade liquids.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: March 20, 2012
    Assignee: Flavor & Food Ingredients, Inc.
    Inventors: Jurgen D. Scheide, John M. Stefanicha
  • Patent number: 8133091
    Abstract: A bra comprising two bra cups is defined. Each bra cup preferably comprises an outermost fabric layer and an innermost fabric layer and at least one intermediate layer intermediate of the outermost fabric layer and the innermost layer. The outermost fabric layer at at least part of at least one of the neckline edge region and underarm edge region of each cup is folded over the intermediate layer and secured at the inner side of the breast cup, preferably joined to the innermost layer through ultrasonic welding. The folded-over portion of the outermost layer is contiguous with and does not overlap the innermost layer. The intermediate layer extends beyond the innermost layer at the neckline edge region and the underarm edge region so that a reduction in thickness is defined at the neckline edge region and the underarm edge region. A method of making the same is also provided.
    Type: Grant
    Filed: November 17, 2008
    Date of Patent: March 13, 2012
    Assignee: Regina Miracle International Limited
    Inventor: Zhen Qiang Liu
  • Patent number: 8128961
    Abstract: This invention relates to the field of chemical pharmaceutical industry, namely, to pharmaceutical formulations for preparation of prolonged release tablets, in particular, tablets for sublingual application, and to methods of preparation of such formulations. Pharmaceutical formulation comprises 96.0 to 99.8% wt. of the pharmaceutical drug microcapsules, 0.1 to 1% wt. of lubricant, and 0.1 to 3% wt. of water, each microcapsule comprising 96.0 to 99.2% wt. of the pharmaceutical drug and 0.8 to 4% wt. of film-forming substance. Dispersant is also introduced into formulation in the amount of 0.1 to 10% wt. of the total mixture obtained. Method of preparation of the pharmaceutical formulation comprises preparation of microcapsules by deposition of coating of film-forming substance on non-agglomerated particles of pharmaceutical drug, and addition of lubricant and dispersant.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: March 6, 2012
    Inventor: Irina Alekseevna Komissarova
  • Patent number: 8119647
    Abstract: The present invention provides transient receptor potential vanilloid (TRPV) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: February 21, 2012
    Assignee: Glenmark Pharmaceuticals S.A.
    Inventors: Prasada Rao V. S. Lingam, Sachin Sundarlal Chaudhari, Abraham Thomas, Neelima Khairatkar-Joshi, Vidya Ganapati Kattige
  • Patent number: 8120853
    Abstract: A monolithic frame for optics used in interferometers where the material of the monolithic frame may have a substantially different coefficient of thermal expansion from the beamsplitter and compensator without warping, bending or distorting the optics. This is accomplished through providing a securing apparatus holding the optics in place while isolating the expansion thereof from the expansion of the frame. Stability in optical alignment is therefore achieved without requiring a single material or materials of essentially identical coefficients of thermal expansion. The present invention provides stability in situations where it is not possible to utilize a single material for every component of the interferometer.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: February 21, 2012
    Assignee: FTRX LLC
    Inventors: Alexander Jacobson, Zvi Bleier