Patents Represented by Attorney, Agent or Law Firm Gordon M. Stewart
  • Patent number: 6461812
    Abstract: Apparatus for delivering a plurality of different biological materials onto discrete locations on a receiving surface, as for example to fabricate an array of different biological material, includes a plurality of orifices in an orifice member, at least six delivery chambers each in fluid conducting relationship with at least one of the orifices, a plurality of reservoirs each in fluid communication with at least one of the delivery chambers, means associated with each orifice for propelling fluid through the associated orifice from the delivery chamber that is in fluid conducting relationship with the orifice, and a vent for commonly venting at least two of the reservoirs. In some embodiments the chambers and reservoirs are loaded with fluids containing selected biomolecules by drawing the selected fluids into the chambers through the orifices; in other embodiments the fluids are introduced into the reservoirs.
    Type: Grant
    Filed: September 9, 1998
    Date of Patent: October 8, 2002
    Assignee: Agilent Technologies, Inc.
    Inventors: Phillip W. Barth, Michael P. Caren, William H. McAllister, Carol T. Schembri, Arthur Schleifer
  • Patent number: 6451998
    Abstract: A method of capping a hydroxy group of a moiety, comprising coupling the moiety to a phosphor or phosphite derivative of a protected alcohol, so as to form the corresponding phosphate or phosphite between the hydroxy and phosphor or phosphite groups. The hydroxy group may be later de-capped by hydrolyzing the resulting compound to deprotect the protected alcohol and cleave the phosphate from the moiety so as to regenerate the hydroxy group of the moiety. The method has particular application to fabrication of addressable polynucleotide arrays and allows failed sequences, as well as inter-feature regions, to be left with a free hydroxy group at the ends of the molecules (failed sequences or linkers) at such locations.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: September 17, 2002
    Assignee: Agilent Technologies, Inc.
    Inventor: Michael G. M. Perbost
  • Patent number: 6446642
    Abstract: A method is described for removing residue from a fluid deposited on the interior surface of an inkjet printhead after the printhead has contained or dispensed the fluid at least once. The method makes use of a reverse flushing technique optionally used in combination with sonication. A cleaning station for flushing an inkjet printhead with a wash fluid, rinse fluid, and/or inert gas is provided as well.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: September 10, 2002
    Assignee: Agilent Technologies, Inc.
    Inventors: Michael P. Caren, Carol T. Schembri
  • Patent number: 6444268
    Abstract: Low surface energy functionalized surfaces on solid supports are provided by treating a solid support having hydrophilic moieties on its surface with a derivatizing composition containing a mixture of silanes. A first silane provides the desired reduction in surface energy, while the second silane enables functionalization with molecular moieties of interest, such as small molecules, initial monomers to be used in the solid phase synthesis of oligomers, or intact oligomers. Molecular moieties of interest may be attached through cleavable sites. Derivatizing compositions for carrying out the surface functionalization process are provided as well.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: September 3, 2002
    Assignee: Agilent Technologies, Inc.
    Inventors: Steven M. Lefkowitz, Geraldine Fulcrand, Douglas J. Dellinger, Charles Z. Hotz
  • Patent number: 6420180
    Abstract: A method, apparatus, and computer program products, for forming an addressable array on a substrate. In the method, for each of multiple addresses on the substrate, a reagent drop set is deposited during a cycle so as to attach a corresponding moiety for that address. The foregoing step is repeated as required, until the addressable array is formed. The reagent drop set deposited during one or more cycles for one or more of the multiple addresses includes, for a corresponding cycle and address, drops of a same reagent which are deposited from different deposition units during the same cycle.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: July 16, 2002
    Assignee: Agilent Technologies, Inc.
    Inventor: Jay K. Bass
  • Patent number: 6411306
    Abstract: An apparatus and method is provided for dynamically modifying both the luminance and contrast of an image as it is displayed on a display unit in response to changing lighting conditions. Sensors are utilized to continually measure the luminance of the light illuminating the display unit and the display surround luminance. Measurement signals generated by the light sensors are processed to provide display luminance and contrast adjustment control signals that gradually cause the adjustment of the display unit's luminance and contrast in response thereto. Continual adjustment of the luminance and contrast of a display unit according to changing lighting conditions such that the brightness and contrast perception of the displayed image remains constant under the varying conditions.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: June 25, 2002
    Assignee: Eastman Kodak Company
    Inventors: Michael E. Miller, James R. Niederbaumer
  • Patent number: 6406849
    Abstract: A method, apparatus for executing the method, and computer program products for use in such an apparatus. The method includes scanning an interrogating light across multiple sites on an array package including an addressable array of multiple features of different moieties, which scanned sites include multiple array features. Signals from respective scanned sites emitted in response to the interrogating light are detected. The interrogating light power is altered for a first site on the array package during the array scan, based on location of the first site or on a determination that the emitted signal from the first site will be outside a predetermined value absent the altering (which allows for protecting a detector against expected overly bright sites), or is altered during the array scan based on the detected interrogating light power (which allows for compensating for light source drift during an array scan).
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: June 18, 2002
    Assignee: Agilent Technologies, Inc.
    Inventors: Andreas N. Dorsel, Kyle J. Schleifer, Elecia C. White, Charles S. Ladd, Debra A. Sillman
  • Patent number: 6399394
    Abstract: A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: June 4, 2002
    Assignee: Agilent Technologies, Inc.
    Inventors: SueAnn C. Dahm, Arthur Schleifer, Carol T. Schembri, Douglas A. Amorese
  • Patent number: 6377330
    Abstract: An apparatus for calibrating a printer of a photofinishing system includes a reference film strip carrying at least one reference image; a reference chart carrying multiple renderings of the reference image representing different printer exposures; and a substrate carrying printer correction factors needed to change a photographic print obtained from the reference image on the reference film strip, to match any desired rendering on the reference chart. A method of producing the above reference chart, and a method of calibrating a printer of a photofinishing system, are also provided.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: April 23, 2002
    Assignee: Eastman Kodak Company
    Inventors: Peter Vanderbrook, Geoffrey John Woolfe
  • Patent number: 6372483
    Abstract: A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a fluid dispensing head. The head has at least one jet which can dispense droplets onto a substrate, the jet including a chamber with an orifice, and including an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes positioning the head with the orifice facing the substrate. Multiple droplets of the biopolymer or biomonomer fluid are dispensed from the head orifice so as to form an array of droplets on the substrate. A gas flow is directed through a venturi which has a throat opening communicating with the dispensing head chamber. A venturi control valve which particularly communicate with an outlet of the venturi, is adjusted to alter the chamber pressure. The venturi may be driven by a source of inert anhydrous compressed gas which assists in maintaining fluid in the head isolated from moisture.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: April 16, 2002
    Assignee: Agilent Technologies, Inc.
    Inventors: Arthur Schleifer, Carol T. Schembri, Michael P. Caren
  • Patent number: 6320196
    Abstract: A method and apparatus for reducing the crosstalk between two or more dye channels in a multiple frequency laser induced fluorescence scanner in which two laser beams and associated optics are employed for focusing the two laser beams on a plurality of spatially separated spots, and for collecting and measuring the resulting emission from the sample labeled with at least two dyes. Crosstalk of the dye emission is minimized as the separated spots provide for a more nearly diagonal transformation matrix between signal channels and dye channels.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: November 20, 2001
    Assignee: Agilent Technologies, Inc.
    Inventors: Andreas N. Dorsel, Charles Z. Hotz
  • Patent number: 6296452
    Abstract: A microfluidic pumping apparatus and method using the apparatus. The apparatus may include a first pulse jet and working fluid in the pulse jet such that the first pulse jet, in response to activation by a set of electrical pulses, moves corresponding pulses of fluid from a first to an second side of the first pulse jet. A chamber with an opening is in pressure communication and with the first side of the first pulse jet such that activation of the first pulse jet causes a reduced pressure at the opening. The method comprising contacting the opening with a fluid and activating the first pulse jet so as to draw a sample fluid through the opening into the chamber. A second pulse jet, oppositely oriented from the first, may be provided to discharge loaded sample fluid.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: October 2, 2001
    Assignee: Agilent Technologies, Inc.
    Inventor: Michael P. Caren
  • Patent number: 6243138
    Abstract: A camera having means for detecting sound in a bi-directional manner. A microphone, for example a first order gradient microphone, is placed within a camera body and is in communication with two apertures extending from the front and rear surfaces of the camera body. Background noise is reduced and sound from the scene being photographed and the user of the camera is preferentially detected by the microphone. Preferably, the microphone is mounted in a substantially resilient and acoustically opaque material to reduce stray noises, such as from the motors of the camera.
    Type: Grant
    Filed: October 22, 1998
    Date of Patent: June 5, 2001
    Assignee: Eastman Kodak Company
    Inventor: Richard Scott Keirsbilck
  • Patent number: 6215559
    Abstract: A method of processing customer images in a photofinishing apparatus. The method includes obtaining customer image signals and associated requests for image products or services incorporating respective images. The images signals are directed into image queues having different associated formats, based on the associated product or service requested for each. The image signals are communicated from the queues to respective image renderers which render the image signals into the different formats associated with each queue. An apparatus which can execute such a method is also provided.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: April 10, 2001
    Assignee: Eastman Kodak Company
    Inventors: Gregory R. Bryniarski, Brian R. Wilson, Lawrence J. Bovenzi
  • Patent number: 6212337
    Abstract: A method of forming a combined image from a filmstrip carrying a plurality of user exposed first images and second image information defining a second image. A user exposed image associated with a predetermined designation for referencing the second image, is identified. The user exposed image associated with the designation is scanned to obtain a resulting scanned image signal. Second image information from the filmstrip is read to obtain a second image signal. A combined image is formed from the resulting scanned image signal and the read second image. A filmstrip and film assemblage is provided which can be used in a method of exposing according to the present invention, then developed and processed according to the above method.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: April 3, 2001
    Assignee: Eastman Kodak Company
    Inventors: Dwight J. Petruchik, Marcello D. Fiscella
  • Patent number: 6195462
    Abstract: An image compression method in which the size of a compressed low resolution version of an image is used to either estimate a compression factor for the image needed to obtain an aim compressed image size, or to estimate the size of the compressed image resulting from a predetermined compression factor. The estimate can be made with the aid of a predetermined relationship between compressed image size, image resolution and compression factor, which relationship may be a linear or linear inverse one. This relationship is preferably obtained from images of the same class as the one to be compressed. The image is then compressed using the estimated or predetermined compression factor. An apparatus using such a method is also provided.
    Type: Grant
    Filed: March 30, 1998
    Date of Patent: February 27, 2001
    Assignee: Eastman Kodak Company
    Inventors: Gregory R. Bryniarski, Brian R. Wilson
  • Patent number: 6191872
    Abstract: An illuminator and a scanner incorporating such an illuminator. In one embodiment, the illuminator has a plurality of arrays of semiconductor light emitting elements, each array having a different integrated spectral output, and a plurality of respective different interference filters each positioned between a corresponding array and the media holder. A media holder holds a media carrying an image for scanning, the media holder being positioned to receive filtered light from the illuminator. A sensor is positioned to receive light from the media holder so as to generate an image signal corresponding to an image on a media positioned at the media holder.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: February 20, 2001
    Assignee: Eastman Kodak Company
    Inventors: Joel D. DeCaro, Mark E. Shafer
  • Patent number: 6181409
    Abstract: A method of providing information on the back side of a developed photographic medium having an image carrying layer on the front side. The method comprises machine reading code on the developed imaging carrying layer on the front side of the photographic medium. In the method, information is printed on the back side of the developed photographic medium with a printer, based on the machine read code. An apparatus, which can execute a method of the invention, for providing information on a back side of a developed photographic medium having an image carrying layer on the front side, has a reader to read machine readable code in the developed imaging carrying layer on the front side of the photographic medium. The apparatus further has a printer communicating with the reader so as to print information on the back side of the developed photographic medium based on the machine read code. The method may include printing and developing the photographic medium.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: January 30, 2001
    Assignee: Eastman Kodak Company
    Inventor: Lee M. Calhoun
  • Patent number: 6157436
    Abstract: An image printing system for generating multiple printed image copies in response to an order. A processor can divide the order into multiple sub-orders for respective image printers, each sub-order having a sub-order header which includes a unique order identification and an indication of the number of copies of the image to be printed by the corresponding printer. A plurality of image printers are connected to the processor, to each receive a corresponding sub-order and print the corresponding sub-order header, and the numbers of image copies indicated in that header. A method which can be executed by such a system and a computer program product which can execute the method on a programmable computer, are also provided.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: December 5, 2000
    Assignee: Eastman Kodak Company
    Inventor: Ronald S. Cok
  • Patent number: 6157435
    Abstract: A method of processing customer image orders, each of at least one image capturing an original scene. An image content identification in the form of an image content identification signal, is generated based on an identification of one or more scene objects, for at least one image of a customer order. The generated image content identification is compared with different image content identifications stored in a memory in association with respective predetermined customer certificate data. When at least a generated image content identification matches a stored image content identification, generating a customer certificate from the stored certificate data associated with the matching stored image content identification. The method can be used with customer image sets which may not be image orders. An apparatus and computer program product which can execute such a method, are also provided.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: December 5, 2000
    Assignee: Eastman Kodak Company
    Inventors: Walter C. Slater, Thomas J. Murray