Patents Represented by Law Firm Hammond & Littell, Weissenberger & Muserlian
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Patent number: 4390724Abstract: Novel 3-formyl-4-methyl-pentanoic acid derivatives of the formula ##STR1## wherein Y is an aromatic group, R.sub.2 and R.sub.3 are individually alkyl of 1 to 4 carbon atoms or taken together with the carbon atom to which they are attached form a carbon homocycle of 3 to 6 carbon atoms, the Rs are alkyl of 1 to 6 carbon atoms or together form a polymethylene of 2 to 3 carbon atoms and Z' is selected from the group consisting of --COOH and Z and Z is selected from the group consisting of cyano and --COOR.sub.1 wherein R.sub.1 is alkyl of 1 to 6 carbon atoms and their preparation which are useful for the preparation of 3-formyl-4-R.sub.2 R.sub.3 -but-3-ene-1-oic acid which is an intermediate for the preparation of a compound of the formula ##STR2## wherein R.sub.4 is hydrogen or the remainder of an alcohol of the formula R.sub.1 OH by the process of copending, commonly assigned U.S. patent application Ser. No. 153,338 filed May 27, 1980.Type: GrantFiled: April 16, 1982Date of Patent: June 28, 1983Assignee: Roussel UclafInventors: Jacques Martel, Jean Tessier, Jean-Pierre Demoute
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Patent number: 4390697Abstract: A novel process for the preparation of triazoloquinazolinones of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, fluorine, chlorine, bromine, --NO.sub.2, --CF.sub.3, --CH.sub.3 and --OCH.sub.3, n is an integer from 2 to 5, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and hydroxyalkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom which they are attached form a saturated heterocycle optionally containing another heteroatom and optionally substituted with at least one member of the group consisting of hydroxy, alkyl and hydroxy alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, acyl of an aliphatic carboxylic acid of 1 to 5 carbon atoms, alkoxycarbonyl of 2 to 6 carbon atoms, aryl and aryl substituted with halogen or --CF.sub.3 and their non-toxic, pharmaceutically acceptable acid addition salts having antihistaminic and bronchospasmolytic activity and novel intermediates.Type: GrantFiled: November 3, 1981Date of Patent: June 28, 1983Assignee: Roussel UclafInventor: Wilfred R. Tully
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Patent number: 4390688Abstract: A water dilutable polyester having a good resistance to hydrolysis based on(A) at least one dicarboxylic acid unit,(B) at least one polycarboxylic monoanhydride and(C) at least one alcohol component containing at least dihydric alcohol,the COOH groups of the polyester being at least partially present in the form of salts with amine, characterized in that the polyester is also derived from(D) at least one epoxy compound which contains at least two oxiran rings and is selected from the group consisting of epoxidized fatty acids, derivatives thereof and epoxidized aliphatic hydrocarbons or mixtures thereof with up to 30% of monoepoxides, the percentage being based on the epoxy groups, and in that the polycarboxylic monoanhydride (B) is incorporated in the form of a half ester and is other than phthalic anhydride and maleic anhydride.The invention also relates to a process for the preparation of such polyester, its use in a coating composition and to articles coated with such coating compositions.Type: GrantFiled: March 12, 1982Date of Patent: June 28, 1983Assignee: Hoechst AktiengesellschaftInventors: Gerd Walz, Thaddaus Wirth, Walter Sprenger
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Patent number: 4389289Abstract: A bipolar diaphragm electrolyzer particularly suitable for electrolysis of alkali metal halide aqueous solutions wherein the bipolar wall separating the electrode compartments is formed of at least two sheets made of different metals, suitable pressure being applied against the metal sheets to provide for electrical continuity across the bipolar wall, said pressure being exerted either by means of resilient elements which are compressed when the electrolyzer is closed or by maintaining the electrode compartments under a sufficient hydrostatic pressure during the electrolytic process.Type: GrantFiled: January 14, 1981Date of Patent: June 21, 1983Assignee: Oronzio deNora Impianti Elettrochimici S.p.A.Inventor: Oronzio deNora
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Patent number: 4389298Abstract: A bipolar diaphragm or membrane electrolyzer comprising a housing containing an end anode element, an end cathode element and a plurality of bipolar elements with their major dimensions lying in a substantially vertical plane and comprised of a bipolar wall separating the anode compartment and the cathode compartment and vertical foraminous electrodes parallel positioned a certain distance from the bipolar wall, diaphragms or membranes separating the anodes and cathodes, a series of baffles distributed along the entire width of the electrode compartment and extending from the bipolar wall to the foraminous electrode to form a series of vertical flow channels extending over a large portion of the height of the wall, the said baffles being alternately inclined one way and the other way with respect to the vertical plane normal to the bipolar wall plane and spaced from one another whereby the ratio of the electrode surface intercepted by the edges of two baffles laterally defining a vertical flow channel to theType: GrantFiled: May 26, 1981Date of Patent: June 21, 1983Assignee: Oronzio deNora Impianti Elettrochimici S.p.A.Inventor: Alberto Pellegri
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Patent number: 4388318Abstract: The method of treating endotoxin shock with 2,2'-[(4,8-bis(diethylamino)-pyrimido[5,4-d]pyrimidine-2,6-diyl)di-(2-meth oxyethyl)imino]diethanol or a non-toxic, pharmacologically acceptable acid addition salt thereof.Type: GrantFiled: September 29, 1981Date of Patent: June 14, 1983Assignee: Boehringer Ingelheim International GmbHInventors: Shozo Koyama, John W. Manning, Jr., William S. Ammons, Hector L. Santiesteban
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Patent number: 4388343Abstract: A method and apparatus for the coating of molding tools which comprises dispersing liquid or suspended lubricant in directional manner before each pressing operation in discrete, specific droplets onto the pressing zones of the molding tools, said dispersing being effected by means of f.i. piezoelectric transducers.Type: GrantFiled: November 30, 1981Date of Patent: June 14, 1983Assignee: Boehringer Ingelheim GmbHInventors: Gunther Voss, Peter Gruber
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Patent number: 4387807Abstract: A case for enclosing a phonograph record, including a circular ring in which the record snap fits, and a circular cover adjacent each side of the record, the covers being hinged to the ring.Type: GrantFiled: October 2, 1981Date of Patent: June 14, 1983Inventor: Jorge de la Rosa
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Patent number: 4388315Abstract: Cephalosporins of the formula ##STR1## wherein A is phenyl, 4-hydroxyphenyl, cyclohexyl, cyclohexene-1-yl, cyclohexa-1,4-diene-1-yl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl or 3,4-disubstituted phenyl, where the substituents, which may be identical to or different from each other, are each chlorine, hydroxyl or methoxy;Y is hydrogen or methoxy;D is hydrogen, hydroxyl, acetoxy, aminocarbonyloxy, pyridinium, aminocarbonyl-pyridinium or the group S-Het, where Het is 1-methyl-tetrazol-5-yl, tetrazol-5-yl, 3-methyl-1,2,4-thiadiazol-5-yl,1,2,4-thiadiazol-5-yl, 1,3,4-thiadiazol-5-yl, 2-methyl-1,3,4-thiadiazol-5-yl, 2-methylamino-1,3,4-thiadiazol-5-yl, 2-dimethylamino-1,3,4-thiadiazol-5-yl, 2-formylamino-1,3,4-thiadiazol-5-yl , 2-acetylamino-1,3,4-thiadiazol-5-yl, 2-methyl-1,3,4-oxadiazol-5-yl, 1,2,3-triazol-4-yl or 1,2,4-triazol-3-yl;R is hydrogen, methyl, cyclopropyl, hydroxyl, methoxy, ethoxy, mercapto, morpholino, thiomorpholino, thiomorpholino-S-oxide, thiomorpholino-S,S-dioxide, ##STR2## E is hydrogen or a proteType: GrantFiled: September 30, 1981Date of Patent: June 14, 1983Assignee: Boehringer Ingeleheim GmbHInventors: Bernd Wetzel, Eberhard Woitun, Roland Maier, Wolfgang Reuter, Uwe Lechner, Hanns Goeth
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Patent number: 4388454Abstract: An organic, high-molecular weight polyester containing substantially chain members of the formula--O--X--O--Y--wherein X is at least one member selected from the group consisting of ##STR1## and Y has the formula ##STR2## having an inherent viscosity of at least 1.0 dl/g, preferably at least 1.2 dl/g measured at 30.degree. C. in a solution of 0.5 g of the polyester in 100 ml of a mixture of 60% by weight of phenol and 40% by weight of 1,1,2,2-tetrachloroethane and whose films cast from a solution in a chlorinated organic solvent have an elongation at break of more than about 20%, preferably at least 40% measured according to ASTM D 882-75 b having excellent properties for electrical insulation as well as other fields.Type: GrantFiled: May 5, 1982Date of Patent: June 14, 1983Assignee: Isovolta Osterreichische IsolierstoffwerkeInventors: Werner Rieder, Martin Fehrle
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Patent number: 4387098Abstract: Novel imidazo[1,2-a]quinolines of the formula ##STR1## wherein R is selected from the group consisting of alkyl of 1 to 8 carbon atoms, thienyl, pyridyl and phenyl optionally substituted with at least one member of the group consisting of halogen, alkyl of 1 to 5 carbon atoms and alkoxy of 1 to 5 carbon atoms, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, halogen, alkyl and alkoxy of 1 to 8 carbon atoms,s cyclohexyl, --NO.sub.2 and phenoxy, R.sub.3 is selected from the group consisting of alkoxy and alkylthio of 1 to 8 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having a remarkable anxiolytic activity and a hypnotic activity and their preparation.Type: GrantFiled: March 25, 1982Date of Patent: June 7, 1983Assignee: Roussel UclafInventors: Alan C. Barnes, Peter A. Robson
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Patent number: 4387209Abstract: An organic, high-molecular weight polyester containing substantially chain members of the formula--O--X--O--Y--wherein X is at least one member of the group consisting of ##STR1## and Y has the formula ##STR2## having an inherent viscosity of at least 1.0 dl/g, preferably at least 1.2, dl/g measured at 30.degree. C. in a solution of 0.5 g of the polyester in 100 ml of a mixture of 60% by weight of phenol and 40% by weight of 1,1,2,2-tetrachloroethane and whose films cast from a chlorinated organic solution have an elongation at break of at least 10%, preferably at least 20%, measured according to ASTM D-882-75 b with the proviso that if the inherent viscosity is between 1.0 dl/g and 1.5 dl/g, Y is a mixture of 70 to 30% of terephthalic acid and 30 to 70% of isophthalic acid having excellent properties for electrical insulation as well as other fields.Type: GrantFiled: May 5, 1982Date of Patent: June 7, 1983Assignee: Isovolta Osterreichische IsolierstoffwerkeInventors: Werner Rieder, Martin Fehrle
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Patent number: 4386085Abstract: Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R.sub.1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the atom immediately adjacent to the 11-carbon atom being carbon, R.sub.2 is a hydrocarbon of 1 to 8 carbon atoms, X is selected from the group consisting of a pentagonal ring and a hexagonal ring optionally substituted and optionally containing a double bond, B and C together form a double bond or an epoxy group, the C.dbd.A group at position 3 is selected from the group consisting of C.dbd.O, ketal, ##STR2## --C.dbd.NOH, --C.dbd.NOAlK.sub.3 and .dbd.CH.sub.2, AlK.sub.1, AlK.sub.2 and AlK.sub.3 are selected from the group consisting of alkyl of 1 to 8 carbon atoms and aralkyl of 7 to 15 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having anti-glucocorticoid activity and a process for their preparation.Type: GrantFiled: January 8, 1982Date of Patent: May 31, 1983Assignee: Roussell UclafInventors: Jean G. Teutsch, Germain Costerousse, Daniel Philibert, Roger Deraedt
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Patent number: 4386210Abstract: Novel syn isomers of 7-amino-thiazolyl-acetamido-3-acetoxymethyl-cephalosporanic acid derivatives of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of --CN, --CONH.sub.2 and --COOR.sub.1 ', R.sub.1 ' is selected from the group consisting of alkyl of 1 to 3 carbon atoms, hydrogen, alkali metal, alkaline earth metal, ammonium, magnesium and a non-toxic, pharmaceutically acceptable organic amine, A is selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, ammonium, magnesium and a non-toxic, pharmaceutically acceptable organic amine, R' and R" are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms with the ##STR2## group in the syn position with the proviso that when R.sub.1 is --COOR.sub.1 ' and R.sub.1 ' is hydrogen, A is hydrogen and when R.sub.1 is --COOR.sub.1 ' and R.sub.Type: GrantFiled: May 4, 1981Date of Patent: May 31, 1983Assignee: Roussel UclafInventor: Rene Heymes
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Patent number: 4386099Abstract: This invention relates to imidazolylphenyl amidines, the preparation thereof, and pharmaceutical compositions containing them. More particularly, this invention relates to compounds of the general formula ##STR1## in which R, R.sub.1, R.sub.3, which may be the same or different, each represent a hydrogen atom or a lower alkyl group, and R.sub.2 represents a linear or branched alkyl, alkenyl, or alkynyl group, a cyano group, a hydroxyl group, a substituted or unsubstituted cycloalkyl or cycloaliphatic alkyl group, a bicyclic group, an aralkyl or aryl group optionally substituted by halogen, methyl, methoxy, or methylenedioxy groups, or a substituted or unsubstituted heterocyclylalkyl or heterocyclic group which may also contain a further hetero atom, or a non-toxic, pharmacologically acceptable acid addition salt thereof. These compounds are useful in treating disorders of the gastrointestinal tract.Type: GrantFiled: November 19, 1981Date of Patent: May 31, 1983Assignee: Istituto de Angeli S.p.A.Inventors: Enzo Cereda, Arturo Donetti, Piero del Soldato, Mario Bergamaschi
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Patent number: 4386194Abstract: A stable, anaerobically-hardening adhesive system based on polymerizable methacrylates and acrylates which are free of peroxides and hydroperoxides and harden at an accelerated rate under anaerobic conditions having, for 100 parts by weight of said polymerizable methacrylates and acrylates, from 0.2 to 10 parts by weight of at least one HN-acidic compound, from 0.2 to 5 parts by weight of at least one tertiary amine having at least one hydrocarbon aryl attached to the nitrogen, and from 0.1 to 5 parts by weight of at least one organic percarboxylic acid. Preferred among the percarboxylic acids are peracetic acid, perpropionic acid, performic acid, perbenzoic acid and chloroperbenzoic acid. The new systems further contain preferably as HN-acidic compounds, sulfonic acid hydrazides, carboxylic acid hydrazides, sulfimides, disulfonyl imides or acyl cyanamides.Type: GrantFiled: February 18, 1982Date of Patent: May 31, 1983Assignee: Henkel Kommanditgesellschaft auf AktienInventor: Werner Gruber
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Patent number: 4385183Abstract: This invention is directed to the telomerization of water-soluble monomers in an aqueous phase. More particularly, this invention is directed to a process for the telomerization of water-soluble monomers and water-insoluble telogens in aqueous phase, wherein the water-insoluble telogens are solubilized by the addition of an effectively solubilizing amount of surface-active compounds.Type: GrantFiled: June 4, 1981Date of Patent: May 24, 1983Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Rainer Hofer, Hans-Christoph Wilk, Bernd Wegemund
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Patent number: 4384900Abstract: This invention is directed to a method for treating metal surfaces. More particularly, this invention is directed to an improved method for cleaning, scouring, and activating metal surfaces prior to phosphatization, which comprises contacting said metal surfaces with an aqueous solution comprising primary and/or secondary alkali metal or ammonium salts of orthophosphates and conventional metal cleaning components, the solution having a pH value of from about 6.3 to 8.2, said pH being lower than the pH value of solutions of the corresponding secondary orthophosphates alone having the same concentration; and containing optionally condensed phosphates in an amount corresponding to the amount necessary to soften the water hardness of the water used.Type: GrantFiled: December 22, 1980Date of Patent: May 24, 1983Assignee: Gerhard Collardin GmbHInventors: Hans Gotta, Karl-Heinz Gottwald
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Patent number: 4384999Abstract: A novel process for the preparation of alkyl isocyanates comprising reacting COX.sub.2 and an alkyl amine hydrohalide of the formulaR-NH.sub.2.HX Iwherein R is alkyl of 1 to 3 carbon atoms and X is a halogen either under pressure in an inert organic solvent or under atmospheric pressure in a high boiling organic solvent to form the corresponding alkyl carbamoyl halide, reacting the latter in an organic solvent with an urea of the formula ##STR1## wherein X' is selected from the group consisting of oxygen and sulfur, R.sub.1 and R.sub.3 are individually selected from the group consisting of alkyl of 1 to 7 carbon atoms, cycloalkyl of 4 to 6 carbon atoms and phenyl and R.sub.2 and R.sub.4 are individually selected from the group consisting of hydrogen, alkyl of 1 to 7 carbon atoms, cycyloalkyl of 4 to 6 carbon atoms and phenyl to obtain the corresponding alkyl isocyanate.Type: GrantFiled: October 9, 1980Date of Patent: May 24, 1983Inventors: Placido M. Spaziante, Luigi Giuffre, Giancarlo Sioli, Mirco Fornaroli
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Patent number: 4385048Abstract: Compositions for the treatment of nasal hypersecretion comprising (8r)-8-isopropyl-3.alpha.-[(.+-.)-tropoyl-oxy]-1.alpha.H, 5.alpha.H-tropanium bromide in a pharmaceutical formulation suitable for topical application to the nasal cavity; and methods of use.Type: GrantFiled: November 14, 1980Date of Patent: May 24, 1983Assignee: Boehringer Ingelheim GmbHInventors: Niels Mygind, Peter Borum, Christiane Grieben