Patents Represented by Attorney Heller Ehrman White & McAuliffe LLP
  • Patent number: 6812335
    Abstract: Human Edg4 and Edg5 polypeptides and their respective amino acid and nucleic acid sequences are provided for use in investigating cytoprotection, apoptosis, cellular proliferation, and other biological pathways in which phospholipid mediators are implicated.
    Type: Grant
    Filed: March 23, 1999
    Date of Patent: November 2, 2004
    Assignee: The Regents of the University of California
    Inventors: Edward Goetzl, Songzhu An
  • Patent number: 6803194
    Abstract: Double stranded DNAs, expression vectors and methods for their use are provided in which the intracellular expression of the double stranded DNAs is used to alter the phenotype of a target cell so that the function of a target nucleic acid that includes a nucleotide sequence encoding a motif of interest can be determined using a combinatorial ribozyme library. The members of the library are catalytic RNAs that disrupt the expression of the transcription product of the target nucleic acid. Disruption of transcription product expression results in an altered cell phenotype which is used to determine the function of the target nucleic acid. The specific phenotype or response may be associated with normal cellular processes, or it may contribute to the generation of pathogenesis involved in disease development. The compositions find use in high-throughput screens to assign gene functions.
    Type: Grant
    Filed: August 9, 2000
    Date of Patent: October 12, 2004
    Assignee: HK Pharmaceuticals, Inc.
    Inventors: James G. Keck, Justin G. P. Wong
  • Patent number: 6802081
    Abstract: The moisture-absorbent/releasable heat-generating intermediate material of the present invention is inserted between an outer material and a lining, both having a moisture-permeable/waterproof property, a windproof property and other desired properties, thereby constituting a heat-retaining article. It comprises a blend of a heat-retaining fiber including an air layer of not less than 50 ml per 1 gram and a moisture-absorbent/releasable heat-generating fiber. The moisture-absorbent/releasable heat-generating fiber generates heat by absorbing moisture in a vapor phase or in a liquid phase discharged from a human body and an immobile air layer formed by the heat-retaining fiber retains the heat.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: October 12, 2004
    Assignee: Mizuno Corporation
    Inventors: Takeshi Ogino, Shigeru Aoyama
  • Patent number: 6800733
    Abstract: Modifications in the sequence of Aequorea wild-type GFP provide products having markedly different excitation and emission spectra from corresponding products from wild-type GFP. In one class of modifications, the product derived from the modified GFP exhibits an alteration in the ratio of two main excitation peaks observed with the product derived from wild-type GFP. In another class, the product derived from the modified GFP fluoresces at a shorter wavelength than the corresponding product from wild-type GFP. In yet another class of modifications, the product derived from the modified GFP exhibits only a single excitation peak and enhanced emission relative to the product derived from wild-type GFP.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: October 5, 2004
    Assignee: The Regents of the University of California
    Inventors: Roger Y. Tsien, Roger Heim
  • Patent number: 6800728
    Abstract: Reagents and methods are provided for crosslinking and immobilizing biomolecules, drugs and synthetic polymers. The reagents possess (i) a thiol or amino reactive group; and (ii) a hydrazino or oxyamino moiety. Conjugates and immobilized biomolecules are also provided.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: October 5, 2004
    Assignee: Solulink Biosciences, Inc.
    Inventor: David A. Schwartz
  • Patent number: 6796245
    Abstract: A unitary header/base/shorting bar holder for a micro gas generator; and a micro gas generator containing it.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: September 28, 2004
    Assignee: LifeSparc, Inc.
    Inventors: Todd S. Parker, Michael D. Campbell
  • Patent number: 6794517
    Abstract: The present invention relates to hydantoins of formula I, in which R is the residue of an amino carboxylic acid or of an amino carboxylic acid derivative, which is obtained formally by removing an NH2 group from an amino carboxylic acid or an amino carboxylic acid derivative, to the preparation thereof and to the use thereof as intermediates, in particular for preparing pharmaceutically active ingredients.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: September 21, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Klaus Burger, Alexander Golubev, Sergej Ossipov
  • Patent number: 6790458
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Grant
    Filed: April 7, 2003
    Date of Patent: September 14, 2004
    Assignee: AP Pharma Inc.
    Inventors: Steven Y. Ng, Hui-Rong Shen, Jorge Heller
  • Patent number: 6787372
    Abstract: The present invention discloses methods for manufacturing MTJ cell of MRAM wherein two annealing process with different magnitudes of applied magnetic fields are performed. In accordance with the method, the formation process of second pinned magnetic layer comprises a first annealing process and a second annealing process, wherein a magnitude of a magnetic field applied during the first annealing process being larger than that of a magnetic field applied during the second annealing process.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: September 7, 2004
    Assignee: Hynix Semiconductor, Inc.
    Inventors: Kye Nam Lee, In Woo Jang, Young Jin Park
  • Patent number: 6786933
    Abstract: A medical prosthesis for use within a body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radial. Preferred prosthesis exhibits reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. Methods of manufacturing wear resistant medical prosthesis and materials used therein are also provided.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: September 7, 2004
    Assignees: The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Edward W. Merrill, William H. Harris, Murali Jasty, Orhun Muratoglu, Charles R. Bragdon, Daniel O. O'Connor, Premnath Venugopalan
  • Patent number: 6784205
    Abstract: The present invention relates to a new and improved method for treating diabetes and or its associated complications by modulating the activity of protein tryosin phosphatase 1B (“PTP-1B”). The inventive compounds modulate the activity PTP-1B by binding to a novel binding site referred herein as the PTP-1B exosite that is distal to the active site of PTP-1B. The present invention also relates to a new and improved method of treating immune system disorders by modulating the activity of T-cell protein tyrosine phosphatase (“TC-PTP”). The inventive compound modulate the activity of TC-PTP by binding to a novel binding site referred herein as the TC-PTP exosite that is distal to the active site of PTP-1B.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: August 31, 2004
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Kenneth Barr, Bruce Fahr, Stig Hansen, Christian Wiesmann
  • Patent number: 6780649
    Abstract: Semiconductor materials having a porous texture are modified with a recognition element and produce a photoluminescent response on exposure to electromagnetic radiation. The recognition elements, which can be selected from biomolecular, organic and inorganic moieties, interact with a target analyte to produce a modulated photoluminescent response, as compared with that of semiconductor materials modified with a recognition element only.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: August 24, 2004
    Assignee: Iatroquest Corporation
    Inventors: David W. Armstrong, Martine L. Lafrance
  • Patent number: 6777196
    Abstract: NTNR&agr;, NTNR&agr; extracellular domain (ECD), NTNR&agr; variants, chimeric NTNR&agr; (e.g., NTNR&agr; immunoadhesion), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNR&agr;-ligands, for example NTN, by providing NTNR&agr; to the cell.
    Type: Grant
    Filed: September 1, 1999
    Date of Patent: August 17, 2004
    Assignee: Genentech, Inc.
    Inventors: Robert D. Klein, Arnon Rosenthal, Mary A. Hynes
  • Patent number: 6777390
    Abstract: Stable pharmaceutical preparations containing blood coagulation Factor VII is disclosed. The pharmaceutical preparations containing blood coagulation Factor VII are free of coagulation inhibitors and are stable over a wide range of environmental conditions. Also provided are blood coagulation Factor VII preparations having a minimum activity of 50 Units/mg of protein that contain less than 5% activated blood coagulation Factor VII (Factor VIIa). The blood coagulation Factor VII containing preparations may also contain other blood coagulation factors and are free from detectable transmissible human pathogens.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: August 17, 2004
    Assignee: Baxter Aktiengesellschaft
    Inventors: Peter Matthiessen, Peter Turecek, Hans-Peter Schwarz
  • Patent number: 6773160
    Abstract: A combined imaging plate scanning and erasing system, comprising: (a) a housing; (b) an imaging plate cassette infeed assembly positioned within the housing, the maging plate cassette infeed assembly comprising: (i) a mechanism to pull an imaging plate cassette into the housing; (ii) a mechanism to open the imaging plate cassette; and (iii) a mechanism to remove an imaging plate from the cassette; (c) a scanner positioned within the housing; (d) a curved path erasing assembly positioned between the imaging plate infeed assembly and the scanner; and (e) an imaging plate transportation assembly to move the imaging plate back and forth in a path extending from the imaging plate cassette, past the erasing assembly and through a scan area adjacent to the scanner.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: August 10, 2004
    Assignee: Alara, Inc.
    Inventors: Wayne Evans, H. Keith Nishihara, Brian P. Wilfley, Douglas A. Reim, William F. Witt, Sung Kim, Ron Smith, Perry Anderson, Heather Klaubert, Gary Cantu, James Olef Jensen, Eric J. Shrader
  • Patent number: 6773706
    Abstract: The present invention is a substantially purified sortase-transamidase enzyme from Gram-positive bacteria, such as Staphylococcus aureus.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: August 10, 2004
    Assignee: The Regents of the University of California
    Inventors: Olaf Schneewind, Sarkis Mazmanian, Gwen Liu, Hung Ton-That
  • Patent number: 6774118
    Abstract: The invention provides for the use of oligodeoxynucleotide decoys for the prophylactic or therapeutic treatment of diseases associated with the binding of endogenous transcription factors to genes involved in cell growth, differentiation and signalling or to viral genes. By inhibiting endogenous trans-activating factors from binding transcription regulatory regions, the decoys modulate gene expression and thereby regulating pathological processes including inflammation, intimal hyperplasia, angiogenesis, neoplasia, immune responses and viral infection. The decoys are administered in amounts and under conditions whereby binding of the endogenous transcription factor to the endogenous gene is effectively competitively inhibited without significant host toxicity. The subject compositions comprise the decoy molecules in a context which provides for pharmacokinetics sufficient for effective therapeutic use.
    Type: Grant
    Filed: September 8, 1995
    Date of Patent: August 10, 2004
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Victor J. Dzau, Gary H. Gibbons, Ryuichi Morishita
  • Patent number: 6772692
    Abstract: A semiconductor bridge (SCB) device. In one embodiment, the SCB device includes a laminate layer on top of an insulating material, wherein the laminate layer comprises a series of layers of at least two reactive materials, and wherein the laminate layer comprises two relatively large sections that substantially cover the surface area of the insulating material, and a bridge section joining the two relatively large sections. At least one conductive contact pad is coupled to at least one of the series of layers, wherein a predetermined current through the conductive contact pad causes the bridge section to initiate a reaction in which the laminate layer is involved. In one embodiment, the SCB device includes an integrated diode formed by an interface of the insulating material with another material, such as a metal.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: August 10, 2004
    Assignees: LifeSparc, Inc., Auburn University
    Inventors: Thomas A. Baginski, Todd S. Parker, Wm. David Fahey
  • Patent number: 6774277
    Abstract: Methods of treatment of cyanide-containing waste are provided. In particular, methods for treatment of spent potliner prior to landfill disposal are provided. These methods, which involve treatment of the waste with a mixture containing an aqueous oxidizing solution containing an agent, such as a metal chloride, that increases the oxidation potential of the solution, can be performed at ambient temperature and pressure.
    Type: Grant
    Filed: March 7, 2000
    Date of Patent: August 10, 2004
    Assignee: Waste Management, Inc.
    Inventor: Gary Fisher
  • Patent number: 6764822
    Abstract: The present invention is related to the fields of genetic mapping and genetic identity detection, including forensic identification and paternity testing. This invention is more specifically directed to the use of mass spectrometry to detect length variation in DNA nucleotide sequence repeats (including variants of common alleles), such as microsatellites and short tandem repeats, and to DNA sequences provided as primers for the analysis of DNA tandem nucleotide repeat polymorphisms at specific loci on specific chromosomes.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: July 20, 2004
    Assignee: Sequenom, Inc.
    Inventors: John M. Butler, Jia Li, Joseph A. Monforte, Christopher H. Becker