Patents Represented by Attorney Heller Ehrman White & McAuliffe
  • Patent number: 6852772
    Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: February 8, 2005
    Assignees: Massachusetts Gerneral Hospital, Cambridge Polymer Group, Inc.
    Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg, Gareth H. McKinley
  • Patent number: 6852848
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: February 8, 2005
    Assignee: Genentech, Inc.
    Inventors: Audrey Goddard, Austin L. Gurney, William I. Wood
  • Patent number: 6852559
    Abstract: A semiconductor device and a method for forming the same are disclosed. The semiconductor device includes an epitaxial source/drain junction layer having an insulating film thereunder. The method comprises the step of forming a under-cut under an epitaxial source/drain junction layer so that an insulating film filling the under-cut can be formed.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: February 8, 2005
    Assignee: Hynix Semiconductor Inc.
    Inventors: Byung Il Kwak, Kyung Jun Ahn
  • Patent number: 6852493
    Abstract: The invention provides a method for increasing the hybridization rate of nucleic acids in a nucleic acid assay by labeling nucleic acid molecules with paramagnetic labels and activating a magnetic field inducing rapid migration of the labeled molecules to a solid support, where the labeled molecule hybridizes with its complementary pair. The paramagnetic label may be present on the target nucleic acid or the probe nucleic acid, depending upon whether the target or probe are the immobile phase.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: February 8, 2005
    Assignee: Iris Biotechnologies, Inc.
    Inventors: Jaime E. Ramirez-Vick, Simon Chin
  • Patent number: 6849710
    Abstract: A fragment condensation process for the synthesis of analogs of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP), in which amino acid residues (22-31) form a synthetic amphipathic ?-helix, is provided.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: February 1, 2005
    Assignee: F. Hoffmann-La Roche AG
    Inventor: Humberto Arzeno
  • Patent number: 6850447
    Abstract: A nonvolatile ferroelectric memory device having a multi-bit control function performs read/write operations by selecting a plurality of cells simultaneously, thereby improving the operation speed of a chip. In the nonvolatile ferroelectric memory device, a plurality of cells are selected at the same time, and stable sensing values of data having a small distribution can be obtained by using average characteristics of a plurality of selected cells. Accordingly, since two or more cells are simultaneously selected and a plurality of bits are read/written in the cells depending on stabilized charge, the operation speed of a chip can be improved.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: February 1, 2005
    Assignee: Hynix Semiconductor Inc.
    Inventor: Hee Bok Kang
  • Patent number: 6850896
    Abstract: A method and system for managing sales data. One embodiment is a software application that assists in classification, review and approval of data to be stored in a database for the use of a product supplier or seller. In one embodiment, a method includes storing a plurality of data components as groups of data components in a database, wherein the plurality of data components comprises information relating to products, and information relating to customers. The method further includes assigning a subset of the plurality of users to a content review group (“CRG”), and notifying each user in the CRG to provide input regarding individual data components of a group of data components. Input may include indicating whether data components are accurate, entering comments regarding the data components, entering edits to the data components. The method further includes receiving and storing the input, notifying a content director (“CD”) to review the input.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: February 1, 2005
    Assignee: Market-Touch Corporation
    Inventors: Ariel Kelman, Corey Sommers
  • Patent number: 6842060
    Abstract: The present invention discloses a digital control logic circuit having a characteristic of time hysteresis for controlling transition of a digital control signal for a predetermined period, comprising a first time hysteresis unit, a second time hysteresis unit and an inverter. The first time has the characteristic of time hysteresis when an input signal transits from a first level to a second level. The second time hysteresis unit has the characteristic of time hysteresis connected to the first hysteresis in series when the input signal transits from the second level to the first level.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: January 11, 2005
    Assignee: Hynix Semiconductor Inc.
    Inventor: Sang Sic Yoon
  • Patent number: 6842884
    Abstract: An equivalence checking method provides first and second logic functions. Don't care gates are inserted for don't care conditions in the first and second logic functions. The insertion of the don't care gates creates a first intermediate circuit and a second intermediate circuit. All 3DC gates of the first intermediate circuit are propagated and merged into a single 3DC gate when 3DC gates and SDC gates coexist in either of the first and second intermediate circuits. All 3DC gates of the second intermediate circuit are propagated and merged into a single 3DC gate when 3DC gates and SDC gates coexist in either of the first and second intermediate circuits. First and second circuits are produced in response to propagating and merging the 3DC gates. A combinational equivalence check is then performed of the first circuit to the second circuit under different equivalence relations.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: January 11, 2005
    Assignee: Verplex Systems, Inc.
    Inventors: Yung-Te Lai, Chioumin Chang, Kung-Chien Chen, Chih-Chang Lin
  • Patent number: 6838050
    Abstract: Methods of providing anti-infective activity to a medical device including the steps of exposing the medical device to an anti-infective oxidant, and transferring the anti-infective oxidant into a wall of the medical device. One embodiment includes the step of exposing a medical device that is at least in part within a patient to the anti-infective oxidant. Another embodiment includes the steps of exposing a medical device to an aqueous solution which produces the anti-infective oxidant and transferring a sufficient amount of the anti-infective oxidant into the medical device wall to provide the medical device with anti-infective activity. Also provided is an oxidant releasing member that has anti-infective oxidant releasably contained therein and that is configured to be disposed adjacent to the medical device.
    Type: Grant
    Filed: June 2, 2000
    Date of Patent: January 4, 2005
    Assignee: Oxibio, Inc.
    Inventors: Terrence R. Green, Jack Fellman
  • Patent number: 6838439
    Abstract: The present invention relates to compounds of the formula I which are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belongs to the group of integrins. The invention also relates to processes for the preparation of formula I, pharmaceutical compositions containing compounds of formula I, and the treatment or prophylaxis of various diseases caused by or are associated with excess leucocyte adhesion and/or leucocyte migration, as well as diseases associated with cell-cell or cell-matrix interactions, which on interactions of VLA-4 receptors with their ligands play a part of, for example, inflammatory processes, rheumatoid arthritis or allergic disorders.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: January 4, 2005
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Hans Ulrich Stilz, Volkmar Wehner, Christoph Huls, Dirk Seiffge
  • Patent number: 6838369
    Abstract: A method for forming a contact hole of a semiconductor device, wherein a polymer residual on a bottom surface of the contact hole is treated with plasma of mixture gas containing oxygen to convert the polymer residual into a pure silicon oxide film free of carbon and fluorine for easy removal in a subsequent washing process is disclosed. The method comprises (a) sequentially forming a capping layer and a planarized interlayer insulating film on a semiconductor substrate having a predetermined lower structure; (b) selectively etching the interlayer insulating film to expose a predetermined region of the capping layer; (c) removing the exposed capping layer; (d) subjecting the resulting structure to a plasma treatment using a mixture gas containing oxygen; and (e) performing a cleaning process.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: January 4, 2005
    Assignee: Hynix Semiconductor Inc.
    Inventors: Ho Seok Lee, Dong Sauk Kim, Jin Woong Kim
  • Patent number: 6838086
    Abstract: The invention discloses the use of low molecular weight hyaluronic acid fragments, which can be suitably modified, where appropriate, for producing vaccines. The vaccines are particularly suitable for controlling cancer diseases. Surprisingly, it has been found that low molecular weight hyaluronic acid fragments, which can be suitably modified, where appropriate, can be used both for preparing mature dendritic cells and directly, together with antigens or peptides or carrier systems, as an adjuvant in vaccines. It is likewise possible to couple the low molecular weight hyaluronic acid fragments, which can be suitably modified, where appropriate, to an antigen, peptide or carrier system. The coupled system can then be advantageously employed as a vaccine, in particular for treating cancer diseases.
    Type: Grant
    Filed: August 26, 1999
    Date of Patent: January 4, 2005
    Assignee: Universitaetsklinikum Freiburg
    Inventors: Jan Simon, Stefan Martin, Christian Termeer
  • Patent number: 6838430
    Abstract: The present invention concerns the use of stable HIF-1? variants to accelerate wound healing. More particularly, the present invention provides a method of accelerating wound healing in a mammal comprising administering a stable variant of an HIF-1? polypeptide comprising an oxygen-dependent degradation domain. The stable HIF-1? variant preferably comprises an insertion, deletion or substitution in the oxygen-dependent degradation domain.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: January 4, 2005
    Assignee: The Regents of the University of California
    Inventor: Jefferey M. Arbeit
  • Patent number: 6836439
    Abstract: A ferroelectric memory device features a main cell array, a row redundancy cell array, a first column redundancy cell array, a second column redundancy cell array, main bitline pull-up controllers, and column selection controllers. The main cell array includes main bitlines and sub bitlines. The row redundancy cell array is configured to share the main bitlines with the main cell array. The first column redundancy cell array is configured to share wordlines and platelines with the main cell array. The second column redundancy cell array is configured to share redundancy wordlines and redundancy platelines with the row redundancy cell array, and to share redundancy main bitlines with the first column redundancy. The main bitline pull-up controllers pull up main bitlines and redundancy main bitlines in response to first control signals, respectively.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: December 28, 2004
    Assignee: Hynix Semiconductor Inc.
    Inventor: Hee Bok Kang
  • Patent number: 6833437
    Abstract: Replacement of codons in DNA encoding the first three SCRs of LHR-A of CR1 with others encoding the predicted amino acids in the CR1-like sequence can give rise to chimeric genes which can be expressed to give active complement inhibitors with functional complement inhibitory, including anti-haemolytic activity. There is provided a soluble polypeptide comprising, in sequence, one to four short consensus repeats (SCR) selected from SCR 1, 2, 3 and 4 of long homologous repeat A (LHR-A) as the only structurally and functionally intact SCR domains of CR1 and including at least SCR3, in which one or more of the native amino acids are substituted with the following: Val 4, Asp 19, Scr 53, Lys 57, Ala 74, Asp 79, Arg 84, Pro 91, Asn 109, Lys 116, Val 119, Ala 132, Thr 137, Ile 139, Ser 140, Tyr 143, His 153, Leu 156, Arg 159, Lys 161, Lys 177, Gly 230, Ser 235, His 236.
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: December 21, 2004
    Assignee: AdProTech Limited
    Inventors: Danuta Ewa Irena Mossakowska, Vivienne Frances Cox, Richard Anthony Godwin Smith
  • Patent number: 6833132
    Abstract: Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used sucessfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various functional forms from spontaneously secreting cells or from DNA segments introduced into cells. These forms variously enable biochemical and functional studies of this novel protein as well as production of antibodies. Means are described for determining the level of expression of genes for the KGF protein, for example, by measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: December 21, 2004
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Jeffrey S. Rubin, Paul W. Finch, Stuart A. Aaronson
  • Patent number: 6831060
    Abstract: The present invention is directed to novel chimpanzee erythropoietin polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, and antibodies which bind to the polypeptides of the present invention.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: December 14, 2004
    Assignee: Genentech, Inc.
    Inventors: Frederic DeSauvage, Dennis J. Henner
  • Patent number: 6829155
    Abstract: The nonvolatile ferroelectric memory device comprises a plurality of cell array blocks; a plurality of drivers; and a plurality of decoders connected to the cell array blocks, respectively, wherein the decoder comprises a first sub-decoder for generating the decoding signal applied to the driver and a second sub-decoder for generating a signal selecting the driver. As a result, the nonvolatile ferroelectric memory device can reduce the area of the device and improve the driving speed.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: December 7, 2004
    Assignee: Hynix Semiconductor Inc.
    Inventor: Hee Bok Kang
  • Patent number: 6829154
    Abstract: The present invention relates to a ferroelectric memory device comprising a cell array block, a data bus unit and a control circuit unit. The cell array block has a bitline structure including a main bitline and a plurlaity of sub bitlines. The main bitline is connected to a column selection controller, and the plurality of sub-bitlines have both terminals connected to the main bitline, respectively, and connected to a plurality of unit cells. The data bus unit is connected to the column selection controller. The control circuit unit includes a sense amplifier array connected between a data I/O buffer and a sense amplifier data bus connected to the data bus unit. A plurality of the cell array blocks are arranged like a matrix. The control circuit unit is disposed in a first center line of symmetry wherein the first center line is parallel to the main bitline, and the data bus unit is disposed in a second center line of symmetry wherein the second center line is vertical to the main bitline.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: December 7, 2004
    Assignee: Hynix Semiconductor Inc.
    Inventor: Hee Bok Kang