Patents Represented by Attorney, Agent or Law Firm J. Michael Dixon
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Patent number: 6294206Abstract: The invention relates to a powdered human milk fortifier comprising a protein component typically present in an amount of from about 24 wt/wt % to about 55 wt/wt % of the fortifier powder, and a fat component typically present in an amount of from about 1 wt/wt % to about 30 wt/wt % of the fortifier powder and a carbohydrate component present in a quantity of from about 15 wt/wt % to about 75 wt/wt % of the fortifier powder. Preferably, the powdered human milk fortifier is provided in a unit dose container which holds from about 0.5 gm to about 10 gm of powder. The instant invention also relates to a method of providing nutrition to preterm infants by adding a fortifier powder to human milk and administering the fortified human milk to a premature infant. The invention further provides a method of promoting growth of a premature infant by administering fortified human milk to a premature infant.Type: GrantFiled: March 21, 2000Date of Patent: September 25, 2001Assignee: Abbott LaboratoriesInventors: Bridget Barrett-Reis, Patricia A. Reynolds, Michael B. Montalto, Deborah L. O'Connor
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Patent number: 6258375Abstract: It has been discovered that certain phosphoinositides demonstrate antibacterial activity. Particularly, these phosphoinositides have been discovered to prevent the adhesion of H. influenzae onto the nasopharyngeal cells of mammals, and, in particular, humans. Phosphoinositides useful with the present invention have the following formula: wherein R1 and R2 are selected from the group consisting of hydrogen and monounsaturated and saturated fatty acids having a carbon chain length of C6 to C20 and R1 and R2 can be the same or different; and R3 to R7 are selected from the group consisting of hydrogen or a phosphate moiety with at least two of R3 to R7 being a phosphate moiety; and hydrates and pharmaceutically acceptable salts thereof.Type: GrantFiled: March 5, 1998Date of Patent: July 10, 2001Assignee: Abbott LaboratoriesInventors: Shie-Ming Hwang, Yung-Sheng Huang, Jim-Wen Liu, Pradip Mukerji, Steven Neal Anderson, Jonathan A. Meulbroek
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Patent number: 6258387Abstract: The present invention is directed to an elemental liquid nutritional product useful for providing nutrition to a patient having a malabsorption condition by enterally feeding to the patient a nutritionally effective amount of the liquid nutritional products of the present invention. One nutritional product of the present invention includes a protein system in which at least 65 w/w % of said proteins have a molecular weight of less than 5,000 daltons. The proteins system includes soy protein hydrolysate, and partially hydrolyzed caseinate. The preferred products further include a structured lipid formed from marine oil and medium chain triglyceride oil. Palatability of elemental nutritional products has been improved by keeping caloric density in a range from 0.60 kcal/ml to about 1.05 kcal/ml and incorporating sufficient amounts of selected palatability enhancers.Type: GrantFiled: May 3, 2000Date of Patent: July 10, 2001Assignee: Abbott LaboratoriesInventors: John W. McEwen, Kent L. Cipollo, John H. R. Cramblit, Frances C. Pendley, Stephen J. DeMichele, Jeffery Kenneth Weis
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Patent number: 6255341Abstract: In its broadest aspect, the present invention is directed to the discovery of immunonutritional products that are useful in reducing the immunological system suppression that results from stress. The stress may be in the form of physical exertion, mental exhaustion, disease states and the like. In one embodiment, the invention relates to a nutritional composition comprising a structured glyceride component and an antioxidant system. This nutritional composition has been shown to be highly effective in reducing immune system down regulation or dysregulation as a result of stress.Type: GrantFiled: March 12, 1999Date of Patent: July 3, 2001Assignee: Abbott LaboratoriesInventors: Stephen J. DeMichele, John W. McEwen, Steven M. Wood
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Patent number: 6248784Abstract: The invention is directed to an improved infant formula containing a lipid blend that softens the firmer stools associated with typical infant formula. A specific formula in accordance with the invention comprises carbohydrates, proteins, vitamins and minerals and a lipid mixture of high oleic safflower oil, soy oil and coconut oil at specific levels and ratios. The invention also discloses novel mixtures of fatty acids that provides infant stool patterns more closley resembling the breast-fed infant.Type: GrantFiled: February 4, 2000Date of Patent: June 19, 2001Assignee: Abbott LaboratoriesInventors: Matthew A. Kuchan, Marc L. Masor, Debra L. Ponder, Robin J. Halter, John D. Benson, Gary E. Katz
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Patent number: 6248372Abstract: The present invention is directed to a rice flour extract (RFE) which can be used in the prophylaxis and treatment of bacterial infections, particularly bacterial infections caused by Haemophilus influenzae and to a method of preparing and using such an antibacterial rice flour extract. The anti-Haemophilus influenzae rice flour extract of the present invention can be prepared from commercial food grade rice flours or non-commercial food grade rice flours.Type: GrantFiled: October 27, 1999Date of Patent: June 19, 2001Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Shie-Ming Hwang, Yung-Sheng Huang, Jim-Wen Liu, Steven Neal Anderson, Jonathan A. Meulbroek
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Patent number: 6245803Abstract: This invention relates to a palatable elemental nutritional formula that is nutritionally complete for humans with specialized dietary needs. The nutritional of the present invention uses specific free amino acids to provide the source of amino nitrogen (protein equivalents) and a special blend of fats that provides 38 to 50% of the total Calories in a pleasant tasting formula. The nutritionally complete formula of this invention is useful for children having multiple protein allergies, short gut syndrome, sick gut, diarrhea and the like. More specifically, the nutritional product, in accordance with this invention, utilizes L-asparagine monohydrochloride and L-glutamine in place of L-aspartic acid and L-glutamic acid, respectively. In addition, the source of fat comprises soy, fractionated coconut oil (medium chain triglycerides), high oleic safflower oil and esterified glycerol emulsifiers.Type: GrantFiled: June 1, 1999Date of Patent: June 12, 2001Assignee: Abbott LaboratoriesInventors: Phyllis J. B. Acosta, Marlene W. Borschel, Patricia A. Reynolds, Christopher T. Cordle, Geralyn O. Duska-McEwen
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Patent number: 6228886Abstract: A nutritional formulation containing bactericidal amounts of diacetyltartaric acid esters of mono- and diglycerides is provided. A process of inhibiting bacterial infections including the step of feeding the nutritional composition to a subject is also provided.Type: GrantFiled: May 22, 2000Date of Patent: May 8, 2001Assignee: Abbott LaboratoriesInventors: Steven N. Anderson, Milo Duane Hilty, Terry Bruce Mazer, Joseph Schaller, Melinda Guzman-Harty, Theresa Siu-Ling Wai Lee, Lisa Ann Reaves, Jin-Zhou Liu
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Patent number: 6207203Abstract: In general this invention relates to a powder composition that provides a low fat vitamin and mineral fortified coffee drink when reconstituted with water. The nutritional composition being in the form of a soluble powder containing an instant coffee component, a protein component, a vitamin/mineral component providing at least 25% of U.S. RDI per 8 oz serving, and a carbohydrate component in about 140 Cal per 8 oz serving.Type: GrantFiled: July 30, 1998Date of Patent: March 27, 2001Assignee: Abbott LaboratoriesInventors: Judith R. Atkinson, David A. Deis, Amy L. Marchio
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Patent number: 6194379Abstract: The present invention is directed to an elemental liquid nutritional product useful for providing nutrition to a patient having a malabsorption condition by enterally feeding to the patient a nutritionally effective amount of the liquid nutritional products of the present invention. One nutritional product of the present invention includes a protein system in which at least 65 w/w % of said proteins have a molecular weight of less than 5,000 daltons. The proteins system includes soy protein hydrolysate, and partially hydrolyzed caseinate. The preferred products further include a structured lipid formed from marine oil and medium chain triglyceride oil. Palatability of elemental nutritional products has been improved by keeping caloric density in a range from 0.60 kcal/ml to about 1.05 kcal/ml and incorporating sufficient amounts of selected palatability enhancers.Type: GrantFiled: May 1, 1998Date of Patent: February 27, 2001Assignee: Abbott LaboratoriesInventors: John W. McEwen, Kent L. Cipollo, John H. R. Cramblit, Frances C. Pendley, Stephen J. DeMichele, Jeffery Kenneth Weis
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Patent number: 6160007Abstract: This invention relates to a method for enhancing the absorption of oil soluble (lipophilic) compounds such as oil soluble vitamins, hormones, nutrients and drugs in an animal. The inventive method comprises administering a lipophilic compound in conjunction with a structured glyceride component characterized in that at least 40% of the glyceride species have: (i) about 33 to 70 wt. % of acyl moieties having 4 to 12 carbon atoms; (ii) about 30 to 67 wt. % of acyl moieties having more than 12 carbon atoms; and (iii) an equivalent carbon number greater than 30 and less than 48. This invention also relates to compositions suitable for administrating to an animal comprising a lipophilic compound and a structured glyceride component characterized in that at least 40% of the glyceride species have: (i) about 33 to 70 wt. % of acyl moieties having 4 to 12 carbon atoms; (ii) about 30 to 67 wt. % of acyl moieties having more than 12 carbon atoms; and (iii) an equivalent carbon number greater than 30 and less than 48.Type: GrantFiled: September 1, 1999Date of Patent: December 12, 2000Assignee: Abbott LaboratoriesInventors: Stephen J. DeMichele, Theresa W. Lee, Patrick Tso
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Patent number: 6149946Abstract: This invention provides a composition comprising notochord and extracts thereof in therapeutic amounts. The invention more specifically relates to a method of treating arthritis in mammals, more particularly rheumatoid arthritis in humans through the enteral administration of notochord, notochord extracts or mixtures thereof. In a preferred embodiment, collagen obtained from sturgeon is enterally administered to a human at from 1.0 .mu.g to 1.05 gms per day.Type: GrantFiled: October 9, 1998Date of Patent: November 21, 2000Assignee: Abbott LaboratoriesInventors: Seiji Aoyagi, Stephen J. DeMichele, Paul W. Johns, Terrence B. Mazer
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Patent number: 6150399Abstract: The present invention relates generally to a complete nutritional product that provides soy protein and enhanced levels of isoflavones. Preferably, the soy protein comprises at least 0.7 mg isoflavones / gm soy protein and at least 0.5 mg genistein / gm soy protein. The product is fortified at 35% of the RDI for calcium and contains an antioxidant package. The invention also describes the method to produce a heat stable isoflavone-enriched soy protein complete nutritional.Type: GrantFiled: June 30, 1998Date of Patent: November 21, 2000Assignee: Abbott LaboratoriesInventors: Gauravkumar C. Patel, Michael Allen Chandler, Kent Lee Cipollo, Lisa Diane Craig, Theresa W. Lee
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Patent number: 6136858Abstract: The invention is directed to an improved infant formula containing a lipid blend that softens the firmer stools associated with typical infant formula. A specific formula in accordance with the invention comprises carbohydrates, proteins, vitamins and minerals and a lipid mixture of high oleic safflower oil, soy oil and coconut oil at specific levels and ratios. The invention also discloses novel mixtures of fatty acids that provides infant stool patterns more closely resembling the breast-fed infant.Type: GrantFiled: March 7, 1997Date of Patent: October 24, 2000Assignee: Abbott LaboratoriesInventors: Matthew A. Kuchan, Marc L. Masor, Debra L. Ponder, Robin J. Halter, John D. Benson, Gary E. Katz
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Patent number: 6136855Abstract: A process of treating infection by a pathogenic microorganism in a subject in need of such treatment comprising the step of administering to the subject an effective antimicrobial amount of diacetyltartaric acid esters of mono- and diglycerides is provided. Pharmaceutical compositions containing diacetyltartaric acid esters of mono- and diglycerides as an active antimicrobial agent are also provided.Type: GrantFiled: July 16, 1999Date of Patent: October 24, 2000Assignee: Abbott LaboratoriesInventors: Melinda Guzman-Harty, Milo Duane Hilty, Steven N. Anderson, Joseph Schaller, Terry Bruce Mazer, Theresa Siu-Ling Wai Lee, Lisa Ann Reaves, Jin-Zhou Liu
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Patent number: 6130244Abstract: In its broadest aspect, the present invention is directed to the discovery of immunonutritional products that are useful in reducing the immunological system suppression that results from stress. The stress may be in the form of physical exertion, mental exhaustion, disease states and the like. In one embodiment, the invention relates to a nutritional composition comprising a structured glyceride component and an antioxidant system. This nutritional composition has been shown to be highly effective in reducing immune system down regulation or dysregulation as a result of stress.Type: GrantFiled: February 25, 1998Date of Patent: October 10, 2000Assignee: Abbott LaboratoriesInventors: Stephen J. DeMichele, Steven M. Wood
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Patent number: 6106874Abstract: This invention relates to a low pH nutritional beverage that utilizes pectin-free fruit juice as a major component and a source of calcium selected from natural milk mineral, calcium lactate gluconate and mixtures thereof. The beverage preferably also contains water soluble vitamins, flavors and carbohydrates. The use of a pectin-free and clarified pear juice in a preferred embodiment of the beverage provides a fat-free beverage with a substantially clear appearance and a light, refreshing mouthfeel. The beverage is preferably produced using a "cold water process" that results in excellent physical stability of the beverage over shelf life and the reduction of browning.Type: GrantFiled: November 18, 1998Date of Patent: August 22, 2000Assignee: Abbott LaboratoriesInventors: Jeffery Wayne Liebrecht, Kenneth Mark Phillips
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Patent number: 6077828Abstract: The present invention relates to methods and nutritional compositions for the prevention and treatment of cachexia and anorexia. The methods of the invention comprise administering a composition comprising effective amounts of .omega.-3 fatty acids such as alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid or mixtures thereof; of branched-chain amino acids valine, leucine, isoleucine or mixtures thereof; with or without reduced levels of tryptophan and 5-hydroxytryptophan; and of antioxidant system selected from the group comprising beta-carotene, vitamin C, vitamin E, selenium, or mixtures thereof.Type: GrantFiled: April 24, 1997Date of Patent: June 20, 2000Assignee: Abbott LaboratoriesInventors: Bonnie Chandler Abbruzzese, Mark Anthony McCamish, Frederick Oliver Cope, Stephen Joseph Demichele
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Patent number: 6066344Abstract: Process methods are described for combining compounds of mineral nutrients into chemically stable powder mixtures that notably preserve chromium in a soluble form conducive to both absorption and bioavailability. The methods include the compounds of minerals in preferred chemical forms, procedures for treatment of certain compounds to maintain solubility, appropriate sequences for combination of the compounds and other premix ingredients, and blending to provide an adequately homogeneous mixture. The methods provide premixes of minerals that support bioavailable chromium and that exhibit good stability, solubility, odor and color for addition to nutritional products.Type: GrantFiled: March 1, 1999Date of Patent: May 23, 2000Assignee: Abbott LaboratoriesInventors: Danold Wayne Golightly, Donald Lee Sgontz, Jr., Bogdan Kazimierz Kedzierski, Frank Stanley Abel, Benita Co Yao
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Patent number: 6066669Abstract: A nutritional formulation containing bacterial amounts of diacetyltartaric acid esters of mono- and diglycerides is provided. A process of inhibiting bacterial infections including the step of feeding the nutritional composition to a subject is also provided.Type: GrantFiled: April 16, 1999Date of Patent: May 23, 2000Assignee: Abbott LaboratoriesInventors: Steven N. Anderson, Milo Duane Hilty, Terry Bruce Mazer, Joseph Schaller, Melinda Guzman-Harty, Theresa Siu-Ling Wai Lee, Lisa Ann Reaves, Jin-Zhou Liu