Abstract: A method for the treatment and/or prophylaxis of incontinence in mammals, which method comprises administering to the mammal an effective amount of the compound pinacidil or a pharmaceutically acceptable salt or solvate thereof.
Type:
Grant
Filed:
July 17, 1987
Date of Patent:
December 6, 1988
Assignee:
Beecham Group p.l.c.
Inventors:
Thomas C. Hamilton, Robin E. Buckingham
Abstract: Cured resins of high fracture toughness are prepared from N,N'-bisimides of formula I ##STR1## and alkenyl compounds of formula IID(G).sub.m IIin which D is an m-valent group and G represents a phenyl ring having at least one alkenyl (e.g. allyl or 1-propenyl) substituent.
Abstract: An aqueous contact cement, which comprises a dispersion in water of a chloroprene copolymer of 2-chloro-1,3-butadiene and methacrylic acid and a resinous polyelectrolyte of an ionizable resinous mixture which is ionized with a volatile ionizing atent, and ionizable resinous mixture being the reaction product of a rosin, a carboxylic acid, and a C.sub.1 -C.sub.18 mono-alcohol, said ionizable resinous mixture having a softening point not substantially above about 125.degree. C. and an acid number of between about 30 and 150, said reaction product comprising the carbocyclic nucleus of rosin having at least one carboxylic acid group and at least one carboxylic acid ester group of said mono-alcohol.
Abstract: A method for the treatment and/or prophylaxis of reversible airways obstruction and asthma in mammals, which method comprises administering to the mammal in need of said treatment an effective amount of a compound of formula (I): ##STR1## wherein R.sub.1 -R.sub.8 and X are as set forth herein.
Abstract: A pharmaceutical composition comprising the analgesic and anti-inflammatory agent 2-(2-fluoro-4-biphenylyl)propionic acid or a pharmaceutically acceptable salt thereof and certain esters of natural vegetable oil fatty acids, provides a rapid release of 2-(2-fluoro-4-biphenylyl)propionic acid into the body, and hence a very rapid analgesic and anti-inflammatory effect.
Abstract: A vented louspeaker has a speaker and a vent tube within the loudspeaker enclosure, the vent tube being arranged obliquely to the wall on which it is mounted and being longer than the distance between that wall and the opposite wall.
Abstract: A device suitable for the topical administration of a pharmacologically active agent to an animal is described. The device comprises an active agent impermeable barrier layer, a reservoir containing the active agent which is in contact with the inner surface of the barrier layer and a removable protector layer in contact with the other surface of the reservoir. The reservoir comprises a fibrous mat into which the pharmacologically active agent is incorporated either by dissolving in the polymer forming the mat or by impregnation of a preformed mat. Alternative forms of the reservoir comprise a fibre mat coated on a skin contacting surface with a pressure sensitive adhesive and a fibre mat contained within a gel matrix. The device may be used to deliver nitroglycerin, oxybutynin or phenazocine transdermally.
Type:
Grant
Filed:
June 2, 1987
Date of Patent:
November 15, 1988
Assignee:
Smith and Nephew Associated Companies PLC
Abstract: A compound of the formula (I): ##STR1## wherein R is hydrogen or unsubstituted or substituted 1-naphthyl. These compounds are useful to obtain inhibition of aldose reductase in animals, including humans.
Abstract: A method for the treatment of cerebral vascular and neuronal degenerative disorders associated with learning, memory and cognitive dysfunctions including cerebral senility, multi-infarct dementia and senile dementia of the Alzheimer type and/or peripheral vascular disease and/or proliferative skin disease in mammals, such as humans, which comprises administering to the mammal in need of such treatment an effective amount of 1,3-di-n-butyl-7-(2-oxypropyl) xanthine or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
September 11, 1987
Date of Patent:
November 15, 1988
Assignee:
Beecham Wuelfing GmbH & Co. KG
Inventors:
Dieter Angersbach, Charles D. Nicholson, Joachim Goring, Brian Morgan, Jonathan R. S. Arch
Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: one of R.sub.1 and R.sub.2 is hydrogen or C.sub.1-4 alkyl and the other is C.sub.1-4 alkyl or R.sub.1 and R.sub.2 together are C.sub.2-5 -polymethylene;either R.sub.3 is hydrogen, hydroxy, C.sub.1-6 alkoxy or C.sub.1-7 acyloxy and R.sub.4 is hydrogen or R.sub.3 and R.sub.4 together are a bond;R.sub.5 is hydrogen C.sub.1-6 alkyl optionally substituted by halogen hydroxy, C.sub.1-6 alkoxy, C.sub.1-6 alkoxycarbonyl, carboxy or amino optionally substituted by one or two independent C.sub.1-6 alkyl groups, or C.sub.2-6 alkenyl, amino optionally substituted by a C.sub.1-6 alkyl or C.sub.1-6 alkenyl group or by a C.sub.1-6 alkanoyl group optionally substituted by up to three halo atoms, by a phenyl group optionally substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halogen, or aryl or hetroaryl, either being optionally substituted by one or more groups or atoms selected from the class of C.sub.1-6 alkyl, C.sub.
Type:
Grant
Filed:
August 29, 1986
Date of Patent:
November 1, 1988
Assignee:
Beecham Group P.L.C.
Inventors:
Frederick Cassidy, Geoffrey Stemp, John M. Evans
Abstract: A sterilized cassette and a transparent cover for the cassette are stored in sterile packaging. A sterilizing gas flows through the cassette to maintain the operating field sterile while the cassette is in place on the patient.
Abstract: Pesticidal compounds of formula IR.sub.A CR.sub.3 .dbd.CR.sub.4 CHDR.sub.B Iin which formula:R.sub.A represents a group ArCR.sub.1 R.sub.2 --in which Ar represents a phenyl or naphthyl group optionally substituted by one or more halogen, alkoxy, haloalkoxy, methylenedioxy, C.sub.1 -C.sub.6 alkyl or haloalkyl groups;R.sub.1 and R.sub.2 together with the carbon to which they are attached represent a C.sub.3 -C.sub.6 cycloalkyl group optionally substituted by one or more halogen atoms or C.sub.1 -C.sub.6 alkyl groups.R.sub.3 and R.sub.4 which may be identical or differ, represent hydrogen halogen or C.sub.1 -C.sub.6 alkyl groups andR.sub.B represents the residue of an alcohol R.sub.B CHDOH in which D is hydrogen or cyano and of which the [1R, cis]2,2-dimethyl-3-(2,2-dibromovinyl) cyclopropane carboxylic ester is significantly insecticidal,the configuration of R.sub.A and CHDR.sub.
Type:
Grant
Filed:
April 5, 1985
Date of Patent:
October 11, 1988
Assignee:
National Research Development Corporation
Inventors:
Michael Elliott, Norman F. Janes, Bhupinder P. Singh Khambay, Ahmet Baydar
Abstract: An automotive vehicle with rhomoboidal configuration includes a bearing frame or chassis (1), a central driving system (10), trapezoidal oscillating suspensions (7) for the central wheels (2, 3), and L-shaped floating arm type suspensions (8) for front (4) and rear (5) wheels.All four wheels (2, 3, 4, 5) are driving wheels, the front (4) and rear (5) wheels both being steered by one single gearbox (14).Steering of the wheels (4, 5) will be through a knuckle (9) mounted on a floating arm (8), whereas the steering rod (18) is mounted on the extension of the bearing shaft (34) on which the wheels are mounted.
Abstract: A suspended ceiling suspended from the structural ceiling of a room, which comprises a plurality of parallel, elongated, snap-bars, each having a pair of longitudinally extending, opposed spring-like arms biased to be closely together, and a plurality of metal ceiling tiles held by snap bars in side-by-side relationship, each said ceiling tile having a planar metal body having opposed sides, opposed ends, top and bottom faces and 90.degree. corners, a pair of spaced tabs at each side projecting from said top face, and a layer of vitreous material on said bottom surface, the tabs of one side of one ceiling tile being held within the same snap-bar as the tabs of the immediately adjacent side of the next adjacent ceiling tile.
Abstract: In a light valve, comprising a cell containing a suspension of small anisometrically shaped particles suspended in an electrically resistive liquid suspending medium, said liquid suspending medium having a polymer dissolved therein and bonded to or associated with said particles, the improvement wherein said liquid suspending material comprises a liquid ester or ether of the formulaR.sup.1 --X--R.sup.2wherein R.sup.1 and R.sup.