Patents Represented by Law Firm Jacobs & Jacobs
  • Patent number: 4877784
    Abstract: A compound of the formula I ##STR1## wherein R is lower alkyl has been found to have antiepileptic properties and to be useful in the treating of epilepsy in humans and animals. Pharmaceutical compositions and methods of treatment are described herein.
    Type: Grant
    Filed: June 20, 1988
    Date of Patent: October 31, 1989
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Kiyoshi Kimura, Takashi Ogasawara, Takeshi Mushiroi
  • Patent number: 4877783
    Abstract: .beta.-Lactam antibiotics having an .alpha.-formamido substituent on the carbon atom adjacent to the carbonyl group of the .beta.-lactam ring and in particular bicyclic compounds having the partial structure: ##STR1## Intermediates and processes for the preparation of the compounds are further disclosed.
    Type: Grant
    Filed: January 24, 1985
    Date of Patent: October 31, 1989
    Assignee: Beecham Group p.l.c.
    Inventor: Peter H. Milner
  • Patent number: 4876086
    Abstract: Injectable pharmaceutical compositions are provided which comprise fine particles of amoxycillin trihydrate coated with a dispersing agent, the ratio of amoxycillin trihydrate to dispersing agent being from 1000:1 to 20:1. A preferred dispersing agent is a mixture of polyvinylpyrrolidone and lecithin. Such compositions give surprising prolonged blood levels of amoxycillin after administration. The compositions can be used in the treatment of both humans and domestic animals.
    Type: Grant
    Filed: September 17, 1987
    Date of Patent: October 24, 1989
    Assignee: Beecham Group p.l.c.
    Inventor: John S. Dowrick
  • Patent number: 4874762
    Abstract: Compounds of the formula I ##STR1## and pharmaceutically acceptable salts thereof wherein R.sup.1 is hydrogen, lower alkyl, aryl or haloaryl, in combination with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: May 20, 1988
    Date of Patent: October 17, 1989
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Kiyoshi Kimura, Fusao Ueda, Masaru Tamura
  • Patent number: 4874774
    Abstract: Nifedipine is formulated into a reactally administrable composition for administration to humans and animals to effect coronary dilation and for hypotensive effect.
    Type: Grant
    Filed: August 12, 1986
    Date of Patent: October 17, 1989
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Koichi Ushimaru, Tomoaki Hamakawa, Tomio Koga
  • Patent number: 4873002
    Abstract: Liquid detergent fabric conditioning compositions are prepared which are useful for providing detergency, fabric softening and anti-static properties to fabrics during the wash cycle in the laundering process which comprises from about 2% to about 12% of a cationic fabric conditioning agent having fabric softening and anti-static properties, from about 10% to about 50% of a nonionic surfactant having detergent properties which is compatible with said cationic fabric conditioning agent, and an aqueous solvent system.
    Type: Grant
    Filed: November 23, 1982
    Date of Patent: October 10, 1989
    Assignee: Beecham Inc.
    Inventor: Nader Ibrahim
  • Patent number: 4873240
    Abstract: A method for increasing the weight gain and/or improving the feed utilization efficiency of livestock is described which comprises the oral or non-oral administration to livestock of an effective, non-toxic amount of a compound of formula (XX): ##STR1## or a salt thereof, in which W is phenyl optionally substituted by halogen or trifluoromethyl, or a benzofuran-2-yl group, R.sup.1x is hydrogen or methyl, R.sup.2x is carboxyl or a group O--Z.sup.4 --CO.sub.2 H or an ester or amide thereof; a group O--E.sup.1 --NR.sup.3x R.sup.4x or a group O--E.sup.1 --OR.sup.5x, wherein R.sup.3x, R.sup.4x and R.sup.5x each represents hydrogen or C.sub.1-6 alkyl, Z.sup.4 is a C.sub.1-6 straight or branched alkylene chain, x is 1 or 2, y is 2 or 3, and E.sup.1 is C.sub.2-7 straight or branched alkylene chain with at least two carbon atoms separating the two heteroatoms in the group R.sup.2x.
    Type: Grant
    Filed: July 8, 1988
    Date of Patent: October 10, 1989
    Assignee: Beecham Group p.l.c.
    Inventor: Jonathan R. Arch
  • Patent number: 4873130
    Abstract: A process for the preparation of a coherent protective layer on a substrate surface of a body, the substrate surface comprising elemental metal or an alloy thereof, which process comprises applying to the substrate surface an aqueous solution of a partially neutralised homo- or copolymer of a mono- or polybasic ethylenically unsaturated acid; and heat-curing the layer so formed at a temperature above 180.degree. C.
    Type: Grant
    Filed: August 22, 1988
    Date of Patent: October 10, 1989
    Assignee: National Research Development Corporation
    Inventors: John W. Nicholson, Alan D. Wilson
  • Patent number: 4872869
    Abstract: A low profile ostomy device includes an ostomy bag with an opening, a first coupling member attached to the ostomy bag at the opening, and a second coupling member for attachment to a user's body. The first and second coupling members are engaged by the joining of an engaging element on each of the members, the engagement providing a tight mechanical seal between the members within the ostomy bag.
    Type: Grant
    Filed: June 24, 1988
    Date of Patent: October 10, 1989
    Assignee: Smith & Nephew (Latin America), Inc.
    Inventor: Owen L. Johns
  • Patent number: 4873242
    Abstract: Compounds of the formula I ##STR1## and pharmaceutically acceptable salts thereof wherein R.sup.1 is hydrogen or lower alkyl and R.sup.2 and R.sup.3 are the same or different and each is hydrogen, lower alkoxy or halo, in combination with a pharmaceutically acceptable carrier have been found to be useful as nootropic agents.
    Type: Grant
    Filed: May 20, 1988
    Date of Patent: October 10, 1989
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Kiyoshi Kimura, Fusao Ueda, Takashi Ogasawara
  • Patent number: 4871821
    Abstract: Cured resins of high fracture toughness are prepared from N,N'-bisimides of formula I ##STR1## and alkenyl compounds of formula IID(G).sub.m IIin which D is an m-valent group and G represents a phenyl ring having at least one alkenyl (e.g. allyl or 1-propenyl) substituent.
    Type: Grant
    Filed: March 25, 1988
    Date of Patent: October 3, 1989
    Assignee: Technochemie GmbH
    Inventors: Horst Stenzenberger, Peter Koenig
  • Patent number: 4868588
    Abstract: A snorkel camera system has a light-admitting opening at one end of a housing and the prime lens of a camera connected to the other end of the housing, and the housing is rotatably mounted on the prime lens such that the housing can be rotated about the camera to any desired position, the optical system being such that the image seen in the view-finder of the camera is maintained in the correct attitude regardless of the position to which the snorkel housing is rotated.
    Type: Grant
    Filed: February 10, 1989
    Date of Patent: September 19, 1989
    Inventor: Stephen Hajnal
  • Patent number: 4865752
    Abstract: A composition and method of cleansing and regenerating contaminated filtration membranes is described together with the synergized antimicrobial aqueous solution of an inorganic peroxide and a polymeric solubilized iodine complex. The membrane to be regenerated is of the type used in ultrafiltration, reverse osmosis and microfiltration and the construction and composition of the member is per se known.
    Type: Grant
    Filed: December 5, 1988
    Date of Patent: September 12, 1989
    Inventor: Albert L. Jacobs
  • Patent number: 4863915
    Abstract: Crystalline anhydrous amoxycillin is prepared by removing bound solvent molecules from a crystalline solvate (other than the trihydrate) of amoxycillin. A preferred crystalline solvate is the monomethanolate.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: September 5, 1989
    Assignee: Beecham Group p.l.c.
    Inventor: Neil Ward
  • Patent number: 4863437
    Abstract: An administration set which is suitable for giving an infusion of liquid to a patient by gravity flow from a container of liquid through the set and to the patient comprises a fluid reservoir, a flow regulator and a barostat device which compensates for changes in fluid pressure during the infusion. The fluid reservoir is positioned upstream of the flow regulator and the barostat device is downstream of the flow regulator. In a preferred embodiment a piercing needle connects with a closable tube and injection site which enter the main body of the reservoir by a secure seal. One side of the top of the reservoir extends in a curving manner to be in front of the closable tube and joins an air channel that leads to an airtight chamber which holds the barostat device. An outlet passage leads from the bottom of the reservoir to a collapsible region and descends to an outlet tube which leads via the regulator to the barostat device.
    Type: Grant
    Filed: March 17, 1987
    Date of Patent: September 5, 1989
    Inventor: Ellis W. Clarke
  • Patent number: 4863778
    Abstract: The present invention is directed to an elastic apertured film which contains voids. The film comprises a blend of polyurethane and an incompatible polymer which forms a discrete phase within the matrix of polyurethane. The film is in the form of a net. The area of apertures is 5 to 75% of the total area of the film or alternatively, the film is in the form of an interrupted film containing a pattern of holes which have a maximum dimension of not more than 3 times the thickness of the film.
    Type: Grant
    Filed: April 21, 1983
    Date of Patent: September 5, 1989
    Assignee: Smith and Nephew Associated Companies p.l.c.
    Inventor: Peter J. Metcalfe
  • Patent number: 4861280
    Abstract: This terminal is consisting of two elements, one of which is formed by a metal coupling mechanism (1) a first ring (2) connected to the coupling mechanism (1) and a second ring (6) connected to the first ring (2) by means of a narrow lower link (5), so that the second ring (6) is externally projecting beyond the first ring (2), whereas the other element is formed by a hollow, tubular insulating envelope or sleeve internally featuring various subsequent shapes, i.e. a flaring or bellmouth (8) forming an initial step (9), followed by an annular recess (10), a second step (11) almost centrically located with respect to a cylindrical end section (12), so that the terminal to be used by the operator is obtained by introducing the second ring (6) in the sleeve (7) until it is positioned in the annular recess (10) and resting against the first step (9). After connection to the lead by crimping the first ring (2), the sleeve is moved axially so as to uncover the coupling zone, i.e.
    Type: Grant
    Filed: June 15, 1988
    Date of Patent: August 29, 1989
    Assignee: Grafoplast S.p.A.
    Inventors: Ivana Piana, Silvano Piana
  • Patent number: 4860737
    Abstract: A low adherency wound dressing which comprises a wound facing layer, an intermediate absorbent layer and an outer layer wherein the wound facing layer comprises a conformable net of elastomer, the intermediate absorbent layer comprises a conformable open cell foam of hydrophilic polymer, and the outer layer comprises a conformable microporous film; and a process for making said dressing.
    Type: Grant
    Filed: August 11, 1983
    Date of Patent: August 29, 1989
    Assignee: Smith and Nephew Associated Companies p.l.c.
    Inventors: Stephen M. Lang, David F. Webster
  • Patent number: 4859767
    Abstract: Compounds of formula I are useful in the prophylaxis or treatment of hyperglycemic symptoms ##STR1## wherein R is alkyl substituted by one or more hydroxy.
    Type: Grant
    Filed: October 10, 1986
    Date of Patent: August 22, 1989
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Makoto Sugiyama, Yoji Ezure, Yoshiaki Yoshikuni, Takayuki Ozaki, Nobutoshi Ojima
  • Patent number: 4857515
    Abstract: A compound of formula (I): ##STR1## wherein R.sup.1 is alkenyl or alkyl or both of the depicted R.sup.1 groups together represent trimethylene and form a six-membered ring together with the depicted oxygen and phosphorus atoms, R.sup.2 is nitro, trifluoromethyl or halogen, R.sup.3 is alkyl, and R.sup.4 is dimethoxymethyl, formyl, hydroxymethyl or nitrile.
    Type: Grant
    Filed: October 30, 1987
    Date of Patent: August 15, 1989
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Kiyoshi Kimura, Masahiro Kise, Iwao Morita, Toshio Tomita, Masami Tsuda