Patents Represented by Law Firm Jacobs & Jacobs
  • Patent number: 4855415
    Abstract: A compound of formula (I) ##STR1## wherein: B is a divalent substituted or unsubstituted, cyclic or acyclic, saturated or unsaturated hydrocarbon group;A is a linking group selected from the group consisting of --O--, --S--, --N(H)--, --N(R)--, --C(O)-- and combinations of two or more thereof or A is a direct bond; andR is a monovalent substituted or unsubstituted, cyclic or acyclic, saturated or unsaturated hydrocarbon group, a monovalent substituted or unsubstituted aromatic hydrocarbon group, or a monovalent substituted or unsubstituted heterocyclyl provided that B--A--R may not represent hydrogen, lower alkyl, or a monovalent cyclic or acyclic hydrocarbon group having one or more hydroxyl groups, which is useful for inhibiting an increase in blood glucose in humans and for the treatment of diabetes mellitus.
    Type: Grant
    Filed: September 1, 1987
    Date of Patent: August 8, 1989
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Makoto Sugiyama, Yoji Ezure, Yoshiaki Yoshikuni, Yukio Fujita
  • Patent number: 4855291
    Abstract: Quinolones of the formula I ##STR1## in which the dotted line between positions 2 and 3 of the quinolone ring represents an optional bond; R is hydrogen or lower alkyl; R.sub.1 is lower alkyl; and R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, are hydrogen, halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulphinyl, lower alkylsulphonyl, trifluoromethyl, cyano, fluorinated lower alkoxy, phenyl optionally substituted by one or two substituents selected from lower alkyl, lower alkoxy, lower alkylthio, halo and trifluoromethyl, the group --OAr or the group --S(O).sub.n Ar in which Ar is phenyl optionally substituted by one or two substituents selected from lower alkyl, lower alkoxy, lower alkylthio, halo and trifluoromethyl and n is 0, 1 or 2, or the group --NR.sub.5 R.sub.6 or the N-oxide thereof in which R.sub.5 and R.sub.
    Type: Grant
    Filed: June 25, 1987
    Date of Patent: August 8, 1989
    Assignee: The Boots Company plc
    Inventor: Roy V. Davies
  • Patent number: 4853391
    Abstract: A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R.sub.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halogen;R.sub.2 and R.sub.3 are both hydrogen or together represent a bond;R.sub.4 is hydrogen and R.sub.5 is hydrogen or R.sub.4 and R.sub.5 together represent an oxo group;R.sub.6 is hydrogen; C.sub.1-6 alkyl; C.sub.3-7 cycloalkyl; C.sub.3-7 cycloalkyl-C.sub.1-4 alkyl; phenyl or phenyl C.sub.1-7 alkyl in which the phenyl moiety is optionally substituted by one or two of halogen, ortho-nitro, meta-or para-methoxy, methyl or NR.sub.8 R.sub.9 wherein R.sub.8 and R.sub.9 are independently hydrogen or C.sub.1-6 alkyl or R.sub.8 and R.sub.9 together are C.sub.2-6 polymethylen, or 3,4-disubstituted by methylenedioxy or ethylenedioxy; or monocyclic heteroaryl-C.sub.1-4 alkyl or aliphatic heterocyclyl-C.sub.
    Type: Grant
    Filed: June 28, 1985
    Date of Patent: August 1, 1989
    Inventors: Guy Nadler, Jean-Bernard Le Polles, Marie-Noelle Legave
  • Patent number: 4849229
    Abstract: A therapeutically active solid unit dosage form having a controlled and prolonged release pattern upon administration, comprising a mixture of a high viscosity grade methylcellulose or hydroxypropylmethylcellulose, an alkali metal sulfate or sulfonate and a therapeutically active medicament.
    Type: Grant
    Filed: January 5, 1988
    Date of Patent: July 18, 1989
    Assignee: Forest Laboratories, Inc.
    Inventors: Norman G. Gaylord, Joseph M. Schor
  • Patent number: 4847242
    Abstract: 11-ether derivatives of erythromycin, and corresponding 9-(optionally substituted)-amino, 9-imino, and 9-(optionally substituted)-oxime derivatives are novel antibacterially active compounds, and can be prepared by alkylation of the 11-hydroxy group under mild conditions.
    Type: Grant
    Filed: March 10, 1986
    Date of Patent: July 11, 1989
    Assignee: Beecham Group p.l.c.
    Inventor: John S. Davies
  • Patent number: 4846829
    Abstract: A pad for protecting female undergarments from light vaginal discharges is described in which pad a body liquid impermeable layer of pressure sensitive adhesive serves to prevent transmission of body liquids through the pad and also serves to adhere the pad to the undergarment.
    Type: Grant
    Filed: June 21, 1984
    Date of Patent: July 11, 1989
    Assignee: Smith and Nephew Associated Companies Limited
    Inventor: Ronald Lloyd
  • Patent number: 4844892
    Abstract: Compounds of formula ##STR1## in which R represents hydrogen, formyl or an alkanoyl group of two to twenty-five carbon atoms and R' represents an alkyl group of one to thirty-five carbon atoms are of value as mosquito attractants, mosquitoes being attracted to a location where they and/or their eggs or larvae are then destroyed.
    Type: Grant
    Filed: October 14, 1988
    Date of Patent: July 4, 1989
    Assignee: National Research Development Corporation
    Inventors: Brian R. Laurence, John A. Pickett
  • Patent number: 4844983
    Abstract: Glass or plastics substrates which in use are susceptible to misting and which have on at least one surface thereof an antimist coating. The coating is formed from a hydrophilic polymer which comprises a hydrophilic polyurethane which contains from 35 to 60% by weight of water when hydrated and which has a thickness of from 3 .mu.m to 50 .mu.m in its anhydrous state. Substrates in which the coating comprises a first layer formed from a polyurethane which contains from 0 to 35% by weight of water when hydrated and in which a second and subsequent layers are formed from a polyurethane which contains 60 to 90% by weight of water are also described. Methods for forming the coatings are also described.
    Type: Grant
    Filed: July 21, 1988
    Date of Patent: July 4, 1989
    Assignee: Smith and Nephew Associated Companies p.l.c.
    Inventors: Robert S. R. Parker, John G. B. Howes
  • Patent number: 4843070
    Abstract: Anti-bacterial and anti-fungal compounds of formula I and pharmaceutically acceptable salts thereof: ##STR1## in which R.sup.1 is hydrogen, alkyl or substituted or unsubstituted phenyl; R.sup.2 is hydrogen, alkyl, alkoxy, hydroxy, halgen, nitro or substituted or unsubstituted amino; R.sup.3 is hydrogen or substituted or unsubstituted alkyl; R.sup.4 and R.sup.5 are the same or different and are alkyl or hydroxyalkyl or R.sup.4 and R.sup.5 together with the nitrogen atom to which they are attached form an unsubstituted or substituted heterocyclic ring having the depicted nitrogen atom as the sole heteroatom or which may have nitrogen, oxygen or sulphur atoms as additional heteroatoms; and X is halogen.
    Type: Grant
    Filed: May 13, 1987
    Date of Patent: June 27, 1989
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Masahiro Kise, Masahiko Kitano, Masakuni Ozaki, Kenji Kazuno, Ichiro Shirahase, Yoshifumi Tomii, Jun Segawa
  • Patent number: 4842164
    Abstract: A nozzle insert for a nozzle of a striped paste dispenser has a hollow cylindrical body through which a first pasty material may be dispensed, the external surface of the hollow body having circumferentially spaced apart plateaus separated by grooves through which a second pasty material may be dispensed, the body preventing contact between the two pasty materials downstream of the discharge end of the insert.
    Type: Grant
    Filed: June 25, 1987
    Date of Patent: June 27, 1989
    Assignee: Beecham Group p.l.c.
    Inventors: Adrian F. Davis, Peter R. Watt
  • Patent number: 4840895
    Abstract: A secondary monoclonal antibody against a complex of a molecule of molecular weight less than 5000 and a binding protein against said molecule which secondary monoclonal antibody is not an antibody against molecule or against its binding protein.
    Type: Grant
    Filed: November 18, 1985
    Date of Patent: June 20, 1989
    Assignee: Cambridge Patent Development Limited
    Inventor: Colin H. Self
  • Patent number: 4837953
    Abstract: A device for displaying photographs or the like, comprises a sheet-holding assembly comprising first and second plastic members each having a planar face and an outer edge defining the boundary thereof, the members being secured face-to-face to define between the faces an empty slot having an opening extending completely around the edges, the members being so closely spaced as to frictionally engage and secure a photograph or the like having a thickness of a few mils inserted into the slot, and the members being beveled at the opening of the slot to facilitate entry of the photograph or the like into the slot for frictional engagement by the members, and an attachment device for attaching one of the plastic members to a vertical surface with the slot disposed substantially in a vertical plane.
    Type: Grant
    Filed: May 20, 1988
    Date of Patent: June 13, 1989
    Inventor: Ken Tannenbaum
  • Patent number: 4839155
    Abstract: Iodotamoxifen derivatives which are compounds of formula (3) ##STR1## wherein X represents 3- or 4- iodo and R.sup.1 and R.sup.2, which may be the same or different, represent C.sub.1-3 alkyl, especially methyl or ethyl, groups or R.sup.1 represents a hydrogen atom and R.sup.2 a C.sub.1-3 alkyl group or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached represent a saturated heterocyclic group, especially a pyrrolidino, piperidino, 4-methylpiperidino or morpholino group, and their pharmaceutically acceptable acid addition salts are potent anti-estrogenic compounds useful for treatment of estrogen receptor-positive (hormone-dependent) breast cancers.Radioisotopic iodotamoxifen derivatives of formula (3) are useful in radiotherapy or gamma ray imaging of these cancers.
    Type: Grant
    Filed: September 9, 1987
    Date of Patent: June 13, 1989
    Assignee: National Research Development Corporation
    Inventor: Raymond McCague
  • Patent number: 4836768
    Abstract: A body having a substrate surface which comprises corrodible material and on which substrate surface is present a coherent protective layer of an anti-corrosion composition which comprises a solid matrix of electrical conductivity .gtoreq.10.sup.-6 mho cm.sup.-1 and formed by reaction between at least water-soluble Bronsted acid and at least one Lewis base in which matrix is incorporated an elemental metal, or an alloy thereof, the matrix and metal being effective in service as electrolyte and sacrificial anode, respectively.
    Type: Grant
    Filed: April 15, 1987
    Date of Patent: June 6, 1989
    Assignee: National Research Development Corporation
    Inventors: Alan D. Wilson, Havard J. Prosser, Anthony J. Dunsdon, John C. Skinner, Pauline J. Brookman
  • Patent number: 4837240
    Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R.sub.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halogen;R.sub.2 and R.sub.3 are both hydrogen or together represent a bond;R.sub.4 is hydrogen and R.sub.5 is hydrogen or R.sub.4 and R.sub.5 together represent an oxo group;R.sub.6 is phenyl, phenyl C.sub.1-7 alkyl or phenyl C.sub.1 -7 alkanoyl, in which the phenyl moiety is substituted by NR.sub.8 R.sub.9 wherein R.sub.8 is C.sub.1-6 alkyl substituted by a group R.sub.10 selected from hydroxy, halo, CF.sub.3 or COR.sub.11 where R.sub.11 is hydroxy, C.sub.1-4 alkoxy or amino optionally substituted by one or two C.sub.1-4 alkyl groups, and R.sub.9 is hydrogen, C.sub.1-6 alkyl or R.sub.8 ; andR.sub.7 is hydrogen or C.sub.1-4 alkyl.
    Type: Grant
    Filed: June 30, 1987
    Date of Patent: June 6, 1989
    Assignee: Beecham-Wuelfing GmbH & Co. KG
    Inventors: Dietrich Thielke, Dagmar Holtje, Guy Nadler
  • Patent number: 4835150
    Abstract: .beta.-Lactam antibiotics are disclosed which have the formula (IA) or pharmaceutically acceptable salts or pharmaceutically acceptable in vivo hydrolyzable esters thereof: ##STR1## wherein R.sub.1 is phenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 3-aminophenyl, 4-aminophenyl, or 3,4-dihydroxyphenyl, the hydroxy and amino groups being optionally protected, and R is C.sub.1-8 alkyl; and also the use thereof.Processes for the preparation of the compounds are disclosed together with intermediates for use therein.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: May 30, 1989
    Assignee: Beecham Group p.l.c.
    Inventors: Clive L. Branch, Arun C. Kaura
  • Patent number: 4834471
    Abstract: A method for the production of frames from rigid plastic profiles for use on refrigerator cabinets and in particular on chest freezers, which comprises forming the plastic profiles, mitering and welding the edges of the plastic profiles to form a frame having sharp-edged corners, and rounding at least one of the sharp-edged corners by means of thermo-forming.The invention also comprises the finished frame thereby obtained and its application in the field of refrigerator cabinets and in particular, chest freezers.
    Type: Grant
    Filed: September 28, 1987
    Date of Patent: May 30, 1989
    Assignee: Pantasote Inc.
    Inventor: Bruno Pasqualini
  • Patent number: 4835271
    Abstract: A compound of the formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R.sub.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halogen;R.sub.2 and R.sub.3 are both hydrogen or together represent a bond;R.sub.4 is hydrogen and R.sub.5 is hydrogen or R.sub.4 and R.sub.5 together represent an oxo group;R.sub.6 is C.sub.1-7 alkyl substituted by NR.sub.8 R.sub.9 where R.sub.8 and R.sub.9 are independently hydrogen or C.sub.1-4 alkyl or together are C.sub.3-7 polymethylene optionally containing a further hetereoatom which is oxygen, sulphur or nitrogen substituted by R.sub.10 where R.sub.10 is hydrogen, C.sub.1-4 alkyl or benzyl, and optionally substituted by one or two C.sub.1-4 alkyl, C.sub.2-5 alkanoyl, C.sub.1-4 alkoxycarbonyl, aminocarbonyl optionally substituted by one or two C.sub.1-6 alkyl groups or by a benzyl group, cyano, phenyl or benzyl and wherein any phenyl or benzyl group is optionally substituted in the phenyl ring by one or two halo, CF.sub.3, C.sub.1-4 alkyl, C.sub.
    Type: Grant
    Filed: June 26, 1986
    Date of Patent: May 30, 1989
    Assignee: Beecham-Wuelfing GmbH & Co., KG
    Inventors: Dagmar Hoeltje, Dietrich Thielke
  • Patent number: 4833143
    Abstract: Compounds of formula I ##STR1## in which R.sub.1 is a heterocyclic ring containing one or more heteroatoms selected from N, O and S;in which R.sub.2 is H, a straight or branched chain alkyl group containing 1 to 4 carbon atoms, an alkenyl group containing 3 to 6 carbon atoms, an alkynyl group containing 3 to 6 carbon atoms or a cycloalkyl group containing 3 to 7 carbon atoms;in which R.sub.3, is H, a straight chain alkyl group containing 1 to 3 carbon atoms or a formyl groupin which R.sub.4, R.sub.5 and R.sub.6 which may be the same or different, are H, halo, trifluoromethyl, hydroxy, an alkyl group containing 1 to 3 carbon atoms, an alkoxy group containing 1 to 3 carbon atoms, phenyl or R.sub.4 and R.sub.5, together with the carbon atoms to which they are attached, form an optionally substituted second benzene ring;and their pharmaceutically acceptable salts have utility in the treatment of depression. Pharmaceutical compositions and processes for the preparation of compounds of formula I are disclosed.
    Type: Grant
    Filed: September 28, 1983
    Date of Patent: May 23, 1989
    Assignee: The Boots Company PLC
    Inventors: Bernard J. Armitage, John R. Housley, James E. Jeffery, David N. Johnston
  • Patent number: 4831050
    Abstract: Compounds of formula (I): ##STR1## wherein: either one of R.sub.1 and R.sub.2 is hydrogen and the other is selected from the class of C.sub.1-6 alkylcarbonyl, C.sub.1-6 alkoxycarbonyl, C.sub.1-6 alkylcarbonyloxy, C.sub.1-6 alkylhydroxymethyl, nitro, cyano, chloro, trifluoromethyl, C.sub.1-6 alkylsulphinyl, C.sub.1-6 alkylsulphonyl, C.sub.1-6 alkoxysulphinyl, C.sub.1-6 alkoxysulphonyl, C.sub.1-6 alkylcarbonylamino, C.sub.1-6 alkoxycarbonylamino, C.sub.1-6 alkyl-thiocarbonyl, C.sub.1-6 alkoxy-thiocarbonyl, C.sub.1-6 alkyl-thiocarbonyloxy, 1-mercapto C.sub.2-7 alkyl, formyl, or aminosulphinyl, aminosulphonyl or aminocarbonyl, the amino moiety being optionally substituted by one or two C.sub.1-6 alkyl groups, or C.sub.1-6 alkylsulphinylamino, C.sub.1-6 alkylsulphonylamino, C.sub.1-6 alkoxysulphinylamino or C.sub.1-6 alkoxysulphonylamino, or ethylenyl terminally substituted by C.sub.1-6 alkylcarbonyl, nitro or cyano, or --C(C.sub.1-6 alkyl(NOH or --C(C.sub.1-6 alkyl)NNH.sub.2, or one of R.sub.1 and R.sub.
    Type: Grant
    Filed: October 21, 1987
    Date of Patent: May 16, 1989
    Assignee: Beecham Group p.l.c.
    Inventors: Frederick Cassidy, Erol A. Faruk