Patents Represented by Attorney James C. Bolding
  • Patent number: 5139881
    Abstract: A process for surface modifying a variety of polymeric support surfaces is disclosed in which a predetermined modifying polymer is irreversibly absorbed onto essentially all the surfaces of the support polymer accessible to the modifying polymer. The modifying polymer is selected to impart the desired surface characteristics to the modified polymeric surface.
    Type: Grant
    Filed: November 17, 1988
    Date of Patent: August 18, 1992
    Assignee: Monsanto Company
    Inventors: Jay M. Henis, Mary K. Tripodi, Donald I. Stimpson
  • Patent number: 5129943
    Abstract: Disclosed herein are 2- or 6-fluoromethyl-3-pyridinecarboxylate derivatives with 5-[(heterocyclic)ylidene]amino substitution useful as herbicides and herbicide intermediates.
    Type: Grant
    Filed: May 20, 1991
    Date of Patent: July 14, 1992
    Assignee: Monsanto Company
    Inventors: Shridhar G. Hegde, Len F. Lee, Robert D. Bryant
  • Patent number: 5130320
    Abstract: Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, optionally substituted alkyl radicals having from 1 to about 10 carbon atoms, optionally substituted alkenyl radicals having from 1 to about 10 carbon atoms, optionally substituted aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and optionally substituted acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.
    Type: Grant
    Filed: March 21, 1991
    Date of Patent: July 14, 1992
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo
  • Patent number: 5128347
    Abstract: Novel compounds represented by the formula: ##STR1## wherein R represents hydrogen, alkyl radicals having from 1 to about 10 carbon atoms, alkenyl radicals having from 1 to about 10 carbon atoms, aryl, alkaryl and aralkyl radicals having from about 6 to about 16 carbon atoms and acyl and acyloxy radicals having from about 1 to about 10 carbon atoms, manifest glycosidase inhibition activity.
    Type: Grant
    Filed: October 18, 1990
    Date of Patent: July 7, 1992
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo
  • Patent number: 5122513
    Abstract: A method is described for increasing growth of fish which comprises administering bovine placental lactogen.
    Type: Grant
    Filed: March 19, 1991
    Date of Patent: June 16, 1992
    Assignee: Monsanto Company
    Inventors: Robert H. Devlin, Edward M. Donaldson, Ernest G. Jaworski, Gwenn G. Krivi
  • Patent number: 5117063
    Abstract: A method of producing 4-ADPA is disclosed wherein aniline and nitrobenzene are reacted under suitable conditions to produce 4-nitrodiphenylamine and/or 4-nitrosodiphenylamine and/or their salts, either or both of which are subsequently reduced to produce 4-ADPA. The 4-ADPA can be reductively alkylated to produce p-phenylenediamine products which are useful as antiozonants.
    Type: Grant
    Filed: June 21, 1991
    Date of Patent: May 26, 1992
    Assignee: Monsanto Company
    Inventors: Michael K. Stern, James K. Bashkin
  • Patent number: 5116991
    Abstract: A process for dehydration of a 4-(lower alkyl)-2,6-bis(trifluoromethyl)-2,6-bis(hydroxy)-piperidine-3,5-dicarboxyl ic acid thioesters and esters.
    Type: Grant
    Filed: March 19, 1990
    Date of Patent: May 26, 1992
    Assignee: Monsanto Company
    Inventors: Helen L. Janoski, Sherrol L. Baysdon, Mitchell L. Pulwer
  • Patent number: 5115102
    Abstract: The present invention is directed at variant proteins and polypeptides having an enhanced affinity, i.e., greater binding strength, for immobilized-metal affinity resins and resides in engineering one or more specific metal-chelating amino acid sequences into a protein or polypeptide, the specific sequence depending on the metal-binding amino acids utilized and the secondary structure associated with the portion of the protein or polypeptide to include such sequence.
    Type: Grant
    Filed: July 21, 1989
    Date of Patent: May 19, 1992
    Assignee: Monsanto Company
    Inventors: Barry L. Haymore, Gary S. Bild, Gwen G. Krivi
  • Patent number: 5114555
    Abstract: A method and apparatus for the continuous separation of a target protein from a protein mixture containing two or more proteins and at a pH equal to the pI of the target protein is disclosed. The method and apparatus employ a non-ionic, non-electrically conductive porous conduit through which the protein mixture is passed. The conduit is subjected to the influence of an electrical field substantially perpendicular to the flow of fluid therethrough resulting in movement of all charged protein from the conduit lumen. The target protein, which is unaffected by the electric field since it is not charged at a pH equal to its pI, is collected from the conduit outlet in substantially purified form.
    Type: Grant
    Filed: November 23, 1988
    Date of Patent: May 19, 1992
    Assignee: Monsanto Company
    Inventor: Donald I. Stimpson
  • Patent number: 5114465
    Abstract: 2- or 6-fluoromethyl-3-pyridinecarboxylate derivatives with 5-(haloalkyl) carboxamide or 5-(haloalkyl)carbamate substitution, useful as herbicides and herbicide intermediates.
    Type: Grant
    Filed: June 17, 1991
    Date of Patent: May 19, 1992
    Assignee: Monsanto Company
    Inventors: Robert D. Bryant, Shridhar G. Hegde, Len F. Lee
  • Patent number: 5112980
    Abstract: Disclosed herein is a process for cyclizing pyridinecarboxylate derivatives with 5-(haloalkyl) carboxamide or 5(haloalkyl)carbamate substitutions to prepare compounds useful as herbicides.
    Type: Grant
    Filed: May 20, 1991
    Date of Patent: May 12, 1992
    Assignee: Monsanto Company
    Inventor: Shridhar G. Hegde
  • Patent number: 5104729
    Abstract: Surface modified support membranes and a process therefor are disclosed wherein the support membrane has a substantially uniform layer of hydrogel deposited on essentially the entire surface area thereof.
    Type: Grant
    Filed: August 20, 1990
    Date of Patent: April 14, 1992
    Assignee: Monsanto Company
    Inventor: Erwin R. Stedronsky
  • Patent number: 5105002
    Abstract: Ammonium salt of methyl 4,4,4-trifluoro-3-oxobutanethioate (TMTFAA).
    Type: Grant
    Filed: April 8, 1991
    Date of Patent: April 14, 1992
    Assignee: Monsanto Company
    Inventors: Sherrol L. Baysdon, Mitchell J. Pulwer, Helen L. Janoski
  • Patent number: 5100461
    Abstract: Disclosed herein are herbicidal pyridine compounds substituted at the 3- and/or 5-position with a carboxylic acid-derived heterocyclic moiety, as well as herbicidal compositions and use of these compounds.
    Type: Grant
    Filed: November 13, 1990
    Date of Patent: March 31, 1992
    Assignee: Monsanto Company
    Inventors: Yuen-Lung L. Sing, Len F. Lee
  • Patent number: 5098569
    Abstract: A surface-modified support membrane is disclosed wherein the membrane coating is resistant to cleaning agents such as surfactants and solvents. Also disclosed is a process for preparing such membranes. The subject membranes have a modifying polymer irreversibly adsorbed onto essentially all of the surface area thereof, which modifying polymer is uniformly cross-linked.
    Type: Grant
    Filed: December 13, 1990
    Date of Patent: March 24, 1992
    Assignee: Monsanto Company
    Inventor: Erwin R. Stedronsky
  • Patent number: 5099024
    Abstract: A process for dehydrofluorination of a 2,6-(bis)trifluoromethyl-dihydropyridine-3,5-dicarbothioic acid ester.
    Type: Grant
    Filed: March 19, 1990
    Date of Patent: March 24, 1992
    Assignee: Monsanto Company
    Inventors: Mitchell J. Pulwer, William Miller, Sherrol L. Baysdon
  • Patent number: 5099023
    Abstract: A process for dehydrofluorination of a 2,6-(bis) trifluoromethyl-dihydropyridine-3,5-dicarbothioic acid ester.
    Type: Grant
    Filed: March 19, 1990
    Date of Patent: March 24, 1992
    Assignee: Monsanto Company
    Inventors: William Miller, Mitchell J. Pulwer
  • Patent number: 5089407
    Abstract: Biological materials such as enzymes, proteins and peptides are encapsulated by forming a mixture of the material and an aqueous non-ionic polymer solution, spraying the mixture into a circulating water-immiscible nonsolvent for the polymer at a temperature sufficient to freeze the beads and drying the frozen beads to remove essentially all unbound water such as to provide a water content of about 1-2 weight percent. Suitable non-ionic polymers are poly(vinyl alcohol), polyvinylpyrollidone, dextran and derivatized cellulose. A densification agent such as alumina may be present in the polymer solution to enhance specific gravity of the beads formed. Encapsulated material such as microbes produced by this process provide useful agricultural agents which can be delivered to the market in a dormant state and suitable for delivery to soil or plant leaves. The beads can be applied dry, via a planting or an insecticide box, or wet via a spray nozzle.
    Type: Grant
    Filed: November 17, 1989
    Date of Patent: February 18, 1992
    Assignee: Monsanto Company
    Inventors: Carol A. Baker, Albert A. Brooks, Robert Z. Greenley, Jay M. Henis
  • Patent number: 5070204
    Abstract: Described herein is a process for preparation of substituted pyridine dicarboxylate compounds.
    Type: Grant
    Filed: March 19, 1990
    Date of Patent: December 3, 1991
    Assignee: Monsanto Company
    Inventors: William Miller, Mitchell J. Pulwer
  • Patent number: 5068421
    Abstract: There is disclosed herein improved processes for the preparation of ether carboxylates by reacting in an alkaline reaction medium the salts of maleic acid and malic acid in the presence of a calcium ion catalyst wherein unreacted acid salts are recovered from the reaction medium by lowering the pH of the reaction medium to a range of from about 4 to about 6 in two steps, the first step ending at a pH in the range of from about 7 to about 8.5. The precipitate is removed and the pH of the reaction medium is then lowered further to a pH in the range of from 4 to 6. The precipitated salts are recycled to the synthesis reaction to prepared additional amounts of product.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: November 26, 1991
    Assignee: Monsanto Company
    Inventor: Liou-Liang Horng