Patents Represented by Attorney James H. Callwood
-
Patent number: 5029115Abstract: An electronic prepress process for the preparation of camera-ready mechanicals for color printing. The process facilitates the integration of both visual and textual and both black and white and color inputs from various sources into a final set of output files which can be read by Page Description software as a process step in the creation of camera-ready mechanicals for printing.Type: GrantFiled: September 12, 1989Date of Patent: July 2, 1991Assignee: Laserfast IndustriesInventor: Joel F. Geraci
-
Patent number: 4463016Abstract: The present disclosure is directed to a method of treating razor bumps which comprises administering to an individual suffering from razor bumps an effective amount of a 4-chloro-3,5-diloweralkylphenol compound in combination with a vehicle which facilitates topical application of said 4-chloro-3,5-diloweralkylphenol compound.Type: GrantFiled: September 22, 1982Date of Patent: July 31, 1984Assignee: Nel's Laboratory, Inc.Inventor: Nelson L. Burgess
-
Patent number: 4365070Abstract: The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.Type: GrantFiled: October 16, 1981Date of Patent: December 21, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Robert W. Guthrie, Richard W. Kierstead, Francis A. Mennona, Ann C. Sullivan
-
Patent number: 4361578Abstract: The invention is directed to 3-oxo-D-homosteroids and derivatives thereof which are useful as antiantigens.Type: GrantFiled: November 16, 1981Date of Patent: November 30, 1982Inventors: Leo Alig, Andor Furst, Peter Keller, Marcel Muller, Ulrich Kerb, Rudolf Wiechert
-
Process and intermediates for the synthesis of Vitamin D.sub.3 metabolites and chenodeoxycholic acid
Patent number: 4360470Abstract: The present disclosure is directed to a process for the synthesis of chenodeoxychloic acid, 25-hydroxycholesterol and 1.alpha.,25-dihydroxycholesterol from 17-keto steroids. A cholic acid side chain is stereospecifically introduced by reaction of the appropriate 17-keto steroid with ethyltriphenylphosphonium halides to produce the 17-ethylidene derivative which is allowed to react with acrylic acid esters or propiolic acid esters followed by hydrogenation.Type: GrantFiled: October 22, 1980Date of Patent: November 23, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Andrew D. Batcho, Milan R. Uskokovic, Peter M. Wovkulich -
Patent number: 4354039Abstract: The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.Type: GrantFiled: September 21, 1981Date of Patent: October 12, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Robert W. Guthrie, Richard W. Kierstead, Francis A. Mennona, Ann C. Sullivan
-
Patent number: 4352758Abstract: The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.Type: GrantFiled: August 7, 1981Date of Patent: October 5, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Robert W. Guthrie, Richard W. Kierstead, Francis A. Mennona, Ann C. Sullivan
-
Patent number: 4341781Abstract: The present invention relates to pyridazopyridazine derivatives, a process for the preparation thereof, pharmaceutical preparations containing said derivatives and the use of said derivatives as antihypertensive agents.Type: GrantFiled: September 11, 1980Date of Patent: July 27, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Cedric H. Hassall, Christopher J. Moody
-
Patent number: 4340736Abstract: Aminoaryl esters and amino-lower alkyl amides of carboxy substituted barbiturates are linked via an amide linkage to carboxylated latex polymers to form reagents which are useful in a sensitive diagnostic test to detect the presence of barbiturates in body fluids.Type: GrantFiled: December 5, 1979Date of Patent: July 20, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Antonino Focella, John E. Heveran, Sidney Teitel, Manfred Weigele
-
Patent number: 4340754Abstract: The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.Type: GrantFiled: September 21, 1981Date of Patent: July 20, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Robert W. Guthrie, Richard W. Kierstead, Francis A. Mennona, Ann C. Sullivan
-
Patent number: 4330465Abstract: The solid-phase syntheses of [Ala.sup.2 ]-, [D-Leu.sup.2 ]-, [D-Lys.sup.2 ], [Leu.sup.5 ]- and [D-Ala.sup.2, D-Leu.sup.5 ] .beta.-endorphins are described. The synthetic peptides were purified by chromatography on carboxymethylcellulose and partition chromatography on Sephadex G-50. They were characterized by partition chromatography on agarose, thin-layer chromatography, paper electrophoresis, and amino acid analyses of acid and enzymic hydrolysates. Bioassay of the synthetic analogs for analgesic activity by the tail-flick-method showed the D-Leu.sup.2 analog to be 48% as potent as .beta..sub.h -endorphin while the Ala.sup.2, D-Lys.sup.2, Leu.sup.5, and [D-Ala.sup.2, D-Leu.sup.5 ] analogs were 8 to 17% as active.Type: GrantFiled: March 2, 1978Date of Patent: May 18, 1982Assignee: Hoffmann-La Roche Inc.Inventor: Choh H. Li
-
Patent number: 4329488Abstract: Propionic acid esters of the general formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of from 1 to 6 carbon atoms or phenyl, R.sub.2 is alkyl of from 1 to 6 carbon atoms, alkenyl of from 2 to 6 carbon atoms, alkynyl of from 2 to 6 carbon atoms or phenyl, or R.sub.1 and R.sub.2 together with the carbon atom to which they are attached form a cycloalkane ring containing 4 to 10 carbon atoms which can be mono-, di- or trisubstituted with alkyl of from 1 to 3 carbon atoms, R.sub.3 represents a halogen, trifluoromethyl or nitro, and R.sub.4 and R.sub.5 each represent a hydrogen or halogen atom, processes for their manufacture, herbicidal compositions containing these compounds as the active ingredient and methods of use of the herbicidal compositions are disclosed.Type: GrantFiled: December 5, 1980Date of Patent: May 11, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Georg Frater, Jean Wenger
-
Patent number: 4329281Abstract: Novel hapten compositions consisting of 4-[4-[2-(aminopropyl)]phenyl]butanoic acid and its N-methyl derivative are useful in preparing immunogens which can be respectively employed in the elicitation of antibodies selective to amphetamine and methamphetamine. These antibodies can be used as reagents in immunoassays for these two compounds.Type: GrantFiled: December 21, 1979Date of Patent: May 11, 1982Assignee: Hoffmann-La Roche Inc.Inventors: James G. Christenson, Benjamin Pecherer
-
Patent number: 4312885Abstract: The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.Type: GrantFiled: December 26, 1978Date of Patent: January 26, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Robert W. Guthrie, Richard W. Kierstead, Francis A. Mennona, Ann C. Sullivan
-
Patent number: 4312812Abstract: The present disclosure is directed to a process for the preparation of cholesterol derivatives from corresponding 21-hydroxymethyl steroidal compounds.Type: GrantFiled: January 19, 1981Date of Patent: January 26, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Andor Furst, Ludwig Labler, Werner Meier
-
Patent number: 4310488Abstract: A tubular sample or reagent container for analytical devices, such as automated centrifugal analyzers, in which typically a multiplicity of such containers are arranged in a carrier plate or other means which forms part of the analyzers, with each container having a peripheral edge for bearing on the carrier plate. An abutment is provided on the containers disposed below the peripheral edge and at the periphery of the containers, which abutment is deformable in the centripetal direction.Type: GrantFiled: May 19, 1980Date of Patent: January 12, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Jurg Rahm, Lothar Waltz
-
Patent number: 4310467Abstract: The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D.sub.3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via intermediates having the natural steroid configuration at the 20-position. These novel intermediates are prepared from 17-keto steroids by reaction with ethyltriphenylphosphonium halides followed by reaction with formaldehyde to form comounds having the natural steroid configuration at the 20-position and which are suitable substrates for the preparation of the aforementioned Vitamin D.sub.3 metabolites.Type: GrantFiled: October 22, 1980Date of Patent: January 12, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Andrew D. Batcho, Donald E. Berger, Jr., Milan R. Uskokovic
-
Patent number: 4307094Abstract: The present disclosure is directed to 1-substituted or unsubstituted lower alkylene, 5-carboxy, alkanoyloxy or carbamoyloxy triazolopyridazine derivatives, salts of the acids and pharmaceutically-acceptable bases thereof. The triazolopyridazine derivatives provided by the present invention are useful as angiotensin-related antihypertensive agents.Type: GrantFiled: July 17, 1980Date of Patent: December 22, 1981Assignee: Hoffmann-La Roche Inc.Inventors: Cedric H. Hassall, Christopher J. Moody
-
Patent number: 4301246Abstract: A multi-step synthesis of chenodeoxycholic acid from 3-keto-bisnorcholenol, a compound readily obtained from the abundant plant sterol .beta.-sitosterol, is described. A key step in the synthesis is the stereoselective microbial introduction of the 7-alpha hydroxy group into 3-keto-bisnorcholenol.Type: GrantFiled: January 18, 1980Date of Patent: November 17, 1981Assignee: Hoffmann-La Roche Inc.Inventors: Carl Despreaux, Thomas A. Narwid, Norberto J. Palleroni, Milan R. Uskokovic
-
Patent number: 4292288Abstract: A method for the removal of CO from flue gas which comprises contacting a spent noble metal reforming catalyst with flue gas from a cat cracker regenerator at 1000.degree.-1350.degree. F. to effectively oxidize CO to CO.sub.2. The spent catalyst while no longer efficient in a reforming process is found to be effective in reducing the CO level to a concentration range of 5000 parts per million and less.Type: GrantFiled: October 18, 1977Date of Patent: September 29, 1981Assignee: Exxon Research & Engineering Co.Inventor: Elroy M. Gladrow