Abstract: A novel one-pot cost efficient process for the preparation of homo-, co- and terpolymers of p-hydroxystyrene or substituted p-hydroxystyrene and alkyl acrylates. The process involves polymerization of esters of p-hydroxystyrene (or its substituted analogs), alkyl acrylate monomers and/or one or more of ethylenically unsaturated monomers in an alcohol solvent in the presence of a free radical initiator. The reaction mixture containing the so formed polymer is subjected to transesterification conditions using a catalytic amount of catalyst to result in co- and/or terpolymers of p-hydroxystyrene without cleavage of the alkyl ester in the acrylate repeat unit, and then removing the catalyst from the system. Preferred embodiments include homopolymers of p-hydroxystyrene, copolymer of p-hydroxystyrene and tert-butyl acrylate and terpolymer of p-hydroxystyrene, tert-butyl acrylate and styrene. These polymers have a wide variety of applications including as photoresists in microelectronics industry.

Abstract: A low energy process for producing acetic acid by the carbonylation of methanol is disclosed. The process involves a rhodium-catalyzed system operated at less than about 14% water utilizing up to 2 distillation columns. The process is preferably controlled such that the product stream has a low level of propionic acid impurity and the level of aldehyde impurities is minimized by way of aldehyde removal or minimizing aldehyde generation. The level of iodides is controlled by contacting the product, at elevated temperatures, with ion exchange resins. In preferred embodiments, at least one silver or mercury exchanged macroreticular strong acid ion exchange resin is used to purify the product. The high temperature treatment provides the added benefit of controlling the Color Value (Pt—Co units) of the product stream.

Abstract: Polymers derived from 4-acyloxystyrene are purified by fractionalization plus heating and cooling of the polymers in alcoholic solvents.

Abstract: The present invention is directed to the generation and use of recombinant rotavirus fusion proteins as immunogens to produce a protective immune response from immunized individuals. In one embodiment, the present invention contemplates a recombinant rotavirus fusion protein vaccine composition comprising a rotavirus subunit protein or immunogenic fragment thereof, and an adjuvant in combination with the recombinant rotavirus subunit fusion protein. In one aspect of this embodiment, the recombinant rotavirus fusion protein comprises a rotavirus subunit protein and a fusion partner protein in genetic association with the rotavirus subunit protein, wherein the fusion partner protein does not interfere with expression and immunogenicity of the rotavirus subunit protein, the fusion partner protein prevents complex formation by the rotavirus subunit protein, and the fusion partner protein facilitates purification of the recombinant rotavirus fusion protein.

Abstract: The invention provides a novel process for improving the glass transition temperatures of polymers by partitioning the polymer between immiscible solvents to remove the low molecular weight polymer from the desired product.

Abstract: Disclosed is a method to manufacture high purity acetic acid. Although described in relation to that produced by a low water carbonylation process the present invention is applicable to other mechanisms for production of acetic acid which results in formation of permanganate reducing compounds such as acetaldehyde and its derivatives, and alkyl iodide impurities in intermediate process streams. It has been found that permanganate reducing compounds and alkyl iodides may be conveniently removed from a light phase of an intermediate stream in the reaction process by employing a multiple distillation process coupled with an optional post extraction of acetaldehyde. The distillation process involves first distilling a light phase to concentrate the permanganate reducing compounds, and in particular the acetaldehyde, and then separating the permanganate reducing compounds and alkyl iodides in a second distillation tower.

Abstract: A method of removing organic iodides from non-aqueous organic media includes contacting the organic media with a silver or mercury-exchanged cationic ion exchange substrate at a temperature greater than about 50° C. The method is particularly effective for removing high molecular weight organic iodides from organic media such as acetic acid or acetic anhydride. Particular species removed include decyl iodides and dodecyl iodides from organic media such as acetic acid.

Abstract: Macroporous, strong-acid polysiloxane ion exchange resins which have been converted to the silver or mercury form are utilized to remove iodides from non-aqueous organic media. In a particularly preferred method, hexyl iodide is removed from acetic acid.

Abstract: A process for treating a composition containing a substantial proportion of trimethylolpropane bis-monolinear formal (TMP-BMLF) or trimethylolethane bis-monolinear formal (TME-BMLF), e.g., a heavy ends residue obtained from the purification of a crude trimethylolpropane (TMP) or trimethylolethane (TME) product, wherein the composition is contacted at an elevated temperature with a strong acid catalyst, e.g., methanesulfonic acid, to produce a composition containing significantly increased amounts of TMP and trimethylolpropane monocyclic formal (TMP-MCF) or TME and trimethylolethane monocyclic formal (TME-MCF) respectively.

Abstract: The present invention provides novel water-soluble diphosphines having the formula ##STR1## wherein X, Y, R.sub.1-18 and n are defined herein, and which can be complexed with a transition metal to form a novel catalyst useful in such applications as hydroformylation.

Abstract: The present invention provides novel water-soluble diphosphines having the formula ##STR1## wherein X, Y, R.sub.1-18 and n are defined herein, and which can be complexed with a transition metal to form a novel catalyst useful in such applications as hydroformylation.

Abstract: Novel ligands for use in MRI contrast agents and which have the formula ##STR1## wherein R.sub.1 -R.sub.14, M", l, m, and n are defined herein.

Abstract: A composition of matter having the formula ##STR1## wherein R.sub.1 -R.sub.14, M, l, m, and n are defined herein and which have application as MRI contrasting agents.

Abstract: Novel ligands for use in MRI contrast agents and which have the formula ##STR1## wherein R.sub.1 -R.sub.14, M", l, m, and n are defined herein.

Abstract: A composition of matter having the formula ##STR1## wherein R.sub.1 -R.sub.14, M, l, m, and n are defined herein and which have application as MRI contrasting agents.

Abstract: Novel precursors of ligands or use in MRI contrast agents and which have the formula ##STR1## wherein R.sub.2-R.sub.10 are defined herein.

Abstract: A composition of matter having the following ##STR1## wherein R, R.sub.1 -R.sub.10 and M are defined herein.

Abstract: The present invention provides novel a phosphine as a ligand (L) and having the formula ##STR1## wherein k, l, m, R', R", R.sub.1 -R.sub.9 and n are defined herein, and which can be complexed with a transition metal (M') and an auxiliary ligand Y to form a novel catalyst having the formula M'L.sub.x Y.sub.Z useful in such applications as hydroformylation.

Abstract: The present invention provides novel highly branched macromolecule polymers that have highly controlled molecular architectures, and having the formula: ##STR1## wherein R.sub.4, R.sub.5, and R.sub.6 are defined herein.

Abstract: The present invention provides novel aryl diphosphines having the formula ##STR1## wherein X, Y, R.sub.1-18, m, m' and n are defined herein, and which can be complexed with a transition metal to form a novel catalyst useful in such applications as hydroformylation.