Patents Represented by Attorney, Agent or Law Firm James R. Nelson
  • Patent number: 5008111
    Abstract: A method of enhancing transdermal delivery of a pharmaceutically active drug from a transdermal delivery system as well as a transdermal delivery system capable of providing a desirable flow interface between the delivery system and the skin surface are disclosed. The method involves pre-treating an area of skin with an anticholinergic agent in an amount sufficient to have a local antisecretory effect on the area treated, such amount being insufficient to cause systemic effects; and applying the transdermal delivery system to the pre-treated area. The delivery system of the present invention is comprised of a carrier means, a pharmaceutically active drug and an anticholinergic agent. With both the method and the delivery system, the anticholinergic agent is preferably a quaternary ammonium salt which is itself transdermally delivered to the area beneath the delivery system in an amount sufficient to suppress perspiration in that area.
    Type: Grant
    Filed: December 14, 1988
    Date of Patent: April 16, 1991
    Assignee: Schering Corporation
    Inventor: Nicholas Bodor
  • Patent number: 5006560
    Abstract: A method for treating cough in a mammal comprising administering to said mammal an anti-tussive effective amount of a GABA-B selective agonist such as ##STR1## is described.
    Type: Grant
    Filed: December 20, 1989
    Date of Patent: April 9, 1991
    Assignee: Schering Corporation
    Inventors: William Kreutner, Donald Bolser, Richard Chapman, Sultan Aziz
  • Patent number: 5004810
    Abstract: Oligomers that are complementary in base sequence to the initiation region on mRNA coding for herpes simplex virus transactivating proteins inhibit the replication of the virus.
    Type: Grant
    Filed: September 30, 1988
    Date of Patent: April 2, 1991
    Assignee: Schering Corporation
    Inventor: Kenneth G. Draper
  • Patent number: 5000962
    Abstract: A long acting diltiazem formulation is disclosed that comprises more than 35 percent by weight of a swellable hydrophilic polymer.Release rate is also controlled by the application of diffusion controlled membrane to the matrix tablet containing swellable hydrophilic polymers. The diffusion rate through the membrane depends upon the composition or ratio of hydrophilic to hydrophobic coating agent.
    Type: Grant
    Filed: August 25, 1989
    Date of Patent: March 19, 1991
    Assignee: Schering Corporation
    Inventors: Surendra Sangekar, Winston A. Vadino, Eugenio A. Cefali
  • Patent number: 4999189
    Abstract: Stable sustained release wax- and polymer-coated drug-ion exchange resin complexes especially useful in preparing oral suspensions are disclosed.
    Type: Grant
    Filed: November 14, 1988
    Date of Patent: March 12, 1991
    Assignee: Schering Corporation
    Inventors: Patricia W. Kogan, Edward M. Rudnic, Joel A. Sequeira, Imtiaz A. Chaudry
  • Patent number: 4997771
    Abstract: The invention describes a method for determining the BZ-1 receptor activity of a test sample or a potential anxiolytic drug.
    Type: Grant
    Filed: April 27, 1987
    Date of Patent: March 5, 1991
    Assignee: Schering Corporation
    Inventors: Allen Barnett, William Billard, Gordon Crosby, Jr., Louis Iorio, Martin Steinman
  • Patent number: 4996202
    Abstract: Substituted 8-amino-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines useful in treating mental disorders and which have activities of prolonged duration are disclosed. Methods for preparing these compounds and methods for their use are also described.
    Type: Grant
    Filed: October 17, 1985
    Date of Patent: February 26, 1991
    Assignee: Schering Corporation
    Inventors: Joel G. Berger, Wei K. Chang, Elijah H. Gold, Arthur J. Elliott
  • Patent number: 4992591
    Abstract: A method for producing a compound of the formula ##STR1## wherein: R.sup.1, R.sup.11 and R.sup.12 may be the same or different and each is hydrogen or alkyl;Q is methylene, --O-- or --S--;m and n are independently variable and may each have a value of 0, 1 or 2;X is hydrogen, halo, alkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, hydroxy, alkoxy or trifluoromethyl;Y is hydrogen, hydroxy, alkoxy, ##STR2## --N(R.sup.1).sub.2, ##STR3## where R.sup.1 is as defined above; ring t represents a fused thiophene or fused benzene ring, said fused benzene ring optionally being substituted with a substituent Z as defined below; andZ is X as defined above, amino, alkylamino or ##STR4## {wherein R.sup.10 is hydrogen, alkyl or aryl}, comprising reacting a compound of formula II or formula III ##STR5## with a compound of the formula where Hal is a halogen; andR.sup.13 is acetyl, or Si(R.sup.14).sub.3 where each R.sup.14 independently is alkyl or aryl is disclosed.
    Type: Grant
    Filed: December 21, 1989
    Date of Patent: February 12, 1991
    Assignee: Schering Corporation
    Inventors: Donald Hou, Janet L. Mas
  • Patent number: 4992277
    Abstract: An immediate release diltiazem tablet is disclosed that exhibits an unexpectedly rapid bioavailability profile when the active ingredient is diltiazem.
    Type: Grant
    Filed: August 25, 1989
    Date of Patent: February 12, 1991
    Assignee: Schering Corporation
    Inventors: Surendra Sangekar, Winston A. Vadino, Eugenio A. Cefali
  • Patent number: 4988705
    Abstract: Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune response in mammals. Methods for preparing said compounds are also disclosed.
    Type: Grant
    Filed: February 7, 1989
    Date of Patent: January 29, 1991
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Richard J. Friary, John H. Schwerdt, Marvin I. Siegel, Sidney R. Smith, Vera A. Seidl, Edmund J. Sybertz
  • Patent number: 4988722
    Abstract: A process for preparing aqueous parenteral compositions of drugs which are weak bases and are only slightly soluble in water is disclosed. Aqueous parenteral compositions of the antifungal agent (.+-.) (2R*, 3R*)-2-(2,4-difluorophenyl)-3-methylsulfonyl-1-(1,2,4-triazol-1-yl)butan-2 -ol are also disclosed.
    Type: Grant
    Filed: October 3, 1989
    Date of Patent: January 29, 1991
    Assignee: Schering Corporation
    Inventor: Pui-Ho Yuen
  • Patent number: 4983396
    Abstract: Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the range of about 50% to 100% based on the weight of the carrier. The oleic acid may be used in combination with 2-ethyl-1, 3-hexanediol in an amount of about 1 to 40% based on the weight of the carrier to provide a synergistic effect with respect to percutaneous penetration enhancement. The compound 2-ethyl-1, 3-hexanediol as used alone and/or in combination with the oleic acid has been found to significantly enhance the delivery of a drug, to a patient, from a transdermal delivery system.
    Type: Grant
    Filed: September 26, 1989
    Date of Patent: January 8, 1991
    Assignee: Key Pharmaceuticals, Inc.
    Inventors: Nicholas Bodor, Thorsteinn Loftsson
  • Patent number: 4973586
    Abstract: Disclosed are fused benzazepine compounds, pharmaceutical compositions including such compounds, methods of using such compounds, for example, in the treatment of psychoses and/or depression, and intermediates useful in the preparation of such compounds.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: November 27, 1990
    Assignee: Schering Corporation
    Inventors: Joel G. Berger, Wei K. Chang, Elijah H. Gold, John W. Clader
  • Patent number: 4971972
    Abstract: Antihypertensive phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan derivative portion are disclosed.
    Type: Grant
    Filed: March 23, 1989
    Date of Patent: November 20, 1990
    Assignee: Schering Corporation
    Inventors: Ronald J. Doll, Deen Tulshian, Charles V. Magatti
  • Patent number: 4960244
    Abstract: An atomizing nozzle for use in a fluidized coating bed includes an elongated hollow tube defining a chamber therein, the tube including an atomizing end in fluid communication with the chamber and a supply end; an air supply port at the supply end in fluid communication with the chamber; a coating liquid supply port at the supply end, the coating liquid supply port being separated from the air supply port; and a flow control tube extending within the hollow tube between the liquid supply port and the atomizing end, for supplying the coating liquid to be atomized to the atomizing end, the flow control tube having an reduced diameter inner bore providing a controlled flow constriction to the liquid travelling from the liquid supply port to the atomizing end so as to supply the coating liquid from the coating liquid supply port to the atomizing end with a controlled flow constriction, such that there is no need to provide a metering pump or flow meter for each atomizing nozzle of the fluidized coating bed and co
    Type: Grant
    Filed: May 8, 1989
    Date of Patent: October 2, 1990
    Assignee: Schering Corporation
    Inventors: Gustav A. Maag, John N. Wells
  • Patent number: 4950783
    Abstract: Compositions containing (-)-5-{(R)-1-Hydroxy-2[(R)-1-methyl-3-phenylpropyl)amino]ethyl}salicylamid e exhibit potent vasodilating .beta.-adrenergic blocking properties and are useful for the treatment of hypertension.
    Type: Grant
    Filed: October 24, 1986
    Date of Patent: August 21, 1990
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Wei K. Chang
  • Patent number: 4948738
    Abstract: Monoclonal antibodies to .gamma.-interferon and hybridomas producing such antibodies are disclosed. The antibodies are preferably of the immunoglobulin subclass IgG.sub.1, .kappa., and do not bind to interferon-.alpha..sub.2.
    Type: Grant
    Filed: July 14, 1989
    Date of Patent: August 14, 1990
    Assignee: Laboratoires UNICET
    Inventors: Jacques Banchereau, Odile Djossou, John Wijdenes, Helene Cabrillat, Catherine Favre
  • Patent number: 4945095
    Abstract: A method and composition for suppressing the immune response are disclosed which employ an immunosuppressing effective amount of certain substituted spiro pyridine derivatives.
    Type: Grant
    Filed: December 12, 1985
    Date of Patent: July 31, 1990
    Inventors: Sidney R. Smith, Marvin I. Siegel
  • Patent number: 4944429
    Abstract: A spraying apparatus is disclosed which employs a manually operable pump adapted to discharge a dosage of a liquid, such as a pharmaceutical preparation, from an associated container. The pump includes a reciprocating stem which extends through a screw cap of the container. An actuator is mounted on the stem of the pump for conjoint reciprocating movement therewith relative to the screw cap. Upon the extension of the actuator and hence the stem, liquid is withdrawn from the container by the pump. Upon the depression of the actuator and hence the stem, the liquid is delivered to a spray nozzle formed integrally with the actuator and then discharged from the nozzle in the form of a spray or mist. In order to ensure the smooth and effective operation of the spraying apparatus, lugs on the actuator cooperate with ribs on the screw cap to inhibit the actuator from rocking on the stem as the actuator is depressed.
    Type: Grant
    Filed: August 28, 1987
    Date of Patent: July 31, 1990
    Assignee: Schering Corporation
    Inventors: Keith H. Bishop, William S. Blake
  • Patent number: 4944781
    Abstract: An assembly for coupling a Hewlett-Packard Model HP 7673A autosampler mounted on a mounting plate to a Varian VISTA 6000 Model gas chromatograph having an injection site, includes a first bracket secured to the gas chromatograph on one side of the injection site and a second bracket secured to the gas chromatograph on the opposite side of the injection site, with the mounting plate secured to and mounted on the first and second brackets so as to permit access to the injection site by the autosampler; and securement screws for securing the mounting plate on the brackets.
    Type: Grant
    Filed: July 12, 1989
    Date of Patent: July 31, 1990
    Assignee: Schering Corporation
    Inventors: Donald A. Ruggirello, Christopher R. Banfield