Patents Represented by Attorney Jill L. Woodburn
  • Patent number: 7341830
    Abstract: The invention relates to a method and reagent system for detecting an analyte in a sample by means of an enzymatic reaction, involving the use of an enzyme-coenzyme complex as a stoichiometric reaction partner for the analyte present in the sample.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: March 11, 2008
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Carina Horn, Joachim Hoenes, Wolfgang-Reinhold Knappe
  • Patent number: 7291159
    Abstract: System for withdrawing body fluid from a body part in particular the finger pad, comprising a compression unit that is deformed when the body part is pressed against it and increases the internal pressure in a region of the body part, and a withdrawal device. Deformation of the compression unit partially converts the primary pressing movement into a secondary movement which leads to an increase in the internal pressure in a region of the body part. The invention also comprises a system for stimulating the outflow of body fluid using a deformable compression unit.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: November 6, 2007
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Guenther Schmelzeisen-Redeker, Thomas Weiss, Frank Deck, Klaus Peter Ebert
  • Patent number: 7287318
    Abstract: A biosensor is provided that comprises a plate element with a pre-determined reaction zone and a recess positioned adjacent to the reaction zone. The biosensor also comprises a reagent that is positioned on the reaction zone. In preferred embodiments, the recess circumscribes at least a portion of the reaction zone.
    Type: Grant
    Filed: November 7, 2003
    Date of Patent: October 30, 2007
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Raghbir S. Bhullar, Christopher D. Wilsey, Brian S. Hill
  • Patent number: 7267992
    Abstract: A method is provided to determine the presence of an analyte in a sample. The method provides an element with a sample application zone, a detection zone, a zone containing immobilized analyte or analyte analogue, a conjugate that has a first bioaffine binding partner capable of a specific binding reaction with the analyte and a first detectable label, and a universal conjugate, which can be detached by liquid and comprises a second bioaffine binding partner and a visually detectable label. The second bioaffine binding partner is capable of a specific binding reaction with the first detectable label. The method also includes contacting the sample application zone with the sample, contacting the sample with the conjugate and the universal conjugate to react the analyte with the and the universal conjugate to form a detection complex, and determining the presence of the detection complex in the detection zone of the element.
    Type: Grant
    Filed: February 7, 2006
    Date of Patent: September 11, 2007
    Assignee: Roche Diagnostics GmbH
    Inventors: Ada Goerlach-Graw, Reiner Schlipfenbacher
  • Patent number: 7238534
    Abstract: The invention concerns a device for withdrawing samples of liquid samples for analytical elements. The capillary-device channel is essentially formed by a carrier, a cover and optionally an intermediate layer between the cover and carrier. A notch is located in one of the surfaces forming the channel capable of capillary liquid transport at the edge of the test element forming the sample application opening so that one side of the edge of the test element forming the sample application opening is at least partially discontinuous and the surface opposite to the notch is exposed. It also concerns a method for withdrawing a liquid sample into an analytical element with the aid of a device according to the invention.
    Type: Grant
    Filed: December 3, 1998
    Date of Patent: July 3, 2007
    Assignee: Roche Diagnostics GmbH
    Inventor: Volker Zimmer
  • Patent number: 7211437
    Abstract: A method and a device for removing an analytic consumable product, in particular a test element, from a storage container having chambers which are sealed by foils from which the consumable product is pushed out by means of a plunger (7) can be optimized in that the magnitude of the thrusting force exercised by the plunger (7) during its forward motion can be controlled in dependence on the plunger (7) position.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: May 1, 2007
    Assignee: Roche Diagnostics GmbH
    Inventors: Michael Schabbach, Karl Miltner, Thomas Klemm, Rolf Baumann, Meinrad Dilger
  • Patent number: 7169600
    Abstract: The invention concerns an arrangement for determining the concentration of glucose in a tissue fluid. In the microdialysis technology used for this purpose, perfusate-containing glucose is transported in intermittent delivery pulses through a microdialysis probe inserted into the tissue fluid and dialysate obtained in this process is passed to a measuring cell to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the tissue fluid by means of a control device in accordance with a command variable derived from the measurement signals of the measuring cell. When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the tissue fluid.
    Type: Grant
    Filed: February 19, 2004
    Date of Patent: January 30, 2007
    Assignee: Roche Diagnostics GmbH
    Inventors: Udo Hoss, Hans-Joerg Pfleiderer, Ralf Gessler, Hans-Ulrich Zieten, Rolf Fussgaenger
  • Patent number: 7073246
    Abstract: A method of making a biosensor is provided. The biosensor includes an electrically conductive material on a base and electrode patterns formed on the base, the patterns having different feature sizes. The conductive material is partially removed from the base using broad field laser ablation so that less than 90% of the conductive material remains on the base and that the electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 ?m.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: July 11, 2006
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Raghbir S. Bhullar, Eric R. Diebold, Brian S. Hill, Nigel A. Surridge, Douglas P. Walling
  • Patent number: 7063774
    Abstract: A biosensor is provided that comprises a substrate, a sample site positioned on the substrate, a cover coupled to the substrate, and biocide positioned between the substrate and the cover. The biosensor may also include desiccant. The cover is operative to selectively block access to the sample site. The cover includes a fixed end coupled to the substrate, an opposite free end, and a middle portion extending across the sample site. The middle portion is releasably and recloseably adhered to the substrate.
    Type: Grant
    Filed: October 28, 2002
    Date of Patent: June 20, 2006
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Raghbir Singh Bhullar, Douglas Paul Walling, Brian S. Hill
  • Patent number: 7045054
    Abstract: Sensors (10, 110, 210, 310, 410) and a method for detecting an analyte are described. Sensors (10, 110, 210, 310, 410) each have a volume of a hydrophilic medium (24) that retains an amount of analyte proportionate to the concentration of analyte in a biological fluid, electrodes (12) and a redox enzyme in contact with medium (24), and an electron transfer mediator. The fluid contacts sensors (10, 110, 210, 310, 410) and at initially predetermined intervals intermittently applies a potential to electrode (12) sufficient to oxidize the mediator and sensing current through electrode (12) as a function of the duration of the applied potential. The applied mediator oxidizing applied potential is maintained for a period of time sufficient to determine the rate of change of current with time through electrode (12). The current flow is correlated with the current flow for known concentrations of the analyte in medium (24).
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: May 16, 2006
    Assignee: Roche Diagnostics Corporation
    Inventors: Harvey B. Buck, Matthias Essenpreis
  • Patent number: 7025836
    Abstract: A process is provided for the production of a surface coating as well as the use of surface coatings to increase the surface tension of objects. The surface coating is obtained by depositing a layer of at least one element that can be oxidized with water or an alloy that can be oxidized with water. Subsequently, the deposited layer is subjected to boiling water or water vapor. The element is generally derived from the following group of elements: Al, Si, Ti, V, Cr, Mn, Fe, Co, Ni, Zn, Ga, Ge, Zr, Nb, Cd, In, Sn, Sb.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: April 11, 2006
    Assignee: Roche Diagnostics GmbH
    Inventors: Volker Zimmer, Hans-Peter Braun
  • Patent number: 7026002
    Abstract: The invention concerns an element for the determination of an analyte in a liquid by means of a specific binding reaction of two bioaffine binding partners containing in or on material which enables liquid transport between the zones. The element comprises a sample application zone; a detection zone located downstream thereof that is devoid of binding reagents and is the last zone on the element that allows liquid transport; a zone containing immobilized analyte or analyte analogue between the sample application zone and the detection zone; and impregnated conjugate that can be detached by liquid located in the sample application zone or upstream or downstream thereof composed of a bioaffine binding partner capable of a specific binding reaction with the analyte to be determined and a detectable label.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: April 11, 2006
    Assignee: Roche Diagnostics GmbH
    Inventors: Ada Goerlach-Graw, Reiner Schlipfenbacher
  • Patent number: 6945251
    Abstract: An apparatus is provided to fix a thermoplastic mask to a patient. The apparatus includes a member formed to be positioned adjacent a cranio facial bone, a fixation member coupled to the member, and a fastener plate. The fastener plate couples the mask to the fixation member so that the member is in a fixed position relative to the mask.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: September 20, 2005
    Inventor: Robert T. Woodburn, III
  • Patent number: 6925393
    Abstract: A system for the extrapolation of a glucose concentration has a data input device for entering administered insulin doses and their times of administration, a data input device for entering the carbohydrates consumed or to be consumed, a unit for determining an actual glucose concentration at a point in time (ta) in a patient's bodily fluid, a memory unit, and an evaluation unit for evaluation of the data stored in the memory unit, and for the extrapolation of a glucose concentration at a point in time tp, whereby tp is after ta The extrapolation includes determining the portion (Iwirk) of insulin doses that become effective between ta and tp; determining the portion of consumed carbohydrate units KHwirk, that become effective between ta and tp; and determining an extrapolated glucose concentration Gp at the point in time tp with consideration for Iwirk and KHwirk.
    Type: Grant
    Filed: November 13, 2000
    Date of Patent: August 2, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Brit Kalatz, Udo Hoss
  • Patent number: 6880968
    Abstract: Test element analysis system (1) for the analytical investigation of a sample (8), in particular of a body liquid, of human beings or of animals, comprising test elements (3) with a test zone (7), to be brought in contact with the sample to be investigated for the purpose of performing an analysis, in order to measure a measurement quantity characteristic for the analysis, and an evaluation instrument (2) with a test element holder (5) for positioning a test element (3) in a measuring position in order to perform a measurement, and a measurement and evaluation electronics (15) for measuring the characteristic change and for determining a result of the analysis, based on the result of the measurement. In order to provide increased measuring accuracy by improved temperature compensation, it is proposed, in the scope of the invention, that the evaluation instrument (2) for the determination of the temperature prevailing in the test zone (7) of the test element (3) comprises an infrared detector (20).
    Type: Grant
    Filed: October 26, 2000
    Date of Patent: April 19, 2005
    Assignee: Roche Diagnostics GmbH
    Inventor: Hans-Peter Haar
  • Patent number: 6881378
    Abstract: The invention concerns an analytical device containing at least two components in which at least two of the components are joined together with the aid of an adhesive, which is characterized in that the adhesive contains an adsorptive material. The invention additionally concerns the use of adhesives which contain adsorptive material to manufacture analytical devices.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: April 19, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Volker Zimmer, Hans-Peter Braun
  • Patent number: 6872315
    Abstract: The present invention concerns a method of producing flow rates of a transport liquid of about 1 to 1000 nl/min. The method provides a pump having a housing defining a space and including a channel and a wettable membrane positioned in the housing, the membrane including a first side facing toward the channel and a second side facing the space. The method further includes at least partially filling the channel with the transport liquid, contacting the wettable membrane with the transport liquid to generate an underpressure in the channel,evaporating the transport liquid at the wettable membrane to remove the transport liquid from the channel and to create an underpressure in the channel, and maintaining a generally constant vapor pressure of the transport liquid in the space.
    Type: Grant
    Filed: August 5, 2004
    Date of Patent: March 29, 2005
    Assignee: Roche Diagnostics Corporation
    Inventors: Carlo Effenhauser, Herbert Harttig, Peter Kraemer
  • Patent number: 6866758
    Abstract: A biosensor is provided in accordance with the present invention. The biosensor includes an electrode support substrate, electrodes positioned on the electrode support, each electrode including a meter-contact portion and a measurement portion, and a sensor support substrate. The sensor support substrate cooperates with the electrode support substrate to define channel in alignment with the measurement portion of the electrodes. Additionally, the sensor support substrate includes opposite ends and at least one window. The at least one window is spaced-apart from the ends and in alignment with the meter-contact portion of at least one of the electrodes.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: March 15, 2005
    Assignee: Roche Diagnostics Corporation
    Inventors: Raghbir S. Bhullar, Brian S. Hill, John T. Austera
  • Patent number: 6860993
    Abstract: The present invention concerns a pump for flow rates from about 1 to 1000 nl/min in which liquid transport takes place by evaporation of a transport liquid through a wettable membrane. The pumps according to the invention are particularly suitable for applications in the field of medical diagnostics such as microdialysis or ultrafiltration.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: March 1, 2005
    Assignee: Roche Diagnostics Corporation
    Inventors: Carlo Effenhauser, Herbert Harttig, Peter Kraemer
  • Patent number: 6852500
    Abstract: The invention concerns a method and an arrangement for determining the concentration of glucose in a body fluid. In the microdialysis technology used for this purpose, perfusate containing glucose is transported in intermittent delivery pulses through a microdialysis probe (10) inserted into the body fluid and dialysate obtained in this process is passed to a measuring cell (16) to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the body fluid by means of a control device (18, 20) in accordance with a command variable derived from the measurement signals of the measuring cell (16). When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the body fluid.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: February 8, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Udo Hoss, Hans-Joerg Pfleiderer, Ralf Gessler, Hans-Ulrich Zieten, Rolf Fussgaenger