Abstract: Antisense oligonucleotides specific for the muscarinic type 2 acetylcholine receptor mRNA have been identified. Administration of these oligonucleotides to animals resulted in an increase in memory and learning. Methods for discovering other oligonucleotides with the same activity are taught, as are uses of the antisense molecules for treatment of human and animal diseases.

Abstract: A high energy propellant comprising 1,3,3-Trinitroazetidine or TNAZ, admi with up to about five percent of cellulose acetate butyrate or CAB by adding the CAB at a temperature slightly above the melting point of the TNAZ. A preferred amount of CAB is from about one percent to about three percent by weight of CAB, based on the weight of TNAZ. When the mixture is melt cast, the crystal structure is finer or smaller than that of pure explosive, producing increased mechanical strength and better resistance to impact. Inclusion of a thermoplastic binder is also contemplated to improve the mechanical integrity of the explosive. Preferred binders are BAMO/AMMO, HYTREL and ESTANE. The formulation permitted inclusion of small quantities of other high explosives because a uniform dispersion was obtained. Preferred high explosive are S-TNT, S-TNB, RDX, HMX and mixtures thereof.

Abstract: A solar-powered, illuminated aircraft warning marker for connection to suspended cables and overhead transmission lines includes a polygonal housing having a plurality of light elements attached to different sides of the housing. The warning marker includes solar cells, storage batteries and electrical circuit apparatus for selectively illuminating the light elements during low ambient light and nighttime conditions.

Abstract: A quantitative method for determining the plasma levels of thrombin-specific inhibitors is based on the quantitative thrombin time using plasma dilutions, excess fibrinogen and thrombin. The plasma dilutions and excess fibrinogen act in concert to eliminate the effects that coagulopathies have on standard coagulation tests. The method is relatively simple and provides superior results to standard conventional tests. The method is suitable for performance in clinical hematology laboratories on a routine basis using commercially available instrumentation.

Abstract: It is now possible to immunize susceptible mammals against the pathological effect of exposure to rice, including inhalation of ricin, by administration of an immunogenic effective amount of ricin toxin sub-units, including subunits of both the A chain and the B chain of the ricin toxin given separately to provide safe, efficacious protection.

Abstract: A winch includes a cylinder containing a movable piston to which are respectively mounted a fixed and a movable pulley assembly around which a line to be pulled is entrained. The pulley assemblies are located within the working chamber and the line enters the cylinder through one end formed remote from the chamber and through a one way brake mounted to that remote end. The brake permits line to enter the cylinder as the working chamber is pressurized to move the piston and thereby the movable assembly towards the remote end. The one way brake prevents line from exiting the cylinder at this location. The line extends slidingly through the piston and may exit the cylinder at the opposite end thereof which is also equipped with a one way brake which prevents line from entering the cylinder but allows the line to exit the cylinder. End of stroke positions of the piston are sensed by means of Hall Effect Sensors to control pressurization and venting of the working chamber through a three way valve.

Abstract: An improved small animal restraint device is provided which enables an inidual to conduct ocular examinations of a small animal. The device minimizes manipulation of the eyes of the animal and eliminates recovery time associated with anesthetics, while also reducing examination time. The restraint device comprises a cylinder having a longitudinal slot in the wall thereof. A conical member which is attached to one end of the cylinder includes a pair of eye openings in the upper wall thereof and a nose opening at the apex thereof. A plunger placed in the cylinder at the other end thereof assists in holding the animal in place. A set screw, which extends through the slot in the wall of the cylinder, secures the plunger in place.

Abstract: It has been discovered that certain (+)-3-substituted-N-alkylmorphinans are ffective anticonvulsant and neuroprotective agents. Novel compounds having these biological properties are presented in a method of use for preventing, treating or controlling convulsions in mammals having a need for such treatment. The compounds do not lead to dependency, have low toxicity, and provide effective anticonvulsant or neuroprotective treatment with little or no behavioral detriment to the recipient. A number of pharmacological formulations and methods of administering compounds of the invention are suitable for anticonvulsive or neuroprotective treatments.

Abstract: An automated, computer-driven amino acid indexer for peptide synthesis uses programmed computer, a circuit board controller, and a combination of microtiter sample well trays, light emitting diodes to illuminate each sample well, and circuitry to control the illumination of the diodes. The apparatus simplifies technical difficulties present in large-scale laboratory syntheses of peptides by substantially reducing the time required for dispensing amino acids into sample trays and reducing the occurrence of error in the process to negligible levels in typical syntheses. A programmed, automated technique for synthesizing peptides is also provided.

Abstract: Encapsulated PI compositions such as liposomes containing plant PI and th use to prevent mitogenic transformation of normal splenic lymphoid cells (including lymphocytes transformed induced by treatment of cells with lipid A) by exposing the cells thereto.

Abstract: A cassette holder and positioning assembly device for a portable x-ray mane, comprising: a mounting plate; oppositely adjustable vertical arms disposed in parallel relationship on the mounting plate attached in proximity to an outer periphery along vertical axes of the plate and opposite horizontal arms mounted fixedly on the plate and disposed in perpendicular relationship to the vertical arms; a selection handle disposed pivotally between alignment guides on a handle gear that meshes with a circumferential gear pivotally attached to linkage arms in perpendicular relationship to portions of the mounting plate beneath the alignment guides and pivotally attached to a backstop linkage arm in perpendicular relationship to the alignment guides, the backstop linkage arm is pivotally attached to a platform fixed to the mounting plate; a semi-circular indexing plate containing a plurality of notches in its inner arc and fixed in raised relation on the mounting plate above the selection handle; the selection handle h

Abstract: The gate-source capacitance of a power MOSFET (1) can be protected against positive and negative excess voltages by two integrated Zener diodes (3, 4) the anodes of which are coupled to each other and the cathodes of which are respectively coupled to the gate and source terminals of the power MOSFET. However, when a control voltage is applied, the parasitic bipolar transistor associated with one of the Zener diodes is switched on and prevents the MOSFET from completely switching on. The parasitic bipolar transistor is rendered harmless by the fact that the anode terminal is coupled to a source terminal (S) MOSFET (1) when a gate-source voltage is applied.

Abstract: A circuit arrangement for the equalization of digital signals received in analog form. The circuit arrangement is used in a digital signal receiving system for the equalization of digital signals received in analog form through an analog/digital converter which have been distorted by precursors and postcursors of subsequent or previously transmitted digital signals. In this case, the circuit arrangement includes a postcursor equalizer and a precursor equalizer connected with it that is designed as a transverse filter and multiplies a digital signal received at a sampling interval n by a main coefficient and, in addition, a predetermined number of digital signals immediately following the digital signal in question in each case by a predetermined secondary coefficient and sums that resulting product signal, with the aid of an adder, to a sum signal.

Abstract: A process for receiving a binary digital signal by a method for the reception of a binary digital signal, which may also have phase shifts, with a supplied clock that may have any desired phase position with respect to the digital signal and may deviate somewhat in frequency from the bit sequence frequency of the digital signal. From the clock (T1) there is formed over a delay chain (7-13, 52-55) a series of clocks (T2-T12), which have approximately equal phase intervals. Short pulses (I11-I110) are derived from the clocks (T1-T12). T12). Upon the arrival of each edge of a digital signal (D1) that has been selected as the effective edge, there is derived a read pulse (I21) which may also be delayed (I2x), with which the presence of pulses (I11-I110) may be determined through AND gates (20-25, 60-63). Through SR flip-flops (26-31, 64-67) and AND gates (32-37, 68-71), clocks (F1-F10) selected with the pulses (I11-I110) that are present are switched through and OR-linked (38) for use as an input clock (Te).

Abstract: Apparatus for playing record carriers includes a memory (6) and means (1, 3) for storing in the memory (6) record-carrier identifications together with preferred selections which indicate specific parts of the record-carrier associated with the record-carrier identification. Prior to playing of a record-carrier loaded into the apparatus, the record-carrier identification of this record-carrier is determined and it is detected whether the memory (6) already contains a preferred selection for the detected record-carrier identification. When this is the case, the record-carrier to be played can be played in comformity with one of the associated preferred selections stored in the memory (6). The apparatus comprises means (3) for updating data indicative of the playing frequency of the record-carrier associated with the stored record-carrier identification.

Abstract: Storage case for a plurality of record carrier discs, in particular CD-singles, includes a housing (1) with a plurality of superposed plate-shaped tray bodies (3). The tray bodies each have a supporting surface (5) for supporting one of the discs, and for moving the discs into or out of the housing, they are each individually pivotable about a pivoting spindle (11). The housing has side walls (19, 21) and rugged partitions (37, 47) which extend parallel to said supporting surfaces to guide and support the tray bodies. At least one of the side walls (19) has an inwardly offset wall portion (35) which serves to minimize the dimensions of the partitions (37) for given outer dimensions of the housing.

Abstract: In a multi-track record carrier the data is stored in words which comprise an increased number of smybols as a result of added redundancy. In order to neutralize so-called burst errors, the symbols of a word are stored in a distributed manner, for example by interleaving. In the case of loss of track, a regrouped word may then actually consist of parts of two or more different words (i.e. words situated on several tracks). Decoding of such a word is prevented in practice in that a series of symbols are invalidated in the case of loss of track, for example by inversion or by means of an invalidity flag.

Abstract: A process for making a thyristor device protected against breakover firing is to generate in the semiconductor body (1) of the thyristor an area (A) which has a lower breakdown voltage than the rest of the semiconductor body. This area is protected by suitable measures when the thyristor is overloaded. The invention features a process in which the area (A) of the semiconductor body (1) is irradiated locally with protons, with the proton energy being measured in such a manner that the maximum of the defect density and doping generated by the proton irradiation lies between the PN junction (15) of the first base region (9) and the second base region (10) and the half thickness of the second base region (10), and the semiconductor body (1) is subsequently heat-treated.

Abstract: A push-push (make-break) switch (43) including a thermally operated circuit breaker release is adapted for controlling an electric motor (42). The switch (43) may be employed by itself or used in conjunction with a standard control switch (41) connected to auxiliary contacts (15 and 18) which are normally closed but opened when switch (43) is activated. When switch (43) is momentarily activated, it becomes latched to continue operation of the motor (42) until the motor stalls upon completion of a task. The increased current draw of the motor (42) is sensed by a bi-metalic element (27) whose free end moves to automatically release the switch (43) and disrupt its continuity path. The switch (43) is in a compact, self-contained, design which provides various different operational features. In automotive applications, switch (43) provides convenient express operation of motor operated accessories such as power windows and the like.

Abstract: In a disc-record player which comprises a resiliently support subframe (5) which carries a turntable (6) and a read means (9) a loading device (14) for loading a disc (15) into the record player comprises a servo means (53) which comprises a plurality of control elements for controlling the movements of the loading device (14). An insertion control element (52) cooperates with a transfer device (17, 29) to guide the disc (15) towards the turntable (6). A lift control element (57c) cooperates with the transfer device (17, 29) to control the movement of the disc (15) towards the turntable (6). A clamping-member control element (71b, 72b) controls at least two clamping members (26) of the transfer device (17, 29) which members hold the disc (15) during loading, and causes the clamping members (26) to be disengaged from the disc after the disc has been lowered onto the turntable (6).