Abstract: A syringe for withdrawing fluids which consists of novel new one-handed operated syringe. Said one-handed or therapeutic syringe is described as a therapeutic syringe comprising a double compartmented housing, a piston disposed in one of said compartments, a piston rod connected to said piston controlling the movement of said piston in a barrel, vent means associated with said piston compartment, said other non-piston compartment being formed with needle hub for supporting a needle and having an opening in fluid communication with said piston compartment whereby when said piston is moved forward in said barrel in said piston compartment, air will be discharged therefrom while drawing liquid into said other compartment.

Abstract: Monoclonal antibodies are produced which specifically bind to human ovarian cancer cells. These antibodies are conjugated to Pseudomonas exotoxin in order to produce an immunotoxin suitable for the chemotherapeutic treatment of human ovarian cancer.

Abstract: A hair dryer with a frusto-conical casing tapering from a larger rear air inlet end to a smaller air outlet end contains in coaxial alignment therewith in an electric heater element shaped as a cylindrical open-ended cage and an electric motor extending partly into the cage and driving axial fan positioned rearwardly of the cage. The cage consists of series connected spaced parallel metal strips held by electrically non-conductive end rings and inclined to the cage circumference to form air guide vanes. The cage divides the casing space into an annular outer duct decreasing in cross section toward its front end and closed by contact with the casing and an annular inner duct between the cage and motor. Part of the air from the fan flows through the outer duct and through the vanes to the cage interior while the remainder flows through the inner space to cool the motor. The two air streams mix to the required temperature in the cage interior downstream of the motor for discharge through the air outlet.

Abstract: A method and test kit for the serological diagnosis of human infection by herpes sipmlex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) using immunoaffinity purified virus-coded glycoproteins as target antigens. A preferred embodiment of the method employs a variation of the enzyme-linked immunosorbent assay (ELISA) whereby monoclonal antibodies are used to purify target antigens, and test sera are absorbed with virus-infected cell extracts to remove intertypic cross-reacting antibodies.

Abstract: A derivative of phencyclidine (1) bearing an isothiocyanate moiety on the meta position of the aromatic ring (3; Metaphit as methanesulfonate and HCl salt) has been synthesized and identified as a rapid and specific site-directed acylating agent of the [.sup.3 H]-phencyclidine binding site in rat brain homogenates. Additional related compounds to Metaphit are Thiophit (oxalate salt), Ethylphit (HCl salt), and Isopropylphit (HCl salt).

Abstract: This invention discloses a method of improving the constitution of boiler water by adding thereto an effective amount of a copper transport agent which is either rubeanic acid or a low molecular weight polymer of polypiperazine methyl-para-hydroxysulfonic acid or polypiperazine methyl-para-hydroxybenzoic acid. The copper transport agent satisfactorily separates the copper from iron, calcium, magnesium and other heavy metals with a high degree of selectivity. The chelant may be added in a ratio of 100/1 to 10/1 chelant/copper and an advantageous ratio in the case of the polymer is 50/1 ppm active polymer to 1 ppm Cu. The chelants, which form a soluble chelate with Cu, is capable of removing Cu through boiler blowdown in an operating, layup or cleanup boiler. This adds an anti-corrosion factor to the galvanized boiler corrosion.

Abstract: A process for the recovery and purification of L-asparaginase from Erwinia chrysanthemi is disclosed. The process involves the preparation of cellular acetone powder extract followed by either an ion exchange and affinity chromatography purification steps or by affinity chromatography alone. The column eluent is then dialyzed to produce substantially pure L-asparaginase.

Abstract: The invention comprises pharmaceutical preparations consisting generally of a drug with a substantially low water solubility and an amorphous, water-soluble cyclodextrin-based mixtures. In these preparations a stable amorphous state can be achieved. This improves the dissolution properties of the drug and hence its absorption by the body. The required cyclodextrin-based mixtures were prepared from .alpha.-, .beta.-, or .gamma.-cyclodextrin which were rendered amorphous through non-selective alkylation. The alkylation agents suitable for that purposes are exemplified by propylene oxide, glycidol, iodoacetamide, chloroacetate, or 2-diethylaminoethylchloride; their reactions with cyclodextrins were performed in a manner to yield mixtures containing many components, a circumstance which effectively prevents crystallization processes within the above pharmaceutical preparation.

Abstract: In a short total synthesis of morphinan compounds, derivatives of 1-benzyl-1,2,3,4-tetrahydroisoquinoline are produced. Certain of these compounds, although highly aromatic and functionalized, can be optically resolved. The optically active enantiomers can serve as important intermediates for both natural and unnatural opioids. As a special function of this invention, certain of the derivatives, namely 4'-6' and 7'-9', may be hydrogenated to 1'-3' derivative by asymmetric reduction either of the catalytic or chemical type.

Abstract: A process is disclosed for the construction of synthetic peptides corresponding to amino acid sequences of 55-, 59-, 60-, 67-kilodalton keratin proteins. These synthetic peptides make possible the development of monospecific antisera for individual keratin proteins. The process involves preparing cDNA libraries and reducing the amino sequences of cDNA clones.

Abstract: The present invention is an immortalized B-cell line which produces a human monoclonal antibody IgG-Kk which specifically binds to the envelope antigen of human T-cell leukemia virus Type 1 (HTLV-I). This monoclonal antibody is useful as a diagnostic reagent by binding to the antigen specifically expressed on the surface of HTLV producing cells. Furthermore, this monoclonal antibody is useful as a therapeutic reagent, in combination with complement, for the lysis of HTLV-1 producing cells.

Abstract: This invention is an immortalized T-cell clone, designated ATH8, which is highly sensitive to the cytopathic effect of HTLV-III. The ATH8 T-cell clone is used in mass screening systems to rapidly and easily determine the in vitro capacity of new drugs or other agents to inactivate or inhibit HTLV-III or related cytopathic retroviruses.

Abstract: An electric heating element for a hair-curling wand having a barrel attached at one end to a handle is inserted into a portion of the barrel and consists of a loop cut out of thin flexible nickel foil having free ends forming terminals for connection to a voltage source, the loop being insulatingly embedded between two thin, flexible sheets of an insulating material. The loop is formed in the shape of two parallel straight stretches and reentrant portions at its both ends, whereby more thermal energy is produced by the end portions than by the central portion, resulting in a sustantially uniform temperature distribution. The heating element is pressed onto the inner wall of the barrel by a resilient, longitudinally slotted tube, which has an initially larger diameter than that of the barrel and is inserted along with the heating element into the barrel by a special compressing tool.

Abstract: Certain functionalized cogeners of 1,3-dialkylxanthine exhibit high potency and selectivity as antagonists for A.sub.1 - and A.sub.2 -adenosine receptors and are suitable for attachment to probes, drug carriers, or solid supports. These derivatives are characterized by the presence of a phenyl at the 8 position para-substituted with a functionalized chain to provide high water solubility and high receptor affinity. Some of these analogs, containing a distal amino- or carboxylic-functionalized chain, are suitable for synthesis of amino acid conjugates. The compounds of this invention are suitable for use as antiallergenic, antiasthmatic, or cardiotonic drugs, central nervous system stimulants, and diuretics.

Abstract: An electric forced-convection air heater consisting of an axial fan and a cage-shaped resistance heating element mounted up-stream of the fan impeller, which serves to heat the air passing there through and to guide the air stream smoothly to the impeller. The cage shaped resistance heating element comprises a plurality of spaced longitudinal strips of uniform width, extending parallel to the axis of the cage; the surface of each strip is inclined to the ideal cylindrical surface of the cage and is curved perpendicular to its long axis. The alternate ends of the adjacent strips are jointed by bridging portions of the same material, but of larger cross section. Each bridging portion is perforated by a small opening. The cage is rigidly held in its cylindrical shape by two end rings of a thermoplastic material, provided with outstanding lugs on their circumference, one lug each engaging with one of the openings in the bridging portion atop each end of the cage.

Abstract: The present invention describes the finding of potent antiinflammatory properties in 2,3-didemethylcolchicine and its analogs.

Abstract: An agricultural implement for clearing a field of crop residue after harvest is attached to the linkage of a tractor and serves to cut and shred stalks of plants planted in two parallel rows. It comprises two sheave-shaped rollers on a common axle serving to crush the stalks and to flatten them onto the ground, and two flail-type fast-rotating shredders whose cutter bars cut and shred the stalks pressed on the ground by the rollers, while slightly penetrating in to the soil surface and cutting the upper root portions as well. Each shredder consists of a drum with pivotally attached cutter bars; both shredders are mounted on a horizontal shaft which is driven by the tractor power-take-off through a gear. A casing collects the shredded particles and spreads them on the ground behind the implement.

Abstract: A compound of the formula ##STR1## wherein Z is alkoxy of 1-4 carbon atoms and Y is amino, inhibits the growth of murine ductal carcinoma (MXT mammary tumors). A compound wherein Z is OH and Y is nitro, administered orally, inhibits the growth of MXT mammary tumors.