Patents Represented by Attorney Jon S. Saxe
  • Patent number: 4855297
    Abstract: The compounds of the formula ##STR1## wherein Ra,R.sub.b,R.sub.c R.sub.d are defined in the specification and pharmaceutically acceptable addition salts are disclosed.The compounds of formula I have valuable pharmacological properties and can be used for the control or prevention of illnesses. In particular, they have muscle relevant, seditive-hypnotic, anxiolytic and/or anticonvulsive activity and can accordingly be used in the control or prevention of muscle tensions, stress conditions, isomnia, anxiety states and/or convulsions.
    Type: Grant
    Filed: December 4, 1986
    Date of Patent: August 8, 1989
    Assignee: Hoffman-La Roche Inc.
    Inventors: Ulf Fischer, Fernand Schneider, Widmer Ulrich
  • Patent number: 4855538
    Abstract: A digitizer comprising a measuring table having a substrate on which a grid is mounted, and a movable coil inductively coupled to the grid. When a time variable current is applied, a variable magnetic flux produces a measuring signal in the form of an induced voltage. The grid is a plurality of side-by-side, parallel conductors, each having opposite axial ends and arranged in pairs. A bridge is provided between adjacent ends of a plurality of the pairs of conductors. Current flowing into the opposite end of one conductor of a pair of conductors, thus, produces oppositely directed magnetic fields around the conductors of the pair, or a changing magnetic flux produced by the coil and interacting with the conductors of a pair induces voltages of opposite polarity in the conductors of the pair.
    Type: Grant
    Filed: October 2, 1987
    Date of Patent: August 8, 1989
    Assignee: Kontron Holding A.G.
    Inventors: Wolfgang Jacob-Grinschgl, Udo Muller
  • Patent number: 4853472
    Abstract: A process for producing natural vitamin E and intermediates in this process.
    Type: Grant
    Filed: September 9, 1988
    Date of Patent: August 1, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David L. Coffen, Rudolf Schmid, Mark J. Sebastian
  • Patent number: 4853156
    Abstract: A novel process for the manufacture of quinone derivatives is described.In this process a compound of the formula ##STR1## is reacted with a compound of the formula ##STR2## and the resulting compound of the formula ##STR3## is subjected to a retro-Diels-Alder reaction. The substituents R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the significance given in the description.
    Type: Grant
    Filed: March 24, 1986
    Date of Patent: August 1, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: August Ruttimann, George H. Buchi
  • Patent number: 4851519
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is halogen, C.sub.1-4 -alkyl, halo-(C.sub.1-4 -alkyl) or C.sub.2-4 -alkanoyl,R.sup.2 is hydrogen, hydroxy, C.sub.1-4 alkoxy, C.sub.1-4 -alkylthio or phenyl-(C.sub.1-4 -alkoxy) or , when X is O, also acyloxy,R.sup.3 is hydrogen or C.sub.1-4 -alkyl,R.sup.4 is a carbocyclic group or a heterocyclic group,R.sup.5 is hydrogen or fluorine,m stands for zero, 1 or 2,X is O or NH and Y is a direct bond, --CH.dbd.CH--, --C.tbd.C-- or a group of the formula of--(Z).sub.n --A-- (a)in which A is a C.sub.1-8 alkylene group which is optionally substituted by one or two phenyl groups,Z is O, S, SO or SO.sub.2 and n stands for zero or 1, with the proviso that R.sup.1 is different from iodine, when R.sup.2 is hydroxy or benzoyloxy, R.sup.3 is hydrogen,R.sup.4 is unsubstituted phenyl, R.sup.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: July 25, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert W. Lambert, Joseph A. Martin, Gareth J. Thomas
  • Patent number: 4851585
    Abstract: Novel methyl carbinol derivatives of Vitamin E and a method for their manufacture.
    Type: Grant
    Filed: November 12, 1987
    Date of Patent: July 25, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • Patent number: 4849347
    Abstract: Lactic acid produced by cells in culture is detected and used in a bioassay to determine cell growth and vitality. Lactic acid is detected by coupling the lactate dehydrogenase conversion of lactic acid to pyruvic acid to a reaction using micotinamide adenine dinucleotide in reduced form (NADH) to reduce a tetrazolium dye. The process can be used to serve as a bioassay for measuring biologically active compounds, particularly lymphokines.
    Type: Grant
    Filed: November 29, 1984
    Date of Patent: July 18, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Philip C. Familletti, Judith W. Swanson
  • Patent number: 4847273
    Abstract: Dihydropyridine derivatives of the formula ##STR1## wherein the symbols R and R.sup.1 to R.sup.6 have the significance given in claim 1, have a pronounced calcium-antagonist activity and can accordingly be used as medicaments, especially in the control or prevention of angina pectoris, ischemia, high blood pressure and/or migraine.
    Type: Grant
    Filed: June 5, 1986
    Date of Patent: July 11, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roland Jaunin, Henri Ramuz
  • Patent number: 4844085
    Abstract: A method and a device for measuring mechanical property parameters of the pulmonary system of a patient which comprises;inflating and deflating the lung with a predetermined gas volume with a pump;measuring the pressure changes generated in the lung during inflation and deflation with a pressure sensor;transforming the volume and the measured pressure data into digital form;calculating typical or clinically significant volume to pressure ratios in a data processor and;displaying the result of the calculation.
    Type: Grant
    Filed: November 14, 1988
    Date of Patent: July 4, 1989
    Inventor: Luciano Gattinoni
  • Patent number: 4841070
    Abstract: The novel 5,6-sulfinyl-L-ascorbic acid and its stereoisomers, their manufacture by sulfinylating L-ascorbic acid or corresponding stereoisomers, compositions having oxidation-inhibiting properties which contain 5,6-sulfinyl-L-ascorbic acid or a stereoisomer thereof as well as the use of 5,6-sulfinyl-L-ascorbic acid or a stereoisomer thereof as an antioxidant are described.
    Type: Grant
    Filed: June 24, 1988
    Date of Patent: June 20, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Horst Pauling, Christof Wehrli
  • Patent number: 4841045
    Abstract: A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.
    Type: Grant
    Filed: May 18, 1987
    Date of Patent: June 20, 1989
    Assignee: University of Vermont & State Agricultural College
    Inventor: Martin Kuehne
  • Patent number: 4839382
    Abstract: Compositions comprising a mixture of the antibiotic frenolicin B with one of the ionophorous polyether anticoccidial agents, useful for the treatment and prevention of coccidiosis in animals and methods of treating coccidiosis ar disclosed.
    Type: Grant
    Filed: May 11, 1987
    Date of Patent: June 13, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gianpaolo Maestrone, Eugene G. Schildknecht, Govind G. Untawale
  • Patent number: 4837311
    Abstract: A-B-C wherein A and C are each independently 2',3' dideoxynucleosides and B is a linking group; and a method of treating or preventing a retroviral injection in a subject by administering the compounds of the invention.
    Type: Grant
    Filed: June 22, 1987
    Date of Patent: June 6, 1989
    Assignees: Hoffman-La Roche Inc., United States of America
    Inventors: Steve Tam, Manfred Weigele, Samuel Broger, Hiroaki Mitsuya
  • Patent number: 4834534
    Abstract: A flow cell for high performance chromatography, in which the measuring chamber is formed by a bore (12) in a plate (11) and the supply and discharge ducts are formed by bores (13, 14) in the plate (11) communicating with grooves (16, 18) in the plate surfaces (15, 17), the grooves being covered by transparent plates (19, 20) bonded on the plate surfaces, and thus forming closed ducts.
    Type: Grant
    Filed: April 21, 1988
    Date of Patent: May 30, 1989
    Assignee: Kontron Holding A.G.
    Inventor: Peter Wiget
  • Patent number: 4833774
    Abstract: A transparent disk with a round periphery is produced, for example, by a grinding operation, and a mark is placed at the geometric center of the disk. A coil is then wound about the periphery of the disk. As a consequence, the mark at the geometric center of the disk coincides with the electrical center point of the coil, thus obviating the need for a bobbin, or coil former, on which the coil can be wound.The transparent disk is first ground into a round shape, and a metallic film is deposited on a surface of the disk. The film is coated with a photosensitive resist material, and then exposed through a mask to define an image of a mark at the geometric center of the disk. The film is then etched to remove all but the mark from the disk.In manufacturing the coil, the disk, is concentrically clamped between two plates of a winding jig, each plate having annular peripheral flanges that are radially larger than the disk and thus project beyond the periphery of the disk.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: May 30, 1989
    Assignee: Kontron Holding A.G.
    Inventors: Wolfgang Jacob-Grinschgl, Udo Muller
  • Patent number: 4833259
    Abstract: The novel sunscreen agents which are esters, namely esters of p-methoxy-cinnamic acid with d,1-.alpha.-tocopherol, pantolactone or panthenol.
    Type: Grant
    Filed: August 24, 1987
    Date of Patent: May 23, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gustav Erlemann, Christian Fizet, Horst Pauling
  • Patent number: 4833245
    Abstract: The invention is concerned with novel heterocyclic compounds of the formula ##STR1## wherein R is C.sub.1-12 -alkyl, C.sub.3-12 -alkenyl, C.sub.3-12 -alkynyl or C.sub.3-8 -cycloalkyl and X signifies oxygen or sulfur, and none of the possible multiple bonds of R is present in the .alpha.-position of X, and their acid addition salts, processes for their manufacture, pest control compositions which contain these compounds as the active substance as well as the use of such compounds or compositions for the control of pests. Moreover, the invention is concerned with starting materials used for the preparation of such compounds.
    Type: Grant
    Filed: July 15, 1988
    Date of Patent: May 23, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans Bruderer, Renee Zurfluh
  • Patent number: 4833073
    Abstract: Novel cannabinol derivatives are provided which can be used in improved immunoassays for the detection in blood or urine samples of cannabinol metabolites.
    Type: Grant
    Filed: January 27, 1987
    Date of Patent: May 23, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alan J. McNally, Alan Schwartz, Magdalena Usategui
  • Patent number: 4830470
    Abstract: Compounds of the formula ##STR1## wherein m represents is the number 0 or 1; A is a single covalent bond, --CH.sub.2 --CH.sub.2 --, --OCH.sub.2 --, --COO-- or --OOC--; rings B, C and D are 1,4-phenylene optionally substituted with cyano, halogen or lower alkyl; Y.sup.1 and Y.sup.2 are hydrogen or one of them also is cyano; and R.sup.1 and R.sup.2 each represents C.sub.1 -C.sub.18 -alkyl or C.sub.2 -C.sub.18 alkenyl, either of which is optionally halogen-substituted, in which one CH.sub.2 group or two non-adjacent CH.sub.2 groups is/are optionally replaced by oxygen; with the provisos that at least one of R.sup.1 and R.sup.2 has a chiral carbon atom or a C--C double bond or both when A is --COO-- and at least one of R.sup.1 and R.sup.2 has a C--C double bond when A is a single covalent bond, their preparation, liquid crystalline mixtures containing these compounds and their use for electro-optical purposes are described.
    Type: Grant
    Filed: May 20, 1987
    Date of Patent: May 16, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Buchecker, Hans-Jurgen Fromm, Stephen Kelly, Martin Schadt
  • Patent number: 4831130
    Abstract: Compounds of the formula ##STR1## wherein A is one of the following: ##STR2## in which R.sub.1, is acyl, R.sub.2 is hydrogen, lower alkyl, lower alkoxycarbonyl or aminocarbonyl, R.sub.3 is hydrogen or lower alkyl and R.sub.4 and R.sub.4 ' are hydrogen, lower alkyl, lower alkoxy, acyl or aralkyl, as well as pharmaceutically acceptable salts of such compounds, are useful as antibacterial agents.
    Type: Grant
    Filed: July 10, 1987
    Date of Patent: May 16, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Harry A. Albrecht, Frederick M. Konzelmann, Dennis D. Keith