Patents Represented by Attorney, Agent or Law Firm Joseph B. Barrett
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Patent number: 5551942Abstract: A centrifuge comprising a yoke element that rotates about a rotational axis and a processing chamber having an axis. The processing chamber includes a bowl element, a spool element, and a mechanism for joining the spool and bowl elements for relative movement between a mutually cooperating position for centrifugal processing and a mutually separated position for loading. A hinge attaches the processing chamber to the yoke element for pivotal movement between an operating position and an access position. In the operating position, the spool and bowl elements are in their mutually cooperating position and oriented for rotation with the yoke element about the rotational axis. In the access position, the processing chamber axis lies outside the axis of rotation and the spool and bowl elements are oriented for movement from their mutually cooperating position into their mutually separated position.Type: GrantFiled: December 22, 1993Date of Patent: September 3, 1996Assignee: Baxter International Inc.Inventors: Richard I. Brown, Warren P. Williamson, Paul M. Di Perna
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Patent number: 5549458Abstract: A peristaltic pumping apparatus includes a pump rotor carrying a roller and a drive mechanism for rotating the rotor. The drive mechanism includes a carrier for holding the pump rotor. The apparatus includes a release pin mechanism carried on the pump rotor and exposed to access by a user. The release pin mechanism is movable by the user between a first position that connects the pump rotor to the carrier and a second position that disconnects the pump rotor from the carrier. Placing the release pin mechanism in the second position allows quick separation of the pump rotor from the drive mechanism.Type: GrantFiled: July 1, 1994Date of Patent: August 27, 1996Assignee: Baxter International Inc.Inventors: Arthur S. Chapman, Richard L. Afflerbaugh
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Patent number: 5549540Abstract: An insert nestingly receivable within a centrifuge cup to support a pair of fluid containing bags therein is formed from a pair of concave shapes having an upper end and a lower end and which are centrally adhered together in back-to-back relationship. The shapes together with an interior surface of the centrifuge cup together form a pair of elliptically shaped chambers for supporting a pair of the bags within the cup. A pair of pins extend through the concave shapes and extend outwardly therefrom. The bags each are provided with a pair of spaced-apart holes to receive the pins, thereby supporting the bags within the elliptically shaped chambers. Preferably a block is fitted between the adhered together surfaces of the shapes at each lateral edge at the lower ends thereof. These blocks preferably extend laterally outwardly beyond the lateral extremities of the shapes, and the edges of the concave shapes and the blocks are rounded to thereby be nestingly receivable in the interior of the cup.Type: GrantFiled: October 13, 1994Date of Patent: August 27, 1996Assignee: Baxter International Inc.Inventors: Glenn Moore, Caryl Ellis
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Patent number: 5549834Abstract: Systems and methods are provided for reducing the number of leukocytes in cellular products like platelets collected in an on line or continuous blood separation processes. The systems and methods reduce the number of leukocytes from a cellular suspension before its separation into a cellular-rich concentration. This leads to effective and efficient leukocyte removal and a high quality blood product suited for therapeutic use, with and without long term storage.Type: GrantFiled: May 30, 1995Date of Patent: August 27, 1996Assignee: Baxter International Inc.Inventor: Richard I. Brown
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Patent number: 5549264Abstract: A support assembly for process control equipment includes a cabinet containing processing equipment. A vertical support pole is supported on said cabinet through a collar for extension and retraction. Process control equipment such as electronic control equipment and a video monitor is mounted on the upper end of the pole. At least one, and preferably two, constant force springs biased into a fully coiled position are attached at one end to the lower end of the pole. The opposite end of the springs are mounted for free rotation on a spool which is secured to the cabinet, whereby raising and lowering of the process control equipment is facilitated.Type: GrantFiled: July 1, 1994Date of Patent: August 27, 1996Assignee: Baxter International Inc.Inventor: Richard L. West
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Patent number: 5547453Abstract: A centrifugation system includes frame has at least one weight bearing member for engaging a support surface generally lying in a horizontal plane. The system also includes a centrifuge assembly including a chamber that can be rotated about an axis. A base supports the centrifuge assembly on the frame within the interior area with the rotational axis oriented in a plane that lies outside a vertical plane perpendicular to the horizontal support surface. The sloped orientation of the rotational axis conserves vertical height. It makes it possible to place the rotating centrifuge components for access in a zone that lies between the knees and the chest of the intended user, when standing.Type: GrantFiled: September 28, 1995Date of Patent: August 20, 1996Assignee: Baxter International Inc.Inventor: Paul M. Di Perna
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Patent number: 5538405Abstract: A peristaltic pumping apparatus and associated method to control power to the pump rotor to establish, during a preestablished first time period, a selected first angular velocity and sequentially establishing during a preestablished second time period immediately following the first time period a second angular velocity different than the first angular velocity. In this fashion, the apparatus and method achieve flow rates well below the minimum continuous flow rate of the rotor.Type: GrantFiled: July 1, 1994Date of Patent: July 23, 1996Assignee: Baxter International Inc.Inventors: Timothy J. Patno, Richard I. Brown, William H. Cork
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Patent number: 5536238Abstract: Systems and methods remove a contaminant from a fluid like blood, regardless of whether the contaminant is carried free within the fluid or entrained within cellular matter carried within the fluid. The systems and methods rely upon photodynamic processes to remove free contaminants from the fluid. The systems and methods rely upon separation processes to remove the cellular matter and, with it, the contaminants it entrains from the fluid.Type: GrantFiled: August 11, 1994Date of Patent: July 16, 1996Assignee: Baxter International Inc.Inventor: Daniel F. Bischof
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Patent number: 5529691Abstract: Systems and methods for separating a suspension of plasma and platelets from whole blood rotate a chamber about an axis to create within the chamber a low-G zone radially close to the axis and a high-G zone spaced radially further from the axis than the low-G zone. The systems and methods introduce whole blood into an inlet region of the chamber to initiate separation of red blood cells toward the high-G zone of the inlet region. This creates a strong flow of plasma that moves radially toward the low-G zone of the inlet region and elutes platelets into suspension with it. The systems and methods direct the radial flow of plasma and eluted platelets within the inlet region to a port in the inlet region for transport out of the chamber. The systems and methods also drag the interface into this radial plasma flow, eluting even the largest of platelets into suspension for collection.Type: GrantFiled: November 8, 1994Date of Patent: June 25, 1996Assignee: Baxter International Inc.Inventor: Richard I. Brown
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Patent number: 5529567Abstract: A blood processing assembly includes a centrifuge contained within a heated housing or chamber. A fail safe spill or splash detector is located within the inner wall of the housing. The detector includes a pair of parallel electrodes separated from each other from a small gap. The circuit detects a splash or droplet of liquid which conducts current between the electrodes.Type: GrantFiled: July 1, 1994Date of Patent: June 25, 1996Assignee: Baxter International Inc.Inventors: Ronald E. Toth, William H. Cork
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Patent number: 5527704Abstract: A method and apparatus for inactivating viruses in a body fluid. A mixture including a therapeutically effective amount of methylene blue and an amount of a body fluid is formed in a container under sterile conditions and then the container is irradiated with a light field of a suitable intensity and wavelength for activating the methylene blue for a time sufficient to inactivate viruses in the mixture. The mixture is maintained in a substantially static state within the container.Type: GrantFiled: May 4, 1995Date of Patent: June 18, 1996Assignee: Baxter International Inc.Inventors: Ludwig Wolf, Jr., William Bratten, John Foley
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Patent number: 5527472Abstract: Systems and methods for processing blood direct blood through the inlet of a separation device for removing undesired matter while directing the blood substantially free of undesired matter from the outlet of the separation device and into a collection container through the first port. The systems and methods expel residual air from the collection container through a second port different than the first port.Type: GrantFiled: June 14, 1993Date of Patent: June 18, 1996Assignee: Baxter International Inc.Inventors: Marc Bellotti, Daniel M. Karlovsky, Samira E. Johnson
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Patent number: 5525218Abstract: A centrifuge provides simplify access to the processing chamber. In one arrangement, the processing chamber separates into a bowl and spool element to receive a disposable processing bag. In another arrangement, the processing chamber pivots between an operating position and an access position to provide improved access. The centrifuge also employs readily accessible holders for releasably retaining tubing that, in use, conveys fluid to and from the chamber. Though greatly accessible, the centrifuge operates without the need of complicated rotating seals and expensive disposable components.Type: GrantFiled: November 4, 1994Date of Patent: June 11, 1996Assignee: Baxter International Inc.Inventors: Warren P. Williamson, IV, Richard I. Brown
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Patent number: 5514106Abstract: A fluid-carrying bag (10) or container is provided as well as a method for forming such a bag. The bag (10) has identifiers (28a, 28b) indicating a status of the contents of the bag (10). To this end, a first layer and a second layer of preferably flexible material are sealed to form an interior (14) capable of holding a fluid. A flap (18) is provided wherein at least one hole (28a) may be punched through the flap (18) which is capable of detection by a sensor to indicate treatment of fluid within the interior (14) of the bag (10). One or more polarizing pieces (116a,b) may be provided between the fused layers (102, 104) in the flap (112) at a location through which the at least one hole (116a,b) is punched indicative of treatment of the fluid in the interior (108) of the bag (110).Type: GrantFiled: December 20, 1994Date of Patent: May 7, 1996Assignee: Baxter International Inc.Inventor: Edmund D. D'Silva
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Patent number: 5514069Abstract: An umbilicus conveys fluid between a stationary body and a rotating body in a small, compact operating environment. The umbilicus comprises an elongated body including a proximal end, a distal end, and a middle region between the proximal and distal ends. A first support block is attached to the proximal end. A second support block is attached to the distal end. The first support block includes a strain relief sleeve. The umbilicus is otherwise free of any other strain relief sleeve. A thrust bearing member in the middle region spaced apart from the strain relief sleeve and the distal end. The umbilicus is otherwise free of any other thrust bearing member. The thrust bearing member has an inner annular body, an outer annular body about the inner annular body, and an array of ball bearings between the inner and outer annular bodies. The ball bearings support the inner annular body for rotation relative to the outer annular body.Type: GrantFiled: December 22, 1993Date of Patent: May 7, 1996Assignee: Baxter International Inc.Inventors: Richard I. Brown, David E. Cerny, T. Michael Dennehey, Indrajit Patel, Dean M. Glash
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Patent number: 5512187Abstract: A blood processing method provides a red blood cell product that is free of microorganisms like Yersinia enterocolitica during storage periods over 24 hours. The red blood cell product is collected in a first container, where it is refrigerating to cool the blood product to a temperature of about 3 to 5 degrees C. The refrigerated product is transferred from the first container into a storage container through a prescribed filter medium that comprises a mass of synthetic fibers having an average fiber diameter of about 10 microns or less and a bulk density of about 0.7 gram per cubic centimeter or less. The filtered product is retained in the storage container at a temperature of about 3 to 5 degrees C. for a storage period over 24 hours after filtration. Using the filter medium, microorganisms like Yersinia enterocolitica present in the red blood cell product at the time of collection are depleted.Type: GrantFiled: September 1, 1994Date of Patent: April 30, 1996Assignee: Baxter International Inc.Inventors: Donald H. Buchholz, Richard L. Kandler
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Patent number: 5507525Abstract: A label for a blood bag comprising a microporous plastic film including a matrix of interconnected pores for allowing gas to flow into and out of the blood bag through a labeled area. The pores allow ink to be absorbed at least on an outer surface of the label allowing the label to be printed and/or written on. The labels of the present invention have breathability with respect to gas that is similar to paper. However, the label is more durable than a paper label in that it can tolerate moisture, abrasion, temperature extremes, dimensional changes, and the like. Accordingly, the labels do not crack or wrinkle as easily as paper labels.Type: GrantFiled: December 27, 1993Date of Patent: April 16, 1996Assignee: Baxter International Inc.Inventor: Mark Leuenberger
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Patent number: 5507904Abstract: A port is formed in a thermoplastic container wall by slitting the wall, inserting a thermoplastic tube through the slit, placing a mandrel in the tube, placing opposed dies defining a bore over the sheet and tube, and dielectrically heating the thermoplastic to fuse the tube and sheet. Preferably the bore defined by the dies is of a diameter slightly less than that of the tube, and has an enlarged central area which forms a thickened section of material over the slit.Type: GrantFiled: September 27, 1994Date of Patent: April 16, 1996Assignee: Baxter International Inc.Inventors: David P. Fisher, Allen R. Wons
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Patent number: 5498520Abstract: The present invention provides a method for testing a blood unit for viral contamination without rendering the blood unit unusable for therapeutic applications. The method comprises the steps of: removing and collecting from a blood unit a majority of the leukocytes present therein with a leukocyte filter; and using the leukocytes collected in and on the filter to test the blood unit for viral contamination. The present invention also provides a method for validating viral inactivation processes.Type: GrantFiled: March 24, 1993Date of Patent: March 12, 1996Assignee: Baxter International Inc.Inventor: John R. Chapman
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Patent number: 5496302Abstract: Methods are disclosed for sterilizing a selected portion of a product and for assembling a sterile product from two or more parts which can not be sterilized with the same form of sterilization. A sterile product produced by these methods is also disclosed. The method for sterilizing may include sterilizing a selected portion of the product by exposing the selected portion to an electron beam, while shielding the remainder of the product from the radiation of the electron beam. The method of assembling a sterile product from two or more component parts may include the steps of sterilizing the first part of the product, isolating a portion of the first part from the remainder of the first part, attaching the second part to the isolated portion of the first part, and exposing the isolated portion to a form of sterilization which is deleterious to the remainder of the first part, while shielding the remainder of the first part from such form of sterilization.Type: GrantFiled: April 29, 1992Date of Patent: March 5, 1996Assignee: Baxter International Inc.Inventors: Billy W. Minshall, John E. Nygard, Kwame Sintim-Damoa, Richard Giesler, Archie Woodworth, Kailash Purohit