Patents Represented by Attorney, Agent or Law Firm Joseph M. Mazzarese
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Patent number: 6489342Abstract: This invention provides aryloxy indole derivatives which are useful for the treatment of diseases affected by disorders of the serotonin-affected neurological systems, such as depression and anxiety, the compounds having the formula: wherein R1 is H or alkyl; R2, R3, and R4 are H, alkyl, or halogen; X is H, halogen, CN, or C1-C6 alkoxy; Z is (CH2)n or carbonyl; n is 1 or 2; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 15, 2001Date of Patent: December 3, 2002Assignee: WyethInventors: Richard E. Mewshaw, Dahui Zhou, Ping Zhou
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Patent number: 6489303Abstract: An anthelmintic composition including an Antibiotic S541 compound or a chemical derivative thereof, together with an insoluble anthelmintic compound. The composition is stabilized by between about 0.15% and about 5.0% of an antioxidant by weight of the total composition.Type: GrantFiled: October 9, 2001Date of Patent: December 3, 2002Assignee: WyethInventor: Arunas H. Jancys
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Patent number: 6479537Abstract: The present invention provides methods for synergistic control of ectoparasitic arthropods with a synergistically effective amount of a combination of the macrocyclic lactone moxidectin and an arylpyrrole compound. Also provided are methods of protecting animals from infestation and attack by ectoparasites with said combination. The present invention also provides synergistic insecticidal compositions comprising as essential active ingredients the macrocyclic lactone moxidectin and an arylpyrrole compound.Type: GrantFiled: November 21, 2001Date of Patent: November 12, 2002Assignee: American Cyanamid CompanyInventors: Kathleen Heaney, Mary E. Doscher, Douglas Rugg
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Patent number: 6465482Abstract: Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise Wherein: R1, R2 and R3 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, MeSO2, or together can form a 5-7 membered carbocyclic or heterocyclic ring; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, alkylaryl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is carbon or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.Type: GrantFiled: October 3, 2001Date of Patent: October 15, 2002Assignee: WyethInventors: Richard E. Mewshaw, Ping Zhou, Dahui Zhou, Kristin L. Meagher, Magda Asselin, Deborah A. Evrard, Adam M. Gilbert
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Patent number: 6446579Abstract: An animal restraining device which includes a rigid, cylindrically-shaped, hollow tube open at both ends and having a longitudinal slit from one end to the other end. The device also includes a base and a tab. The tube is attached to the base to keep it stationary. The tab is attached at one end of the tube and provides a surface for placing the tail of an animal. The animal may be placed in the tube backwards, with its tail in the slit, and backed in toward the tab. The tube is sized to admit the animal without allowing excess space for movement. This invention is useful for conveniently and efficiently restraining an animal that is to be given a dose of medicine or the like, particularly when an injection must be administered to the animal.Type: GrantFiled: September 4, 2001Date of Patent: September 10, 2002Assignee: WyethInventor: Cheryl Ann Griebling
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Patent number: 6376494Abstract: This invention relates to compounds which have activity as 5-HT1A agonists and antagonists which may be useful for the treatment of anxiety, depression, cognitive deficits, and prostate cancer, having the formula wherein: X is a moiety selected from the group of: n is selected from the integers 1 through 5; R1 is optionally substituted aryl or mono or bicyclic heteroaryl, with a proviso that heteroaryl is not thiadiazole; R2 is H or alkyl; R3 is H, COR5, COOR5, and CONR5R6; R4 is H, alkyl, alkenyl, alkynyl, aryl, mono or bicyclic heteroaryl, aralkyl, and mono or bicyclic heteroaralkyl, wherein the aryl or heteroaryl groups are optionally substituted; R5 and R6 are H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, adamantyl, and noradamantyl or R5 and R6 taken together may form a 5-7 membered azacyclic ring, optionally containing an additional heteroatom selected from O, S, or NR4; when R5 or R6 are chosen from cycloalkyl or cycloalkenyl, the cyclic group may optionallyType: GrantFiled: November 28, 2000Date of Patent: April 23, 2002Assignee: American Home Products CorporationInventors: Wayne E. Childers, Michael G. Kelly, Yvette L. Palmer, Edward J. Podlesny
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Patent number: 6340671Abstract: The invention relates to certain stable microsphere compositions containing a fat, a wax or a mixture thereof; an active ingredient selected from LL-F28249&agr;-&lgr; compounds, 23-oxo or 23-imino derivatives of LL-F28249&agr;-&lgr; compounds, milbemycin compounds and avermectin compounds; an antioxidant and, optionally, an oil, a semi-soft fat, a fatty acid derivative or mixture thereof. The invention also relates to a method for introducing and maintaining levels of the active compound in the blood of warm-blooded animals for extended periods of time and for the prevention or treatment of infections and infestations caused by helminths, nematodes, acarids and endo- and ectoparasitic arthropods in warm-blooded animals by the parenteral administration of compositions of the invention.Type: GrantFiled: June 22, 1994Date of Patent: January 22, 2002Assignee: American Cyanamid CompanyInventors: Susan Mancini Cady, William David Steber, Phillip Wayne Hayes, Mary Ehlers Doscher, Kurt Allen Schwinghammer
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Patent number: 6337326Abstract: This invention provides novel compounds and methods and compositions using them in the treatment of central nervous system disorders, including depression and anxiety, the compounds having the formula: wherein Ar is an aryl group of 4 to 10 carbon atoms or a heteraryl group of 4 to 10 carbon atoms; R1 and R2 are independently selected from hydrogen, straight chain alkyl of 1 to 12 carbon atoms, branched alkyls of 3 to 10 carbon atoms or cycloalkyl of 3 to 10 carbon atoms; R3 is H, straight chain, branched or cyclic alkyl, halogen, alkoxy, haloalkyl, OH, nitro, nitrile, amino, CN, carboxy, alkoxycarbonyl, alkylcarbonyl, aminocarbonyl and alkylaminocarbonyl; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 6, 2000Date of Patent: January 8, 2002Assignee: American Home Products CorporationInventors: Adam M. Gilbert, Richard E. Mewshaw
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Patent number: 6313126Abstract: Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise Wherein: R1, R2 and R3 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, MeSO2, or together can form a 5-7 membered carbocyclic or heterocyclic ring; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, alkylaryl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is carbon or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.Type: GrantFiled: December 30, 1999Date of Patent: November 6, 2001Assignee: American Home Products CorpInventors: Richard E. Mewshaw, Ping Zhou, Dahui Zhou, Kristin L. Meagher, Magda Asselin, Deborah A. Evrard, Adam M. Gilbert
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Patent number: 6313114Abstract: Compounds are provided which have the following formula: wherein: R is hydrogen, alkyl of 1 to 6 carbon atoms, phenyl, or substituted phenyl; X and Y are each, independently, hydrogen, halogen, cyano, or alkoxy of 1 to 6 carbon atoms; and m is 1 to 5; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 30, 1999Date of Patent: November 6, 2001Assignee: American Home Products CorpInventors: Richard E. Mewshaw, Dahui Zhou, Ping Zhou
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Patent number: 6310066Abstract: The present invention provides novel compounds of the general formula: wherein R1 and R2 are H, OH, F, Cl, Br, I, 1 to 6 carbon alkyl or alkenyl, 1 to 6 carbon alkoxy, aryl, OR5, nitro, amino, CF3 or R1 and R2 are taken together to form a fused ring at the 2,3- or 3,4-positions providing a fused phenyl group or a benzodioxane group, or a 4- or 7-substituted indole group, or a 4- or 5- or 8-substituted quinoline group; R3 represents a group selected from hydrogen, a 1 to 6 carbon alkyl, a 1 to 4 carbon alkoxy or a halogen; R4 represents a group selected from hydrogen, 1 to 6 carbon alkyl or R5; R5 is CH2Ph in which the phenyl ring can be optionally substituted by a group selected from OMe, halogen, CF3; X is selected from a group represented by N, CR4, CHR4 and CHCH; A is selected from a group represented by N, NH, CH and CH2; B is selected from a group represented by ═O, ═S, H and H2; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and mType: GrantFiled: February 16, 2000Date of Patent: October 30, 2001Assignee: American Home Products Corp.Inventors: Michael G. Kelly, Young H. Kang
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Patent number: 6291683Abstract: Compounds useful for alleviating symptoms of depression are provided which have the following formula: wherein: R1 is hydrogen, lower alkyl or aryl; R2 is hydrogen, lower alkyl, phenyl or substituted phenyl; X and Y are each, independently, hydrogen, lower alkyl, lower alkoxy, or halogen, or together combine with the carbon atoms to which they are attached to complete a cyclopentyl, cyclohexyl, phenyl, pyrrolyl, pyranyl, pyridinyl, dihydrofuranyl, furanyl, dioxanyl, oxazolyl or isoxazolyl group; Z is hydrogen, halogen or lower alkoxy; with the proviso that when X, Y or Z represent lower alkoxy, they are not present at the ortho position; W is hydrogen, halogen, lower alkyl, cyano or a trifluoromethyl group; and n is 2-5; or pharmaceutically acceptable salts thereof.Type: GrantFiled: June 13, 2000Date of Patent: September 18, 2001Assignee: American Home Products CorpInventors: Richard E. Mewshaw, Dahui Zhou
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Patent number: 6288011Abstract: Pesticidal 1,4-diaryl-2,3-difluoro-2-butene compounds having the structural formula I and compositions and methods comprising those compounds for the control of insect and acarid pests.Type: GrantFiled: November 11, 1998Date of Patent: September 11, 2001Assignee: American Cyanamid Co.Inventors: Terence James Bentley, Keith Douglas Barnes
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Patent number: 6245780Abstract: Compounds are provided which have the formula: wherein: R1, R2, R3, and R4 are, independently, hydrogen, halogen, alkoxy, or carboxamide; R5 is hydrogen, halogen, CF3, CN, carbamide or alkoxy; and X is (CH2)n or a 4-6 membered carbocyclic ring, wherein n is an integer of 2 to 4; or pharmaceutically acceptable salts thereof.Type: GrantFiled: April 17, 2000Date of Patent: June 12, 2001Assignee: American Home Products CorpInventors: Richard E. Mewshaw, Kristin L. Meagher
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Patent number: 6245799Abstract: This invention provides novel compounds and pharmaceutical compositions and methods of using the compounds in the treatment of central nervous system disorders, such as anxiety and depression, the compounds having the formula I: wherein: X is N—R, O, S(O)m; m is 0 to 2; n is 0 to 4; Ar is an aryl group of 6 to 12 carbon atoms optionally substituted with 1 to 3 R3 groups, or a heteroaryl group of 4 to 10 carbon atoms optionally substituted with 1 to 3 R3 groups; R and R2 are independently H, straight chain alkyl of 1 to 6 carbon atoms, branched alkyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, alkoxycarbonyl of 1 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon atoms, aminocarbonyl, or alkylaminocarbonyl of 1 to 4 carbon atoms; R1 and R3 are independently H, straight chain alkyl of 1 to 4 carbon atoms, branched alkyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, halo, alkoxy group of 1 to 4 carbon atoms, haloalkyl of 1 to 4 carbon atoms, OH, nitro, amino,Type: GrantFiled: November 6, 2000Date of Patent: June 12, 2001Assignee: American Home Products CorpInventors: Magda Asselin, John W. Ellingboe, Richard E. Mewshaw
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Patent number: 6239134Abstract: The present invention provides compounds of the general formula (1): wherein: two atoms of X, Y, or Z are nitrogen and the third atom is sulfur or oxygen; R is H, halogen, OH, SH, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, phenoxy, thiophenoxy, phenyl or substituted phenyl; A is C, CH, or N; R1 is aryl, heteroaryl, or cycloalkyl groups, optionally substituted by from 1 to 3 substituents selected from C1-C6 alkyl, C1-C6 alkoxy; CF3, Cl, Br, F, CN, or CO2CH3; R2is H or alkyl R3 is C1-C6 alkyl, optionally substituted aryl, optionally substituted 5- or 6-membered heteroaryl, C3 to C8 cycloalkyl optionally substituted by C1-C6 alkyl, or a 3 to 8-membered heterocyclic ring containing one or more heteroatoms selected from O, S or N; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods of treating central nervous system disorders using these compounds.Type: GrantFiled: February 25, 2000Date of Patent: May 29, 2001Assignee: American Home Products Corp.Inventors: Annmarie L. Sabb, Robert L. Vogel, Michael G. Kelly, Yvette L. Palmer, Wayne E. Childers
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Patent number: 6235754Abstract: The present invention relates to methods and compositions for treating animals and humans, and for controlling, preventing and protecting animals and humans from infestation and infection by arthropod and helminth parasites by administering or applying to the animals, humans or their environment a 1,4-diaryl-2-fluoro-2-butene or 1,4-diaryl-2,3-difluoro-2-butene compound having the structural formulaType: GrantFiled: January 22, 1999Date of Patent: May 22, 2001Assignee: American Cyanamid CompanyInventors: David Wesley Watson, Kathleen Heaney, Kurt Schwinghammer
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Patent number: 6228880Abstract: Compounds having dopaminegic activity are provided, having the formula: wherein R1 and R2 are each, independently, hydrogen, C1-10 alkyl, or (CH2)mR4, wherein R4 is phenyl or naphthyl which may be substituted by one or two substituents selected from the group consisting of C1-6 alkyl, halogen, C1-6 alkoxide and trifluoromethyl and m is 1 to 5; and R3 is hydrogen or C1-6 alkyl; or pharmaceutically acceptable salts thereof.Type: GrantFiled: April 7, 1999Date of Patent: May 8, 2001Assignee: American Home Products CorpInventors: James A. Nelson, Mira A. Kanzelberger, Richard E. Mewshaw
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Patent number: 6204269Abstract: The novel optically active compounds of formula I: (R1, Hal and L1 through L5 are defined in the specification) wherein the enantiomeric excess of the (S)-enantiomer is at least 70%., show enhanced selective fungicidal activity. The new compounds are processed with carriers, and optionally with adjuvants, to form fungicidal compositions.Type: GrantFiled: September 24, 1999Date of Patent: March 20, 2001Assignee: American Cyanamid Co.Inventors: Waldemar Pfrengle, Klaus-Juergen Pees, Guido Albert, Paul Carter, Annerose Rehnig, Henry Van Tuyl Cotter
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Patent number: 6200994Abstract: Compounds useful for the treatment of disorders of the serotonin-affected neurological systems are provided which have the following formula: wherein: X is carbon or nitrogen; R1 and R2 are each, independently, hydrogen, halogen, CF3, alkyl, alkoxy, or MeSO24; R3 is hydrogen, halogen, or alkyl; R4 is hydrogen, alkyl, alkylaryl, or aryl; and R5 is hydrogen, halogen, CF3, CN, carbamide, or alkoxy; or pharmaceutically acceptable salts thereof.Type: GrantFiled: December 30, 1999Date of Patent: March 13, 2001Assignee: American Home Products CorpInventors: Richard E. Mewshaw, Reinhardt B. Baudy