Patents Represented by Attorney Julian S. Levitt
  • Patent number: 4264735
    Abstract: The antibiotic MSD 890A.sub.9 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotic 890A.sub.9) is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: September 10, 1979
    Date of Patent: April 28, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Patrick J. Cassidy, Sheldon B. Zimmerman, Josefino B. Tunac, Sebastian Hernandez
  • Patent number: 4264734
    Abstract: This invention relates to the new antibiotic, desacetyl 890A.sub.10, active against both gram-positive and gram-negative bacteria, which is produced by treating 890A.sub.10 with an N-acetyl-890A.sub.10 amidohydrolase produced by a soil microorganism isolated by enrichment techniques. This invention also relates to the process by which 890A.sub.10 is enzymatically deacetylated.
    Type: Grant
    Filed: September 11, 1979
    Date of Patent: April 28, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan
  • Patent number: 4264621
    Abstract: Antibiotic 5-substituted-3-(2-aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3 .2.0]hept-2-ene-2-carboxylic acids (I) are disclosed: ##STR1## wherein R is alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or heteroaryl.
    Type: Grant
    Filed: July 25, 1979
    Date of Patent: April 28, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, David B. R. Johnston, Susan M. Schmitt
  • Patent number: 4263399
    Abstract: A novel process is described for making a low calcium xanthan gum exhibiting smooth flow properties which comprises the use of high levels of phosphate in the fermentation medium.
    Type: Grant
    Filed: May 31, 1979
    Date of Patent: April 21, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Empey, Jurgen G. Dominik
  • Patent number: 4263207
    Abstract: Novel dibenzo[b,f][1,4]thiazepine derivatives are employed in the treatment and control of allergic conditions such as allergic asthma.
    Type: Grant
    Filed: August 1, 1978
    Date of Patent: April 21, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Joshua Rokach, Edward J. Cragoe, Jr., Clarence S. Rooney
  • Patent number: 4263306
    Abstract: This invention relates to a new class of antibiotics (I): ##STR1## wherein the stylized radical (hereafter referred to as R'): ##STR2## attached to the 3-amino nitrogen of nocardicin represents a mono- or polycyclic N-containing heterocyclic group; R is, inter alia, hydrogen, substituted and unsubstituted: alkyl, aryl, alkenyl, heterocyclylalkyl, heterocyclylalkenyl, aralkenyl, aralkyl, --NR.sub.2, COOR, CONR.sub.2, --OR, or CN.
    Type: Grant
    Filed: August 1, 1979
    Date of Patent: April 21, 1981
    Assignee: Merck & Co., Inc.
    Inventor: John Hannah
  • Patent number: 4262009
    Abstract: Disclosed are 6- and 1-substituted-1-carbadethiapen-2-em-3-carboxylic acids I of the following structure: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are, inter alia, independently selected from the group consisting of alkyl, aryl, and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: December 3, 1979
    Date of Patent: April 14, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, David H. Shih
  • Patent number: 4262011
    Abstract: Disclosed are 1-substituted-pen-2-em-3-carboxylic acids (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics; such compounds are prepared by total synthesis. ##STR1## wherein R.sup.1 and R.sup.2 are, inter alia, substituted and unsubstituted alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, and spirocycloalkyl.
    Type: Grant
    Filed: December 3, 1979
    Date of Patent: April 14, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, David H. Shih
  • Patent number: 4262010
    Abstract: Disclosed are 1-substituted-6-(1-hydroxyethyl)-2-(2-aminoethylthio)-1-carbadethiapen-2-e m-3-carboxylic acids (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics; such compounds are prepared by total synthesis. ##STR1## wherein R.sup.1 and R.sup.2 are, inter alia, substituted and unsubstituted alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl and the spiro substituent formed by the joinder of R.sup.1 and R.sup.2.
    Type: Grant
    Filed: December 3, 1979
    Date of Patent: April 14, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, David H. Shih
  • Patent number: 4261975
    Abstract: The outer membrane of influenza virus is attached to a liposome by two different techniques. In addition, one of the techniques allows the entrapment of intact virus, usually one virus per liposome. The techniques can be performed with either influenza virus A or B.
    Type: Grant
    Filed: September 19, 1979
    Date of Patent: April 14, 1981
    Assignee: Merck & Co., Inc.
    Inventors: W. Wardle Fullerton, Bohdan Wolanski
  • Patent number: 4262002
    Abstract: There is disclosed a new antibiotic agent, A73A, produced by Streptomyces viridifaciens MA-4864 (ATCC 31495) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.
    Type: Grant
    Filed: June 22, 1979
    Date of Patent: April 14, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Ray S. Dewey, James E. Flor, Sheldon B. Zimmerman, Patrick J. Cassidy, Satoshi Omura, Ruiko Oiwa
  • Patent number: 4260543
    Abstract: Disclosed is crystalline N-formimidoyl thienamycin and a process for its preparation.
    Type: Grant
    Filed: April 30, 1979
    Date of Patent: April 7, 1981
    Assignee: Merck & Co., Inc.
    Inventor: Thomas W. Miller
  • Patent number: 4260618
    Abstract: Disclosed are 6-(1'-hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acids of the following structure: ##STR1## wherein R is, inter alia, hydrogen, --OR, --SR, --NR.sub.2, alkyl, aryl, aralkyl, or heterocylcyl; n is 0 or 1; when n=1 R is as defined but not --SR. Such compounds and their pharmaceutically acceptable salt and ester derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: October 10, 1978
    Date of Patent: April 7, 1981
    Assignee: Merck & Co., Inc.
    Inventor: Burton G. Christensen
  • Patent number: 4260741
    Abstract: A form of xanthan gum is disclosed which is less dense than regular xanthan gum and which exhibits an increased hydration rate.
    Type: Grant
    Filed: June 22, 1979
    Date of Patent: April 7, 1981
    Assignee: Merck & Co., Inc.
    Inventor: Harry R. Schuppner, Jr.
  • Patent number: 4260627
    Abstract: Disclosed are 1-, 6- and 2-substituted-1-carba-2-penem-3-carboxylic acids of the following structure: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, aryl, and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: October 24, 1978
    Date of Patent: April 7, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, David H. Shih
  • Patent number: 4260760
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: March 12, 1979
    Date of Patent: April 7, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Patent number: 4259451
    Abstract: A pure culture of a varient strain of A. radiobacter is disclosed.
    Type: Grant
    Filed: June 20, 1980
    Date of Patent: March 31, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Suzanna M. Steenbergen, Kevin M. Young
  • Patent number: 4259477
    Abstract: Cellulase in xanthan gum can be completely destroyed by treating xanthan gum beer with about 0.08 to 0.1% alkali metal hypochlorite followed by heat treatment.
    Type: Grant
    Filed: June 4, 1979
    Date of Patent: March 31, 1981
    Assignee: Merck & Co., Inc.
    Inventor: Kang, Kenneth S.
  • Patent number: 4259324
    Abstract: Compounds of the formulae Y--R wherein Y is 1-thio-.beta.-L-fucose, 1-thio-.beta.-D-galactose or 1-thio-.beta.-lactose and R is 2-(1-adamantyl)ethyl, 3-[(p-tetrafluorophenethyl)phenyl]propyl, 6-(5-cholesten-3.beta.-yloxy)hex-3-ynl, oleyl, or hexadecyl are useful immunologic adjuvants in vaccines.
    Type: Grant
    Filed: July 31, 1979
    Date of Patent: March 31, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Mitree M. Ponpipom, Tsung-Ying Shen, Robert L. Bugianesi
  • Patent number: 4258040
    Abstract: Novel cephalosporin compounds having a 3'-.alpha.-methyl, a 3-aryl or 3-heterocycle substituent are prepared by total synthesis. The novel cephalosporin compounds are active against gram-negative and gram-positive microorganisms.
    Type: Grant
    Filed: May 4, 1978
    Date of Patent: March 24, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Ronald W. Ratcliffe