Patents Represented by Attorney, Agent or Law Firm Julie K. Smith
  • Polypeptides having NMDA receptor activity, nucleic acids encoding those polypeptides and applications
    Patent number: 5648259
    Abstract: The present invention concerns novel polypeptides having NMDA receptor activity and genetic material permitting their expression. It also concerns a method for demonstrating and isolating ligands and/or modulators of the activity of these polypeptides and their utilization as drugs.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: July 15, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jacques Mallet, Tania Smirnova
  • Method for producing recombinant proteins and host cells used therein
    Patent number: 5633146
    Abstract: Novel genetically engineered yeast strains of genus Kluyveromyces lactis, their preparation, and the use thereof for producing recombinant proteins, are described.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: May 27, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Reinhard Fleer, Alain Fournier, Patrice Yeh
  • K. lactis RP28 ribosomal protein gene promoter and use thereof
    Patent number: 5627049
    Abstract: The present invention concerns DNA sequences comprising all or part of the K.lactis RP28 ribosomal protein promoter gene or a derivative thereof, and having transcriptional promoter activity. The invention also relates to the use of said sequences for the expression of recombinant genes.
    Type: Grant
    Filed: February 1, 1995
    Date of Patent: May 6, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Sandrine Menart, Monique Bolotin
  • Yeast promoter and its use
    Patent number: 5627046
    Abstract: DNA sequences comprising all or part of the ADH4 gene promoter of K. lactis or a derivative of the latter, and having transcriptional promoter activity. The invention also concerns the use of said sequences for the expression of recombined genes.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: May 6, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Claudio Falcone, Reinhard Fleer, Michele Saliola
  • K. lactis transaldolase gene promoter and use thereof
    Patent number: 5616474
    Abstract: The present invention relates to DNA sequences comprising all or part of the K. lactis TAL1 gene promoter or of a derivative thereof and having a transcriptional promoter activity. It also relates to the use of these sequences for expression of recombinant genes.
    Type: Grant
    Filed: February 1, 1995
    Date of Patent: April 1, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Monique Bolotin, Sandrine Menart
  • Human serun albumin, preparation and use
    Patent number: 5612196
    Abstract: The present invention relates to a preparation of serum-human albumin having a colorimetry index lower than 0.2 resulting from the expression, in a eukaryotic or prokaryotic host, of an exogenous DNA sequence.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: March 18, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: J er ome Becquart, Reinhard Fleer, G erard Jung
  • Expression cloning of c-src SH3-domain binding proteins
    Patent number: 5541109
    Abstract: This invention provides a unique SH3 binding domain core motif of the sequence RPLPXXP and cDNA clones encoding proteins which interact with the SH3 domain of c-src, as well as the amino acid sequences which mediate this binding.Another embodiment of this invention is a method of identifying SH3-binding proteins and elucidating the sequences which mediate binding. This method may be used as an assay to select compounds which bind to this site and which inhibit or enhance the binding of the SH3 domain.
    Type: Grant
    Filed: April 19, 1994
    Date of Patent: July 30, 1996
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: George H. Searfoss, III, Yuri D. Ivashchenko, Michael C. Jaye, Victoria J. South, Stephen M. French, Christopher Cheadle, George A. Ricca
  • Phosphonate derivatives of lipophilic amines
    Patent number: 5441946
    Abstract: This invention relates to a class of novel phosphonate derivatives of lipophilic amines which exhibit squalene synthase inhibition properties. More specifically the compounds are bis aryl cycloalkylamino and azacycloalkyl phosphonates. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
    Type: Grant
    Filed: April 14, 1994
    Date of Patent: August 15, 1995
    Assignee: Rhone-Poulenc-Rorer Pharmaceuticals, Inc.
    Inventors: Henry W. Pauls, Yong-Mi Choi, Dilip V. Amin