Patents Represented by Attorney Kazuyuki Yamasaki
  • Patent number: 5360770
    Abstract: A glass composition, containing barium oxide, which provides a source of leachable fluoride and which can be incorporated into a dental cement composition which, when cured, is radiopaque and translucent.
    Type: Grant
    Filed: January 7, 1992
    Date of Patent: November 1, 1994
    Assignee: Den-Mat Corporation
    Inventor: Thomas C. Chadwick
  • Patent number: 5288763
    Abstract: Porous, polymer particles comprising a functionalized cross-linked copolymer having microporous regions and macroporous regions in the polymer matrix thereof, wherein the functional groups are essentially present only within the macroporous regions, as well as processes for preparing these particles based on a template polymerization technique followed by removal of the template polymer from the particles are disclosed. The particles of the invention are useful in chromatography, and in various analytical, diagnostic techniques and solid state peptide, DNA synthesis.
    Type: Grant
    Filed: December 23, 1992
    Date of Patent: February 22, 1994
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Nai-Hong Li, Kam W. Leong
  • Patent number: 5281583
    Abstract: An analgesic composition comprising an effective amount of at least one member of LPS whose macrophage activation ED.sub.50 is 0.
    Type: Grant
    Filed: August 22, 1991
    Date of Patent: January 25, 1994
    Assignees: Den'Ichi Mizuno, Gen-Ichiro Soma
    Inventors: Gen-Ichiro Soma, Kiyoshi Yoshimura, Daisuke Tsukioka, Den'Ichi Mizuno, Haruyuki Oshima
  • Patent number: 5274137
    Abstract: A taxol intermediate selected from the group consisting of: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each selected from hydrogen, hydroxyl, or a protected hydroxyl; or R.sup.1 and R.sup.2 together form an oxo or a protected oxo; R.sup.3 is formyl, a protected formyl, or --CH(X)--OY wherein X is hydrogen or a monovalent metal and Y is hydrogen or a hydroxyl protecting group; and R.sup.4 and R.sup.5 are different and each selected from chloro or cyano; or R.sup.4 and R.sup.5 together form an oxo or a protected oxo, with the proviso that R.sup.1 and R.sup.2 are not both hydroxyl; R.sup.6 is hydroxyl or a protected hydroxyl; R.sup.7 is hydrogen, hydroxyl, or a protected hydroxyl; R.sup.8 is carboxyl, hydroxylmethyl, or a protected hydroxylmethyl; or R.sup.7 and R.sup.8 when taken together with carbon atoms 3 and 4, form an oxetane ring; or R.sup.6 and R.sup.8 when taken together with carbon atoms 1 and 4, form a bridged lactone; R.sup.9 is hydrogen or a hydroxyl protecting group; R.sup.
    Type: Grant
    Filed: June 23, 1992
    Date of Patent: December 28, 1993
    Inventors: K. C. Nicolaou, Chan-Kou Hwang, Erik J. Sorensen, Jin-Jun Liu