Abstract: A method of measuring the gas flow of an incondensable gas in a flowing mixture of said incondensable gas and a condensable gas comprising the steps of calibrating a leak detector; injecting a known quantity of gauge gas at a known mass flow rate into said flowing mixture of gases; drawing a sample of the said gauge mix off at a sample point; passing said sample through a condenser so as to remove said condensable gas from the gauge mix, resulting in a test mix; passing the said test mix into the leak detector so as to measure the concentration of the gauge gas within the test mix; and calculating the mass flow rate of said incondensable gas within said flowing mixture. There is also provided a method of measuring the rate of ingress of an incondensable gas at an ingress point along a flow path of a flowing mixture of said incondensable gas and a condensable gas.

Abstract: A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated measurements of the ventricular system by MRI scans using quantitative anatomical protocols, determining a measurement of biomarker levels in CSF that has been extracted, correcting the measurement of the level of said at least one biomarker'according to the ventricular size, and providing a corrected result of the measurement determined in step (b), said corrected result accounting for concentration dilution due to the change in ventricular size. The method is particularly suited for the measurement of all biomarkers found in the CSF, such as those associated with mild cognitive impairment (MCI) and Alzheimer's Disease.

Abstract: The system has special application in the manufacture of aircraft wing covers (10 made of carbon fiber and the stringers (3) cured jointly with the wing cover during the polymerization in autoclave. The tool pieces (4) being used are defined by angular elements (5, 6) copying the geometry of the stringers (3). The shape of these stringers corresponds to the “T” section. The angular elements (5, 6) comprise, in their upper part, a pair of battlements (7) in order to be caught by part of the clamps (9) of a head (10) linked to a robot (11) of the spherical type with articulated arm with six axes. The angular elements (5, 6) are made of INVAR material and they are used to keep in position the stringers during the curing cycle in the autoclave.

Abstract: A method of treating tuberculosis comprising administering an aerosolized interferon such as interferon ?, interferon ? or interferon ? in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) are provided.

Abstract: Methods, compositions and articles of manufacture useful for the treatment of various Group B streptococci (GBS) bacteria using various lysins, including certain PlyGBS mutant lysins, are provided.

Abstract: A method of treating tuberculosis comprising administering an aerosolized interferon such as interferon ?, interferon ? or interferon ? in a therapeutically effective amount is provided herein. Further, a method of reducing the infectivity of tuberculosis or reducing the number of infectious organisms present in the lungs of a patient suffering from tuberculosis comprising administering an aerosolized interferon such as interferon ?, interferon ? or interferon ? in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) are provided.

Abstract: A method and apparatus for practicing the method are provided for separating droplets of finely aerosolized elemental mercury from a gaseous stream in which the droplets are dispersed. In the method a gold plated metallic capillary surface is contacted with the gaseous stream, causing the aerosolized droplets to deposit on the capillary surface and by capillary action to coalesce with other of such droplets to form increasingly large drops of mercury. The surface is oriented to allow the mercury to flow by gravitational forces and capillary action to the lowermost portions of the surface, at which it accumulates, and is then collected at a suitable vessel.

Abstract: A method of treating a pulmonary disease such as, for instance idiophathic pulmonary fibrosis (IPF), mixed connective tissue disease and asthma, comprising administering an aerosolized interferon such as interferon ? in a therapeutically effective amount is provided herein. Also, pharmaceutical compositions of one or more aerosolized interferon(s) alone or in combination with other therapeutic agents are provided.

Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Abstract: The present invention relates to the use of Rspondins, particularly Rspondin2 (Rspo2) or Rspondin3 (Rspo3) or Rspondin nucleic acids, or regulators or effectors or modulators of Rspondin, e.g. Rspo2 and/or Rspo3 to promote or inhibit angiogenesis and/or vasculogenesis, respectively. The invention is based on the demonstration that Rspo3 and Rspo2 are angiogenesis promoters, and the identification of Rspo2 and 3 as positive regulators of vascular endothelial growth factor (VEGF). These results indicate a major role for Rspondins, particularly Rspo3 and/or Rspo2 in the signaling system during angiogenesis. The invention also relates to the use of regulators or effectors or modulators of Rspondin3, including agonists and antagonists, in the treatment of conditions where treatment involves inhibiting or promoting angiogenesis and/or vasculogenesis.

Abstract: A novel compound able to inhibit JAK is disclosed, that comprises a compound according to Formula I: or a pharmaceutically acceptable salt thereof. The compound may be prepared as a pharmaceutical composition, and may be used for the treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.

Abstract: A dispersion apparatus for dispersing a treating agent into a fluid treatment system that includes a flow duct in which a fluid stream flowing through the duct is mixed with the treating agent. The apparatus is based on a multi-pipe lance positioned in the stream flow, where each pipe supplies a minimum of feed discharge nozzles (typically one to four), and the individual pipes branch off from the same location. Use of the multi-pipe lance, in combination with a suitable baffle, results in better overall dispersion/distribution of the injected medium by surface area. By improving the surface area distribution, better utilization of the injected sorbent can be achieved. The baffle acts to generate a low pressure zone on its downstream side and creates a high-intensity turbulence plume in the fluid. The orifices of the pipe are located to inject the treating agent into the turbulence plume to better distribute and intermix the injected treating agent into the surrounding fluid.

Abstract: The present invention provides new polypeptides. Said polypeptides are of use in the screening, diagnosis and prognosis of B-cell non-Hodgkin's lymphoma, breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute T-cell leukaemia), melanoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer and renal cell cancer, in monitoring the effectiveness of B-cell non-Hodgkin's lymphoma, breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute T-cell leukaemia), melanoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer and renal cell cancer treatment, and in drug development. Also provided are antibodies (and other affinity reagents such as Affibodies) which interact with or modulate the expression or activity of the polypeptides.

Abstract: A sealing member for sealing over a structural joint or compound expansion joint. The sealing member has an elastomeric portion to overlie the lines of the joint and an adhesive receiving region to the sides of the elastomeric portion. The adhesive receiving region is adapted to be adhered to material adjacent to the structural joint. The elastomeric portion extends along each line of the structural joint in use to allow relative movement along each joint to be absorbed by the elastomeric portion.

Abstract: Fused heterocyclic compounds are provided according to formula 1: where R1, R2, R3, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

Abstract: Sequences are provided that are capable of directing circular adeno-associated virus replication, useful in vectors for providing therapeutic agents to a subject in need thereof. The vectors of the invention are particularly useful in the treatment of acute medical conditions requiring rapid gene expression. Further provided are methods for producing packaged defective viral vectors.