Patents Represented by Attorney Klauber & Jackson
  • Patent number: 8227200
    Abstract: The present invention relates to a composition useful for the diagnosis and therapy of diseases associated with aberrant expression of the gene encoding the receptor Kremen 1 and/or Kremen 2 e.g. tumors or diseases of the kidneys, bones and eyes, lipid and glucose metabolism and obesity. The present invention also relates to a pharmaceutical composition containing a compound which is capable of modifying (a) the expression of the gene encoding Kremen 1 and/or Kremen 2 or (b) the activity of the Kremen 1 and/or Kremen 2 receptor.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: July 24, 2012
    Assignee: Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts
    Inventors: Christof Niehrs, Bingyu Mao
  • Patent number: 8208825
    Abstract: An electrostatographic printing machine has a liquid toner supply chain incorporating at least a toner supply device (10), a metering roller (21) and a development member (31) and an image carrying member (41). An electrostatic charging device (33) acts onto the development member to impress an electrostatic charge onto the development member and to induce a voltage thereon with respect to a machine electrical common earth potential. The toner supply roller, the metering roller and the developer member are each electrically connected to the machine electrical common earth potential (37) via a respective voltage regulating or controlling means (25, 27, 35) to regulate or control induced voltages on each of the toner supply roller, the metering roller and the developer member.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: June 26, 2012
    Assignee: Xeikon IP BV
    Inventor: Minghua Mao
  • Patent number: 8188238
    Abstract: An antibody capable of potentiating immune responses and modifying existing states of immune responsiveness is described, as is the sequence of the antibody. Also described are compositions containing the antibody, as well as methods for using the antibody and the compositions to enhance immune responses, to enhance DC function, to modify an existing state of immune responsiveness, to immunize individuals, or to treat or inhibit conditions such as allergic asthma.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: May 29, 2012
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Larry R Pease, Virginia Van Keulen, Bogoljub Ciric
  • Patent number: 8186621
    Abstract: The invention relates to an assembly between a front fitting and the traction coupling of the two lateral boxes of the horizontal stabilizer of an aircraft comprising a front fitting (1, 1a and 1b), a front shear plate (2), an upper shear plate (4), a lower shear plate (5) and a “rib post” union piece (3) in such a way that the loads being transferred to the lateral boxes are minimized, and at the same time it allows a proper trimming of the horizontal stabilizer. Moreover, the present invention describes a compact front fitting, made of one piece, as a whole, and in composite material.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: May 29, 2012
    Assignee: Airbus Operations S.L.
    Inventor: Carlos García Manzano
  • Patent number: 8183435
    Abstract: The present invention relates to improved cultivars, varieties, lines or plants of annual medics (Medicago genus) wherein the majority of seed pods, upon reaching maturity, remain attached to their respective pedicels. In particular, the present invention relates to improved cultivars, varieties, lines or plants of annual medics (Medicago genus), having a mutant form of the gene for pod shedding, thereby resulting in a “pod holding” trait. The invention also extends to methods for isolating such plants. A yet further aspect of the invention relates to a method of transferring the “pod holding” trait from an annual medic having this trait to another annual medic of the genus Medicago by a process of controlled cross-breeding. A still further aspect of the invention relates to a method of obtaining plants having the “pod holding” trait from a population of annual medics of the genus Medicago.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: May 22, 2012
    Assignee: Pristine Forage Technologies Pty Ltd
    Inventors: Andrew Wylde Hingston Lake, Rickie Elizabeth Drewry
  • Patent number: 8183040
    Abstract: The present invention is directed to an in vitro method for promoting differentiation and proliferation of human T helper lymphocytes that express IL17 (Th-IL17+ cells). The instant method may be used to generate a population of human T helper lymphocytes that express IL17 (Th-IL17+ cells) in vitro. Methods for screening to identify agents capable of modulating Th-IL17+ cell differentiation are also encompassed by the present invention. Isolated, pure populations of homogeneous Th-IL17+ cells that do not express cellular markers characteristic of Th1, Th2, or Treg cells are also encompassed herein.
    Type: Grant
    Filed: April 15, 2009
    Date of Patent: May 22, 2012
    Assignee: New York University
    Inventors: Nicolas Manel, Dan R. Littman
  • Patent number: 8183249
    Abstract: The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or killing a cancer cell or other cell in which expression of an Akt protein is elevated or constitutively active, comprising contacting the cell with an effective amount of a compound of formula I. The subject invention also concerns methods for treating cancer or a tumor in a person or animal comprising administering all effective amount of a compound of formula I to the person or animal.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: May 22, 2012
    Assignee: University of South Florida
    Inventors: Jin Q. Cheng, Mei Sun, Said M. Sebti
  • Patent number: 8183225
    Abstract: The invention provides methods and compositions for reducing or inhibiting bone resorption, osteoclast differentiation and stimulation and the loosening of medical prostheses by administering a compound or agent that modulates an adenosine receptor such as the adenosine A2A receptor, in particular, an agonist of an adenosine A2A receptor. The invention also extends to pharmaceutical compositions comprising such an agent that modulates an adenosine receptor such as an adenosine A2A agonist and to prosthetic devices containing such an agent that modulates an adenosine receptor such as an A2A agonist on one or more surfaces or within the prosthetic device such as, for example, suspended in the cement forming the prosthetic device.
    Type: Grant
    Filed: November 10, 2008
    Date of Patent: May 22, 2012
    Assignee: New York University
    Inventors: Bruce N. Cronstein, Zhong Sheng Peng
  • Patent number: 8182372
    Abstract: The present invention provides a device designed to increase the accuracy of both the throwing, bouncing, propelling by stick and kicking of a baseball, football, lacrosse ball or soccer ball. The apparatus is constructed of a frame, for example of aluminum tubing. A net is attached to or hung over the aluminum tubing to provide a series of pouches aligned horizontally at various heights. These pouches provide target areas for a ball. The pouches may be designed to allow the ball to drop from a pouch it enters into a second pouch or to the bottom of the device for easy removal. The device is held by a base that may have wheels and may be steadied by one or more transverse supports running across the bottom or the back of the base.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: May 22, 2012
    Inventor: Bernard Hayes
  • Patent number: 8178084
    Abstract: A method of treating a natural soft skeletal tissue injury in a patient the method comprising administering to the patient a composition of mesenchymal stem cells in liquid suspension enriched compared to the natural source of said cells, or tenocytes derived therefrom. The method is particularly suited to the regeneration of tendons in competitive mammals, such as the superficial digital flexor tendon of the horse.
    Type: Grant
    Filed: September 8, 2003
    Date of Patent: May 15, 2012
    Assignee: Quy Biosciences Limited
    Inventors: Roger Kenneth Whealands Smith, Kenneth Gregory McGarrell, Allen Edward Goodship, Gordon William Blunn
  • Patent number: 8168667
    Abstract: Compounds of formula (I): wherein X is O or S, R1 is acyl, aldehyde, cycloalkyl, an optionally substituted alkyl, alkenyl or alkynyl, R2 is H, alkyl, hydroxyalkyl, haloalkyl, alkenyl, or alkynyl; substituted alkyl; alkylcarbonyl; R3 and R4 are H, halogen, alkyl, alkenyl, alkynyl, alkoxyl, alkylthio, hydroxyalkyl, haloalkyl, haloalkenyl, or haloalkynyl; or R3 and R4 form an, optionally aromatic or heterocyclic, optionally substituted ring, R5 is H, halogen, trifluoromethyl, —CN, or —NO2; not all of R3, R4, and R5 being H, R6 and R9 are H, halogen, OH; alkyl, hydroxyalkyl, alkoxyl, thioalkyl, haloalkyl, alkenyl, or alkynyl; R7 and R8 are H, halogen, OH, SH; alkoxyl or alkylthio optionally substituted by OH and/or halogen; one of R7 and R8 not being H or halogen; or one of R7 and R8 is a pharmaceutically acceptable ester or thioester grouping, or R6 is C1-3-alkyl or, together with either R1 or R2, represents C1-3 alkylene or alkenylene linking group, optionally substituted by methyl, trifluoromethyl, OH, or
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: May 1, 2012
    Assignee: Galapagos NV
    Inventors: Francois Nique, Catherine Jagerschmidt, Philippe Clement-Lacroix
  • Patent number: 8163748
    Abstract: Novel s-triazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, where microbial infection is either a direct cause or a related condition.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: April 24, 2012
    Assignee: New York University
    Inventors: Neville Robert Kallenbach, Young-Tae Chang, Zhigang Liu, Chunhui Zhou, Jaeki Min
  • Patent number: 8163901
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: April 24, 2012
    Assignee: Evotec AG
    Inventors: Matthew Duncton, Donogh John Roger O'Mahony, Matthew Cox, Maria De Los Angeles Estiarte-Martinez
  • Patent number: 8153651
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: April 10, 2012
    Assignee: Evotec AG
    Inventors: Matthew Cox, Donogh John Roger O'Mahony, Maria De Los Angeles Estiarte-Martinez, Tadashi Kawashima, Satoshi Nagayama, Yuji Shishido, Hirotaka Tanaka, Matthew Alexander James Duncton, Andrew Antony Calabrese
  • Patent number: 8151970
    Abstract: The present improvement is useful for orienting and feeding blow molded preforms. Cylindrical preforms have larger threaded necks with larger encircling discs below the necks. A pair of belts is provided for conveying objects downstream. The gap between these belts is less than the disc diameter of the preforms. An output means is provided for receiving the oriented objects and directing them downstream. A means is provided at the output of the belts for deflecting any improperly oriented preforms back for recirculation. An increase in the feed rate of the preforms is achieved by an agitation means such as a blower positioned to disperse the interlocked assemblages and help move the preforms down into the belts.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: April 10, 2012
    Assignee: Norwalt Design Inc.
    Inventors: Walter McDonald, Norbert J. Seitel
  • Patent number: 8150241
    Abstract: The present invention relates to a baseboard heater guard or security device designed to shield the upper and front surfaces of a baseboard heater. The guard or security device comprises two or more vertical members that substantially follow the contour of the outside surface of the baseboard heater forming a frame around the heater. The vertical members comprise or are attached to a fixing member designed for attachment on the wall above the baseboard heater and a second fixing member designed for attachment at a second point on the floor. One or more first horizontal members are attached to the two or more vertical members near the top surface of the baseboard heater. One or more second horizontal members are attached to the two or more vertical members near the front surface of the baseboard heater.
    Type: Grant
    Filed: May 2, 2008
    Date of Patent: April 3, 2012
    Inventor: Eugene Michael Kretkowski
  • Patent number: D658947
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: May 8, 2012
    Assignee: Capital Products, LLC
    Inventors: Dean B. Chapman, Matthew L. Chin, Olivia Blechschmidt, David Lee
  • Patent number: D659911
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: May 15, 2012
    Inventor: Mario Zeppetzauer
  • Patent number: D661243
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: June 5, 2012
    Assignee: Nokian Tyres PLC
    Inventors: Jouni Raatikainen, Henri Kossi, Niko Haanketo
  • Patent number: D663524
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: July 17, 2012
    Assignee: Iittala Group Oy AB
    Inventor: Anu Penttinen