Patents Represented by Attorney, Agent or Law Firm Lauren L. Stevens
  • Motor proteins and methods for their use
    Patent number: 6387644
    Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: May 14, 2002
    Assignee: Cytokinetics, Inc.
    Inventor: Christophe Beraud
  • Nucleic acids encoding HSKIF21B, a kinesin motor protein
    Patent number: 6383796
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif21b, antibodies to HsKif21b, methods of screening for HsKif21b modulators using biologically active HsKif21b, and kits for screening for HsKif21b modulators.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: May 7, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Human kinesin-related protein HsKrp5
    Patent number: 6379941
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKrp5, antibodies to HsKrp5, methods of screening for HsKrp5 modulators using biologically active HsKrp5, and kits for screening for HsKrp5 modulators.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: April 30, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Motor proteins and method for their use
    Patent number: 6379912
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif15, antibodies to HsKif15, methods of screening for HsKif15 modulators using biologically active HsKif15, and kits for screening for HsKif15 modulators.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: April 30, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Roman Sakowicz, Kenneth W. Wood
  • Human kinesin-related protein HsKip3b
    Patent number: 6368841
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKip3b, antibodies to HsKip3b, methods of screening for HsKip3b modulators using biologically active HsKip3b, and kits for screening for HsKip3b modulators.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: April 9, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Human HSET motor proteins and methods for their use
    Patent number: 6361993
    Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: March 26, 2002
    Assignee: Cytokinetics Inc.
    Inventor: Christophe Beraud
  • Nucleic acids encoding Hskif16b, a kinesin motor protein
    Patent number: 6355471
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif16b, antibodies to HsKif16b, methods of screening for HsKif16b modulators using biologically active HsKif16b, and kits for screening for HsKif16b modulators.
    Type: Grant
    Filed: November 24, 2000
    Date of Patent: March 12, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Motor proteins and methods for their use
    Patent number: 6355466
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif15, antibodies to HsKif15, methods of screening for HsKif15 modulators using biologically active HsKif15, and kits for screening for HsKif15 modulators.
    Type: Grant
    Filed: May 17, 2000
    Date of Patent: March 12, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Roman Sakowicz, Kenneth W. Wood
  • Motor proteins and methods for their use
    Patent number: 6355447
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif9, antibodies to HsKif9, methods of screening for HsKif9 modulators using biologically active HsKif9, and kits for screening for HsKif9 modulators.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: March 12, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Motor proteins and methods for their use
    Patent number: 6346410
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif6, antibodies to HsKif6, methods of screening for HsKif6 modulators using biologically active HsKif6, and kits for screening for HsKif6 modulators.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: February 12, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Motor proteins and methods for their use
    Patent number: 6335189
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKifC2, antibodies to HsKifC2, methods of screening for HsKifC2 modulators using biologically active HsKifC2, and kits for screening for HsKifC2 modulators.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: January 1, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Motor proteins and methods for their use
    Patent number: 6333184
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif16a, antibodies to HsKif16a, methods of screening for HsKif16a modulators using biologically active HsKif16a, and kits for screening for HsKif16a modulators.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: December 25, 2001
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Motor proteins and methods for their use
    Patent number: 6331424
    Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: December 18, 2001
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Roman Sakowicz
  • Motor proteins and methods for their use
    Patent number: 6331430
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif9, antibodies to HsKif9, methods of screening for HsKif9 modulators using biologically active HsKif9, and kits for screening for HsKif9 modulators.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: December 18, 2001
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Motor proteins and methods for their use
    Patent number: 6294371
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKip3b, antibodies to HsKip3b, methods of screening for HsKip3b modulators using biologically active HsKip3b, and kits for screening for HsKip3b modulators.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: September 25, 2001
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Antifungal assay
    Patent number: 6284480
    Abstract: The present invention provides high throughput screening systems for identifying antifungal compounds. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: September 4, 2001
    Assignee: Cytokinetics, Inc.
    Inventors: Corey E. Nislow, Roman Sakowicz, Christophe Beraud
  • System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
    Patent number: 6168914
    Abstract: The invention provides a system and method for synthesizing chemicals onto supports in a parallel manner to produce a combinatorial collection of compounds. The system includes a plurality of middle plates, with each middle plate defining a plurality of reaction zones arranged in a two dimensional array. The reaction zones are adapted to receive a solid support, such as a sheet of membrane, and the middle plates are stackable on each other to form a three dimensional array of reaction zones. The system also includes a pair of end plates, where the middle plates are located between the end plates, and where the end plates include an array of fluid guides corresponding to the array of reaction zones, to allow for selective routing of reagents through the reaction zones.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: January 2, 2001
    Assignee: Glaxo Wellcome Inc.
    Inventors: David A. Campbell, Valery V. Antonenko, Harold E. Selick, Robert M. Gavin, Satoru Ida, Arthur H. Muir
  • Reaction vessel agitation apparatus
    Patent number: 6165778
    Abstract: A device and method for efficiently synthesizing diverse molecular products on substrates. A parent vessel 200 contains a suspension of substrates. The suspension is pressurized with argon and transferred to a plurality of reaction vessels 201-209 in one or more reaction vessel banks where monomer addition reactions take place. Optionally, the substrates may be tagged with a tag monomer. A vortexing motor 300 vortexes the contents of reaction vessels 201-209 during monomer addition reactions to enhance synthesis. After the desired monomer and/or tag monomer addition reaction, the suspension is pressurized with argon and transferred back to parent vessel 200 for mixing. Thereafter, the suspension may be pressurized with argon and reallocated among reaction vessels 201-209 for further synthesis.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: December 26, 2000
    Assignee: Affymax Technologies N.V.
    Inventor: Haim Kedar
  • Method of synthesizing diverse collections of oligomers
    Patent number: 6165717
    Abstract: A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligomer.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: December 26, 2000
    Assignee: Affymax Technologies N.V.
    Inventors: William J. Dower, Ronald W. Barrett, Mark A. Gallop
  • Peptide library and screening method
    Patent number: 6156511
    Abstract: A random peptide library constructed by transforming host cells with a collection of recombinant vectors that encode a fusion protein comprised of a DNA binding protein and a random peptide and also encode a binding site for the DNA. binding protein can be used to screen for novel ligands. The screening method results in the formation of a complex comprising the fusion protein bound to a receptor through the random peptide ligand and to the recombinant DNA vector through the DNA binding protein.
    Type: Grant
    Filed: January 21, 1998
    Date of Patent: December 5, 2000
    Assignee: Affymax Technologies N.V.
    Inventors: Peter J. Schatz, Millard G. Cull, Jeff F. Miller, Willem Peter Christiaan Stemmer, Christian M. Gates