Patents Represented by Attorney Law Office of Michael A. Sanzo, LLC
  • Patent number: 8342172
    Abstract: The present invention is directed to devices, systems, and methods for monitoring inhaled drug usage to predict when an acute attack or exacerbation of a disease, such as a respiratory disease, is imminent. Instrumented inhalers that use modular designs with standard components are disclosed, as are systems for monitoring the instrumented inhalers. Also disclosed are methods for determining whether or not a patient's inhaled drug usage pattern indicates that an acute attack or disease exacerbation is imminent, and notifying appropriate medical personnel of any usage patterns indicative of an attack or disease exacerbation. If such an attack or exacerbation is imminent, additional therapeutic agents may be dispensed to the patient or other interventions made.
    Type: Grant
    Filed: February 3, 2008
    Date of Patent: January 1, 2013
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Bruce D. Levy, Michael S. Singer
  • Patent number: 8304223
    Abstract: The invention relates to novel mutants of ?PLE, to vehicles containing the same and to their use in the production of enantiomer-enriched alcohols, carboxylic acids and esters.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: November 6, 2012
    Assignee: Enzymicals AG
    Inventors: Uwe Bornscheuer, Anke Hummel, Dominique Böttcher, Elke Brüsehaber, Kai Doderer, Harald Trauthwein
  • Patent number: 8277765
    Abstract: Process for recovering molybdate or tungstate from an aqueous solution, in which molybdate or tungstate is bound to a water-insoluble, cationized inorganic carrier material from the aqueous solution at a pH in the range from 2 to 6, the laden carrier material is separated off and the bound molybdate or tungstate is liberated once again into aqueous solution at a pH in the range from 6 to 14. The process is suitable for recovering molybdate or tungstate in the delignification of pulp with hydrogen peroxide in the presence of molybdate or tungstate as catalyst. The recovered molybdate or tungstate can be recycled to the delignification.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: October 2, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Thomas Dietz, Hans Ulrich Süss
  • Patent number: 8236274
    Abstract: The invention relates to a carbon black having an aggregate size distribution which has a (d90-d10)/d50 ratio of less than or equal to 1.1. The carbon blacks are produced by admixing hot air if desired to a gas mixture comprising a carrier gas and a carbon black feedstock, passing the gas mixture into a burner pipe, burning the gas mixture at the burner pipe openings, and drawing the flames under suction, together with the ambient air drawn in freely under suction from the outside, through a cooled, narrowing gap, and carrying out cooling, the cooled, narrowing gap having a height (h) to width (b) ratio of 1-100, the width (b) being 0.5 to 10 mm, and the flow rate at the narrowest point of the gap being 10-200 m/s. The carbon blacks of the invention can be used as non-reinforcing filler, reinforcing filler, UV stabilizer, conductive black, pigment or reducing agent.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: August 7, 2012
    Assignee: Evonik Carbon Black GmbH
    Inventors: Catharina Quitmann, Alfons Karl, Matthias Katzer, Kai Krauss, Michael Stanyschöfsky
  • Patent number: 8236941
    Abstract: The present invention is directed oncolytic Herpes simplex-1 viruses whose replication is controlled using a tetracycline operator/repressor system. The invention also includes DNA sequences used in making the viruses and methods in which these viruses are used in the treatment of cancer patients with solid tumors.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: August 7, 2012
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventor: Feng Yao
  • Patent number: 8177859
    Abstract: The present invention is directed to methods for flameproofing cellulose fibres and articles containing these fibres. The method involves treatment of materials with cyanuric chloride.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: May 15, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Manfred Schmidt, Stephanie Schauhoff, Frank Gähr
  • Patent number: 8173616
    Abstract: The invention is directed to RNA molecules that can be used to inhibit protein synthesis and to induce cells to undergo apoptosis. It also includes pharmaceutical compositions containing the RNAs that can be used in treating or preventing tumors; abnormal dermatological growths and viral infections.
    Type: Grant
    Filed: May 1, 2009
    Date of Patent: May 8, 2012
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Paul Anderson, Satoshi Yamasaki
  • Patent number: 8153404
    Abstract: The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: April 10, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Brigitte Bathe, Natalie Schischka, Georg Thierbach
  • Patent number: 8153576
    Abstract: Sodium percarbonate particles with a coating layer which comprises from 70 to 99.8% by weight of anhydrous sodium sulfate and from 0.2 to 20% by weight of a sodium borate, and whose proportion by weight is from 1 to 10% based on the mass of the sodium percarbonate particle, exhibit a high storage stability in detergent and cleaning composition formulations through a synergistic effect of sodium sulfate and sodium borate on the storage stability, and at the same time only have a small content of boron.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: April 10, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Stefan Leininger, Harald Jakob, Ralph Overdick
  • Patent number: 8148430
    Abstract: The present invention focuses on a process for the hydrogenation of aromatic or heteroaromatic compounds and in particular on the ring hydrogenation of compounds having the formula (I). Aromatic amino acids and amino alcohols can be successfully ring-hydrogenated using a platinum-rhodium mixed catalyst. The products can be used inter alia as mimetics in bioactive peptide active ingredients.
    Type: Grant
    Filed: June 19, 2004
    Date of Patent: April 3, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Rolf Hartung, Franz Hitzel-Zerrahn, Thomas Müller, Jörg Pietsch
  • Patent number: 8138365
    Abstract: The invention relates to a method for producing organosilanes of general formula I, [R(R)(R?O)Si—R?—]2Sm??I by reaction of (halo-organo)alkoxysilanes of formula II, [R(R)(R?O)Si—R?-Hal??II with a sulfuring reagent, selected from alkaline hydrogensulfide, alkaline sulfide Me2S, alkaline polysulfide Me2Sg and any combination thereof and optionally additionally with sulfur and/or with H2S in a solvent, the alkaline hydroxy content of all materials used being <0.44 wt. %.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: March 20, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Karsten Korth, Philipp Albert, Susann Witzsche, Ingo Kiefer, Jörg Kiefer, Stefan Lotter, Jaroslaw Monkiewicz, Jörg Schmidt
  • Patent number: 8133714
    Abstract: The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: March 13, 2012
    Assignees: Evonik Degussa GmbH, Forschungszentrum Jülich GmbH
    Inventors: Brigitte Bathe, Bastian Blombach, Bernhard Eikmanns, Verena Engels, Georg Thierbach, Volker Wendisch
  • Patent number: 8133857
    Abstract: The present invention is directed to methods of treating or preventing atherosclerosis and other cardiovascular diseases by administering agents that inhibit or modulate the NOTCH signaling pathway. In addition, the invention encompasses methods for assaying compounds for their ability to treat atherosclerosis based upon their effects on NOTCH signaling, and for measuring levels of amount, function, or activity of NOTCH pathway components in biological samples.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: March 13, 2012
    Assignee: The Brigham and Women's FHospital, Inc.
    Inventor: Masanori Aikawa
  • Patent number: 8128886
    Abstract: A reactor which comprises a vessel (1) with a vessel bottom (2), a stirrer (3) arranged in the vessel, an emergency discharge valve (4) arranged in the vessel bottom for emptying the reactor in less than 600 seconds and at least one filtration device (5) arranged in the vessel bottom is suitable for the safe preparation of organic peroxides. The process for preparing an organic peroxide comprises the steps of preparing a solid hydroperoxide in the form of a suspension in the reactor, filtering the suspension through the filtration device (5) arranged in the vessel bottom (2) while retaining the solid hydroperoxide in the reactor and reacting the hydroperoxide with an alkylating agent, an acylating agent or a carbonyl compound.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: March 6, 2012
    Assignee: United Initiators GmbH & Co. KG
    Inventors: Hans Appel, Joseph Weinmaier
  • Patent number: 8123394
    Abstract: A mixer having a mixing pipe (1), a rotatable mixing unit (3) having back-mixing action, and a supply of the liquid colorant (4, 5) through the wall of the mixing pipe in the area of the mixing unit allows uniform mixing of liquid colorants of differing viscosities even with fixed-cycle supply of the liquid colorants. Mixing liquid colorants using this mixer allows direct dosing of the mixed liquid colorant into a plastic processing machine in the event of volumetric dosing of the employed liquid colorants.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: February 28, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Simon Becht, Andreas Kluge, Maurice Weelen, Martin Welp
  • Patent number: 8106037
    Abstract: The present invention is directed to specific chromosomal rearrangements that are associated with prostate tumors that respond to compounds acting at estrogen receptors. Patients having the TMPRSS2-ERG fusion, may be treated with agonists of the estrogen beta receptor or antagonists of the estrogen alpha receptor.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: January 31, 2012
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Mark Rubin, Kirsten Mertz, Sunita Setlur
  • Patent number: 8069687
    Abstract: A working medium for refrigeration processes comprising at least one sorbent material and at least one refrigerant, characterized in that the sorbent material contains at least one nonvolatile organic salt which is liquid under standard conditions, or a mixture of organic salts, with the proviso that this is liquid under standard conditions, wherein the salt or the mixture has a thermal stability above 150° C.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: December 6, 2011
    Assignee: Evonik Degussa GmbH
    Inventors: Carsten Jork, Matthias Seiler, Bernd Weyershausen
  • Patent number: 8012749
    Abstract: A novel cell suited for mass production of Hemagglutinating Virus of Japan (HVJ), a method for obtaining the cell and use of the cell are disclosed. The human cell is originated from a transformed human kidney cell line, the doubling time thereof in logarithmic growth phase in suspension culture in a serum-free medium is not more than 40 hours, the cell has a freeze-recovery property, the maximum density of viable cells in suspension culture is not less than 106 cells/mL, and HVJ can grow in the cell. The method for obtaining the human cell comprises the steps of suspension-culturing a human transformed kidney cell line in a serum-free medium, and cloning the grown cells; and selecting, from the cloned cells, a cell whose doubling time in logarithmic growth phase in suspension culture in a serum-free medium is not more than 40 hours, which has a freeze-recovery property, whose maximum density of viable cells in suspension culture is not less than 106 cells/mL, in which HVJ can grow.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: September 6, 2011
    Assignee: GenomIdea, Inc.
    Inventors: Takahiro Yano, Tetsuji Nagasawa, Akiko Temma, Naho Suzuki, Kazue Miyaji
  • Patent number: 7994110
    Abstract: The invention relates to a solid redispersible emulsion, which is comprised of an oil-in-water emulsion consisting of a laundry care constituent, which is encapsulated in an enclosure. This enclosure is stabilized by polyvalent metal ions and, initially, is water-insoluble and is rendered soluble by adding metal ions. The enclosure material is preferably a biodegradable material and, in particular, a polysaccharide, such as alginates, pectins or carageenans. These solid and redispersible emulsions are used, in particular, in laundry care products.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: August 9, 2011
    Assignee: Evonik Degussa GmbH
    Inventors: Hans Wenk, Georg Schick, Kathrin John
  • Patent number: 7956027
    Abstract: Sodium percarbonate particles with a coating layer comprising sodium sulfate in the form of a high-temperature phase of sodium sulfate and/or of a high-temperature phase of a double salt of composition Na4(SO4)1+n(CO3)1?n where n is from 0 to 0.5 have an improved storage stability in detergent and cleaning composition formulations as compared with sodium percarbonate particles which comprise sodium sulfate in the coating layer only in the form of sodium sulfate (V) or burkeite.
    Type: Grant
    Filed: July 4, 2007
    Date of Patent: June 7, 2011
    Assignee: Evonik Degussa GmbH
    Inventors: Stefan Leininger, Harald Jakob, Ralph Overdick