Patents Represented by Attorney Madge R. Kanter

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  • Compositions and methods for inducing gene expression
    Patent number: 7053062
    Abstract: The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of transcriptional activation. The present invention also provides recombinant viral and non-viral vectors that are able to infect and/or transfect and sustain expression of a biologically active chimeric transactivator proteins in mammalian cells. Also provided are host cell lines and non-human transgenic animals capable of expressing biologically active chimeric transactivator proteins. In another aspect, compositions and methods for treating or preventing ischemic damage associated with hypoxia-related disorders are provided.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: May 30, 2006
    Assignee: Genzyme Corporation
    Inventors: Richard J. Gregory, Karen Vincent
  • Transplants for myocardial scars
    Patent number: 6682730
    Abstract: A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: January 27, 2004
    Assignee: Genzyme Corporation
    Inventors: Donald A. G. Mickle, Ren-Ke Li, Richard D. Weisel
  • Transplants for myocardial scars
    Patent number: 6579523
    Abstract: A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: June 17, 2003
    Assignee: Genzyme Corporation
    Inventors: Donald A. G. Mickle, Ren-Ke Li, Richard D. Weisel
  • Compositions and methods for inducing gene expression
    Patent number: 6432927
    Abstract: The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of transcriptional activation. The present invention also provides recombinant viral and non-viral vectors that are able to infect and/or transfect and sustain expression of a biologically active chimeric transactivator proteins in mammalian cells. Also provided are host cell lines and non-human transgenic animals capable of expressing biologically active chimeric transactivator proteins. In another aspect, compositions and methods for treating or preventing ischemic damage associated with hypoxia-related disorders are provided.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: August 13, 2002
    Assignee: Genzyme Corporation
    Inventors: Richard J. Gregory, Karen Vincent
  • Monoclonal antibodies to transforming growth factor-beta and methods of use
    Patent number: 6419928
    Abstract: Monoclonal antibodies to transforming growth factor beta (TGF-B) are prepared from hybrid cell lines by immunizing with TGF-B2. The antibodies may be of any isotype and may be of any mammalian origin such as murine or human origin. Therapeutic applications utilizing the TGF-B monoclonal antibody are also disclosed.
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: July 16, 2002
    Assignee: Genzyme Corporation
    Inventors: James R. Dasch, Doran R. Pace, III, Wendy O. Waegell