Patents Represented by Attorney, Agent or Law Firm Marianne Fuierer
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Patent number: 7384641Abstract: The present invention relates to a composition and method for enhancing the efficacy of a vaccine in a subject treated with the vaccine by administering to the subject an antigen in conjunction with a chemokine.Type: GrantFiled: March 4, 2005Date of Patent: June 10, 2008Assignee: University of Maryland Biotechnology InstituteInventors: Alfredo Garzino-Demo, Anthony L. DeVico
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Patent number: 7107226Abstract: A searchable database comprising a multiplicity of tables including an attributes table and a values table for a multiplicity of target search items constructed and arranged so that selection of values for one or more target search item attributes yields an attribute-value construct specifying a particular one of said target search items and precluding an indeterminate search result. Such database may be employed in an online comparison shopping system comprising a database containing product information of multiple vendors, manufacturers and/or products and a user interface generating a virtual shopping cart, and constructed and arranged to enable a user to selectively aggregate an order in said virtual shopping cart, comprising products represented in said database, and means for electronically disaggregating said order to generate vendor-specific orders to respective vendors.Type: GrantFiled: January 20, 1999Date of Patent: September 12, 2006Assignee: Net32.com, Inc.Inventors: Patrick Cassidy, James Evans
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Patent number: 7067145Abstract: A method of enhancing a culturing characteristic of fish larvae, including administering to said larvae in a nutritional diet essential fatty acids including DHA and AA in a ratio effective to enhance the culturing characteristic of such fish larvae relative to a corresponding nutritional diet lacking DHA and AA. The culturing characteristic may be at least one of stress resistance, immunoresistance, hatching rate, and growth rate. In a preferred aspect, the DHA and AA together comprise from about 10 to about 30% of total fatty acids in enrichment lipids, and the dietary ratio of DHA: AA is less than 10.Type: GrantFiled: September 7, 2001Date of Patent: June 27, 2006Assignee: University of Maryland Biotechnology InstituteInventors: Allen R. Place, Moti Harel
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Patent number: 7033767Abstract: The present invention to amino acid sequences of proteins that are associated with apoptosis and the use of these proteins in the diagnosis, prevention and treatment of disorders associated with abnormal cell proliferation and apoptosis. The invention relates as well to nucleotide sequences encoding the peptides, recombinant vectors carrying the sequences, recombinant host cells including either the sequences or vectors, and recombinant peptides. The invention further includes methods for using the nucleotide sequences and recombinant peptides in diagnostic and therapeutic applications.Type: GrantFiled: October 29, 2001Date of Patent: April 25, 2006Assignee: University of Maryland Biotechnology InstituteInventor: Eric H. Baehrecke
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Patent number: 7029724Abstract: A method of forming an A site deficient thin film manganate material on a substrate from corresponding precursor(s), comprising liquid delivery and flash vaporization thereof to yield a precursor vapor, and transporting the precursor vapor to a chemical vapor deposition reactor for formation of an A site deficient manganate thin film on a substrate. The invention also contemplates a device comprising an A site deficient manganate thin film, wherein the manganate layer is formed on the substrate by such a process and is of the formula LaxMyMnO3, where M=Mg, Ca, Sr, or Ba, and (x+y)<1.0, and preferably from about 0.5 to about 0.99.Type: GrantFiled: July 20, 2000Date of Patent: April 18, 2006Assignee: Advanced Technology Materials, Inc.Inventors: Thomas H. Baum, Galena Doubinina, Daniel Studebaker
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Patent number: 7005303Abstract: A low temperature CVD process for deposition of bismuth-containing ceramic thin films suitable for integration to fabricate ferroelectric memory devices. The bismuth-containing film can be formed using a tris(?-diketonate) bismuth precursor. Films of amorphous SBT can be formed by CVD and then ferroannealed to produce films with Aurivillius phase composition having superior ferroelectric properties suitable for manufacturing high density FRAMs.Type: GrantFiled: April 30, 2004Date of Patent: February 28, 2006Assignee: Advanced Technology Materials, Inc.Inventors: Frank S. Hintermaier, Christine Dehm, Wolfgang Hoenlein, Peter C. Van Buskirk, Jeffrey F. Roeder, Bryan C. Hendrix, Thomas H. Baum, Debra A. Desrochers
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Patent number: 6972101Abstract: A method and device for regulating the composition of a solution(s) in the production of cellulosic mouldings. The device comprises multiple measuring devices for the measurement of non-optical properties of the solution. According to invention, by measuring the non-optical properties of the solutions and comparison of the measured value with a preset value, the composition(s) of the solution(s) can be controlled.Type: GrantFiled: September 29, 2000Date of Patent: December 6, 2005Assignee: Zimmer AGInventors: Frank-Gunter Niemz, Wilhem Meyer, Tanja Mainzer-Althof
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Patent number: 6972102Abstract: The invention relates to a method for continually producing an extrusion solution for producing cellulosed shaped bodies, such as fibres and films, according to the lyocell method. According to the inventive method, (a) a cellulose suspension is produced from cellulose and an aqueous phase in a mass ratio ranging from 1:3 to 1:40, whereby shearing is maintained for between 5 to 200 minutes. (b) The cellulose suspension is dewatered to form a material having a cellulose content ranging from 20 to 80 mass % and the aqueous phase produced thereby is at least partially returned to step (a). (c) The humid cellulose material being homogenised is transported through a first shearing zone in the absence of N-methylmorpholine-N-oxide.Type: GrantFiled: September 29, 2000Date of Patent: December 6, 2005Assignee: Zimmer AGInventors: Ralf-Uwe Bauer, Uwe Kind
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Patent number: 6946248Abstract: Bioremediative microorganisms comprising a 16S ribosomal subunit nucleic acid sequence and useful in various methods for dechlorinating chlorinated biphenyls (PCBs), including anaerobic dechlorination of ortho- and double-flanked chloro substituents of PCBs. The methods of bioremediation may employ consortia of microbially effective species, e.g., aerobic as well as anaerobic species, to dechlorinate corresponding PCB mixtures containing widely varying and significant numbers of PCB congeners.Type: GrantFiled: May 18, 2001Date of Patent: September 20, 2005Assignees: University of Maryland, Biotechnology Institute Medical University of South CarolinaInventors: Kevin R. Sowers, Harold D. May
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Patent number: 6935354Abstract: A valve assembly for controlling gas delivery from a higher pressure fluid source to a lower pressure processing tool comprising a valve poppet movingly engageable with a valve seating member and a fluid permeable insert positioned between the valve poppet and the valve seating member that is unexposed to flowing fluid when the valve poppet is in a closed position thereby preventing fluid flow through the valve assembly and provides a diffusional path for transfer of all flowing fluid when the valve poppet is in an open position. The permeable insert can be inserted into the sealable and engageable surface of either the valve seat member or the valve poppet.Type: GrantFiled: December 9, 2002Date of Patent: August 30, 2005Assignee: Advanced Technology Materials, Inc.Inventor: Glenn Tom
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Patent number: 6936256Abstract: The present invention relates to sub-unit vaccines comprising structural polypeptides of Infectious Pancreatic Necrosis Virus (IPNV) comprising structural proteins VP2 and VP3 folded as an empty IPNV viral capsid that approximates the size and structural conformation of native IPNV virus.Type: GrantFiled: August 12, 2002Date of Patent: August 30, 2005Assignee: University of Maryland Biotechnology InstituteInventor: Vikram N. Vakharia
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Patent number: 6930169Abstract: The present invention describes a calcium-binding myristoylated protein with homology to calcineurin B which interacts preferentially with presenilin 2 protein. Also, the present invention relates to methods that alter protein-protein interaction of the calcium-binding myristoylated protein with presenilin 2 thereby reducing deleterious effects of the protein-protein interaction, such as apoptosis. The present invention further relates to introducing and expressing a mutant presenilin 2 protein or mutant calcium-binding myristoylated protein to modulate cell functions relating to calcium signaling and apoptosis.Type: GrantFiled: June 11, 2001Date of Patent: August 16, 2005Assignee: University of Baltimore Biotechnology InstituteInventors: Mervyn J. Monteiro, Stacy Stabler
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Patent number: 6924288Abstract: An essentially pure compound of the formula: (?)3-((S)-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)(3-thienyl)methyl)phenol or a pharmaceutically acceptable salt thereof, having utility as a receptor-binding species, e.g., as a therapeutic agent for mediating analgesia; as a co-administered agent with various other bioactive compositions, including anesthetics, barbiturates, analgesics, etc.; for reducing, treating, reversing or preventing drug-mediated respiratory depression that may be directly or indirectly caused by use of such various bioactive compositions; as a conjugate in agonist/antagonist pairs for verifying/assaying receptor and neurotransmitter function; and as a therapeutic agent having utility in combating pain, cardiac disorders, mental and emotional disorders cough, diarrhea and gastro-intestinal disorders.Type: GrantFiled: September 25, 2002Date of Patent: August 2, 2005Assignee: Ardent Pharmaceuticals, Inc.Inventor: Kwen-Jen Chang
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Patent number: 6921062Abstract: A vaporizer delivery system for use in semiconductor manufacturing processes including a plurality of vertically stacked containers for holding a vaporizable source material. Each of the vertically stacked containers includes a plurality of vented protuberances extending into the interior of the each stacked container thereby providing channels for passage of a carrier gas between adjacent vertically stacked containers.Type: GrantFiled: July 23, 2002Date of Patent: July 26, 2005Assignee: Advanced Technology Materials, Inc.Inventors: John Gregg, Scott Battle, Jeffrey I. Banton, Donn Naito, Marianne Fuierer
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Patent number: 6919196Abstract: The present invention relates to a parvovirus NS1 variant having a shifted equilibrium between the DNA replication and transcription activities (a) and the cytotoxicity activity (b). Furthermore, this invention relates to DNAs coding for these parvovirus NS1 variants and methods of producing them. Additionally, this invention concerns antibodies directed against the parvovirus NS1 variants as well as the use of the DNAs and the parvovirus NS1 variants.Type: GrantFiled: August 11, 2000Date of Patent: July 19, 2005Assignee: Deutsches Krabsforschungzentrum Stiftung Des Offentlichen RechtsInventors: Jürg Nüesch, Jean Rommelaere
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Patent number: 6919319Abstract: The present invention relates to a composition and method for enhancing the efficacy of a vaccine in a subject treated with the vaccine by administering to the subject an antigen in conjunction with a chemokine.Type: GrantFiled: May 27, 2003Date of Patent: July 19, 2005Assignee: University of Maryland Biotechnology InstituteInventors: Alfredo Garzino-Demo, Anthony L. DeVico
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Patent number: 6919350Abstract: A method of reducing, treating or preventing drug-mediated respiratory depression, muscle rigidity, or nausea/vomiting in an animal, incident to the administration to said animal of a mixed delta/mu opioid agonist or a respiratory depression-mediating drug, comprising administering to the animal receiving said drug an effective amount of a delta receptor agonist compound. Preferred examples of such delta receptor agonist compound include diarylmethyl piperazine compounds and diarylmethyl piperidine compounds, and pharmaceutical compositions thereof, having utility in medical therapy for reducing respiratory depression associated with certain analgesics, such as mu opiates.Type: GrantFiled: October 9, 2001Date of Patent: July 19, 2005Assignee: Ardent Pharmaceuticals, Inc.Inventors: Kwen-Jen Chang, Robert W. McNutt, Jr., Hugh O. Pettit, Michael J. Bishop
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Patent number: 6908612Abstract: The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co-receptor. Such chimeric molecules therefore exhibit functional properties characteristic of a receptor-coat protein complex and are useful as agents that inhibit virus infection of cells due to occupancy of a co-receptor present on the cell. In particular aspects, the chimeric polypeptide includes an immunodeficiency virus envelope polypeptide, such as that of HIV, SIV, FIV, FeLV, FPV and herpes virus. Receptor sequences suitable for use in a chimeric polypeptide include, for example, CD4 D1D2 and CD4M9 sequences.Type: GrantFiled: August 21, 2001Date of Patent: June 21, 2005Assignee: University of Maryland Biotechnology InstituteInventors: Anthony Louis Devico, Timothy R. Fouts, Robert G. Tuskan
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Patent number: 6909839Abstract: The present invention relates to a delivery system for vaporizing and delivering vaporized solid and liquid precursor materials at a controlled rate having particular utility for semiconductor manufacturing applications. The system includes a vaporization vessel, a processing tool and a connecting vapor line therebetween, where the system further includes an input flow controller and/or an output flow controller to provide a controlled delivery of a vaporizable source material to the vaporization vessel and a controlled flow rate of vaporized source material to the processing tool.Type: GrantFiled: July 23, 2003Date of Patent: June 21, 2005Assignee: Advanced Technology Materials, Inc.Inventors: Luping Wang, Thomas H. Baum, Chongying Xu
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Patent number: 6902690Abstract: The invention relates to a method for producing cellulosed shaped bodies. (a) Cellulose and an aqueous aminoxide are mixed, whereby a suspension is produced. (b) A cellulose solution is produced from the suspension, whereby water evaporates. (c) A first property and a second property of the produced cellulose solution is measured and the measured value is used for correcting the composition of the solution and (d) the cellulose solution is extruded through a gap of air and into an aqueous regenerating bath where said solution is coagulated to form shaped bodies.Type: GrantFiled: September 29, 2000Date of Patent: June 7, 2005Assignee: Zimmer AGInventors: Frank Gunter Niemz, Wilhelm Meyer, Tanja Mainzer Althof