Abstract: A method of producing a site for tissue ingrowth on a surgical implant by embedding a space occupier possessing a desired pattern in the surface of the implant at the desired location for ingrowth and then solubilizing the embedded space occupier to leave the pattern on the implant surface. Preferably, the implant is fabricated from a composite comprising a semi-crystalline thermoplastic resin such as polyetheretherketone or polyphenylene sulfide, and the space occupier is an acid-soluble metal plate machined to produce the desired pattern and removed by aqueous acid solution.

Abstract: The invention relates to a process for the preparation of monocarbonyl or biscarbonyl compounds by reacting organic carbon compounds having one or more olefinic or aromatic double bonds in the molecule with the equivalent amount of ozone and by subsequently catalytically hydrogenating the ozonization products, wherein the peroxide-containing ozonization solution is fed continuously into a suspension of the hydrogenation catalyst in a lower aliphatic alcohol, while a peroxide content of not more than 0.1 mole/l is maintained, and the ozonization products are continuously cleaved reductively to give the corresponding carbonyl compounds.

Abstract: A bone prosthesis comprising at least one joint component replacing a natural joint half, which is provided with a shank adapted to be connected to the bone, wherein a set of joint components is provided, and the shank is designed as a bone replacement member, with a connection portion provided adapted to be connected to the bone at one end and at the other end to the shank.

Abstract: The invention relates to a fluidized-bed method for simultaneously obtaining the dry matter from aqueous solutions of extract substances from deproteinized calves blood and producing granules which can be compressed to give solid medicament forms and contain at least 50% by weight of extract substances, relative to the total dry weight of the granules, a binder and pharmaceutically acceptable fillers and carriers, by spraying an aqueous solution of the extract substances and of the binder on to the fillers and carriers and granulating the mixed material at a defined water content in the fluidized bed. After drying, granules ready for compression are obtained, and they are used for producing solid medicament forms of high stability and constant quality.

Abstract: Enantiomerically pure mono acetal-protected diols of the formula ##STR1## wherein A, B, C and D are hydrogen or a methyl group in any combination, M and N are aliphatic or araliphatic hydrocarbons, m and n are the numbers 0, 1 or 2, whereby the total of m plus n must be the number 1 or 2, their preparation and use for the syntheses of the pheromones (1R-exo)-Brevicomin, (1S-exo)-Brevicomin, (1R-endo)-Brevicomin and (1S-endo)-Brevicomin.

Abstract: A device for transferring high energy electromagnetic radiation from a laser to an optical fiber, which comprises a cone-shaped coupler having a wide proximal end and a narrow distal end, wherein the proximal end is in the form of a convex surface which acts as a focussing lens adapted to receive radiation from a laser and to transmit said radiation into and through said optical fiber and the distal end is attached to the input end of the optical fiber to form an integral assembly therewith, said cone-shaped coupler having a taper angle .theta. defined by the equation ##EQU1## wherein N.A. is the numerical aperture of the fiber material and .mu. is the refractive index of the material of the coupler at the wavelength of the incident radiation. A process for removing an obstruction by laser surgery using said device is also disclosed.

Abstract: A cosmetic case and applicator are disclosed in which the handle of the applicator extends partially outside the case and serves to open the case when turned.

Abstract: A three-component acetabular cup assembly for receiving and releasably retaining the femoral head component of a prosthesis, said cup assembly comprising an outer metal shell, a cup-shaped inner bearing of substantially rigid plastic fixedly secured within said metal shell, and a locking ring made from the same plastic as the inner bearing; the outer surface of the bearing and the inner surface of the locking ring having cooperating configurations forming a secure but releasable latch.

Abstract: Preparation of chemically defined pure enantiomeric 1,2-diacyl-sn-glycero-3-phosphocholines and 1,2-diacyl-sn-glycero-3-phosphoethanolamines which are substituted in positions 1 and 2 of the glycerol, by acylation of triphenylmethyl derivatives of sn-glycero-3-phosphocholine and sn-glycero-3-phosphoethanolamine.

Abstract: A spinal implant adapted to replace a disc between adjacent vertebrae having a predetermined thickness and profile chosen to match the space between said vertebrae and characterized by elongated protuberances adapted to be located in grooves drilled in said vertebrae and a porous coating on at least a portion of its surface. A method and apparatus for placement of said spinal implant are also disclosed.

Abstract: A dispersion strengthened cobalt-chromium-molybdenum alloy produced by gas atomization containing a fine oxide dispersion, and characterized, after fabrication by gas atomization, thermomechanical processing and further high temperature exposure, by excellent corrosion resistance, high fatigue strength, high ductility and high temperature stability; a process for producing said alloy and prostheses formed from said alloy.

Abstract: A heterocyclic-substituted 2-quinolone compound of the formula: ##STR1## or a pharmaceutically-acceptable salt thereof, wherein "Het" is an optionally substituted 5-or 6-membered monocyclid aromatic heterocyclic group attached by a carbon atom to the 5-, 6-, 7- or 8- position of the quinolone nucleus; R, which is attached to the 5-, 6-, 7- or 8- position, is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulphinyl, C.sub.1 -C.sub.4 alkylsulphonyl, halo, CF.sub.3, hydroxy, hydroxymethyl, or cyano; R.sup.1 is hydrogen, cyano (C.sub.1 -C.sub.4 alkoxy)carbonyl, C.sub.1 -C.sub.4 alkyl, nitro, halo, --NR.sup.3 R.sup.4 or --CONR.sup.3 R.sup.4 where each of R.sup.3 and R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl or R.sup.3 and R.sup.4 together with the nitrogen atom to which they are attached form a saturated 5- or 6-membered heterocyclic group optionally containing a further heteroatom or group selected from O, S and N--R.sup.5 where R.sup.

Abstract: Device for cutting band-shaped or strand-shaped material, having a cutting device in the form of a cutter roller, in which outwardly-pointing cutting edges which are arranged at a uniform distance from one another connect two circular disc-shaped or annular bodies to one another, which bodies hold the cutting edges, and the material to be cut via these cutting edges forms a lap superimposed in several coil layers, the radial innermost position of which lap is cut by the pressure which acts in intensified manner as a result of a loading body. The cutter blades, the cutting edges of which cut the material, are arranged for reducing the bending stress in such a way that they are at a setting angle alpha of 5.degree. to 25.degree. to the radial direction of the device, with the cutting edges pointing in the direction of movement of the cutter roller.

Abstract: A method for the treatment of gastrointestinal disorders in a patient which comprises administering to the patient a gastric anti-secretory effective amount of a 2-amino-5-hydroxy-4-methylpyrimidine or a substituted amino derivative thereof, optionally in admixture with an additional gastric anti-secretory agent.

Abstract: A process for the preparation of a thieno-imidazole derivative, particularly descarboxybiotin, a useful intermediate for the preparation of d-biotin, which comprises reacting a thio-substituted intermediate, for example descarboxythiobiotin, with an epoxy compound in an alkanol solvent; and a process for the preparation of said intermediate by reacting a substituted imidazothiazole alcohol with anhydrous hydrogen fluoride.

Abstract: A dispersion strengthened cobalt-chromium-molybdenum alloy produced by gas atomization containing a fine oxide dispersion, and characterized, after fabrication by gas atomization, thermomechanical processing and further high temperature exposure, by excellent corrosion resistance, high fatigue strength, high ductility and high temperature stability; a process for producing said alloy and prostheses formed from said alloy.

Abstract: A device for conveying high energy electromagnetic radiation from a laser source to an optical fiber which comprises a sleeve having a proximal end and a distal end and being adapted to enclose a liquid which is transparent to said radiation, the distal end of said sleeve being adapted to be attached to the input end of the optical fiber; and a focussing lens attached to the proximal end of said sleeve said liquid having a refractive index which substantially matches the refractive index of the lens and of the optical fiber. A process for removing an obstruction by laser surgery using said device is also disclosed.

Abstract: Novel biologically-active tetracyclic spiro-hydantoin derivatives which are potent inhibitors of aldose reductase and useful in treating diabetic complications are disclosed. Pharmaceutical compositions containing the novel compounds and a method of treating chronic diabetic complications are also disclosed. A preferred compound is 9'-chloro-5',6'-dihydro-2'-phenyl-spiro[imidazolidine-5,7'-7'H-pyrido(1,2, 3-de)quinoxaline]2,3',4-trione.

Abstract: A differential thermal testing system comprising a first thermal conductive sensing plate whose temperature is maintained at a constant first temperature, and a second thermal conductive sensing plate whose temperature can be altered. The temperature differential between the first thermal conductive sensing plate and second thermal conductive sensing plate is detected.

Abstract: Compounds of the formula: ##STR1## and pharmaceutically-acceptable acid addition salts thereof, wherein R.sup.1 is at the 3 or 4 position and is phenyl or phenyl substituted by halo, (C.sub.1 -C.sub.4)alkoxy, or (C.sub.2 -C.sub.5)alkoxycarbonyl; R.sup.2 is at the 2 or 7 position and is a group of the formula X(CH.sub.2).sub.n NR.sup.3 R.sup.4 where X is --CH.dbd.CH-- or --(CH.sub.2).sub.2 --; n is 1, 2, 3 or 4; and each of R.sup.3 and R.sup.4 is hydrogen or (C.sub.1 -C.sub.4)alkyl, or R.sup.3 and R.sup.4 together with the nitrogen atom to which they are attached form a 1-pyrrolidinyl or piperidino group; Y is hydrogen, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy or (C.sub.2 -C.sub.5)-alkoxycarbonyl at the 4, 5, 6 or 7 position; and wherein R.sup.2 is at the 2-position, R.sup.1 is at the 3- or 4-position, or alternatively when R.sup.2 is at the 7-position, R.sup.1 is at the 3-position; are useful for the treatment of diarrhea in humans and animals.