Abstract: A method of determining the total fibrinolytic activity in plasma, is characterized in thata) a quantity of fibrin sufficient to produce turbidity is added to a dilute platelet poor plasma sample or is produced in situ and the time dependent change in turbidity or the time-dependent formation of fibrin cleavage products is measured; orb) a chromogenic plasmin substrate and a quantity of fibrin, fibrinogen cleavage products or an enzyme which produces fibrin in situ, insufficient to produce turbidity, is added to a dilute platelet poor plasma sample and the time dependent color formation is measured.
Abstract: The invention relates to new diazephines of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined herein, processes for preparing them and their use as pharmaceutical compositions useful for treating PAF-induced disease.
Type:
Grant
Filed:
January 15, 1992
Date of Patent:
February 9, 1993
Assignee:
Boehringer Ingelheim KG
Inventors:
Karl-Heinz Weber, Werner Stransky, Ulrike Kuefner-Muehl, Hubert Heuer, Franz Birke, Wolf-Dietrich Bechtel
Abstract: Disclosed are new cyclic amine derivatives of the formula I ##STR1## wherein the substituents are defined in the specification. These compounds are useful as for treating sinus tachycardia.
Type:
Grant
Filed:
July 3, 1991
Date of Patent:
December 29, 1992
Assignee:
Boehringer Ingelheim GmbH
Inventors:
Manfred Psiorz, Joachim Heider, Andreas Bomhard, Manfred Reiffen, Norbert Hauel, Klaus Noll, Berthold Narr, Christian Lillie, Walter Kobinger, Jurgen Dammgen
Abstract: Pharmacologically active R(-) 3-quinuclidinol derivatives are described which are muscarinic receptor blocking agents useful for the treatment of gastrointestinal and respiratory tract disorders of the following formula (I) ##STR1## wherein R represents a linear or branched lower alkyl group, a cycloalkyl-C.sub.1-2 alkyl or an aralkyl group, or it is absent;X represents the anion of an organic or inorganic acid, or it is absent, when R is absent;R.sub.1 represents H, a linear or branched lower alkyl group or an acyl group of the type R.sub.2 --CO, in which R.sub.
Type:
Grant
Filed:
June 20, 1990
Date of Patent:
November 17, 1992
Assignee:
Istituto de Angeli S.p.A.
Inventors:
Enzo Cereda, Giuseppe Bietti, Giovanni B. Schiavi, Arturo Donetti, Antonio Schiavone, Henri N. Doods
Abstract: Disclosed herein are cyclic peptide derivatives of the formula ##STR1## wherein A is absent or the tripeptide radical Thr.rarw.Gly.rarw.Ala, R.sup.1 is benzyl or benzyl monosubstituted at position 4 of the aromatic ring with halo, hydroxy, lower alkyl or lower alkoxy, R.sup.2 and R.sup.4 each independently is hydrogen or lower alkyl, R.sup.3 is lower alkyl or lower alkyl monosubstituted with a hydroxy, R.sup.5 is lower alkyl, Y is oxo or thioxo and Z is hydroxy or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 each independently is hydrogen or lower alkyl. The derivatives are useful for treating herpes infections.
Type:
Grant
Filed:
July 3, 1990
Date of Patent:
September 22, 1992
Assignee:
Bio-Mega, Inc.
Inventors:
Julian Adams, John DiMaio, Raymond Plante
Abstract: The invention relates to new 2-hydroxy-n-propylamines of the formulaR.sub.1 --O--CH.sub.2 --CHOH--CH.sub.2 --NH--A--R.sub.2 (I)whereinR.sub.1, R.sub.2 and A are defined as in claim 1, the tautomers, enantiomers and acid addition salts thereof, particularly for pharmaceutical use the physiologically acceptable acid addition salts thereof with inorganic or organic acids, which have valuable pharmacological properties, more particularly a simultaneous cardiotonic and .beta.-blocking activity, and the use thereof as pharmaceutical compositions and processes for preparing them.
Type:
Grant
Filed:
May 30, 1990
Date of Patent:
August 4, 1992
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Norbert Hauel, Annerose Mauz, Jacques van Meel, Michael Entzeroth, Rainer Zimmermann, Willi Diederen
Abstract: By using .sub..alpha. -mimetics, particularly compounds of general formulae I to III and the compounds listed in Table I, as feed additives in fattening animals, it has surprisingly been possible to improve the daily weight gain, the utilization of fodder and the ratio of muscle to fat in favor of the proportion of muscle and protein.
Type:
Grant
Filed:
September 5, 1990
Date of Patent:
August 4, 1992
Assignee:
Boehringer Ingelheim Vetmedica GmbH
Inventors:
Werner Bomann, Franz Esser, Ulrich Hamel, Helmut Stable
Abstract: There is described a process for the simultaneous chemical and biological elimination of solid and liquid waste and apparatus for performing this process in the form of a loop reactor corresponding to FIG. 1 in conjunction with a specially designed nozzle which ensures an intimate mixing of substrate with air and the spraying-in of oxidizing agents while permitting only a short contact time between the oxidizing agents and the substrate.
Type:
Grant
Filed:
May 16, 1991
Date of Patent:
June 9, 1992
Assignee:
Dr. Karl Thomae GmbH
Inventors:
Alfred Kull, Matthias Mather, Hans-Joachim Schmeiss
Abstract: The invention relates to the transdermal administration of 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazole or the (-)-enantiomer thereof and transdermal systems containing these active substances.
Type:
Grant
Filed:
November 8, 1990
Date of Patent:
May 12, 1992
Assignee:
Boehringer Ingelheim KG
Inventors:
Bernd Zierenberg, Michael Herschel, Uwe Rohr
Abstract: A resorbable osteosynthesis device consisting of: 1) a resorbable plate, in which the side of the plate facing the bone is coated with calcium phosphate and/or hydroxyl apatite; and 2) preferably, a resorbable fixing device consisting of a threaded bolt which is optionally coated with calcium phosphate and/or hydroxyl apatite, and a nut which can be fitted onto the threaded bolt.
Type:
Grant
Filed:
September 15, 1989
Date of Patent:
April 28, 1992
Assignee:
Boehringer Ingelheim GmbH
Inventors:
Jurgen Eitenmuller, Heinz Offergeld, Walter Michaeli
Abstract: Compounds of the formula (I) ##STR1## wherein R represents H or C.sub.1-6 alkyl;R.sub.1 and R.sub.2 represent H, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkythio, C.sub.1-6 alkoxycarbonyl, carboxyl, hydroxy, nitro, cyano, optionally C.sub.1-4 alkyl mono- or disubstituted carbamoyl, optionally C.sub.1-4 alkyl mono- or disubstituted amino, C.sub.1-6 acylamino, C.sub.1-4 alkoxy carbonylamino, C.sub.1-6 alkylsulphynyl, C.sub.1-6 alkylsulphonyl or C.sub.1-6 acyl;R.sub.3 represents H, C.sub.1-6 alkyl, aryl or aralkyl, or it may be absent;A represents CO or C.dbd.S;E represents nitrogen;D represents CO or CR.sub.4 R.sub.5 when the E--D bond is single, or D is C--R when the D--E bond is double, in which R.sub.4 represents H, C.sub.1-6 alkyl, aryl, aralkyl, hydroxy or C.sub.1-4 alkoxy and R.sub.5 represents H;X represents oxygen or N--R, or it is absent;Y represents a basic group selected from: ##STR2## in which n is 2 or 3; p is 0 or 1 at the same time or not; q is 0,2 or 3; R.sub.6 and R.sub.
Type:
Grant
Filed:
February 2, 1990
Date of Patent:
April 21, 1992
Assignee:
Istituto de Angeli S.p.A.
Inventors:
Marco Turconi, Rosamarie Micheletti, Giovanni B. Schiavi, Arturo Donetti, Angelo Sagrada, Henri N. Doods
Abstract: Disclosed are novel pyridodiazepines. These compounds, as well as certain known 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ones are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection.
Type:
Grant
Filed:
February 4, 1991
Date of Patent:
February 11, 1992
Assignees:
Boehringer Ingelheim Pharmaceuticals, Inc., Dr. Karl Thomae GmbH
Inventors:
Karl D. Hargrave, Gunther Schmidt, deceased, Wolfhard Engel, Vokhard Austel
Abstract: Novel aqueous oxytetracycline compositions comprising oxytetracycline, polyethylene glycol with a mean molecular weight of 400, and magnesium oxide. These compositions have good clarity and low viscosity.
Type:
Grant
Filed:
December 12, 1989
Date of Patent:
December 24, 1991
Assignee:
Boehringer Ingelheim Animal Health, Inc.
Inventors:
Jacob A. Zupan, Deborah L. Steinbrenner
Abstract: Disclosed herein are peptides of the formulaY--R.sup.1 --R.sup.2 --R.sup.3 --R.sup.4 --R.sup.5 --R.sup.6 --Zwherein R.sup.1 to R.sup.5 are designated amino acid residues; R.sup.6 is Phe, homoPhe or an amino acid residue derived from 2-amino-3-cyclohexylpropionic acid, 2-amino-3-(4-(lower alkoxy)phenyl) propionic acid or 2-amino-3-(4-halophenyl)propionic acid; Y is Phe, desamino-Phe, (lower alkanoyl)-Phe, p-haloPhe, Tyr, desamino-Tyr or (lower alkanoyl)-Tyr, or Y is the decapeptide radical W--Val--R.sup.7 --Ser--R.sup.8 --R.sup.9 --Thr--Glu--R.sup.10 --Ser--Phe wherein W is hydrogen or lower alkanoyl and R.sup.7 to R.sup.10 are designated amino acids residues, or Y is a fragment of the decapeptide radical wherein from one to nine of the amino acid residues (i.e. Val to Ser) may be deleted serially from the amino terminus of the decapeptide radical; and Z is hydroxy, amino, lower alkylamino or di(lower alkyl)amino.
Type:
Grant
Filed:
February 1, 1990
Date of Patent:
December 10, 1991
Assignee:
Bio-Mega Inc.
Inventors:
Yvan Guindon, Pierre Lavallee, Sumanas Rakhit, Gregory P. Cosentino
Abstract: The specification describes a new process and apparatus for the controlled release of metered quantities of lubricating liquids or suspensions for applying a coating of lubricant to mechanically stressed zones of pressing tools in tablet-making machines, wherein the lubricating solution or suspension is fed into one or more liquid valves synchronously with the cadence of the tablet-making machine from a pressureless storage container by means of a pulsation-free pump, and any pressure variations occuring in the liquid supply line to the valves are compensated by changes in the times of opening of the valves.
Abstract: Disclosed are novel opthalmic solutions useful for the treatment of ocular hypertension and glaucoma. These contain mabuterol as a preferred active ingredient.
Abstract: Novel thienylbenzylamine compounds of the formula ##STR1## wherein A and R.sub.1 -R.sub.5 are defined herein. These compounds are useful for the treatment of inflammation.
Type:
Grant
Filed:
February 9, 1990
Date of Patent:
July 9, 1991
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
Inventors:
Clara K. Miao, Karl G. Grozinger, Robert Rothlein, Ronald Faanes, Genus Possanza, John P. Devlin
Abstract: A method for treating inflammation in a patient which comprises administering to the patient a therapeutically effective amount of a compound of the formula: ##STR1## wherein A and R.sub.1 -R.sub.6 are defined herein.
Type:
Grant
Filed:
February 9, 1990
Date of Patent:
July 2, 1991
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
Inventors:
Robert Rothlein, Ronald Faanes, Genus Possanza