Patents Represented by Attorney Mary-Ellen M. Timbers
  • Patent number: 5188940
    Abstract: A method of determining the total fibrinolytic activity in plasma, is characterized in thata) a quantity of fibrin sufficient to produce turbidity is added to a dilute platelet poor plasma sample or is produced in situ and the time dependent change in turbidity or the time-dependent formation of fibrin cleavage products is measured; orb) a chromogenic plasmin substrate and a quantity of fibrin, fibrinogen cleavage products or an enzyme which produces fibrin in situ, insufficient to produce turbidity, is added to a dilute platelet poor plasma sample and the time dependent color formation is measured.
    Type: Grant
    Filed: January 10, 1990
    Date of Patent: February 23, 1993
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Jurgen Krause, Walter Haarmann
  • Patent number: 5185442
    Abstract: The invention relates to new diazephines of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined herein, processes for preparing them and their use as pharmaceutical compositions useful for treating PAF-induced disease.
    Type: Grant
    Filed: January 15, 1992
    Date of Patent: February 9, 1993
    Assignee: Boehringer Ingelheim KG
    Inventors: Karl-Heinz Weber, Werner Stransky, Ulrike Kuefner-Muehl, Hubert Heuer, Franz Birke, Wolf-Dietrich Bechtel
  • Patent number: 5175157
    Abstract: Disclosed are new cyclic amine derivatives of the formula I ##STR1## wherein the substituents are defined in the specification. These compounds are useful as for treating sinus tachycardia.
    Type: Grant
    Filed: July 3, 1991
    Date of Patent: December 29, 1992
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Manfred Psiorz, Joachim Heider, Andreas Bomhard, Manfred Reiffen, Norbert Hauel, Klaus Noll, Berthold Narr, Christian Lillie, Walter Kobinger, Jurgen Dammgen
  • Patent number: 5175291
    Abstract: A process for preparing 1,3-dipropyl-8-(3-oxocyclopentyl)-xanthine.
    Type: Grant
    Filed: April 25, 1991
    Date of Patent: December 29, 1992
    Assignee: Boehringer Ingelheim KG
    Inventor: Ulrike Kufner-Muhl
  • Patent number: 5164386
    Abstract: Pharmacologically active R(-) 3-quinuclidinol derivatives are described which are muscarinic receptor blocking agents useful for the treatment of gastrointestinal and respiratory tract disorders of the following formula (I) ##STR1## wherein R represents a linear or branched lower alkyl group, a cycloalkyl-C.sub.1-2 alkyl or an aralkyl group, or it is absent;X represents the anion of an organic or inorganic acid, or it is absent, when R is absent;R.sub.1 represents H, a linear or branched lower alkyl group or an acyl group of the type R.sub.2 --CO, in which R.sub.
    Type: Grant
    Filed: June 20, 1990
    Date of Patent: November 17, 1992
    Assignee: Istituto de Angeli S.p.A.
    Inventors: Enzo Cereda, Giuseppe Bietti, Giovanni B. Schiavi, Arturo Donetti, Antonio Schiavone, Henri N. Doods
  • Patent number: 5149778
    Abstract: Disclosed herein are cyclic peptide derivatives of the formula ##STR1## wherein A is absent or the tripeptide radical Thr.rarw.Gly.rarw.Ala, R.sup.1 is benzyl or benzyl monosubstituted at position 4 of the aromatic ring with halo, hydroxy, lower alkyl or lower alkoxy, R.sup.2 and R.sup.4 each independently is hydrogen or lower alkyl, R.sup.3 is lower alkyl or lower alkyl monosubstituted with a hydroxy, R.sup.5 is lower alkyl, Y is oxo or thioxo and Z is hydroxy or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 each independently is hydrogen or lower alkyl. The derivatives are useful for treating herpes infections.
    Type: Grant
    Filed: July 3, 1990
    Date of Patent: September 22, 1992
    Assignee: Bio-Mega, Inc.
    Inventors: Julian Adams, John DiMaio, Raymond Plante
  • Patent number: 5135932
    Abstract: The invention relates to new 2-hydroxy-n-propylamines of the formulaR.sub.1 --O--CH.sub.2 --CHOH--CH.sub.2 --NH--A--R.sub.2 (I)whereinR.sub.1, R.sub.2 and A are defined as in claim 1, the tautomers, enantiomers and acid addition salts thereof, particularly for pharmaceutical use the physiologically acceptable acid addition salts thereof with inorganic or organic acids, which have valuable pharmacological properties, more particularly a simultaneous cardiotonic and .beta.-blocking activity, and the use thereof as pharmaceutical compositions and processes for preparing them.
    Type: Grant
    Filed: May 30, 1990
    Date of Patent: August 4, 1992
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Norbert Hauel, Annerose Mauz, Jacques van Meel, Michael Entzeroth, Rainer Zimmermann, Willi Diederen
  • Patent number: 5135929
    Abstract: By using .sub..alpha. -mimetics, particularly compounds of general formulae I to III and the compounds listed in Table I, as feed additives in fattening animals, it has surprisingly been possible to improve the daily weight gain, the utilization of fodder and the ratio of muscle to fat in favor of the proportion of muscle and protein.
    Type: Grant
    Filed: September 5, 1990
    Date of Patent: August 4, 1992
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Werner Bomann, Franz Esser, Ulrich Hamel, Helmut Stable
  • Patent number: 5120442
    Abstract: There is described a process for the simultaneous chemical and biological elimination of solid and liquid waste and apparatus for performing this process in the form of a loop reactor corresponding to FIG. 1 in conjunction with a specially designed nozzle which ensures an intimate mixing of substrate with air and the spraying-in of oxidizing agents while permitting only a short contact time between the oxidizing agents and the substrate.
    Type: Grant
    Filed: May 16, 1991
    Date of Patent: June 9, 1992
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Alfred Kull, Matthias Mather, Hans-Joachim Schmeiss
  • Patent number: 5114935
    Abstract: Novel compounds of the general formula ##STR1## which have antitussive activity, wherein R.sub.1 -R.sub.4 are as defined herein.
    Type: Grant
    Filed: August 15, 1990
    Date of Patent: May 19, 1992
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Helmut Ballhause, Gunther Engelhardt, Claus A. Landgraf, Norbert Mayer, Willy Roth, Kurt Schumacher, Alex Prox
  • Patent number: 5112842
    Abstract: The invention relates to the transdermal administration of 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazole or the (-)-enantiomer thereof and transdermal systems containing these active substances.
    Type: Grant
    Filed: November 8, 1990
    Date of Patent: May 12, 1992
    Assignee: Boehringer Ingelheim KG
    Inventors: Bernd Zierenberg, Michael Herschel, Uwe Rohr
  • Patent number: 5108399
    Abstract: A resorbable osteosynthesis device consisting of: 1) a resorbable plate, in which the side of the plate facing the bone is coated with calcium phosphate and/or hydroxyl apatite; and 2) preferably, a resorbable fixing device consisting of a threaded bolt which is optionally coated with calcium phosphate and/or hydroxyl apatite, and a nut which can be fitted onto the threaded bolt.
    Type: Grant
    Filed: September 15, 1989
    Date of Patent: April 28, 1992
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Jurgen Eitenmuller, Heinz Offergeld, Walter Michaeli
  • Patent number: 5106851
    Abstract: Compounds of the formula (I) ##STR1## wherein R represents H or C.sub.1-6 alkyl;R.sub.1 and R.sub.2 represent H, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkythio, C.sub.1-6 alkoxycarbonyl, carboxyl, hydroxy, nitro, cyano, optionally C.sub.1-4 alkyl mono- or disubstituted carbamoyl, optionally C.sub.1-4 alkyl mono- or disubstituted amino, C.sub.1-6 acylamino, C.sub.1-4 alkoxy carbonylamino, C.sub.1-6 alkylsulphynyl, C.sub.1-6 alkylsulphonyl or C.sub.1-6 acyl;R.sub.3 represents H, C.sub.1-6 alkyl, aryl or aralkyl, or it may be absent;A represents CO or C.dbd.S;E represents nitrogen;D represents CO or CR.sub.4 R.sub.5 when the E--D bond is single, or D is C--R when the D--E bond is double, in which R.sub.4 represents H, C.sub.1-6 alkyl, aryl, aralkyl, hydroxy or C.sub.1-4 alkoxy and R.sub.5 represents H;X represents oxygen or N--R, or it is absent;Y represents a basic group selected from: ##STR2## in which n is 2 or 3; p is 0 or 1 at the same time or not; q is 0,2 or 3; R.sub.6 and R.sub.
    Type: Grant
    Filed: February 2, 1990
    Date of Patent: April 21, 1992
    Assignee: Istituto de Angeli S.p.A.
    Inventors: Marco Turconi, Rosamarie Micheletti, Giovanni B. Schiavi, Arturo Donetti, Angelo Sagrada, Henri N. Doods
  • Patent number: 5087625
    Abstract: Disclosed are novel pyridodiazepines. These compounds, as well as certain known 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ones are useful in the treatment of AIDS, ARC and related disorders associated with HIV infection.
    Type: Grant
    Filed: February 4, 1991
    Date of Patent: February 11, 1992
    Assignees: Boehringer Ingelheim Pharmaceuticals, Inc., Dr. Karl Thomae GmbH
    Inventors: Karl D. Hargrave, Gunther Schmidt, deceased, Wolfhard Engel, Vokhard Austel
  • Patent number: 5075295
    Abstract: Novel aqueous oxytetracycline compositions comprising oxytetracycline, polyethylene glycol with a mean molecular weight of 400, and magnesium oxide. These compositions have good clarity and low viscosity.
    Type: Grant
    Filed: December 12, 1989
    Date of Patent: December 24, 1991
    Assignee: Boehringer Ingelheim Animal Health, Inc.
    Inventors: Jacob A. Zupan, Deborah L. Steinbrenner
  • Patent number: 5071835
    Abstract: Disclosed herein are peptides of the formulaY--R.sup.1 --R.sup.2 --R.sup.3 --R.sup.4 --R.sup.5 --R.sup.6 --Zwherein R.sup.1 to R.sup.5 are designated amino acid residues; R.sup.6 is Phe, homoPhe or an amino acid residue derived from 2-amino-3-cyclohexylpropionic acid, 2-amino-3-(4-(lower alkoxy)phenyl) propionic acid or 2-amino-3-(4-halophenyl)propionic acid; Y is Phe, desamino-Phe, (lower alkanoyl)-Phe, p-haloPhe, Tyr, desamino-Tyr or (lower alkanoyl)-Tyr, or Y is the decapeptide radical W--Val--R.sup.7 --Ser--R.sup.8 --R.sup.9 --Thr--Glu--R.sup.10 --Ser--Phe wherein W is hydrogen or lower alkanoyl and R.sup.7 to R.sup.10 are designated amino acids residues, or Y is a fragment of the decapeptide radical wherein from one to nine of the amino acid residues (i.e. Val to Ser) may be deleted serially from the amino terminus of the decapeptide radical; and Z is hydroxy, amino, lower alkylamino or di(lower alkyl)amino.
    Type: Grant
    Filed: February 1, 1990
    Date of Patent: December 10, 1991
    Assignee: Bio-Mega Inc.
    Inventors: Yvan Guindon, Pierre Lavallee, Sumanas Rakhit, Gregory P. Cosentino
  • Patent number: 5056623
    Abstract: The specification describes a new process and apparatus for the controlled release of metered quantities of lubricating liquids or suspensions for applying a coating of lubricant to mechanically stressed zones of pressing tools in tablet-making machines, wherein the lubricating solution or suspension is fed into one or more liquid valves synchronously with the cadence of the tablet-making machine from a pressureless storage container by means of a pulsation-free pump, and any pressure variations occuring in the liquid supply line to the valves are compensated by changes in the times of opening of the valves.
    Type: Grant
    Filed: March 29, 1990
    Date of Patent: October 15, 1991
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Volker I. Glasel, Gunther M. Voss
  • Patent number: 5049587
    Abstract: Disclosed are novel opthalmic solutions useful for the treatment of ocular hypertension and glaucoma. These contain mabuterol as a preferred active ingredient.
    Type: Grant
    Filed: April 21, 1989
    Date of Patent: September 17, 1991
    Assignee: Basotherm GmbH
    Inventors: Taira Okamoto, Motoyuki Yajima
  • Patent number: 5030647
    Abstract: Novel thienylbenzylamine compounds of the formula ##STR1## wherein A and R.sub.1 -R.sub.5 are defined herein. These compounds are useful for the treatment of inflammation.
    Type: Grant
    Filed: February 9, 1990
    Date of Patent: July 9, 1991
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Clara K. Miao, Karl G. Grozinger, Robert Rothlein, Ronald Faanes, Genus Possanza, John P. Devlin
  • Patent number: 5028630
    Abstract: A method for treating inflammation in a patient which comprises administering to the patient a therapeutically effective amount of a compound of the formula: ##STR1## wherein A and R.sub.1 -R.sub.6 are defined herein.
    Type: Grant
    Filed: February 9, 1990
    Date of Patent: July 2, 1991
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Robert Rothlein, Ronald Faanes, Genus Possanza