Patents Represented by Attorney Mathews, Collins, Shepherd & McKay, P.A.
  • Patent number: 6660908
    Abstract: The invention includes modified dihydroflavonol 4-reductase (DFR) nucleic acids encoding the modified DFR that has altered amino acid sequences at the substrate specificity determining region. The property of the modified DFR is characterized by its ability to reduce dihydrokaempferol (DHK) preferentially over dihydroquercetin (DHQ), and dihydromyricetin (DHM). The invention also includes plants having at least one cell expressing the modified DFR. Such plants are characterized by the increased content of pelargonidin-based pigments. The invention also includes vectors comprising at least a portion of the modified DFR nucleic acids. The invention also includes methods using such vectors for producing plants having the increased content of pelargonidin-based pigments.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: December 9, 2003
    Assignee: Korea Kumho Petrochemical Co., Ltd.
    Inventors: Giltsu Choi, Eric I Johnson, Hankuil Yi, Byongchul Shin
  • Patent number: 6656713
    Abstract: Compositions and methods for modulating the activation of nuclear factor &kgr;B (NF-&kgr;B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I&kgr;B&agr; and/or I&kgr;B&bgr;. Such compositions may be used for treating diseases associated with NF-&kgr;B activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
    Type: Grant
    Filed: April 9, 2001
    Date of Patent: December 2, 2003
    Assignee: Signal Pharmaceuticals, Inc.
    Inventors: Anthony M. Manning, Frank Mercurio, Sharon Amit, Yinon Ben-Neriah, Matti Davis, Ada Hatzubai, Avraham Yaron, Irit Alkalay, Aaron Ciechanover
  • Patent number: 6656459
    Abstract: Compositions comprising non-ionic block copolymers are useful for the treatment of autoimmune, inflammatory and proliferative diseases and for reducing graft/implantation rejection. The present invention also relates to methods of treating animals having various autoimmune, inflammatory and proliferative diseases. The present invention also relates to methods of reducing inflammation in an animal comprising administering the compositions of the invention. Also, the present invention relates to methods of reducing autoimmune responses and to methods of reducing graft/implantation rejection comprising administering the compositions of the inventions. A typical embodiment is a mixture of Pluronics F127 and L61.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: December 2, 2003
    Assignee: Supratek Pharma Inc.
    Inventors: Alexander V. Kabanov, Pierre Lemieux, Nadia Guerin, Valery Alakhov
  • Patent number: 6657079
    Abstract: A method for mixing a plurality of gases including forming a helical flow within a mixing vessel thereby allowing simplification of construction, avoiding pressure drop to the fullest possible extent, and expediting the mixture lest the volume of a gas within the explosion limits should increase, and an apparatus to be used for the method.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: December 2, 2003
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Tetsuji Mitsumoto, Tatsuaki Yoshimura, Takeshi Nishimura, Sei Nakahara
  • Patent number: 6656964
    Abstract: Imido and amido substituted alkanohydroxamic acids reduce the levels of TNF&agr; and inhibit phosphodiesterase in a mammal. A typical embodiment is 3-(3-cyclopentyloxy-4-methoxyphenyl)-N-hydroxy-3-phthalimidopropionamide.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: December 2, 2003
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Hon-Wah Man
  • Patent number: 6651731
    Abstract: For a heat exchanger using a heating medium for the purpose of heating a fluid to be handled during a steady state, this invention provides a method for using relevant devices which enables the heat exchanger to be operated safely and infallibly without suffering the raw material or the reaction product to polymerize in the reactor or the pipes during an unsteady state, suffering the reactor or the pipes to sustain a fracture owing to a rise in the internal pressure of the vessel, and suffering the apparatus for production to sustain serious damage. This invention pertains, mainly in a heat exchanger admitting a heating medium and using it for the purpose of heating a fluid to be handled, to a method for using relevant devices during the unsteady state, characterized by introducing a cooling medium in the place of the heating medium mentioned above.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: November 25, 2003
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Takeshi Nishimura, Yukihiro Matsumoto, Sei Nakahara, Motomi Nakamura
  • Patent number: 6649182
    Abstract: A planting method for preventing pests, especially snails, is disclosed. The method includes the steps of (a) providing a biodegradable material, (b) adding a pesticide into the biodegradable material, and (c) spreading the pesticide-added biodegradable material on a plant-growing substrate. Therefore, a plant growing on the plant-growing substrate will not undergo the damage of pests.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: November 18, 2003
    Assignee: Yuen Foong Yu Paper Mfg. Co., Ltd.
    Inventors: Shih-Pan-Yu Hsieh, Rui-Zhi Huang
  • Patent number: 6641384
    Abstract: The present invention relates to an apparatus for continuous vacuum forming of a thermoplastic material between a pair of rotating flexible belts in which one belt includes a plurality of teeth, which are received in a plurality of indentations of the other belt. Each of the belts includes a mold, which forms a channel when the belts are adjacent to one another. A vacuum is applied to at least one of the flexible belts for drawing material received in the channel and alignment of the belts. Preferably, a vacuum can be applied to both of the belts for improved alignment. Each belt can include a plurality of apertures, which are in fluid flow communication with a plurality of perforations of a flat support belt positioned over a vacuum manifold.
    Type: Grant
    Filed: October 29, 2001
    Date of Patent: November 4, 2003
    Assignee: Bosler Designs Inc.
    Inventors: Kenneth Bosler, Robert Bosler, Ralph Bosler
  • Patent number: 6642414
    Abstract: A method for producing (meth)acrylic acid of high purity by repressing formation of a polymer possibly generated during the course of production is disclosed. The production is accomplished by returning the waste liquid generated at the step of the addition of aldehyde treating agents (d) to the step of the absorption (b) and/or the step of separation (c).
    Type: Grant
    Filed: January 30, 2001
    Date of Patent: November 4, 2003
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Tetsuji Mitsumoto, Yukihiro Matsumoto, Sei Nakahara, Tatsuaki Yoshimura
  • Patent number: 6641700
    Abstract: A purifying apparatus characterized by being equipped with a vapor dispersing device possessing in a vapor inlet part owned by the apparatus on the lateral inside thereof an opening part facing downward from the horizontal direction and a horizontal projected cross section area in the range of 10-40% of the cross section area of said apparatus. In consequence of the incorporation of the vapor dispersing device according to this invention, the drift of the gas is repressed, the efficiency of separation is improved, and the possible polymerization of a compound under treatment in the lower part of the column is prevented.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: November 4, 2003
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Hajime Matsumoto, Takeshi Nishimura, Yukihiro Matsumoto
  • Patent number: 6638919
    Abstract: Compounds of the formula wherein Ar is aryl, R1 and R2 are hydrogen alkyl, alkyl substituted with phenyl, and aryl, O, NH, NR4 and S, R5 is hydrogen, alkyl or aryl or alkylene when taken with R1, and R3 is hydrogen, alkyl, alkyl substituted with phenyl, aryl, a heterocyclic group or a polycyclic group, are antiviral agents. A typical embodiment is (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol O-[phenyl-(methoxy-L-alaninyl)]phosphate.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: October 28, 2003
    Assignees: University College Cardiff Consultants Limited, Rega Foundation
    Inventors: Christopher McGuigan, Jan Balzarini
  • Patent number: 6635148
    Abstract: A method for refining an easily polymerizable matter while preventing an easily polymerizable matter-containing substance from being polymerized and an apparatus for use in the method are disclosed. The method and apparatus for refining and separating the easily polymerizable matter-containing substance by the use of a distillation column provided with a heat exchanger set the linear velocity of a vapor in a connecting line intervening between the distillation column and the heat exchanger at a level of not less than 5 m per second and the retention time of the vapor at a level of not more than 3 seconds.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: October 21, 2003
    Assignee: Nippon Shokubai
    Inventors: Takeshi Nishimura, Yukihiro Matsumoto
  • Patent number: 6627047
    Abstract: A method is provided for preventing an easily polymerizable substance from being polymerized in a thin-film type evaporating device by supplying a solution of the substance to the evaporating heating surface of the device by the centrifugal force of a stirring rotary shaft, characterized by mixing a distilled vapor of the substance with a molecular oxygen-containing gas and supplying the extracted liquid or a solution having lower viscosity than the extracted liquid to a feed raw material inlet thereby adjusting the quantity of a wetting liquid per unit length of the surface in the range of 0.02-2 m3/mHr. In the evaporation of the substance by the use of the device, a method for preventing the substance from polymerization is provided.
    Type: Grant
    Filed: April 21, 2000
    Date of Patent: September 30, 2003
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Yuichi Ijiri, Takeshi Nishimura, Yukihiro Matsumoto
  • Patent number: 6623932
    Abstract: The present invention relates to three sets of novel primers of SEQ ID Nos. 1-6, wherein said three sets of primer are designed from three genes omt, ord, and afl R respectively of aflatoxin biosynthesis pathway of fungi Aspergillus flavus and an improved method of identifying aflatoxinogenic aspergilli using said three sets of primers.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: September 23, 2003
    Assignee: Council of Scientific and Industrial Research
    Inventors: Haravey Krishnan Manonmani, Arun Chandrashekar, Eddiya Rati Rao
  • Patent number: 6623125
    Abstract: A heat-dissipating device for being used in a liquid crystal display projector having liquid crystal displays and polarizers is provided. The heat-dissipating device includes a heat-dissipating channel disposed under the liquid crystal displays and the polarizers and having a main path, a first branch, a second branch, and a plurality of vents corresponding to and adjacent to the liquid crystal displays and the polarizers, respectively, and a fan connected with an end of the heat-dissipating channel, wherein when an airflow is blown from the fan into the main path, the first branch and the second branch and discharged outwardly through the vents, heat generated from the liquid crystal displays and the polarizers is dissipated and temperatures around the liquid crystal displays are kept near isothermal.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: September 23, 2003
    Assignee: Delta Electronics, Inc.
    Inventors: Hsi-Chao Chen, Tom Haven
  • Patent number: 6620969
    Abstract: A shell-and-tube heat exchanger for handling an easily polymerizable substance is disclosed, which is characterized by having no part for stagnation of said process fluid on the surfaces for contact with the process fluid. By eliminating undulations from the inner surfaces of the heat transfer tubes, it is made possible to prevent the easily polymerizable substance from polymerizing and, at the same time, prevent adhesion of a polymer to the surfaces. Thus, the efficiency of heat exchange is enhanced and the protracted continuous operation is realized.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: September 16, 2003
    Assignee: Nippon Shokubai Co. , Ltd.
    Inventors: Takeshi Nishimura, Yukihiro Matsumoto
  • Patent number: 6620115
    Abstract: A method and device in accordance with the present invention enabling detecting mechanical and structural properties of the breast tissue that are indicative of breast cancer. Detection of nodules is achieved by placing the breast into a mechanical scanning unit comprising of a two-dimensional pressure sensor array and a mobile linear pressure sensor array located opposite to the two-dimensional pressure sensor array, and analyzing the signals from the pressure sensors. The device is able to objectively detect presence of lesions suspicious for cancer or other breast pathologies in the breast and provide means for computerized three-dimensional mechanical imaging of the breast.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: September 16, 2003
    Assignee: Armed L.L.C.
    Inventors: Armen P. Sarvazyan, Vladimir Egorov
  • Patent number: 6621216
    Abstract: A plasma display panel (PDP) with a driving circuit one-sidedly and its manufacturing method is disclosed. The PDP includes a first substrate having a first edge, a second substrate spaced apart from the first substrate, a first electrode positioned on the first substrate along a first direction, a second electrode positioned on the second substrate along a second direction, a bonding electrode, and a conductive device. The second direction of the second electrode is substantially perpendicular to the first direction of the first electrode. The first substrate has a first length and the second substrate has a second length shorter than the first length. The bonding electrode is disposed on the first edge of the first substrate uncovered by the second substrate.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: September 16, 2003
    Assignee: Acer Display Technology, Inc.
    Inventors: Po-Cheng Chen, Jiun-Han Wu
  • Patent number: 6613196
    Abstract: A method for stopping a purifying column handling an easily polymerizing compound-containing solution is disclosed, which method is characterized by lowering the inner oxygen concentration of the column below the limit of oxygen concentration by supplying an inert gas to the column while the concentration of the gas of easily polymerizing compound is in the range of 100% to the lower limit of the flammable range in volume % of the purifying column or by further supplying a reflux liquid thereby cooling the interior of the column at a rate in the range of 0.01-10° C./min. This invention enjoys exceptionally high economic value in respect that it is capable of preventing the easily polymerizing compound from the occurrence of polymerization in the purifying column, precluding the interior of the purifying column from being clogged by adhesion of a polymer, and moreover avoiding the possibility of explosion.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: September 2, 2003
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Kei Hamamoto, Yukihiro Matsumoto, Sei Nakahara, Misao Inada
  • Patent number: 6613940
    Abstract: In the reaction of catalytic gas phase oxidation by means of a shell-and-tube type reactor adapted to circulate a heating medium to the shell of the reactor through the medium of a circulation device connecting an annular conduit connected thereto, a method for the catalytic gas phase oxidation characterized by subjecting a part of the heating medium extracted from the shell of the reactor to heat exchange, introducing the heating medium resulting from the heat exchange into the proximity of a heating medium circulation inlet on the inlet side of the circulation device or the annular conduit on the outlet side of the reactor. The flow rate of the heating medium after the heat exchange is preferred to be in the range of 2-40 vol. % based on the flow rate of the heating medium within the shell of the reactor and the temperature difference of the heating medium at the inlet and the outlet to be in the range of 15-150° C.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: September 2, 2003
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Takeshi Nishimura, Masakatsu Mori, Masatsugu Kitaura, Osamu Dodo, Daisuke Nakamura