Patents Represented by Attorney Max D. Hensley
  • Patent number: 4336157
    Abstract: The green shade imparted to serum or plasma by biliverdin is eliminated by contacting the contaminated fluid with dithionite ion.
    Type: Grant
    Filed: June 27, 1980
    Date of Patent: June 22, 1982
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventor: Nicholas J. Kartinos
  • Patent number: 4332786
    Abstract: The binding of vitamin B-12 by natural substances in samples assayed for vitamin B-12 is reduced by heating the test sample in an alkaline buffer comprising thioglycerol and denaturing agent having the formula (R).sub.2 NC(A)N(R).sub.2, wherein R is hydrogen or lower alkyl and A is oxygen or hydroxyl.
    Type: Grant
    Filed: May 15, 1980
    Date of Patent: June 1, 1982
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: Michael D. Cabelli, Ernest V. Groman
  • Patent number: 4328376
    Abstract: The method of removing fluorinated olefin byproduct formed during the synthesis of a fluoromethylhexafluoroisopropyl ether product or the like comprises: adding ammonia or an amine to the mixture to react with the fluorinated olefin byproduct, and thereafter distilling the fluoromethylhexafluoroisopropyl ether product to remove it from the byproduct.
    Type: Grant
    Filed: March 31, 1980
    Date of Patent: May 4, 1982
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: Arthur Berger, Robert L. Simon
  • Patent number: 4323478
    Abstract: An improved method and apparatus is disclosed for producing frozen particulate compositions from liquid feedstock. A continuous stream of liquid feedstock is passed through an orifice and into a liquid freezant without the orifice contacting the freezant. Compositions produced by this improved method have low proportions of fine and large particles, yielding particularly beneficial results in the case of quality control materials. The compositions are advantageously employed in automated weighing and filling apparatus.
    Type: Grant
    Filed: December 19, 1979
    Date of Patent: April 6, 1982
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: Thomas H. Adams, James P. Beck, Robert C. Menson
  • Patent number: 4314087
    Abstract: Hexafluoropropylene may be conventionally oxidized to form an impure mixture comprising hexafluoroacetone and residual hexafluoropropylene, which materials are separable only with difficulty. The impure mixture may be subjected to reducing conditions to hydrogenate the hexafluoroacetone to a hexafluoroisopropanol product, which product is easily separable from the hexafluoropropylene impurity, which impurity may be recycled for further oxygenation and production of the acetone. Alternatively, hexafluoroisopropanol may be conventionally made from hexachloroacetone to form an impure mixture of hexafluoroacetone and HF. When this impure mixture is hydrogenated, the resulting hexafluoroisopropanol, mixed with hydrogen fluoride, is formed. Either of these alcohol products may be reacted with hydrogen fluoride and a formaldehyde to obtain a fluoromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether, which is a useful anesthetic.
    Type: Grant
    Filed: December 26, 1979
    Date of Patent: February 2, 1982
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventor: Phillip C. Radlick
  • Patent number: 4306029
    Abstract: Growth and proliferation of bacteria may be inhibited in urine stored in a urine drainage container by placing urease in the container to generate sufficient ammonia to elevate the pH thereof to an alkaline level unfavorable for supporting microbial growth. Preferably, the urease is sealed in envelope means of semipermeable membrane which is capable of allowing diffusion of urea from urine stored in the container, while preventing substantial diffusion of the urease outwardly from the envelope means. Accordingly, the urease remains indefinitely reusable over many fillings and drainings of the container.
    Type: Grant
    Filed: April 30, 1980
    Date of Patent: December 15, 1981
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventor: David F. Carpenter
  • Patent number: 4297494
    Abstract: Compounds useful as tracers in the radioimmunoassay of xanthine derivatives such as theophylline and pharmacologically related drugs: ##STR1## Wherein at least one R.sub.1, R.sub.3, R.sub.7 or R.sub.8 is a radioiodinated radical and wherein, if not substituted by a radioiodinated radical, the remaining R.sub.1, R.sub.3, R.sub.7 or R.sub.8 groups are otherwise identical to the substituents at these positions in the xanthine derivative to be assayed. Ordinarily, R.sub.1 is hydrogen, acetate or methyl; R.sub.3 is methyl; R.sub.7 is hydrogen, acetate or methyl; and R.sub.8 is hydrogen. The tracers are made by linking radioiodinatable or preradioiodinated radicals to the xanthine derivative which is to be assayed. The tracers may be employed in known radioimmunoassay techniques.
    Type: Grant
    Filed: August 9, 1978
    Date of Patent: October 27, 1981
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: Ernest V. Groman, Michael D. Cabelli
  • Patent number: 4292405
    Abstract: A system is provided for testing the sterility of a plurality of samples. The samples are fed by gravity to and through a first conduit which branches into a pair of conduits terminating in two separate test chambers. Each of the test chambers has a main chamber portion and a filter therein. The sample material is gravity fed into the main chamber portions and a vacuum pump is used to draw the liquid material through the filter and out of the test chamber. Test media is introduced to each of the test chambers through an injection site and the test chambers are incubated.
    Type: Grant
    Filed: February 19, 1980
    Date of Patent: September 29, 1981
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: Carmine C. Mascoli, J. Lee Pope, Jr., Phillip L. Weber
  • Patent number: 4292296
    Abstract: Free analytes in samples containing free analytes and receptorbound analytes are determined by absorbing at least a portion of free analyte from the sample with insolubilized receptor or receptor which is then made insoluble, washing the insoluble receptor, adding labelled sample analyte or labelled sample analyte receptor, incubating, washing the insoluble phase free of the soluble phase and determining the label in either phase. The method solves a long standing need in the assay of free thyroid hormones.
    Type: Grant
    Filed: September 12, 1978
    Date of Patent: September 29, 1981
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventor: George H. Parsons, Jr.
  • Patent number: 4288538
    Abstract: Test methods in which an enzyme conversion of at least one member of a family of compounds to an analyte precedes an immunoassay of the analyte are improved by conducting the enzyme conversion step substantially simultaneous with the immunoassay. A novel composition is provided for conducting the improved test method.
    Type: Grant
    Filed: January 31, 1979
    Date of Patent: September 8, 1981
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: Ernest V. Groman, Marian E. Sacco
  • Patent number: 4287180
    Abstract: Compositions including, in units/ml, factor VIII correctional activity, about from 2-35; prothrombin, about from 1-10; thrombin, less than about 0.003; factor VII, about from 37-190; factor VIIa, about from 8-80; total factor IX, about from 15-112; factor IX precursor, 0 to about 30; factor X, about from 1-30; and factor Xa, about from 1-10 are used in therapeutically effective amounts to treat blood clotting factor inhibitors.
    Type: Grant
    Filed: January 28, 1980
    Date of Patent: September 1, 1981
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventor: William R. Thomas
  • Patent number: 4286056
    Abstract: This is an improved method for producing activated prothrombin complex concentrate which comprises controlling the degree of activation by determining the activation state of the starting material and then varying at least one of the activation conditions in accordance with analyses of the progress of activation of the starting material to arrive at a predetermined activation level.
    Type: Grant
    Filed: January 28, 1980
    Date of Patent: August 25, 1981
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: Thomas J. Andary, L. Raymond Berkebile, William R. Thomas, Daphne C. Tse
  • Patent number: 4271140
    Abstract: The performance of double receptor, specific binding assays is improved by use of a receptor complex having the structureA.sub.BL (BL).sub.n A.sub.1wherein BL is a binding ligand, A.sub.BL is a receptor specific for binding ligand, A.sub.1 is a receptor, BL is covalently bonded to A.sub.1 and A.sub.BL is reversibly bonded to BL. Generally A.sub.BL is absorbed onto an insoluble surface and A.sub.1 is an antibody to the substance being assayed. The complex has particular utility in coated tube and rechargeable radioimmunoassay systems.
    Type: Grant
    Filed: August 1, 1978
    Date of Patent: June 2, 1981
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventor: James R. Bunting
  • Patent number: 4267272
    Abstract: Prostatic acid phosphatase is immunologically unstable under typical laboratory conditions. Thus it is necessary to combine a stabilizing composition with samples taken for immunological assay of prostatic acid phosphatase content, and to similarly stabilize prostatic acid phosphatase-containing reagents in kits used to assay the enzyme.
    Type: Grant
    Filed: November 5, 1979
    Date of Patent: May 12, 1981
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventor: Lee Josephson
  • Patent number: 4250162
    Abstract: Samples are extracted with organic solvents and the organic solvents are then placed directly into antiserum coated test tubes and dried. The improved method combines steps heretofore performed separately, resulting in improved assay convenience, cost and accuracy.
    Type: Grant
    Filed: July 2, 1979
    Date of Patent: February 10, 1981
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventor: Ernest V. Groman
  • Patent number: 4250334
    Abstract: A method of synthesizing fluoromethylhexafluoroisopropyl ether comprises adding hexafluoroisopropyl alcohol to a mixture comprising a stoichiometric excess of paraformaldehyde and hydrogen fluoride, plus sufficient sulfuric acid to sequester most of the water produced by the reaction. The mixture is maintained at a temperature of at least 57.degree. C., to cause vapor formation by boiling of the fluoromethylhexafluoroisopropyl ether formed. The vapor is then collected and condensed, and may be purified by distillation.
    Type: Grant
    Filed: December 26, 1979
    Date of Patent: February 10, 1981
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: Clifford L. Coon, Robert L. Simon
  • Patent number: 4244939
    Abstract: Compounds useful as tracers in the radioimmunoassay of barbiturates: ##STR1## wherein (a) R.sub.1, R.sub.2 and R.sub.4 are identical to the substituents found at these positions in the barbiturate which is to be assayed;(b) at least one R.sub.3 is a radioiodinatable radical; and(c) if only one R.sub.3 is a radioiodinatable radical then the remaining R.sub.3 is identical to the substituent found at this position in the barbiturate which is to be assayed; and the radioiodinated derivatives of said compounds.
    Type: Grant
    Filed: June 12, 1978
    Date of Patent: January 13, 1981
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: George H. Parsons, Jr., Ernest V. Groman
  • Patent number: 4229541
    Abstract: A culture medium for cultivating horseshoe crab amebocytes, called Limulus amebocytes, composed of inorganic salts, vitamins, amino acids, and carbon sources including glucose is given. The process for cultivating the Limulus amebocytes depends on maintaining a pH between 6.5 and 9.0 while agitating the medium. Production of Limulus lysate from these cells is an eventual goal.
    Type: Grant
    Filed: October 6, 1978
    Date of Patent: October 21, 1980
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventor: Frederick C. Pearson
  • Patent number: 4221865
    Abstract: Improvements in the sensitivity and reproducibility of nephelometric endotoxin determinations using endotoxin-activated enzyme from Limulus amebocyte lysate are achieved by contacting endotoxin-coagulated lysate with an ionic surface active suspending agent, generally a mixture of detergent and suspending agent. Instrumentation improvements further enhance results.
    Type: Grant
    Filed: October 6, 1978
    Date of Patent: September 9, 1980
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: John A. Dubczak, Marlys E. Weary
  • Patent number: RE30483
    Abstract: An outer tube has a hollow elongated member, attached to one end of the tube in a coaxial relationship. A rod slidable in the tube causes a replaceable tip, mounted on the hollow elongated member, to fill with fluid when the rod is moved in a first direction and discharges the fluid when the rod is moved in the opposite direction. A first spring surrounds the rod and exerts a force between a stop, mounted at an intermediate position within the tube, and the rod to bias the rod in the first direction. A second spring surrounds the rod and is interposed between the stop and the inner end of the hollow elongated member. A first limiting member is mounted on the rod to compress the second spring when the rod is moved in the opposite direction beyond a predetermined limit.
    Type: Grant
    Filed: April 19, 1978
    Date of Patent: January 20, 1981
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: Lamont J. Seitz, Louis Jerg