Abstract: The present invention relates to optically active quinoline carboxylic acid derivatives, their pharmaceutically acceptable salts, their solvates, and a process for the preparation thereof. More specifically, the present invention relates to optically active quinoline carboxylic acid derivatives containing 4-aminomethyl-4-methyl-3-(Z)-alkoxyirninopyrrolidine substituents causing optical activity at the 7-position of the quinolone nuclei. As the compounds of the present invention have superior antibacterial activity and pharmacokinetic profiles to their enantiomers, their racemates and conventional antibacterial agents, with nearly no phototoxicity, the compounds of this invention are useful for antibacterial agents.

Abstract: The present invention is directed to polymeric-prodrug transport forms of the formula: wherein: E1-4 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls, substituted C1-6 heteroalkyls, C1-6 alkoxy, phenoxy, C1-6 heteroalkoxy, and at least one of E1-4 includes a B moiety, wherein B is a leaving group, OH, a residue of a hydroxyl-or amino-containing moiety or wherein J1 is the same as J, or another member of the group defining J and E5 is the same as E1-4, or another member of the group defining E1-4, Y1-2 are independently O, S or NR9; M is a heteroatom selected from either X or Q; wherein X is an electron withdrawing group and Q is a moiety containing a free electron pair positioned three to six atoms from C(═Y2); R2-5 and R7-9 are independently selected fro

Abstract: Method and apparatus for processing a watery substance, such as sludge or manure, wherein in a mixer-drier (33) the watery substance to be processed, which may or may not be mechanically partly dewatered (in 31) and/or preheated (in 32), is mixed with zeolites of type A, which adsorb water from the watery substance while releasing adsorption heat which causes an amount of moisture to evaporate, while from the mixer-drier vapor and a mixture of zeolites and dried matter are discharged, whereafter the zeolites are regenerated in an oven (35) through heating, and are returned to the mixer-drier after being separated from dry matter residue formed by the heating, such as ash, and released moisture. Prior to the supply to the oven, at least a part of the dried matter can be extracted by a separation device (34) the mixture formed in the mixer-drier.

Abstract: The invention is directed primarily to compounds of Formula I: wherein: R1 is a polymeric residue; L1 is a bifunctional linking group; Y1 and Y2 are independently O, S or NR7; R2-7 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls, substituted C1-6 heteroalkyls, C1-6 alkoxy, phenoxy and C1-6 heteroalkoxy; D is a moiety that is a leaving group or a residue of a compound to be delivered into a cell; Z is selected from the group consisting of: a moiety that is actively transported into a target cell, a hydrophobic moiety, and combinations thereof; Ar is a moiety which when included in Formula (I) forms a multi-substituted aromatic hydrocarbon or a multi-substituted heterocyclic group; and (y) is a positive integer greater than or equal to 1. Methods of making and using the same are also disclosed.

Abstract: An electrosurgical probe including a metal cannula, partially provided with an electroinsulating coating, and filiform electrodes housed in the cannula in a stretched position. The filiform electrodes are provided with an elastic memory of an arched shape and as a result, come out from the cannula to occupy a limited, nearly spherical volume. The electrodes are fixed to the distal end of a control rod slidably arranged inside the cannula so that the electrodes in a stretched position are arranged side by side parallel with the control rod. The cannula includes a series of holes each positioned immediately under the free ends of the filiform electrodes and having a sufficient diameter for the passage of a respective one of the electrodes. The electrodes are removed from the cannula by pulling the control rod and retracted into the cannula by pushing the control rod.

Abstract: A silver halide photographic material is disclosed comprising a blue-sensitive silver halide unit containing a yellow coupler, a green-sensitive silver halide unit containing magenta coupler, and a red-sensitive silver halide unit containing a cyan coupler, wherein a coefficient of utilization of an oxidation product of a color developing agent in a maximum density area of the blue-sensitive unit is not less than 80%, that of the green-sensitive unit is 30 to 75% and that of the red-sensitive unit is not less than 80%.

Abstract: Coffee beans and the like are roasted in an enclosed, pressurized roaster under conditions which provide rapid heat transfer and close control of roasting time-temperature profiles. The roasting chamber desirably has a bottom screen, a top screen and a shutter adapted to momentarily occlude flow through the various portions of the top screen. Roasting gas passes upwardly through the beans, entrains some of the beans and forces them against the top screen. The beans drop back into the chamber when the shutter occludes a particular portion of the top screen holding the beans. Time-temperature profiles can be controlled by monitoring process conditions such as inlet and outlet gas enthalpies.

Abstract: The present invention relates to novel 6-methylnicotinamide derivatives and their pharmaceutically acceptable salts, the process for preparing them, and the pharmaceutical compositions containing said compounds as active ingredients. The 6-methylnicotinamide derivatives of the present invention exhibit their inhibitory activity against the proliferation of human immunodeficiency virus (HIV) as well as hepatitis B virus (HBV) and hepatitis C virus (HCV), such that they can be used for hepatitis B, hepatitis C and acquired immune deficiency syndrome (AIDS).

Abstract: Polymeric conjugates of camptothecin derivatives having increased circulating half-lives are disclosed. In preferred aspects, the E ring lactone of the camptothecin derivative is opened and functionalized to allow attachment of a polymer such as PEG in the 17- or 20-position thereof. A representative example of such compounds is Methods of preparing and using the same are also disclosed.

Abstract: Water purifier using membranes, ion exchange resins and electricity to remove ionic, organic and suspended impurities from water to produce high quality, pure water. Supply water is pre-treated by directing it first into a sediment pre-filter module, a softener module and a sediment removal and dechlorination module. The pre-treated water is supplied to a reverse osmosis module which separates the water into two streams (a purified water stream and a concentrate stream) by collecting fluids from both sides of pressurized membranes. The purified water is passed to an electrodeionization module which further purifies the water and directs the water to an ultraviolet sterilization module. The concentrate stream is divided into a recycle stream which is passed to the inlet of the reverse osmosis module and a waste concentrate stream which flows to an outlet of the machine. A control method for the water purifier is also disclosed.

Abstract: The present invention relates to a molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect, Moreover, a high loading efficiency of hydrophilic drugs can be achieved.

Abstract: The invention relates to a nanocomposite material on the basis of clay having a layered structure and a cation exchange capacity of from 30-250 milliequivalents per 100 gram, a polymeric matrix and a block copolymer or a graft copolymer, which block copolymer or graft copolymer comprises one or more first structural units (A), which are compatible with the clay and one or more second structural units (B), which are compatible with the polymeric matrix.

Abstract: The invention relates to crystalline hydrazinium nitroformate having a length to diameter ratio of at most 2.5 and a sensitivity to friction and shock not below 20 N and 2 J, respectively, as well as to a method for the preparation thereof.

Abstract: Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologically active material are used as attachment sites. Methods of forming the polymer, conjugating the polymers with biologically active moieties and methods of using the conjugates are also disclosed.

Abstract: A method of manufacturing radiators by joining a corrugated fin to a base plate, characterized by low costs and prevention of thermal deformation of the corrugated fin due to low-temperature soldering. A first soldering at the lower ends of the corrugated fin is conducted by a first soldering alloy in a recess heated by a heating plate in a mobile solder tank filled with the molten first soldering alloy. A second soldering alloy is heated by a heating plate on a base plate and the molten second soldering alloy is used to conduct a second soldering. When the corrugated fin is placed on the base plate, pressed and heated, the first and second solders are melted to join the corrugated fin to the base plate.

Abstract: The present invention is to provide a silver halide photographic light-sensitive material comprising a support having thereon a light-sensitive silver halide emulsion layer comprising a compound represented by Formula, Formula 1 Z—S—X wherein Z represents a group represented by Formula 1-2; X represents a hydrogen atom or Z—S—, wherein A1, A2, A3, A4, and A5 each represent ═N—, ═N(→O)—, or ═CR91—, in which R91 represents a substituent, and at least two of A1, A2, A3, A4, and A5 are respectively ═N(→O)— and ═CR91—.

Abstract: The present invention relates to a reference electrode for a potentiometric electrode system, characterized in that the junction in contact with a sample solution is enlarged and an ion-sensitive membrane containing an ion selective material as a protective membrane for the inner reference solution is employed, which comprises a substrate; a metal layer; an insoluble metal salt layer; an insulating film for insulating the metal layer from an aqueous solution; a hydrogel serving as an inner reference solution; the junction on the hydrogel contacting with a sample solution; the ion-sensitive, protective membrane formed over all surface areas of the hydrogel, except for the junction, to separate the sample solution from the inner reference solution or act as an ion-sensing membrane upon the contamination of the junction, whereby the operational abnormality caused by junction contamination may be easily checked and fast activation may be achieved.