Patents Represented by Attorney Muserlian, Lucas & Mercanti, LLP
  • Patent number: 6949682
    Abstract: The present invention relates to cinnamaldehyde derivatives inhibiting growth of tumor cell and regulating cell cycle, the method for preparation and the pharmaceutical composition thereof. The cinnamaldehyde derivatives of the present invention can be effectively used as a cell cycle regulator or a cancer cell growth inhibitor, since it has an ability to regulate cell cycle by holding the cells in G2/M stage of the cell division and has activity to inhibit cancer cell growth.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: September 27, 2005
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Byoung-Mog Kwon, Kwang-Hee Son, Dong Cho Han, Sangku Lee, Jong Han Kim, Sung-Gyu Choi, Mi-Young Lee, Sun Bok Jeon
  • Patent number: 6921500
    Abstract: The present invention relates to a method for fabricating a functional dental element, such as a crown. According to the invention, use is made of a three-dimensional printing technique. The major advantages of the invention are that no mold is needed anymore, which entails a considerable saving of costs, that a great accuracy is achieved, and that the element can be made of different materials.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: July 26, 2005
    Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO
    Inventor: Frits Kornelis Feenstra
  • Patent number: 6916388
    Abstract: The present invention is directed to a solid propellant for rocket motors, gas generators and comparable devices, comprising a cured composition of hydrazinium nitroformate and an unsaturated hydroxyl terminated hydrocarbon compound.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: July 12, 2005
    Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO
    Inventors: Jeroen Louwers, Antonius Eduard Dominicus Maria Van Der Heijden, Petrus Johannes Maria Elands
  • Patent number: 6902609
    Abstract: The present invention is directed to film coating systems for use on oral dosage forms such as compressed tablets and orally-ingestible substrates which have improved pearlescent qualities. The film coating systems can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the pearlescent film coating is prepared as a dry powder mixture containing a cellulosic polymer, a detackifier, a gloss enhancer, and a pearlescent pigment. Film coating compositions containing an aqueous suspension of the powder mixtures, methods of applying the coatings to substrates and the coated substrates are also disclosed.
    Type: Grant
    Filed: February 13, 2004
    Date of Patent: June 7, 2005
    Assignee: BPSI Holdings, Inc.
    Inventors: Rita M. Steffenino, Franklin J. Gulian, Irvin M. Lash, Thomas P. Farrell, Charles D. Fields
  • Patent number: 6893384
    Abstract: A kick boxing training bag includes a foam rubber padding (17) slipped onto a supporting structure provided with a hollow base (3) which can be filled with ballast, the supporting structure including two hollow cylindrical rubber springs (9, 13) connected by a rigid rod (11). The elastically flexible structure prevents any trauma to the athlete, provides greater realism of the training which can be much faster and rhythmic, can take even very strong blows without risking the fall of the bag and allows to easily make devices with different elastic responses according to the needs by changing the flexibility of the springs. Moreover, the base (3) is separable and stackable to facilitate the storage of a plurality of bags.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: May 17, 2005
    Assignee: Real Globe s.r.l.
    Inventor: Aldo Triani
  • Patent number: 6884750
    Abstract: The present invention relates to new chiral salen catalysts and methods for the preparation of chiral compounds from racemic epoxides by using new catalyst. More particularly, the present invention is to provide novel chiral salen catalysts and their uses for producing chiral compounds having high optical purity to be used as raw materials for preparing chiral medicines or food additives in a large scale economically, wherein the chirl salen catalyst having a particular molecules structure can be reused continuously without any activating process of used catalysts and cause no or little racemization after the reaction is completed because it maintains its catalytic activity after the reaction process.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: April 26, 2005
    Assignee: RS Tech Corp.
    Inventors: Geon Joong Kim, Ho Seong Lee, Ho Cheol Kim, Jin Won Yun, Seong Jin Kim
  • Patent number: 6872393
    Abstract: The present invention relates to the chemical modification of single chain polypeptides by means of covalent attachment of strands of poly(ethylene glycol) PEG and similar poly(alkylene oxides) to single chain polypeptide binding molecules that have the three dimensional folding and, thus, the binding ability and specificity, of the variable region of an antibody. Such preparations of modified single chain polypeptide binding molecules have reduced immugenicity and antigenicity as well as having a longer halflife in the bloodstream as compared to the parent polypeptide. These beneficial properties of the modified single chain polypeptide binding molecules make them very useful in a variety of therapeutic applications. The invention also relates to multivalent antigen-binding molecules capable of PEGylation. Compositions of, genetic constructions for, methods of use, and methods for producing PEGylated antigen-binding proteins are disclosed.
    Type: Grant
    Filed: February 26, 2001
    Date of Patent: March 29, 2005
    Assignee: Enzon, Inc.
    Inventors: Marc Whitlow, Robert G. L. Shorr, David R. Filpula, Lihsyng Standford Lee
  • Patent number: 6852512
    Abstract: The present invention relates to novel expression vectors which can produce foreign proteins as soluble forms by using lysyl-tRNA synthetase and a process for preparing foreign proteins by using the expression vectors. Particularly, the present invention relates to the expression vectors which can provide foreign proteins as fused and soluble forms by exploiting the structure and expression pattern of lysyl-tRNA synthetase and the processes for preparing foreign proteins in E. coli effectively, which can be utilized industrially to produce active proteins in mass.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: February 8, 2005
    Assignee: Hanil Synthetic Fiber Co., Ltd.
    Inventors: Seong Il Choi, Baik Lin Seong
  • Patent number: 6838416
    Abstract: The present invention provided with novel 5-benzyloxymethyl-1,2-isoxazoline derivatives of the formula (1), their preparation method and their use as herbicides. The 5-benzyloxymethyl-1,2-isoxazoline derivatives according to the present invention have sufficiently high herbicidal activity against the weeds in the paddy field rice even at low dose rates and excellent selectivity to transferred rice in particular. As thus, the compounds of the present invention are typically useful as herbicides for control of paddy weeds in rice.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: January 4, 2005
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Eung-Kul Ryu, Hyoung-Rae Kim, Dong-Ju Jeon, Jong-Whan Song, Kyoung-Mahn Kim, Jung-No Lee, Hyoung-Cheul Kim, Kyung-Sik Hong
  • Patent number: 6824641
    Abstract: The present invention relates to a process for bevelling an edge of a wood-chip board (1) or a board of similar material, and the bevelled board thereby obtained. The process includes the operative steps of: making at least two grooves (5) along a whole area to be bevelled of the edge of the board (1), the grooves (5) being substantially parallel to each other and to the faces (2, 3) of the board (1) and having a thickness increasing toward the exterior of the board (1); introducing into each groove (5) an insert (6) of uniform thickness equal to a minimum thickness of the same groove (5); and pressing and gluing the walls of the grooves (5) on inserts (6).
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: November 30, 2004
    Assignee: Sacea S.p.A.
    Inventor: Lorenzo Tirinnanzi
  • Patent number: 6812272
    Abstract: The invention relates to a nanocomposite material on the basis of a clay having a layered structure and a cation exchange capacity of from 30 to 250 milliequivalents per 100 gram, a polymeric matrix and a block copolymer or a graft copolymer, which block copolymer or graft copolymer comprises one or more first structural units (A), which are compatible with the clay, and one or more second structural units (B), which are compatible with the polymeric matrix.
    Type: Grant
    Filed: November 1, 2002
    Date of Patent: November 2, 2004
    Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO
    Inventor: Hartmut Rudolf Fischer
  • Patent number: 6777387
    Abstract: The present invention is directed to polymeric prodrug transport forms and methods of making and using the same. In one preferred aspect, the prodrugs are of the formula: wherein G is a polymeric residue; Z is one of: and B is a residue of a biologically active amine-containing moiety or a hydroxyl-containing moiety.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: August 17, 2004
    Assignee: Enzon Pharmaceuticals, Inc.
    Inventors: Richard B. Greenwald, Yun H. Choe
  • Patent number: 6773725
    Abstract: The present invention relates a composition promoting the growth, and increasing preservative capability of human body, animals and plants. The composition of the present invention maximizes physiological activity of human body, animals and plants. In addition, the present invention relates a producing method of the composition composed of the following steps: 1) preparing a composition containing kaoline (white soil) 30-40 wt %, potassium sulfate 15.0-20.0 wt %, sodium sulfate 13.0-17.0 wt %, feldspar 12.0-16.0 wt %, talc 12.0-16.0% and ferric oxide 0.5-1.5 wt %; and 2) mixing the above-mentioned composition using a compressed molding method; and 3) heating the mixed composition at 1000-1300° C. The composition of the present invention can be used in whole fields of industries, and will cause the original changes in the field of industrial matters, and promote the welfare of human beings such as improvement of health and life of human.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: August 10, 2004
    Inventor: Si-Hoon Song
  • Patent number: 6774116
    Abstract: A prodrug composition containing a cinnamate moiety and a biologically active molecule moiety which can be released by hydrolysis or activated by light is disclosed. The cinnamate moiety can have substituents of various electronically donating or electronically withdrawing groups to modify the cinnamate moiety's electric properties as well as photo reactivities for the purpose of achieving a proper hydrolysis rate of the acyl bond between the biologically active molecule moiety and the cinnamic acid backbone. The biologically active molecule can be any biologically active agent or diagnostic, for example, a chemotherapeutic such as a paclitaxel, campotothecin, doxorubicin, amethopterin, etoposide, or fluconazole. The prodrug composition can be modified to add a carrier moiety on the prodrug composition for targeting or to facilitate uptake of the drug. The prodrug compositions can be activated with an energy source to release the drug at the desired site.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: August 10, 2004
    Assignee: Cryolife, Inc.
    Inventors: Carl W. Gilbert, Eleanor B. McGowan, Kirby S. Black, T. Gregory P. Harper
  • Patent number: 6770671
    Abstract: Disclosed are a novel compound represented by the following chemical formula (1), useful for the prophylaxis and treatment of angiogenic diseases, its production, and a novel microorganism producing the same. Aspergillus sp. Y80118 isolated from soil was found to produce 7,8-dihydro-1,7-dihydroxy-3-hydroxymethyl-xanthenone-8-carboxylic acid methylester which inhibits VEGF-induced proliferation of HUVEC, angiogenesis in CAM assay, and tumor growth. The novel compound can be effectively used for the medical treatment of anigiogenic diseases, including cancers, rheumatoid arthritis, and diabetic retinopathy.
    Type: Grant
    Filed: September 4, 2002
    Date of Patent: August 3, 2004
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Jung Joon Lee, Jeong-Hyung Lee, Hang Sub Kim, Young-Soo Hong, Yun Joo Park
  • Patent number: 6764853
    Abstract: The present invention is directed to a method of in vivo and ex vivo gene delivery, for a variety of cells. More specifically, it relates to a novel carrier system and method for targeted delivery of nucleic acids to mammalian cells. More specifically, the present invention relates to carrier system comprising single-chain polypeptide binding molecules having an a region rich in basic amino acid and having the three dimensional folding and, thus, the binding ability and specificity, of the variable region of an antibody. The basic amino acid rich region can comprise oligo-lysine, oligo-arginine or combinations thereof. Such preparations of modified single chain polypeptide binding molecules also have ability to bind nucleic acids at the region rich in basic amino acid residues. These properties of the modified single chain polypeptide binding molecules make them very useful in a variety of therapeutic applications including gene therapy.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: July 20, 2004
    Assignee: Enzon Pharmaceuticals, Inc.
    Inventors: David R. Filpula, Maoliang Wang, Marc D. Whitlow
  • Patent number: 6762176
    Abstract: The invention concerns novel 2-aminopyridine derivatives having an activity inhibiting NO-synthase enzymes producing nitrogen monoxide NO and/or trapping reactive forms of oxygen, the methods for preparing them, pharmaceutical compositions containing them and their therapeutic uses, particularly their use as NO-synthase inhibitors and for trapping reactive forms of oxygen whether selectively or not.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: July 13, 2004
    Assignee: Societe de Consells de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Pierre-Etienne Chabrier de Lassauniere, Serge Auvin, Jerry Harnett, Dominique Pons, Gérard Ulibarri, Dennis Bigg
  • Patent number: 6762189
    Abstract: The present invention relates to novel 5-pyrimidinecarboxamide derivatives and the pharmaceutical compositions containing said derivatives, and more specifically, to 5-pyrimidinecarboxamide derivatives and their pharmacutically able salts, the process for preparing them, and the pharmaceutical compositions containing said compounds as active ingredients. In particular, said 5-pyrimidinecarboxamide derivatives of the present invention, due to their inhibitory activity against the proliferation of human immunodeficiency virus (HIV) as well as hepatitis B virus (HBV), can be used as a therapeutic agent as well as a preventive agent for hepatitis B and acquired immune deficiency syndrome (AIDS).
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: July 13, 2004
    Assignee: Dong Wha Pharm. Ind. Co., Ltd.
    Inventors: Sung June Yoon, Sang Wook Lee, Nam Doo Kim, Yong Kyun Park, Geun Hyung Lee, Jong Woo Kim, Sang Jin Park, Hee Jeoung Park, Hwan Bong Jang
  • Patent number: 6756037
    Abstract: The present invention is directed to polymer conjugates of biologically active agents and methods of preparing the same. In preferred aspects of the invention, the conjugates are of the formula wherein G is a linear or branched polymer residue such as a polyethylene glycol and B is a residue of an amine-containing or a hydroxyl-containing biologically active moiety such as Ara-C.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: June 29, 2004
    Assignee: Enzon, Inc.
    Inventors: Richard B. Greenwald, Yun H. Choe
  • Patent number: D504778
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: May 10, 2005
    Assignee: Polar Bear Trading Ltd.
    Inventor: François-Xavier Mariani