Patents Represented by Attorney Nancy J. Harrison
  • Patent number: 4824863
    Abstract: New polyether antibiotic A80438, its acyl and alkyl ester, alkyl ether and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Method of making A80438 by culture of Streptomyces bobili NRRL 15971 and synergistic compositions comprising (1) and A80438 compound and (2) nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds or metichlorpindol are also provided.
    Type: Grant
    Filed: May 28, 1985
    Date of Patent: April 25, 1989
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Walter M. Nakatsukasa, Raymond C. Yao
  • Patent number: 4820694
    Abstract: New 3'" and/or 4'"-modified macrocin and 3" and/or 4"-modified-lactenocin derivatives of formula 1 have significant antibacterial activity. Compositions positions containing and methods of using these derivatives are also provided.
    Type: Grant
    Filed: September 29, 1986
    Date of Patent: April 11, 1989
    Assignee: Eli Lilly and Company
    Inventors: Manuel Debono, Herbert A. Kirst, James P. Leeds
  • Patent number: 4820695
    Abstract: C-20-Dihydro-deoxy-(cyclic amino)-derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, lactenocin, 2"'-O-demethylmacrocin and 2"-O-demethyllactenocin, which inhibit pathogenic bacteria, especially gram-positive bacteria, Pasteurella species, and Mycoplasma species, and pharmaceutical compositions thereof, are provided.
    Type: Grant
    Filed: May 28, 1987
    Date of Patent: April 11, 1989
    Assignee: Eli Lilly and Company
    Inventors: Manuel Debono, Herbert A. Kirst
  • Patent number: 4800157
    Abstract: Improved fermentation process for producing the gram-positive A-21978C antibiotics which comprises cultivating a new strain of Streptomyces roseosporus, NRRL 15998, and the biologically purified culture of this microorganism are provided.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: January 24, 1989
    Assignee: Eli Lilly and Company
    Inventors: Tom E. Eaton, Lynda M. Ford, Otis W. Godfrey, Jr., Mary L. B. Huber, Milton J. Zmijewski, Jr.
  • Patent number: 4764510
    Abstract: Antibiotic A42125, which is produced by a new strain of Nocardia aerocolonigenes, NRRL 18049, is a useful inhibitor of Gram-positive and methane-generating microorganisms. A42125 also increases feed utilization efficiency in ruminants. A biologically purified culture of N. aerocolonigenes NRRL 18049 and a method for producing A42125 by fermentation of this culture are provided.
    Type: Grant
    Filed: April 11, 1986
    Date of Patent: August 16, 1988
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Ralph E. Kastner
  • Patent number: 4755610
    Abstract: New alkaloids called hapalindoles, which are antibacterial and antifungal agents, and methods of preparing these alkaloids by culturing the blue-green alga Hapalosiphon fontinalis ATCC 39694, are provided.
    Type: Grant
    Filed: February 14, 1986
    Date of Patent: July 5, 1988
    Assignee: University of Hawaii
    Inventors: Richard E. Moore, Gregory M. L. Patterson
  • Patent number: 4713331
    Abstract: Antibiotic A41030, a complex of 7 individual factors, is produced by submerged, aerobic fermentation of new Streptomyces virginiae NRRL 12525, and Streptomyces virginiae NRRL 15156. The antibiotic factors are separated and possess antibacterial activity against Staphylococcus and Streptococcus species which are penicillin resistant. In addition, the antibiotic factors have shown inhibition of Streptococcus pneumonia Park I. The complex and the individual factors enhance feed efficiency in ruminant animals, and are growth promoters in chickens and swine, and are especially valuable in milk production in dairy cattle.
    Type: Grant
    Filed: September 16, 1985
    Date of Patent: December 15, 1987
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Ralph E. Kastner
  • Patent number: 4705807
    Abstract: Novel amines of formula:R--(CH.sub.2).sub.n --NR.sup.1 R.sup.2where R is cis-2-phenylbicyclo[2,2,2]octane or 2-phenylbicyclo[2,2,2]oct-2-ene nucleus, n is 1 to 3, R.sup.1 is C.sub.1-3 alkyl and R.sup.2 is hydrogen or C.sub.1-3 alkyl, and acid-addition salts thereof, which are useful for the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: December 10, 1982
    Date of Patent: November 10, 1987
    Assignee: Lilly Industries Limited
    Inventors: David C. Horwell, Graham H. Timms
  • Patent number: 4698327
    Abstract: Novel glycopeptide antibiotics of formula (I) can be prepared from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D by reaction with a ketone or aldehyde followed, if appropriate, by reduction. The new glycopeptide derivatives are useful antibacterial agents.
    Type: Grant
    Filed: April 18, 1986
    Date of Patent: October 6, 1987
    Assignee: Eli Lilly and Company
    Inventors: Ramakrishnan Nagarajan, Amelia A. Schabel
  • Patent number: 4695545
    Abstract: A hitherto undescribed microorganism, Streptomyces virginiae NRRL 12525, which upon culturing produces the A41030 antibiotic complex comprising several factors. The A41030 antibiotics produced show antibacterial activity against the gram-positive genera Staphylococcus and Streptococcus which are resistant to penicillin. In addition, these antibiotic act to promote growth and improve feed efficiency in ruminant animals, poultry and swine, and other livestock, and to improve milk production in ruminant animals.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: September 22, 1987
    Assignee: Eli Lilly and Company
    Inventor: Walter M. Nakatsukasa
  • Patent number: 4683204
    Abstract: Improved fermentation process for producing the polyether antibiotic A80190 which comprises cultivating a new strain of Actinomodura Oligospora, NRRL 15878, and the biologically purified culture of this microorganism are provided.
    Type: Grant
    Filed: October 9, 1984
    Date of Patent: July 28, 1987
    Assignee: Eli Lilly and Company
    Inventor: LaVerne D. Boeck
  • Patent number: 4683201
    Abstract: New polyether antibiotic A80190, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A80190 by culture of Actinomadura oligospora NRRL 15877 and synergistic compositions of the A80190 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.
    Type: Grant
    Filed: October 15, 1985
    Date of Patent: July 28, 1987
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Raymond C. Yao
  • Patent number: 4663282
    Abstract: New glycopeptide antibiotic CUC/CSV which has the formula: ##STR1## wherein R is L-ristosaminyl;R.sub.1 is the disaccharide mannosyl-glucosyl; andR.sub.2 and R.sub.3 are mannosyl, and its salts, particularly the pharmaceutically acceptable salts, are useful new antibiotics are active against gram-positive bacteria and increase feed-efficiency utilization and enhance milk production in ruminants.
    Type: Grant
    Filed: May 2, 1985
    Date of Patent: May 5, 1987
    Assignee: Eli Lilly and Company
    Inventors: LaVerne D. Boeck, Gladys M. Clem, Charles L. Hershberger, Marie T. Anderson, Karl H. Michel
  • Patent number: 4656258
    Abstract: New macrocin and lactenocin ester derivatives of the formula: ##STR1## wherein R is formyl or hydroxymethyl; R.sup.1 is hydrogen, acetyl or propionyl; R.sup.2 is hydrogen or ##STR2## and R.sup.3 is hydrogen, acetyl, propionyl, n-butyryl or isovaleryl; provided that one of R.sup.1 or R.sup.3 must be other than hydrogen; and the acid addition salts thereof; prepared by bioconversion of macrocin or lactenocin with an acylating enzyme system produced by Streptomyces thermotolerans strains, have improved activity against Mycoplasma species.
    Type: Grant
    Filed: June 11, 1985
    Date of Patent: April 7, 1987
    Assignee: Eli Lilly and Company
    Inventors: Jan R. Turner, Veronica M. Krupinski, David S. Fukuda, Richard H. Baltz
  • Patent number: 4643987
    Abstract: Novel aracyl glycopeptide derivatives of formula 1 and methods for their preparation from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D, are provided. The new glycopeptide derivatives are useful antibacterial agents.
    Type: Grant
    Filed: August 14, 1985
    Date of Patent: February 17, 1987
    Assignee: Eli Lilly and Company
    Inventors: Ramakrishnan Nagarajan, Amelia A. Schabel
  • Patent number: 4639433
    Abstract: Novel glycopeptide derivatives of formula 1 and methods for their preparation from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D, are provided. The new glycopeptide derivatives are useful antibacterial agents.
    Type: Grant
    Filed: August 14, 1985
    Date of Patent: January 27, 1987
    Assignee: Eli Lilly and Company
    Inventors: Ann H. Hunt, R. Michael Molloy, Ramakrishnan Nagarajan, Amelia A. Schabel
  • Patent number: 4629786
    Abstract: C-20-Modified derivatives of macrolide antibiotics which include demycinosyltylosin (DMT), 20-dihydro-23-demycinosyltylosin (dihydro-DMT), 23-de(mycinosyloxy)tylosin (DMOT), 20-dihydro-23-de(mycinosyloxy)tylosin (dihydro-DMOT), 5-O-mycaminosyltylonolide (OMT), 20-dihydro-5-O-mycaminosyltylonolide (dihydro-OMT), 23-deoxy-5-O-mycaminosyltylonolide (DOMT), and 20-dihydro-23-deoxy-5-O-mycaminosyltylonolide (dihydro-DOMT) inhibit pathogenic bacteria, especially gram-positive bacteria, and Mycoplasma species; and pharmaceutical compositions thereof.
    Type: Grant
    Filed: May 25, 1984
    Date of Patent: December 16, 1986
    Assignee: Eli Lilly and Company
    Inventors: Manuel Debono, Herbert A. Kirst
  • Patent number: RE32310
    Abstract: A-21978C cyclic peptide derivatives of the formula ##STR1## wherein R is a substituted benzoyl group of the formula ##STR2## R.sup.2 is C.sub.8 -C.sub.15 alkyl; X is hydrogen, chloro, bromo, iodo, nitro, C.sub.1 -C.sub.3 alkyl, hydroxy, C.sub.1 -C.sub.3 alkoxy, or C.sub.1 -C.sub.3 alkylthio; and R.sup.1 is hydrogen or an amino-protecting group; and the salts thereof, are useful new semisynthetic antibacterial agents or intermediates to such agents.
    Type: Grant
    Filed: September 23, 1985
    Date of Patent: December 16, 1986
    Assignee: Eli Lilly and Company
    Inventor: Manuel Debono
  • Patent number: RE32333
    Abstract: Antibiotic A-21978 complexes, in particular the A-21978C complex, comprising microbiologically active, related factors C.sub.0, C.sub.1, C.sub.2, C.sub.3, C.sub.4, and C.sub.5. A-21978 complex and A-21978C complex are produced by submerged aerobic fermentation of Streptomyces roseosporus NRRL 11379. The individual A-29178C factors are separated and isolated by chromatography. The A-21978 and A-21978C complexes; the A-21978C factors; and pharmaceutically acceptable salts thereof are antibacterial agents and improve growth promotion in poultry.
    Type: Grant
    Filed: September 26, 1985
    Date of Patent: January 20, 1987
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Marvin M. Hoehn
  • Patent number: RE32455
    Abstract: Antibiotic A-21978C complexes, in particular the A-21978C complex, comprising microbiologically active, related factors, C.sub.0, C.sub.1, C.sub.2, C.sub.3, C.sub.4, and C.sub.5. A-21978 complex and A-21978C complex are produced by submerged aerobic fermentation of Streptomyces roseosporus NRRL 11379. The individual A-21978C factors are separated and isolated by chromatography. The A-21978 and A-21978C complexes, the A-21978C factors, and pharmaceutically acceptable salts thereof are antibacterial agents and improve growth promotion in poultry.
    Type: Grant
    Filed: September 26, 1985
    Date of Patent: July 7, 1987
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Marvin M. Hoehn