Patents Represented by Attorney Nancy J. Harrison
  • Patent number: 4609645
    Abstract: Macrolides PTL-448 A and B, which can be prepared by aerobic cultivation of Streptomyces ambofaciens ATCC 15154 in the presence of a macrolide intermediate selected from protylonlide, 5-O-mycaminosylprotylonolide, 20-hydroxy-5-O-mycaminosylprotylonolide and 20-oxo-5-O-mycaminosylprotylonodide, and macrolides PTL-448 C and D, which can be prepared by acidic hydrolysis of PTL-448 A and B are useful antibiotics.
    Type: Grant
    Filed: March 26, 1984
    Date of Patent: September 2, 1986
    Inventor: Satoshi Omura
  • Patent number: 4604239
    Abstract: Antibiotic A41030, a complex of 7 individual factors, is produced by submerged, aerobic fermentation of new Streptomyces virginiae NRRL 12525, and Streptomyces virginiae NRRL 15156. The antibiotic factors are separated and possess antibacterial activity against Staphylococcus and Streptococcus species which are penicillin resistant. In addition, the antibiotic factors have shown inhibition of Streptococcus pneumonia Park I. The complex and the individual factors enhance feed efficiency in ruminant animals, and are growth promoters in chickens and swine, and are especially valuable in milk production in dairy cattle.
    Type: Grant
    Filed: June 11, 1985
    Date of Patent: August 5, 1986
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Ralph E. Kastner
  • Patent number: 4604380
    Abstract: C-23-bicyclic or tricyclic amino derivatives of OMT and 4'-deoxy-OMT, and pharmaceutical compositions comprising and methods of treating infections with these compounds, are provided.
    Type: Grant
    Filed: January 18, 1985
    Date of Patent: August 5, 1986
    Assignee: Eli Lilly and Company
    Inventor: Manuel Debono
  • Patent number: 4594338
    Abstract: 11-Thioether and certain C-20 acetal and thioacetal derivatives of tylosin and demycarosyltylosin are effective antibacterial agents. Processes for preparing, formulations containing, and methods of treating bacterial infections with these derivatives are provided.
    Type: Grant
    Filed: February 19, 1985
    Date of Patent: June 10, 1986
    Inventors: Satoshi Omura, Kazuo Tsuzuki
  • Patent number: 4594417
    Abstract: Crystalline cephalosporin hydrochloride salt represented by the formula ##STR1## wherein the oxime is in the syn configuration, is a useful pharmaceutical form of, and tool for purification of, the corresponding antibiotic free base; processes for its preparation are provided.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: June 10, 1986
    Assignee: Eli Lilly Company
    Inventor: Kuo S. Yang
  • Patent number: 4594337
    Abstract: Methods of controlling Mycoplasma infections which comprise administering to an infected or susceptible warm-blooded animal an effective amount of a new macrocin or lactenocin ester derivative of the formula: ##STR1## wherein R is formyl or hydroxymethyl; R.sup.1 is hydrogen, acetyl or propionyl; R.sup.2 is hydrogen or ##STR2## and R.sup.3 is hydrogen, acetyl, propionyl, n-butyryl or isovaleryl; provided that one of R.sup.1 or R.sup.3 must be other than hydrogen; or a pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: February 27, 1985
    Date of Patent: June 10, 1986
    Assignee: Eli Lilly and Company
    Inventors: Earl E. Ose, Jan R. Turner
  • Patent number: 4587218
    Abstract: New Actinoplanes missouriensis strains CUC 014 (NRRL 15647) and CSV 558 (NRRL 15646) which operate together to cosynthesize the useful glycopeptide antibiotic CUC/CSV.
    Type: Grant
    Filed: October 21, 1983
    Date of Patent: May 6, 1986
    Assignee: Eli Lilly and Company
    Inventor: Charles L. Hershberger
  • Patent number: 4582822
    Abstract: New polyether antibiotic A80190, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A80190 by culture of Actinomodura oligospora NRRL 15877 and synergistic compositions of the A80190 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.
    Type: Grant
    Filed: October 9, 1984
    Date of Patent: April 15, 1986
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, Raymond C. Yao
  • Patent number: 4581346
    Abstract: C-8, 20-cyclo-derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, lactenocin, 2'"-O-demethylmacrocin and 2"-O-demethyllactenocin, which inhibit pathogenic bacteria, especially gram-positive bacteria, and Mycoplasma species, and pharmaceutical compositions thereof, are provided.
    Type: Grant
    Filed: July 12, 1984
    Date of Patent: April 8, 1986
    Assignee: Eli Lilly and Company
    Inventor: Joseph H. Kennedy
  • Patent number: 4563442
    Abstract: New glycopeptide antibiotics of the formula: ##STR1## wherein W is the remaining portion of a glycopeptide antibiotic selected from actaplanin factors B.sub.1, B.sub.2, B.sub.3, C.sub.1, C.sub.2, C.sub.3, D.sub.1, D.sub.2, E.sub.1, G, K, L, M, N, O and actaplanin .psi.aglycone, and salts thereof, particularly the pharmaceutically acceptable salts, are useful new antibiotics are active against gram-positive bacteria and increase feed-efficiency utilization and enhance milk production in ruminants.
    Type: Grant
    Filed: September 24, 1984
    Date of Patent: January 7, 1986
    Assignee: Eli Lilly and Company
    Inventors: Gladys M. Clem, LaVerne D. Boeck, Marie T. Anderson, Karl H. Michel
  • Patent number: 4560509
    Abstract: A new antibiotic of the rifamycin class, A39079 factor S-1, which has the structure ##STR1## is an effective broad-spectrum antibiotic and increases feed-utilization efficiency in animals.
    Type: Grant
    Filed: November 16, 1983
    Date of Patent: December 24, 1985
    Assignee: Eli Lilly and Company
    Inventors: Ronald D. Johnson, Ralph E. Kastner, LaVerne D. Boeck
  • Patent number: 4559301
    Abstract: New macrocin and lactenocin ester derivatives of the formula: ##STR1## wherein R is formyl or hydroxymethyl; R.sup.1 is hydrogen, acetyl or propionyl; R.sup.2 is hydrogen or ##STR2## and R.sup.3 is hydrogen, acetyl, propionyl, n-butyryl or isovaleryl; provided that one of R.sup.1 or R.sup.3 must be other than hydrogen; and the acid addition salts thereof; prepared by bioconversion of macrocin or lactenocin with an acylating enzyme system produced by Streptomyces thermotolerans strains, have improved activity against Mycoplasma species.
    Type: Grant
    Filed: March 3, 1983
    Date of Patent: December 17, 1985
    Assignee: Eli Lilly and Company
    Inventors: Jan R. Turner, Veronica M. Krupinski, David S. Fukuda, Richard H. Baltz
  • Patent number: 4559323
    Abstract: Antibiotic A41030, a complex of 7 individual factors, is produced by submerged, aerobic fermentation of new Streptomyces virginiae NRRL 12525, and Streptomyces virginiae NRRL 15156. The antibiotic factors are separated and possess antibacterial activity against Staphylococcus and Streptococcus species which are penicillin resistant. In addition, the antibiotic factors have shown inhibition of Streptococcus pneumonia Park I. The complex and the individual factors enhance feed efficiency in ruminant animals, and are growth promoters in chickens and swine, and are especially valuable in milk production in dairy cattle.
    Type: Grant
    Filed: August 2, 1984
    Date of Patent: December 17, 1985
    Assignee: Eli Lilly and Company
    Inventors: Karl H. Michel, Ralph E. Kastner
  • Patent number: 4552701
    Abstract: Desvancosaminyl- and des(vancosaminyl-O-glucosyl) glycopeptides, and methods for their preparation by treating a glycopeptide selected from vancomycin, A51568A, A51568B, M43A and M43D with trifluoroacetic acid under controlled conditions, are provided. The new glycopeptides are useful antibacterial agents.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: November 12, 1985
    Assignee: Eli Lilly and Company
    Inventors: Ramakrishnan Nagarajan, Amelia A. Schabel
  • Patent number: 4548924
    Abstract: Antibiotics M43B and M43C, new glycopeptide antibiotics of the vancomycin class, are produced by Nocardia orientalis NRRL 2452. M43B and M43C have antibacterial activity.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: October 22, 1985
    Assignee: Eli Lilly and Company
    Inventor: Karl H. Michel
  • Patent number: 4548925
    Abstract: Antibiotic M43A, a new glycopeptide antibiotic of the vancomycin class, is produced by Nocardia orientalis strains NRRL 2450 and NRRL 2452. M43A has excellent antibacterial activity comparable to that of vancomycin.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: October 22, 1985
    Assignee: Eli Lilly and Company
    Inventors: Harvey M. Higgins, Jr., Kurt E. Merkel, Mack H. McCormick
  • Patent number: 4547488
    Abstract: Antibiotic M43D, a new glycopeptide antibiotic of the vancomycin class, is produced by Nocardia orientalis NRRL 2450. M43D has excellent antibacterial activity comparable to that of vancomycin.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: October 15, 1985
    Assignee: Eli Lilly and Company
    Inventor: Kurt E. Merkel
  • Patent number: 4537957
    Abstract: 23-Demycinosyltylosin (DMT) which has the formula: ##STR1## 20-dihydro-DMT, specified acyl ester derivatives, and their acid addition salts are useful antibacterial agents. Improved methods of making 5-O-mycaminosyltylonolide (OMT) and 20-dihydro-OMT by mild acid hydrolysis of DMT and 20-dihydro-DMT, respectively, are included.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: August 27, 1985
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Gene M. Wild, Eugene T. Seno
  • Patent number: 4537715
    Abstract: New glycopeptide antibiotic CUC/CSV which has the formula: ##STR1## wherein R is L-ristosaminyl;R.sub.1 is the disaccharide mannosyl-glucosyl; andR.sub.2 and R.sub.3 are mannosyl, and its salts, particularly the pharmaceutically acceptable salts, are useful new antibiotics are active against gram-positive bacteria and increase feed-efficiency utilization and enhance milk production in ruminants.
    Type: Grant
    Filed: October 21, 1983
    Date of Patent: August 27, 1985
    Assignee: Eli Lilly and Company
    Inventors: LaVerne D. Boeck, Gladys M. Clem, Charles L. Hershberger, Marie T. Anderson, Karl H. Michel
  • Patent number: RE32311
    Abstract: A-21978C cyclic peptide derivatives of the formula ##STR1## wherein R is hydrogen, a specified aminoacyl or N-alkanoylaminoacyl group, 8-methyldecanoyl, 10-methyldodecanoyl, 10-methylundecanoyl, the specific C.sub.10 -alkanoyl group of A-21978C.sub.0 or the specific C.sub.12 -alkanoyl groups of A-21978C factors C.sub.4 and C.sub.5 or an amino-protecting group; and R.sup.1 is hydrogen, an amino-protecting group, or a specified aminoacyl or N-alkanoylaminoacyl group; provided that, when R is other than aminoacyl or N-alkanoylaminoacyl, R.sup.1 must be aminoacyl or N-alkanoylaminoacyl; and, when R.sup.1 is an amino-protecting group, R must be aminoacyl or N-alkanoylaminoacyl; and the salts thereof, are useful as antibacterial agents or as intermediates to antibacterial agents.
    Type: Grant
    Filed: September 25, 1985
    Date of Patent: December 16, 1986
    Assignee: Eli Lilly and Company
    Inventor: Manuel Debono