Patents Represented by Attorney Paul C. Flattery
  • Patent number: 5352773
    Abstract: The present invention relates to a stable hemoglobin based composition having sufficiently low levels of methemoglobin to effectively function as an oxygen carrying solution upon administration to a patient made by the process comprising: a) adding an oxygenated or deoxygenated form of said blood substitute to an oxygen impermeable package, and b) storing said container at from between 5.degree. C. to 45.degree. C. for sufficient time to permit the autoreduction of methemoglobin. The stable hemoglobin based composition includes hemoglobin, modified hemoglobin and/or encapsulated hemoglobin. To effectively function as an oxygen carrying solution upon administration to a patient, the stable hemoglobin based solution cannot have greater than about 50% of said hemoglobin based solution in the methemoglobin form but, preferably no more than about 15%. The invention further relates to a method to store a stable oxygen carrying solution according to the above discussed process.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: October 4, 1994
    Assignee: Baxter International Inc.
    Inventors: Richard L. Kandler, John C. Spicuzza
  • Patent number: 5352612
    Abstract: A sample analyzer for analyzing the characteristics of a plurality of samples. The analyzer includes a movable sample support for holding samples arranged in a first plurality of holders in a sequence for movement in a first direction. An indexing drive for the sample support advances the sample support in the first direction in a set of one or more increments, wherein one increment in the set is a net amount equal to a second plurality of holders greater than one holder and less than the first plurality such that the second plurality is relatively prime with respect to the first plurality.
    Type: Grant
    Filed: February 9, 1993
    Date of Patent: October 4, 1994
    Assignee: Baxter Diagnostics Inc.
    Inventors: Michael D. Huber, Stephen L. Frye, John C. Mazza
  • Patent number: 5350564
    Abstract: An automated chemical analyzer includes an automated conveyor apparatus for receiving a variety of sizes of test tubes, cuvettes, and sample tubes in a standard carrier member receivable into the analyzer. The standard carrier members may be interlocked in ranks and placed side by side in file to replicate the size and handling convenience of conventional test tube racks. However, the conveyor apparatus also provides for receipt of the carriers either as individuals for stat handling, or in interlocked ranks, or as rank and file groups for routine handling. The interlocked ranks of carriers are automatically unlocked from one another and fed along with the carriers having stat samples therein to a recirculating endless loop conveyor device which conveys the samples to at least one chemical analysis module, as well as providing a storage capacity both for samples in testing, and those samples awaiting verification of test results.
    Type: Grant
    Filed: June 28, 1993
    Date of Patent: September 27, 1994
    Assignee: Baxter Diagnostics Inc.
    Inventors: John C. Mazza, William A. Stark, Richard A. Scribner, Stephen L. Frye, Kempton H. Hardiman
  • Patent number: 5348061
    Abstract: A method and system for staging drugs dispensed from a drug dispensing apparatus including an accumulator operative to temporarily accumulate drugs for later dispensing into vials. The accumulator includes one or more staging containers positioned to receive dispensed drugs that fall freely under the influence of gravity, each container having an outlet that is selectively openable so that the drugs retained therein can be delivered to a vial at a later time. Several orders can be staged in parallel if several such staging containers are provided. The drugs are staged in the accumulators for dispensing before vials are positioned so that dispensing of all the drugs for each vial may be performed simultaneously.
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: September 20, 1994
    Assignee: Baxter International Inc.
    Inventors: Archie Riley, Keith Goodale
  • Patent number: 5344454
    Abstract: Improved Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish an improved chamber for holding the implanted cells. The chambers include first and second wall elements and an intermediate sealing element. The first and second wall elements overlie an open area in the sealing member to form a chamber for holding cells for implantation. A sealed region is created between the wall elements and the sealing element body to close the chamber. In one arrangement, the sealed region is created by means of a sonic weld made while the implanted cells are present in the chamber. In another arrangement, the sealed region is created by means of applying an external force to compress the peripheral edges of the wall elements and the sealing element together while the implanted cells are present in the chamber.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: September 6, 1994
    Assignee: Baxter International Inc.
    Inventors: Robert A Clarke, Robin G. Pauley, Ronald S. Hill, James H. Brauker, Shmuel Sternberg, Daniel R. Boggs
  • Patent number: 5345395
    Abstract: A system uses a photometer that establishes an optical channel between a light emitter and a light detector. The photometer analyses a specimen while it occupies a well in a tray. A movable platform transports the tray to the optical channel for analysis and removes the tray from the optical channel after analysis. The system calibrates the movable platform to assure proper alignment between the specimen and the photometric apparatus used to analyzed the specimen. The system also calibrates the optical channel without use of an external reference.
    Type: Grant
    Filed: October 31, 1991
    Date of Patent: September 6, 1994
    Assignee: Baxter Diagnostics Inc.
    Inventor: Christopher D. Griner
  • Patent number: 5339831
    Abstract: A double pouch is described in which a smaller pouch is located within a larger pouch. The larger pouch can be used to accommodate a patient's leg or other appendage during a surgical procedure while the smaller pouch can be used to retain irrigation fluids and surgical debris. In the preferred embodiment, the smaller pouch can be moved to the outside of the larger pouch when the larger pouch is not intended to be used. In one embodiment, the pouches can be attached to a main drape having a fenestration through which a patient's appendage is inserted.
    Type: Grant
    Filed: January 30, 1992
    Date of Patent: August 23, 1994
    Assignee: Baxter International Inc.
    Inventor: Joseph F. Thompson
  • Patent number: 5336201
    Abstract: An apparatus 10 for driving a plunger 134 of a syringe 16 includes a plate 48 on the top 38 of a frame 36 and a structure 62 on the plate 48 for releasably attaching the cylinder 130 of the syringe 16 to the frame 36 and securing the cylinder 130 against lengthwise movement relative to the frame 36. A lever 76 is pivotably attached to the top 38 of the frame 36 a selected distance from the plate 48. A pair of pivot pins 108,110 releasably pivotably attach the distal end 150 of the plunger 134 of the syringe 16 to the lever 76. In this manner, pivotable movement of the lever 76 is translated into lengthwise movement of the plunger 134. An apparatus 10 for transferring a measured amount of fluid from a first fluid supply 14 to a fluid reservoir 170 includes a syringe 16, the syringe driving apparatus 12 and a two-way check valve 18. The fluid supply 14, the fluid reservoir 70 and the syringe 16 are maintained in fluid communication through the two-way check valve 18.
    Type: Grant
    Filed: June 29, 1992
    Date of Patent: August 9, 1994
    Assignee: Baxter International Inc.
    Inventor: Claus von der Decken
  • Patent number: 5334706
    Abstract: This invention provides a method to therapeutically increase perfusion in a mammal comprising administering stroma-free hemoglobin at a dose ranging from the least amount effective to increase perfusion, up to a dose of about 2500 mg per kilogram of body weight.
    Type: Grant
    Filed: January 30, 1992
    Date of Patent: August 2, 1994
    Assignee: Baxter International
    Inventor: Robert J. Przybelski
  • Patent number: 5331972
    Abstract: Novel bone-marrow biopsy, aspiration and transplant needles are described having several unique features. One unique feature is an offset handle which allows a user to use their index finger to guide a needle into a patient. Another unique feature is a cannula which has multiple cutting teeth that can be used to cut bone when the cannula is axially rotated. Yet another unique feature is a stylet with a highly effective cutting tip.
    Type: Grant
    Filed: December 3, 1992
    Date of Patent: July 26, 1994
    Assignee: Baxter International Inc.
    Inventors: Suresh Wadhwani, Greg Smith
  • Patent number: 5330464
    Abstract: A frangible seal for a fluid path including a frangible seal member secured within a tube defining the fluid path. The frangible seal member having a tubular seal member and a stem extending from the tubular seal member which, upon bending back and forth, breaks away from the seal member thereby to rupture the tubular seal in the fluid path. The tubular seal member and stem are integrally formed of a non-PVC material. The tubular seal member will bond to PVC tubing during steam heating thereof. The tubular seal member and stem are constructed to provide uniform non-reclosable rupturing. The stem includes vanes with spurs that frictionally engage the inner walls of the tube to maintain separation of the stem and ruptured tubular seal member.
    Type: Grant
    Filed: March 11, 1992
    Date of Patent: July 19, 1994
    Assignee: Baxter International Inc.
    Inventors: Jean-Marie Mathias, Jean-Claude Bernes, Ermenegildo Lavezzo, Jack Debrauwere
  • Patent number: 5324422
    Abstract: Systems for performing peritoneal dialysis allow the user to chose from an array of peritoneal dialysis modalities and adjust one or more individual therapy parameters within a selected modality. Still, the systems assure that the selected modality and therapy parameters satisfy preselected composite therapy criteria.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: June 28, 1994
    Assignee: Baxter International Inc.
    Inventors: Lisa Colleran, Rie Inoue, Mark Senninger
  • Patent number: 5322620
    Abstract: A system and method of separation of therapeutic components from blood. The system includes a dual member centrifuge and a disposable single use fluid transfer set. The set includes an elongated flexible separation chamber having an input port, a separated component output port and a residual fluid output port. The input port and the separated component output ports are located at opposite ends of the elongated separation chamber. The centrifuge includes a receiving chamber with a selectively formed annular slot therein. The separation chamber is positioned in the annularly shaped slot and rotated at a predetermined rotational velocity. Fluids such as whole blood flows through the separation chamber and are separated into various therapeutic components such as platelet rich plasma and residual concentrated red blood cells. Platelet rich plasma can be drawn off as the separated therapeutic component. An alternate two part transfer set provides for highly efficient platelet pheresis.
    Type: Grant
    Filed: August 21, 1991
    Date of Patent: June 21, 1994
    Assignee: Baxter International Inc.
    Inventors: Richard I. Brown, Sidney Smith, David E. Cerny, John T. Foley
  • Patent number: 5316666
    Abstract: Systems transmit a control signal between a rotating element and a stationary element of a blood separation centrifuge. The systems employ a sensor mechanism carried by one of the rotating and stationary elements. The sensor mechanism senses an operating condition that is subject to change. The sensor mechanism generates a first output signal that varies according to changes in the sensed operating condition. A first data transfer component on the one element that carries the sensor mechanism emits energy to the other element without mechanical contact with the other element. The first data transfer mechanism modulates the emitted energy according to variations occurring in the intensity of the first output signal. A second data transfer component on the other element receives the modulated energy emitted by the first data transfer component.
    Type: Grant
    Filed: August 19, 1993
    Date of Patent: May 31, 1994
    Assignee: Baxter International Inc.
    Inventors: Richard I. Brown, John T. Foley
  • Patent number: 5316667
    Abstract: A system for monitoring the interface region between cellular constituents and plasma in a blood separation chamber employs a sensor mechanism for emitting upon the interface region energy that is absorbed by the cellular constituents. The sensor mechanism also detects the intensity of the energy that is not absorbed by the interface region to generate an unabsorbed intensity output signal. The system moves the interface region relative to the sensor mechanism during a prescribed time period. A first circuit measures variations in the unabsorbed intensity output signal over the prescribed time period and generates a time based output. A second circuit can derive the physical size of the interface region based upon the time based output.
    Type: Grant
    Filed: August 19, 1993
    Date of Patent: May 31, 1994
    Assignee: Baxter International Inc.
    Inventors: Richard L. Brown, John T. Foley
  • Patent number: 5315887
    Abstract: A multiport equalization probe or needle includes an elongate body with a first and second end. The probe includes two or more lumens and an inlet and outlet for each lumen. It is closed at the first end which has a sharpened, conical configuration. Conduits provide separate connections between the lumens and a pump assembly which removes material through the lumens.
    Type: Grant
    Filed: September 9, 1991
    Date of Patent: May 31, 1994
    Assignee: Baxter Diagnostics Inc.
    Inventor: Robert G. Heitel
  • Patent number: 5316681
    Abstract: The present invention provides an improved method and container for filtering a body fluid. The method comprises the steps of isolating a volume of solution in a first chamber of a container; collecting a body fluid in a second chamber of a container; passing the body fluid through a filter; and rinsing the filter with an isolated volume of solution.
    Type: Grant
    Filed: November 6, 1992
    Date of Patent: May 31, 1994
    Assignee: Baxter International Inc.
    Inventor: Margaret Serres
  • Patent number: 5314421
    Abstract: A label for a blood pack comprising a microporous plastic film including a matrix of interconnected pores for allowing gas to flow into and out of the blood pack through a labeled area. The pores allow ink to be absorbed at least on an outer surface of the label allowing the label to be printed and/or written on. The labels of the present invention have breathability with respect to gas that is similar to paper. However, the label is more durable than a paper label in that it can tolerate moisture, abrasion, temperature extremes, dimensional changes, and the like. Accordingly, the labels do not crack or wrinkle as easily as paper labels.
    Type: Grant
    Filed: March 5, 1992
    Date of Patent: May 24, 1994
    Assignee: Baxter International Inc.
    Inventor: Mark Leuenberger
  • Patent number: 5314471
    Abstract: Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish a boundary between the host and the implanted cells. The boundary has a pore size, an ultimate strength, and a metabolic transit value that assures the survival of the cells during the critical ischemic period and afterward. The boundary allows the fabrication and clinical use of implant assemblies and methodologies that can carry enough cells to be of therapeutic value to the host, yet occupy a relatively small, compact area within the host.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: May 24, 1994
    Assignee: Baxter International Inc.
    Inventors: James H. Brauker, Ronald S. Hill, Laura A. Martinson, Daniel R. Boggs, Robert C. Johnson
  • Patent number: D350394
    Type: Grant
    Filed: March 16, 1992
    Date of Patent: September 6, 1994
    Assignee: Baxter International Inc.
    Inventor: Duane D. Kazal