Abstract: An oral pharmaceutical modified release multiple-units composition for the administration of an analgesically effective amount of an opoid. The composition comprises at least two fractions wherein individual units containing an opoid are coated with a sustained release coating. A first fraction is adapted to relatively fast release while a second fraction is adapted to a delayed release. Such compositions make possible to obtain both a relatively fast onset of the analgesic effect and the maintenance of analgesically active plasma concentration for a relatively long period of time. The invention further relates to a process for the preparation of a composition according to the invention.

Abstract: Disclosed are methods for producing recombinant cells and especially recombinant mammalian cell lines with enhanced expression of an amino acid sequence. Also disclosed are recombinant mammalian cell lines producing high levels of the amino acid sequence. The methods and recombinant cell lines of the invention have a number of useful applications including use in the efficient and large-scale production of recombinant proteins and polypeptides.

Abstract: The invention relates to a towing device for a golf trolley comprising longitudinal resilient linkage means. The linkage comprises a spring, a damper for the resilient portion, the remainder of the linkage being rigid, and means at one end of the linkage for pivotal attachment of the linkage to the bag-carrying part of the trolley. The towing device may be incorporated in the handle of a trolley or may be an accessory attachable to the trolley. The damper may comprise a piston-and-cylinder type damper which may contain air or other gas or oil or other hydraulic fluid. Embodiments using telescopic cylinders are also described. The extent of pivotal movement of the towing device relative to the bag-carrying part of the trolley is restricted by a flexible link or spring. The device may be attached to a belt or other item of clothing on the trunk of a user, and the trolley may have an auxiliary wheel fitted to the bottom of the bag-carrying part.

Abstract: The present invention features novel binding molecules and methods of improving the specific binding affinity of binding molecules, which methods do not use X-ray crystallography. For example, in one aspect, the invention features methods of making antibodies with improved specific binding affinity for a polypeptide produced during prothrombin activation. The present invention is useful for a variety of applications including, e.g., producing binding molecules with improved binding affinity; and screening for binding molecules which are in low abundance.

Abstract: A semiconductor package includes a lead frame having a die pad for a semiconductor chip to be mounted thereon. The die pad is surrounded by a plurality of leads for electrically connecting the semiconductor chip and has one opening formed to decrease the attaching area between the semiconductor chip and the die pad so as to prevent the occurrence of declamination. A base pad is provided to be coupled to the die pad in such a manner that the base pad is positioned underneath or above the die pad and has a bottom surface or a top surface to be exposed to the extension of a resin encapsulant for enclosing the semiconductor chip and a portion of the lead frame, allowing the base pad to serve as a heat dissipater for transferring heat of the semiconductor package to the ambient.

Abstract: A unit dose, gas-filled syringe is provided which is filled with gas and packaged in a gas barrier material prior to use to increase shelf-life, that is, to minimize gas leakage and dilution of the contents of the syringe. The syringe is filled with a selected gas and sealed inside a container made from a high gas barrier material. The container is also filled with the selected gas. The container material is selected to have a gas transmission rate sufficient to prevent the selected gas from diffusing out of the container into the atmosphere. The volume of gas in the container is greater that atmospheric pressure to prevent atmospheric contaminants from entering the container and syringe.

Abstract: Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.

Abstract: The invention includes new hull systems and watercraft. In particular, the invention provides a watercraft hull (10) that has a pivot axis (22) forward of the hull waterline fore-aft center line (24). That pivot axis (22) will be the deep water point of the hull and provides a fulcrum point around which the hull turns during a direction change. The forward pivot axis (22) surprisingly imparts high manoeuvrability (i.e. the ability to execute turns of reduced radius) relative to prior systems, even at low speeds.

Abstract: An integrated photoreceiver is provided. The photoreceiver includes a substrate, a metal-insulator-semiconductor switch (MISS) formed on a first portion of the substrate, and a photoreceiving structure formed on a second portion of the substrate for receiving a light signal and generating a current signal to trigger the MISS in response to said light signal.

Abstract: It is known that the human influenza virus strain A/Puerto Rico/8/34 grows particularly well in eggs and that reasserted viruses having it as a parent may also grow well in eggs. It has now been found that certain reassortants of A/PR/8/34 and equine influenza viruses, namely those which comprise the RNA7 segment from A/PR/8/34, will grow in cell culture, even though the parent equine influenza virus will not.Thus the specification describes and claims: reassorted viruses comprising genes for surface antigens of equine influenza viruses and the RNA7 segment from A/PR/8/34; methods of obtaining such viruses by reassortment; methods of propagating such reasserted viruses in cell culture, especially Vero cells; vaccines against equine influenza comprising such reassorted viruses; and methods of vaccinating equines against influenza.

Abstract: In a glass substrate and thin film combination, the glass substrate has a surface which is at least partially non-smooth, and the thin film is provided on the glass substrate in contact with the non-smooth part of the surface. Such a glass substrate and thin film combination is produced by forming a non-smooth part on at least a part of a surface of a glass substrate; and depositing a thin film on the glass substrate so as to be in contact with the non-smooth part.

Abstract: The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indolinyl and 5,6-dihydrophenanthridinyl compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.

Abstract: Tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune response. It has been determined that 5-lipoxygenase activity, oral availability, and stability in vivo (for example, glucuronidation rate) can vary significantly among the optical isomers of the disclosed compounds.

Abstract: The present invention relates to a pharmaceutical composition comprising anion exchange resin, silicon dioxide, crystalline cellulose, and pharmaceutically acceptable carriers and more particularly to tablets containing anion exchange resin prepared by mixing anion exchange resin, silicon dioxide and crystalline cellulose without adding water and tabletting the mixture. More preferably, the present invention relates to said pharmaceutical composition or tablets wherein the anion exchange resin is non-crosslinked anion exchange resin represented by the formula (I): ##STR1## wherein R.sub.1 is an aralkyl group having from 7 to 10 carbon atoms or An alkyl group having from 1-20 carbon atoms; R.sub.2 and R.sub.3 are each independently the same or different and represent a lower alkyl group having from 1-4 carbon atoms; R.sub.

Abstract: The invention relates to 5-(iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives thereof. The invention also relates to the use of such compounds for the treatment or prevention of neuronal loss in ischemia, hypoxia, brain or spinal chord trauma, as well as for the treatment of Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome.

Abstract: A container (1) for storage or transport of liquids comprises a flexible body (2) which is collapsible and erectable, the body having a base (18) and side walls (7, 8, 11, 12), with pockets (4) therein, and stiffining means (3) in the pockets to stiffen the flexible body (2), wherein a transverse gusset (6) is provided at each corner between adjacent side walls (7, 12, 8, 11), and a reinforcer (5) extends from the corner to the gusset, the reinforcer (5) being provided with stiffening means therein. A liner (not shown) conforms to the octogonal interior configuration of the container body. Two opposite side walls (7, 8) each have two center pockets (4c), and a central joint line (9) between the two center pockets (4c) provides a hinge line for folding of the container. Each side wall (7, 8, 11, 12), reinforcer (5) and gusset (6) may be formed of a single piece of fabric.

Abstract: The present invention provides therapeutically useful substituted guanidines and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.

Abstract: An optical tape including an optical recording layer for permitting information to be optically recorded thereon and a light-reflective magnetic layer. The light-reflective magnetic layer which reflects light projected onto the recording layer, also permits magnetic recording or magneto-optical recording to be performed thereon, thereby increasing a storage capacity of the optical tape remarkably. Further, the optical tape is provided with a layer to form guiding grooves for tracking control. The layer to form guiding grooves is made up of ultraviolet-hardening resin, photo-resist, or a photochromic material. For example, in the case of using ultraviolet-hardening resin, after a guiding groove pattern has been exposed by projecting an ultraviolet ray on a layer made up of ultraviolet-hardening resin, the exposed areas harden to form areas corresponding to guiding grooves between those exposed areas.

Abstract: A substance possessing physiological activity is coupled to a styrene-glycidyl methacrylate polymer through a spacer, and is used to isolate from a mixture a substance that can adhere to the substance possessing physiological activity. Preferably the polymer is in the form of a microsphere, the substance possessing physiological activity is 3-[(5-(2,3-dimethoxy-6-methyl-1,4-benzoquinonyl)]-2-nonyl-2-propionic acid or derivative thereof, and the spacer is an ethylene glycol diglycidyl ether derivative. The mixture may be a cell extract and the substance isolated a protein that is a receptor to the substance possessing physiological activity.

Abstract: The present invention provides a nitrogen-containing cyclic compound represented by the formula (1): ##STR1## wherein R.sup.1 represents an alkyl group; R represents a hydrogen atom or an alkyl group; X represents an oxygen or sulfur atom or NR.sup.3 ; Q.sup.1 represents a hydrogen atom, or an alkyl, cycloalkyl, alkenyl or alkynyl group or a phenyl, naphthyl or heterocyclic group etc.; Q.sup.2 represents an alkyl, cycloalkyl or alkenyl group, or a phenyl or thienyl group etc.; A.sup.1 represents a carbon or nitrogen atom; A.sup.2 represents CR.sup.2 or NR.sup.2, or an oxygen or sulfur atom, or SO or SO.sub.2 ; A.sup.3 represents a single bond, or an oxygen or sulfur atom, or CR.sup.5 or NR.sup.5) and a herbicide comprising the same, which herbicide exhibits very high herbicidal activity at very low application rate and has selectivity against crops.